Posted by: Natalie I. Rine, PharmD, BCPS, BCCCP on Jun 26, 2026


The Benadryl Challenge has been on social media since 2020 but has recently become popular again. The challenge involves taking multiple, large doses of diphenhydramine (also known as Benadryl) to induce hallucinations.

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Pediatric News You Can Use From America’s Largest Pediatric Hospital and Research Center

700 Children’s® features the most current pediatric health care information and research from our pediatric experts – physicians and specialists who have seen it all. Many of them are parents and bring a special understanding to what our patients and families experience. If you have a child – or care for a child – 700 Children’s was created especially for you.

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