John S. Gunn, PhD, is a principal investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital. He is also a professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. Gunn is an associate director of the Ohio State Infectious Diseases Institute and the faculty director of the Biomedical Science Major.
Dr. Gunn received his undergraduate degree from Bowling Green State University and obtained his PhD from The University of Maryland. His postdoctoral studies were performed at Harvard Medical School and The University of Washington. The research program of the Gunn Lab studies host-microbe interactions in the gram-negative pathogens Salmonella and Francisella that lead to both acute and chronic disease. Their primary focus is determining the molecular mechanisms underlying chronic carriage of Salmonella Typhi in the gallbladder, which is mediated by biofilm formation on gallstones. Typhoid fever, caused by S. Typhi, is a global disease that disproportionally affects children.
- Nominated, Distinguished Undergraduate Research Mentor of the Year, The Ohio State University, 2016
- Elected, Fellow, American Academy of Microbiology, 2016
- CMIB Outstanding Senior Faculty Mentor Award, The Ohio State University, 2014
- Nominated, College of Medicine Distinguished Educator Award, The Ohio State University
- Editorial Board Member, Critical Reviews in Microbiology
- Member, American Society for Microbiology, 1988 - Present
- Member, International Endotoxin Society, 1988 - Present
- Member, American Gastroenterological Association, 1988 - Present
- Member, American Heart Association, 1988 - Present
Date of Appointment at Nationwide Children’s Hospital: 11/01/2018
|Graduate School||University of Maryland||Date Completed: 05/01/1993|
|Undergraduate School||Bowling Green State University||Date Completed: 05/01/1988|
2018 - Present The Research Institute at Nationwide Children's Hospital, Principal Investigator
2018 - Present The Ohio State University College of Medicine, Professor
2017 - Present Infectious Diseases Institute, The Ohio State University, Associate Director
2010 - Present The Ohio State University, Director, Biomedical Science Major
2017 - 2018 The Ohio State University, Interim Chair, Department of Microbial Infection and Immunity
Mechanisms of the development and maintenance of Salmonella gallbladder carriage, Principal Investigator
The goal of this project is to determine both the host (gallbladder) and bacterial responses that allow carriage to develop and persist. This work will also further develop novel therapeutic interventions to prevent the development/maintenance of S. Typhi gallbladder carriage
Virulence regulation of small RNAs in Francisella, Principal Investigator
We examine the function of sRNAs in Francisella in regard to the regulation of virulence, and perform experiments to discover sRNAs and genes involved in intramacrophage survival (both host and bacterial genes/sRNAs/miRNAs).