Alex J. Bishop, DPhil
Contact Information
Alexander J. R. Bishop, DPhil, is Director of the Center for Childhood Cancer Research at Nationwide Children’s Hospital, the Richard J. Solove Endowed Chair in Cancer Clinical Developmental Therapeutics, and Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Bishop is a molecular geneticist and cancer biologist whose research has been guided by a fundamental question: how does a cell recognize that it has been damaged, and how does it respond?
Over more than 25 years, his research has approached this question from multiple perspectives, beginning with studies of DNA damage response and repair, homologous recombination, and inherited cancer predisposition syndromes, and more recently extending to transcriptional and metabolic stress in Ewing sarcoma, triple-negative breast cancer, and ataxia telangiectasia. His research is question-driven, drawing on the experimental systems and technologies best suited to understand the underlying biology. This approach has led his laboratory to integrate molecular and cell biology with functional genetic screening, genomics, multi-omic and computational approaches, and preclinical models to uncover mechanisms of cellular stress responses and identify therapeutic vulnerabilities.
As Director of the Center for Childhood Cancer Research, Dr. Bishop leads a multidisciplinary research community spanning fundamental discovery through translational pediatric oncology, with an emphasis on collaboration, scientific innovation, and training the next generation of cancer researchers.
- Richard J. Solove Endowed Chair in Cancer Clinical Developmental Therapeutics, Nationwide Children’s Hospital, 2025
- Cell Systems and Anatomy Award for Excellence in Graduate Student Education, UT Health San Antonio, 2024
- Mays Cancer Center Discovery of the Year, Mays Cancer Center, 2018
- UT System Shine Academy, University of Texas System, 2017
- Presidential Teaching Excellence Award, UT Health San Antonio, 2015
- Academy of Master Teachers, UT Health San Antonio, 2015
- Board Member and Impact Committee Member, CancerFree KIDS, 2025 - Present
- Medical Advisor, Rutledge Cancer Foundation, 2023 - Present
- Member, Children’s Oncology Group Bone Cancer Steering Committee, 2020 - Present
- Associate Member, Children’s Oncology Group, 2011 - Present
- Member, Children’s Oncology Group Ewing Sarcoma Biology Committee, 2011 - Present
- Member, American Association for Cancer Research, 2010 - Present
| Graduate School | University of Oxford | Date Completed: |
|---|---|---|
| Post Doctoral | Harvard University | Date Completed: |
| Post Doctoral | HARVARD MEDICAL SCHOOL | Date Completed: |
2025 - Present Nationwide Children's Hospital, Center for Childhood Cancer Research, Director and Principal Investigator
2025 - Present The Ohio State University, Department of Pediatrics, Professor
2021 - 2025 UT Health San Antonio, Department of Cell Systems and Anatomy, Professor
2004 - 2025 UT Health San Antonio, Greehey Children’s Cancer Research Institute, Principal Investigator
National Cancer Institute
Dysregulated Transcription Processes in Ewing Sarcoma Institution, Principal Investigator
Investigates how dysregulated transcription in Ewing sarcoma alters RNA polymerase II activity, R-loop biology and DNA damage responses, and how these changes create therapeutic vulnerabilities.
National Institute of General Medical Sciences
An Integrated Biochemical and Structural Approach to Delineating the Biology of EWSR1, Co-Investigator
Defines the structure-function relationships of EWSR1 and the molecular mechanisms through which this intrinsically disordered protein regulates cellular processes relevant to Ewing sarcoma.
Jeff Gordon Children’s Foundation
PARP Inhibition and Ferroptosis Targeting in Ewing Sarcoma Institution, Principal Investigator
Evaluates the therapeutic efficacy of combining PARP inhibitors with ferroptosis-inducing agents to target Ewing sarcoma in preclinical models.
Stand Up To Cancer/Cancer Research UK Pediatric Cancer New Discoveries Challenge
Targeting R-loop Stability in Ewing Sarcoma Institution, Principal Investigator
Investigated mechanisms regulating R-loop stability in Ewing sarcoma and their potential exploitation as therapeutic vulnerabilities.