Ben Stanton, PhD, is a principal investigator in the Center for Childhood Cancer & Blood Diseases (CCCBD) at the Abigail Wexner Research Institute at Nationwide Children’s Hospital, and assistant professor at The Ohio State University College of Medicine. Ben received his PhD from Harvard University, and Postdoctoral training at Stanford University School of Medicine and NIH. His group studies chromatin activation and epigenetic repression at the systems level, to gain insight into genome architecture in childhood cancers. He is motivated to understand the essential roles of chromatin regulatory complexes in low mutational burden tumors. For studies in the lab, interdisciplinary approaches are developed to ask (1) how aberrant chromatin repression can drive human disease, (2) why chromatin remodeling is under positive selection in certain pediatric tumors, and (3) whether new methods can enable insights into chromatin deregulation. Ben is excited about mentoring next-generation of scientist and for fundamental insights that enable translational advances.
Gryder BE, Wu L, Woldemichael GM, Pomella S, Quinn TR, Park PMC, Cleveland A, Stanton BZ, Song Y, Rota R, Wiest O, Yohe ME, Shern JF, Qi J, Khan J. Chemical genomics reveals histone deacetylases are required for core regulatory transcription. Nat Commun. 2019 Jul 8; 10: 3004.
Lai B, Tang Q, Jin W, Hu G, Wangsa D, Cui K, Stanton BZ, Ren G, Ding Y, Zhao M, Liu S, Song J, Ried T, Zhao K. Trac-looping measures genome structure and chromatin accessibility. Nat Methods. 2018 Sep; 15: 741-747.
Stanton BZ, Chory EJ, Crabtree GR. Chemically induced proximity in biology and medicine. Science. 2018 Mar 9; 359:
Hodges HC, Stanton BZ, Cermakova K, Chang CY, Miller EL, Kirkland JG, Ku WL, Veverka V, Zhao K, Crabtree GR. Dominant-negative SMARCA4 mutants alter the accessibility landscape of tissue-unrestricted enhancers. Nat Struct Mol Biol. 2018 Jan; 25: 61-72.
Stanton BZ, Hodges C, Crabtree GR, Zhao K. A General Non-Radioactive ATPase Assay for Chromatin Remodeling Complexes. Curr Protoc Chem Biol. 2017 Mar 2; 9: 1-10.
Stanton BZ, Hodges C, Calarco JP, Braun SM, Ku WL, Kadoch C, Zhao K, Crabtree GR. Smarca4 ATPase mutations disrupt direct eviction of PRC1 from chromatin. Nat Genet. 2017 Feb; 49: 282-288.