Zongdi Feng, PhD

Nationwide Children's Hospital Medical Professional

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Dr. Zongdi Feng became an Assistant Professor of Pediatrics at the Ohio State University and a member of the Center for Vaccines and Immunity at Nationwide Children’s Hospital Research Institute in 2014. Dr. Feng received his Ph.D. from the University of Illinois in 2008 and undertook post-doctoral training on the immune responses and pathogenesis associated with hepatitis viruses with Dr. Stan Lemon at the Lineberger Comprehensive Cancer Center at UNC-Chapel Hill.

Dr. Feng’s research mainly focuses on the life cycle and pathogenesis of hepatitis viruses. Previous studies by Dr. Feng have shown that hepatitis A virus (traditionally thought to be nonenveloped) hijacks host membranes to evade antibody response and facilitate its spread (Nature. 496: 367-71). A similar phenomenon exists for hepatitis E virus (Trends Microbiol. 22:59-64), an emerging agent that causes high mortality (up to 28%) in pregnant women and often develops into persistent infection in immunosuppressed individuals. These novel “quasi-enveloped” viruses create a new paradigm in virology and provide novel insights into immunity and vaccination strategies. Projects are focused on understanding how these “quasi-enveloped” viruses (1) structurally differ from their nonenveloped counterparts, (2) enter and exit the cells, (3) become neutralized by antibodies, and (4) interact with “non-permissive” cells.

Academic and Clinical Areas
Awards, Honors & Organizations
  • Recipient, Lineberger Comprehensive Cancer Center Joseph S. Pagano Award, University of North Carolina, Chapel Hill, NC, 2014
  • Best Poster Award, Center of Gastrointestinal Biology and Disease Annual Retreat, UNC, Chapel Hill, 2013
  • 3rd Place, 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum, UNC, Chapel Hill, 2013
  • Travel Award, 31st American Society of Virology Annual Meeting, Madison, WI, 2012
  • Travel Award, American Association for the Study of Liver Diseases (AASLD), 2009
  • Di'ao Graduate Fellowship, Chinese Academy of Sciences, China Practice, 2001
  • Member, American Society of Virology, 2012 - Present
  • Member, American Society of Microbiology, 2008 - Present
Professional Experience

2014 - Present Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Research Principal Investigator

2014 - Present Department of Pediatrics, The Ohio State University, Assistant Professor

2013 - 2014 Lineberger Comprehensive Cancer Center, University of North Carolina (Chapel Hill, NC), Research Associate

2010 - 2013 Lineberger Comprehensive Cancer Center, University of North Carolina (Chapel Hill, NC), Postdoctoral Research Associate

2008 - 2010 Galveston National Laboratory, Department of Microbiology and Immunology, University of Texas Medical Branch, Postdoctoral Fellow

2003 - 2008 Department of Microbiology and Immunology, University of Illinois, Graduate Research Assistant

2000 - 2002 Wuhan Institute of Virology, Chinese Academy of Sciences, Graduate Research Assistant

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Center for Vaccines and Immunity