Interests
- Autoinflammatory Diseases
- Childhood Vasculitis
- Scleroderma
- Vaccination in children with rheumatic diseases
My research interests include childhood vasculitis, scleroderma and vaccination in children with rheumatic diseases. I am the site PI for PedVas, an international Registry for Childhood Vasculitis. I played a key role in the development of standardized treatments for ANCA-associated vasculitis and the American College of Rheumatology 2022 Vaccination guidelines.
I was a co-author in a report of Rel-A- associated autoinflammatory disease in a large family with Behcet’s-like disease. We have established a global registry to study this condition further.
As Clinical Lead for QI, I have multiple publications describing our work improving pneumococcal vaccination, mental health screening, teratogenic medication counseling and outcomes in children with rheumatic diseases such as Juvenile Idiopathic Arthritis and Systemic Lupus Erythematosus.
Publications
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Nourse E, Sivaraman V, Chung CG, Akoghlanian S, Faith EF. Dermatologic Findings of RELA-Associated Autoinflammatory Disease. Pediatr Dermatol. 2026 Jul-Aug; 43: 925-928.
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Cabral DA, Bosman ES, McPhate N, Mann SK, Toor KK, Morishita KA, Luqmani R, Beresford MW, Bistolarides J, Campillo S, Charuvanij S, Cook K, Dancey P, de Guzman M, Deepak S, Eberhard B, Elder M, Gagne S, Harrison K, Huber A, Khan A, Kim S, Klein-Gitelman MS, Lee TC, Li SC, Martin N, McErlane F, Moorthy LN, Orjuela AH, Park J, Riley P, Rosenberg AM, Shenoi S, Sivaraman V, Sutnga S, Tanner T, Tarvin SE, Twilt M, Wagner-Weiner L, Yeung RSM, Brown KL, ARChiVe Investigators Network within the PedVas Initiative. Effective Performance of the 2022 American College of Rheumatology/EULAR Classification Criteria for Antineutrophil Cytoplasmic Antibody-Associated Vasculitis in Pediatric Patients: An ARChiVe Study. Arthritis Rheumatol. 2026 Apr 9;
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Valente Soto S, Ardoin SP, Goldstein-Leever A, Harper L, Akoghlanian S, Driest K, Sivaraman V, Taxter AJ. Anxiety in childhood onset lupus: Longitudinal anxiety symptom screening. Lupus. 2026 Apr; 35: 490-499.
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Brittain A, Ardura MI, Brundrett M, Sivaraman V. Challenges in the Diagnosis of Systemic Lupus Erythematosus in an Adolescent With Sexually Transmitted Infections: A Case Report and Review of the Literature. Cureus. 2026 Jan; 18: e101611.
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De Souza R, Rutstein B, Schletzbaum-Bowler M, Singer N, Kohlheim M, Del Gaizo V, Wise K, Nikahd M, Brock GN, Sadun R, Ardura MI, Bekenstein MH, Sivaraman V, For the CARRA Investigators and the CARRA Vaccination Workgroup (WG). Variability in vaccination practices in children with rheumatic diseases: results of a childhood arthritis and rheumatology research alliance (CARRA)-wide survey. Pediatr Rheumatol Online J. 2026 Jan 31; 24:
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Toor KK, Chen A, Cabral DA, Mammen C, Bosman ES, Shen Y, Bone JN, Noone D, Al-Abadi E, Benseler S, Berard R, Bohm M, Charuvanij S, Cook K, Dancey P, Deepak S, Duffy C, Eberhard B, Elder M, Foell D, Gerstbacher D, Heshin-Bekenstein M, Huber A, James KE, Kim S, Klein-Gitelman M, Martin N, McErlane F, Moorthy LN, Myrup C, Riley P, Shenoi S, Sivaraman V, Tanner T, Tarvin S, Wagner-Weiner L, Yeung RSM, Brown KL, Morishita KA, PedVas Investigator's Network. Evaluating renal disease in pediatric-onset anti-neutrophil cytoplasmic antibody-associated vasculitis: disease course, outcomes, and predictors of outcome. Arthritis Rheumatol. 2024 Dec 3;
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Gagne SJ, Sivaraman V, Bosman ES, Klamer B, Morishita KA, Huber A, Orjuela A, Eberhard B, Myrup C, Gerstbacher D, Foell D, Al-Abadi E, McErlane F, Cook K, Wagner-Weiner L, Elder M, Moorthy LN, Dancey P, Yeung R, Khubchandani R, Deepak S, Charuvanij S, Tarvin S, Shenoi S, Tanner T, Brown K, Cabral DA, ARChiVe Investigators Network within the PedVas Initiative. Comparing Rituximab and Cyclophosphamide in Induction Therapy for Childhood-Onset ANCA-Associated Vasculitis: An ARChiVe registry-cohort study. Arthritis Care Res (Hoboken). 2024 Oct 28;
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Barbar-Smiley FA, Yildirim-Toruner C, Akoghlanian S, AlAhmed O, Ardoin SP, Leone A, Oberle E, Sivaraman V. Improving lupus care index documentation in patients with childhood-onset systemic lupus erythematosus. Front Pediatr. 2024; 12: 1428644.
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Harper L, Ardoin SP, Leever A, Driest K, Sivaraman V, Taxter AJ. Automated mental health screening in pediatric lupus: associations with disease features and treatment. Front Pediatr. 2024; 12: 1427543.
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Argraves M, Murray E, Taxter A, Wise K, Jensen PT, Goldstein-Leever A, Thomas B, Scott A, Gallup J, Leone A, Ardoin SP, Sivaraman V. Implementation of an automated transition readiness assessment in a pediatric rheumatology clinic. Front Pediatr. 2024; 12: 1457651.
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Li SC, Rabinovich CE, Becker ML, Torok KS, Ferguson PJ, Dedeoglu F, Hong S, Sivaraman V, Laxer RM, Stewart K, Ibarra MF, Mason T 2nd, Higgins G, Pope E, Li X, Lozy T, Fuhlbrigge RC, CARRA Registry Investigators. Capturing the Range of Disease Involvement in Localized Scleroderma: The Localized scleroderma Total Severity Scale (LoTSS). Arthritis Care Res (Hoboken). 2023 Dec 26;
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Goldstein-Leever A, Bearer C, Sivaraman V, Akoghlanian S, Gallup J, Ardoin S. Increasing access to psychological services within pediatric rheumatology care. Pediatr Rheumatol Online J. 2023 Jun 2; 21: 51.
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Stubbs LA, Ferry AM, Guffey D, Loccke C, Wade EM, Pour P, Ardalan K, Chira P, Ganske IM, Glaser D, Higgins G, Luca N, Moore KF, Sivaraman V, Stewart K, Vasquez-Canizares N, Hunt RD, Maricevich RS, Torok KS, Li SC, Childhood Arthritis, Rheumatology Research Alliance (CARRA) Scleroderma Workgroup. Barriers to care in juvenile localized and systemic scleroderma: an exploratory survey study of caregivers' perspectives. Pediatr Rheumatol Online J. 2023 Apr 25; 21: 39.
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Mruk VM, Wise KA, Driest K, Oberle EJ, Ardoin SP, Yildirim-Toruner C, Sivaraman V, Stevens J, McGinnis A, Gallup J, Mitchell B, Lemle S, Jones S, Maher J, Berlan ED, Barbar-Smiley F. Preventing Teen Pregnancies on Teratogenic Drugs by Quality Improvement and Behavioral Economics. Pediatrics. 2023 Jan 1; 151:
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Bass AR, Chakravarty E, Akl EA, Bingham CO, Calabrese L, Cappelli LC, Johnson SR, Imundo LF, Winthrop KL, Arasaratnam RJ, Baden LR, Berard R, Bridges SL Jr, Cheah JTL, Curtis JR, Ferguson PJ, Hakkarinen I, Onel KB, Schultz G, Sivaraman V, Smith BJ, Sparks JA, Vogel TP, Williams EA, Calabrese C, Cunha JS, Fontanarosa J, Gillispie-Taylor MC, Gkrouzman E, Iyer P, Lakin KS, Legge A, Lo MS, Lockwood MM, Sadun RE, Singh N, Sullivan N, Tam H, Turgunbaev M, Turner AS, Reston J. 2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases. Arthritis Care Res (Hoboken). 2023 Jan 4;
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Bass AR, Chakravarty E, Akl EA, Bingham CO, Calabrese L, Cappelli LC, Johnson SR, Imundo LF, Winthrop KL, Arasaratnam RJ, Baden LR, Berard R, Bridges SL Jr, Cheah JTL, Curtis JR, Ferguson PJ, Hakkarinen I, Onel KB, Schultz G, Sivaraman V, Smith BJ, Sparks JA, Vogel TP, Williams EA, Calabrese C, Cunha JS, Fontanarosa J, Gillispie-Taylor MC, Gkrouzman E, Iyer P, Lakin KS, Legge A, Lo MS, Lockwood MM, Sadun RE, Singh N, Sullivan N, Tam H, Turgunbaev M, Turner AS, Reston J. 2022 American College of Rheumatology Guideline for Vaccinations in Patients With Rheumatic and Musculoskeletal Diseases. Arthritis Rheumatol. 2023 Jan 4;
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Lloyd AR, Ardura MI, Wise K, Chavarin DJ, Boyle B, Sivaraman V. Barriers to vaccination in immunocompromised children: A needs assessment in children with childhood-onset SLE and inflammatory bowel disease. Front Pediatr. 2023; 11: 1103096.
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Gagne S, Sivaraman V, Akoghlanian S. Interferonopathies masquerading as non-Mendelian autoimmune diseases: pattern recognition for early diagnosis. Front Pediatr. 2023; 11: 1169638.
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Zhou D, King EH, Rothwell S, Krystufkova O, Notarnicola A, Coss S, Abdul-Aziz R, Miller KE, Dang A, Yu GR, Drew J, Lundström E, Pachman LM, Mamyrova G, Curiel RV, De Paepe B, De Bleecker JL, Payton A, Ollier W, O'Hanlon TP, Targoff IN, Flegel WA, Sivaraman V, Oberle E, Akoghlanian S, Driest K, Spencer CH, Wu YL, Nagaraja HN, Ardoin SP, Chinoy H, Rider LG, Miller FW, Lundberg IE, Padyukov L, Vencovský J, Lamb JA, Yu CY, for MYOGEN Investigators.. Low copy numbers of complement C4 and C4A deficiency are risk factors for myositis, its subgroups and autoantibodies. Ann Rheum Dis. 2022 Sep 28;
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Lemus R, Milks K, Stilphen C, Barson W, Sivaraman V. When All Is Not as It Seems: Recurrent Fever and New-onset Joint Pain in a 17-Month-old Girl. Pediatr Infect Dis J. 2022 Aug 1; 41: 681-682.
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Lecerf K, Koboldt DC, Kuehn HS, Jayaraman V, Lee K, Mihalic Mosher T, Yonkof JR, Mori M, Hickey SE, Franklin S, Drew J, Akoghlanian S, Sivaraman V, Rosenzweig SD, Wilson RK, Abraham RS. Case Report And Review Of The Literature: Immune Dysregulation In A Large Familial Cohort Due To A Novel Pathogenic RELA Variant. Rheumatology (Oxford). 2022 Apr 12;
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Chen A, Mammen C, Guzman J, Al-Abadi E, Benseler SM, Berard RA, Gerstbacher D, Heshin-Bekenstein M, Kim S, Klein-Gitelman M, Chavan PP, James KE, Martin N, McErlane F, Myrup C, Noone DG, Raghuram J, Shenoi S, Sivaraman V, Tanner T, Yeung RSM, Cabral DA, Morishita KA, for ARChiVe Investigators within the PedVas Initiative.. Wide variation in glucocorticoid dosing in paediatric ANCA-associated vasculitis with renal disease: a paediatric vasculitis initiative study. Clin Exp Rheumatol. 2022 Apr 1;
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Mulvihill E, Furru R, Goldstein-Leever A, Driest K, Lemle S, MacDonald D, Frost E, Sivaraman V. Targeted provider education and pre-visit planning increase rates of formal depression screening in childhood-onset SLE. Pediatr Rheumatol Online J. 2021 Aug 3; 19: 116.
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Morishita KA, Wagner-Weiner L, Yen EY, Sivaraman V, James KE, Gerstbacher D, Szymanski AM, O'Neil KM, Cabral DA, CARRA ANCA-Associated Vasculitis Workgroup.. Consensus Treatment Plans for Severe Pediatric Antineutrophil Cytoplasmic Antibody-Associated Vasculitis. Arthritis Care Res (Hoboken). 2021 Mar 6;
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AlAhmed O, Way A, Akoghlanian S, Barbar-Smiley F, Lemle S, MacDonald D, Frost E, Wise K, Lee L, Ardoin SP, Sivaraman V. Improving eye screening practice among pediatric rheumatology patients receiving hydroxychloroquine. Lupus. 2021 Feb; 30: 269-279.
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