Jennifer A. Muszynski, MD :: Nationwide Children's Hospital, Columbus, Ohio

Jennifer A. Muszynski, MD

Jennifer A. Muszynski, MD

Contact Information

Critical Care
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3435
FX: (614) 722-3443

Location Information for Patients

Main Campus

Biography

Jennifer A. Muszynski, MD, is a Critical Care physician at Nationwide Children's. She is an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Muszynski attended medical school at the University of Toledo and received her Bachelor of Science from the University of Dayton. She completed both her residency and pediatric critical care fellowship at Nationwide Children's. She is a member of the American Academy of Pediatrics, Alpha Omega Alpha Honor Medical Society and the Society of Critical Care Medicine. Dr. Muszynski is also a principle investigator at the Center for Clinical and Translational Research. Her research area of interest is the innate and adaptive immunobiology of pediatric critical illness, with special emphasis on the relationships between packed red blood cell transfusion and immune function.

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Innate and adaptive immunobiology of pediatric critical illness, with special emphasis on the relationships between packed red blood cell transfusion and immune function.

Education and Training

Medical School

  • Medical College of Ohio at Toledo
    Date Completed: 06/04/2004

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2007

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2011

Department:

  • Pediatrics

Section:

  • Critical Care

Specialty:

  • Pediatric Critical Care
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2007

Publications

  • Hall MW, Muszynski JA. 2015. Immune modulation and immunotherpay in critical illness. In Rogers Textbook of Pediatric Intensive Care. Edited by Nichols, DG. Baltimore, MD: Wolters Kluwer Health.
  • Muszynski JA, Bale J, Nateri J, Nicol K, Wang Y, Wright V, Marsh CB, Gavrilin MA, Sarkar A, Wewers MD, Hall MW. 2015. Supernatants from stored red blood cell (RBC) units, but not RBC-derived microvesicles suppress monocyte function in vitro.  Transfusion. Vol. 55, no. 8. (August): 1937-45.
  • Karam O, Demaret P, Shefler A, Leteurtre S, Spinella PC, Stanworth SJ, Tucci M; Canadian Critical Care Trials Group (CCCTG); Pediatric Acute Lung Injury and Sepsis Investigators (PALISI); BloodNet; PlasmaTV Investigators. 2015. Indications and Effects of Plasma Transfusions in Critically Ill Children.  American Journal of Respiratory and Critical Care Medicine. Vol. 191, no. 15. (June): 1395-402.
  • Muszynski JA; Frazier E; Nofziger R; Nateri J; Hanson-Huber L; Steele L; Nicol K; Spinella PC; Hall MW. 2015. Red blood cell transfusion and immune function in critically ill children: a prospective observational study.  TRANSFUSION. Vol. 55, no. 4. (April): 766-774.
  • Muszynski JA; Nofziger R; Greathouse K; Nateri J; Hanson-Huber L; Steele L; Nicol K; Groner JI; Besner GE; Raffel C; Geyer S; El-Assal O; Hall MW. 2014. Innate Immune Function Predicts the Development of Nosocomial Infection in Critically Injured Children.  Shock. Vol. 42, no. 4. (October): e313–321.
  • Muszynski, JA; Frazier, E; Nofziger, R; Nateri, J; Hanson-Huber, L; Steele, L; Nicol, K; Spinella, PC; Hall, M W. 2014. Red blood cell transfusion and immune function in critically ill children: a prospective observational study.  Transfusion. Vol. [Epub ahead of print], no. October: e..
  • Braun B, Anglim L, Steele L, Hanson-Huber L, Shafiek M, Ramillo O, Muszynski J, Hall MW. 2014. Plasma Biomarkers of Acute Bacterial Pneumonia in Critically Ill Children. In Pediatric Academic Societies Annual Meeting
  • Muszynski JA, Frazier WJ, Hall MW. 2014. Adjunctive and novel therapies for sepsis.  Journal of Pediatric Intensive Care. Vol. 3, no. 4. (January): 255-267.
  • Muszynski, JA; Nofziger, R; Greathouse, K; Steele, L; Hanson-Huber, L; Nateri, J; Hall, MW. 2014. Early adaptive immune suppression in children with septic shock: a prospective observational study.  Critical care. Vol. 18, no. 4. (January): eR145.
  • Muszynski JA, Frazier WJ, Hall MW. 2014. Pro-inflammatory and Anti-inflammatory Mediators in Critical Illness and Injury. In Pediatric Critical Care Medicine. 2nd ed. Edited by Wheeler DS, Shanley T, Wong H. London: Springer.
  • Suttle,Markita; Frazier,W,Joshua; Muszynski,Jennifer. 2013. Aggressive Fluid Resuscitation in Two Pediatric Patients with DKA and Shock. In 43rd Annual Critical Care Congress
  • Braun,Benjamin; Anglim,Larissa; Steele,Lisa; Hanson-Huber,Lisa; Shafiek,Mena; Ramilo,Octavio; Muszynski,Jennifer; Hall,Mark. 2013. Plasma Biomarkers of Acute Bacterial Pneumonia in Critically Ill Children. In 43rd Annual Critical Care Congress
  • Muszynski JA, Sartori J, Steele L, Frost R, Wang W, Khan N, Lee A, Lin A, Hall MW, Ayad O. 2013. Multidisciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the PICU.  Pediatric Critical Care Medicine. Vol. 14, no. 5. (June): 533-538.
  • Nofziger,Ryan; Muszynski,Jennifer; Nicol,Kathleen; Steele,Lisa; Greathouse,Kristin; Hanson,Lisa; Nateri,Jyotsna; Hall,Mark. 2012. LONGER PRBC STORAGE TIME IS ASSOCIATED WITH REDUCED INNATE IMMUNE FUNCTION IN TRANSFUSED CRITICALLY ILL PEDIATRIC TRAUMA PATIENTS. In 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Nofziger,Ryan; Muszynski,Jennifer; Nicol,Kathleen; Steele,Lisa; Greathouse,Kristin; Hanson,Lisa; Nateri,Jyotsna; Hall,Mark. 2012. LONGER PRBC STORAGE TIME IS ASSOCIATED WITH REDUCED INNATE IMMUNE FUNCTION IN TRANSFUSED CRITICALLY ILL PEDIATRIC TRAUMA PATIENTS. In 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer; Frazier,Elfaridah; Hanson,Lisa; Steele,Lisa; Greathouse,Kristin; Nicol,Kathleen; Spinella,Philip; Hall,Mark. 2012. RED BLOOD CELL (RBC) STORAGE TIME AND IMMUNE FUNCTION: A MULTI-CENTER, PEDIATRIC, IN VIVO STUDY. In 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer; Frazier,Elfaridah; Hanson,Lisa; Steele,Lisa; Greathouse,Kristin; Nicol,Kathleen; Spinella,Philip; Hall,Mark. 2012. RED BLOOD CELL (RBC) STORAGE TIME AND IMMUNE FUNCTION: A MULTI-CENTER, PEDIATRIC, IN VIVO STUDY. In 42nd Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Brockson ME, Muszynski JA, Censoplano N, Steele L, Mella C, Bakaletz LO, Hall MW. 2012. Time to appropriate antibiotic administration and outcomes in infants with viral bronchiolitis and secondary bacterial pneumonia. In Pediatric Academic Societies Annual Meeting
  • Muszynski,Jennifer; Nateri,Jyotsna; Nicol,Kathleen; Greathouse,Kristin; Hanson,Lisa; Hall,Mark. 2012. Immunosuppressive effects of red blood cells on monocytes are related to both storage time and storage solution.  Transfusion. Vol. 52, no. 4. (April): 794-802.
  • Muszynski, JA, Hall, MW. 2011. Sepsis-Induced Innate and Adaptive Immune Suppression.  The Open Inflammation Journal. Vol. 4, no. October: 67-73.
  • Mella C, Mejias A, Muszynski JA, Hall MW, Ramillo O. 2011. Shock and hemodynamic instability are frequent complications of severe respiratory syncytial virus (RSV) bronchiolitis. In Pediatric Academic Societies’ Annual Meeting
  • Muszynski JA, Knatz NL, Sargel CL, Fernandez SA, Marquardt DJ, Hall MW. Timing of correct parenteral antibiotic initiation and outcomes from severe bacterial community acquired pneumonia in children. Pediatric Infectious Disease Journal. 2011:30; 295-301. PubMed ID: 21030885
  • Muszynski JA, Knatz, N, Sargel, C, Fernandez, SA, Marquardt, DJ, Hall, MW. 2011. Timing of correct parenteral antibiotic initiation and outcomes from severe bacterial community-acquired pneumonia in children.  The Pediatric Infectious Disease Journal. Vol. 30, no. 4. (April): 295-301.
  • Keyes,Jeffrey; Muszynski,Jennifer; Hanson,Lisa; Hall,Mark. 2010. EFFECT OF BLOOD COLLECTION METHOD IN INNATE IMMUNE MEASUREMENTS IN NEONATES. In 40th Critical Care Congress
  • Muszynski,Jennifer; Greathouse,Kristin; Hanson,Lisa; Nateri,Jyotsna; Hall,Mark. 2010. REGULATORY T CELLS (TREG) AND ADAPTIVE IMMUNE FUNCTION IN PEDIATRIC SEPTIC SHOCK. In 40th Critical Care Congress
  • Greathouse,Kristin; Muszynski,Jennifer; Sargel,Cheryl; Hall,Mark. 2010. GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR (GM-CSF) AS ADJUVANT THERAPY FOR UNRESOLVING INFECTION IN CRITICALLY ILL CHILDREN. In 40th Critical Care Congress
  • Melia,Cesar; Mejias,Asuncion; Muszynski,Jennifer; Hall,Mark; Ramilo,Octavio. 2010. RELATIONSHIPS BETWEEN VIRAL PATHOGEN, BACTERIAL CO-INFECTION, AND OUTCOMES FROM BRONCHIOLITIS IN CRITICALLY ILL CHILDREN. In 40th Critical Care Congress
  • Keyes,Jeffrey; Muszynski,Jennifer; Hanson,Lisa; Hall,Mark. 2010. EFFECT OF BLOOD COLLECTION METHOD IN INNATE IMMUNE MEASUREMENTS IN NEONATES. In 40th Critical Care Congress
  • Muszynski,Jennifer; Greathouse,Kristin; Hanson,Lisa; Nateri,Jyotsna; Hall,Mark. 2010. REGULATORY T CELLS (TREG) AND ADAPTIVE IMMUNE FUNCTION IN PEDIATRIC SEPTIC SHOCK. In 40th Critical Care Congress
  • Muszynski,Jennifer; Greathouse,Kristin; Hanson,Lisa; Nateri,Jyotsna; Hall,Mark. 2010. REGULATORY T CELLS (TREG) AND ADAPTIVE IMMUNE FUNCTION IN PEDIATRIC SEPTIC SHOCK. In 40th Critical Care Congress
  • Greathouse,Kristin; Muszynski,Jennifer; Sargel,Cheryl; Hall,Mark. 2010. GRANULOCYTE MACROPHAGE-COLONY STIMULATING FACTOR (GM-CSF) AS ADJUVANT THERAPY FOR UNRESOLVING INFECTION IN CRITICALLY ILL CHILDREN. In 40th Critical Care Congress
  • Mella,Cesar; Mejias,Asuncion; Muszynski,Jennifer; Hall,Mark; Ramilo,Octavio. 2010. RELATIONSHIPS BETWEEN VIRAL PATHOGEN, BACTERIAL CO-INFECTION, AND OUTCOMES FROM BRONCHIOLITIS IN CRITICALLY ILL CHILDREN. In 40th Critical Care Congress
  • Muszynski,Jennifer; Nateri,Jyotsna; Nicol,Kathleen; Hall,Mark. 2009. EFFECT OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON MONOCYTE MRNA EXPRESSION. In 39th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer; Nateri,Jyotsna; Nicol,Kathleen; Hall,Mark. 2009. EFFECT OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON MONOCYTE MRNA EXPRESSION. In 39th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer; Nateri,Jyotsna; Nicol,Kathleen; Hall,Mark. 2009. EFFECT OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON MONOCYTE MRNA EXPRESSION. In 39th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hall, MW; Muszynski, JA. 2009. Immune modulation in sepsis.  Journal of Pediatric Infectious Diseases. Vol. 4, no. 2. (April): 127-136.
  • Hall MW, Muszynski JA. 2009. Immune modulation in sepsis.  Journal of Pediatric Infectious Diseases. Vol. 4, no. 2. (January): 127-136.
  • Muszynski,Jennifer,A; Nateri,Jyotsna; Nicol,Kathleen,K; Hall,Mark,W. 2008. EFFECTS OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON EX VIVO MONOCYTE FUNCTION. In 38th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Nateri,Jyotsna; Nicol,Kathleen,K; Hall,Mark,W. 2008. EFFECTS OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON EX VIVO MONOCYTE FUNCTION. In 38th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Nateri,Jyotsna; Nicol,Kathleen,K; Hall,Mark,W. 2008. EFFECTS OF PACKED RED BLOOD CELL (PRBC) PRESERVATIVE AND STORAGE TIME ON EX VIVO MONOCYTE FUNCTION. In 38th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hall,Mark,W; Nateri,Jyotsna; Muszynski,Jennifer,A; Wewers,Mark,D. 2007. Monocyte pyrin protein in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Wewers,Mark,D; Nateri,Jyotsna; Hall,Mark,W. 2007. Lymphocyte FOXP3 MRNA expression and innate immune function in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Wewers,Mark,D; Nateri,Jyotsna; Hall,Mark,W. 2007. Lymphocyte FOXP3 MRNA expression and innate immune function in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Wewers,Mark,D; Nateri,Jyotsna; Hall,Mark,W. 2007. Lymphocyte FOXP3 MRNA expression and innate immune function in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hall,Mark,W; Nateri,Jyotsna; Muszynski,Jennifer,A; Wewers,Mark,D. 2007. Monocyte pyrin protein in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Sargel,Cheryl,L; Knatz,Nina,L; Marquardt,David,J; Hall,Mark,W. 2007. Shorter time to correct IV antibiotics is associated with improved outcomes in pediatric severe community acquired pneumonia (CAP). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hoffman,Timothy,M; Muszynski,Jennifer,A; Marquardt,David,J; Yares,Andrew,R; Frazier,Warren,J; Hall,Mark,W. 2007. Increased pulsatility of thyroid stimulating hormone (TSH) release is associated with immunodepression acutely after pediatric cardiopulmonary bypass (CPB). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hall,Mark,W; Nateri,Jyotsna; Muszynski,Jennifer,A; Wewers,Mark,D. 2007. Monocyte pyrin protein in septic children. In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hoffman,Timothy,M; Muszynski,Jennifer,A; Marquardt,David,J; Yates,Andrew,R; Frazier,Warren,J; Hall,Mark,W. 2007. Increased pulsatility of thyroid stimulating hormone (TSH) release is associated with immunodepression acutely after pediatric cardiopulmonary bypass (CPB). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Sargel,Cheryl,L; Knatz,Nina,L; Marquardt,David,J; Hall,Mark,W. 2007. Shorter time to correct IV antibiotics is associated with improved outcomes in pediatric severe community acquired pneumonia (CAP). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Hoffman,Timothy,M; Muszynski,Jennifer,A; Marquardt,David,J; Yares,Andrew,R; Frazier,Warren,J; Hall,Mark,W. 2007. Increased pulsatility of thyroid stimulating hormone (TSH) release is associated with immunodepression acutely after pediatric cardiopulmonary bypass (CPB). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski,Jennifer,A; Sargel,Cheryl,L; Knatz,Nina,L; Marquardt,David,J; Hall,Mark,W. 2007. Shorter time to correct IV antibiotics is associated with improved outcomes in pediatric severe community acquired pneumonia (CAP). In 37th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • David J. Marquardt, W.J. Frazier, Andrew R. Yates, Jennifer A. Muszynski, Timothy M. Hoffman, Mark W. Hall. 2007. Anterior Pituitary (AP) Function Acutely Following Cardiopulmonary Bypass (CPB) in Children. In Pediatric Academic Societies' Annual Meeting
  • Knatz NL, Sargel CL, Muszynski JA, Marquardt DJ, Hall MW. 2007. Empiric antibiotic therapy and outcomes from severe community acquired bacterial pneumonia. In Pediatric Academic Societies’ Annual Meeting
  • Marquardt,David,J; Frazier,W,J; Hall,Mark,W; Yates,Andrew,R; Hoffman,Timothy,M; Muszynski,Jennifer,A. 2006. Anterior pituitary (AP) function acutely following cardiopulmonary bypass (CPB) in children. In 36th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Marquardt,David,J; Frazier,W,J; Hall,Mark,W; Yates,Andrew,R; Hoffman,Timothy,M; Muszynski,Jennifer,A. 2006. Anterior pituitary (AP) function acutely following cardiopulmonary bypass (CPB) in children. In 36th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Marquardt,David,J; Frazier,W,J; Hall,Mark,W; Yates,Andrew,R; Hoffman,Timothy,M; Muszynski,Jennifer,A. 2006. Anterior pituitary (AP) function acutely following cardiopulmonary bypass (CPB) in children. In 36th Critical Care Congress of the Society-of-Critical-Care-Medicine
  • Muszynski JA, Sartori J, Steele L, Frost R, Wang W, Khan N, Lee A, Lin A, Hall MW, Ayad O. A multi-disciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the pediatric intensive care unit.  Pediatric Critical Care Medicine.
  • Hall MW, Muszynski JA. Immune modulation in sepsis. Journal of Pediatric Infectious Diseases. 2009: 4; 127-136.
  • Greathouse K, Frazier WJ, Muszynski JA. Adaptive Immune Function. In Pediatric Critical Care. Edited by Fuhrman B, Zimmerman J.
  • Muszynski JA, Sartori J, Steele L, Frost R, Wang W, Khan N, Lee A, Lin A, Hall MW, Ayad O. A multi-disciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the pediatric intensive care unit.  Pediatric Critical Care Medicine.

Awards, Honors and Organizations

  • Clinical Research Award, 2010 Pediatric Critical Care Colloquium
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000