Role of Urothelium in Epithelial Integrity and Innate Defense of the Kidney
- K08 DK 102594 (Michael “Brian” Becknell) 06/2015 – 05/31/2020
- NIH-NIDDK $661,430.00
Nuclear Receptor and MAP Kinase Signaling in Podocyte Injury (R01)
- R01 DK095059-01-A1 (William E. Smoyer) 07/1/2013 - 08/24/2018
- NIH-NIDDK $218,941
The goal of this project is to define specific molecular signaling pathways able to regulate podocyte injury in NS to develop more targeted and less toxic therapies for NS. The objective is to determine the ability of the glucocorticoid receptor (GR), peroxisome proliferator-activated receptor g (PPARg), and MAPK signaling pathways to regulate podocyte injury, and to exploit this knowledge to develop more effective novel therapies for NS.