Santiago Partida-Sanchez, PhD

My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells.

We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

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Santiago Partida-Sanchez, PhD is a principal investigator in the Center for Microbe and Immunity Research at the Abigail Wexner Research Institute at Nationwide Children’s Hospital. He is an associate professor of Pediatrics at The Ohio State University College of Medicine. Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells. Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.