David R. Brigstock, PhD

• Center for Clinical and Translational Research
  Principal Investigator
• Brigstock Lab
  Principal Investigator
• Perinatal Surgery Fellowship
  Faculty

• Editorial Board Member, Journal of Cell Communication and Signaling
• USA Editor, Journal of Endocrinology
• Scientific Committee Vice Chair, The International CCN Society

We are studying the role of connective tissue growth factor (CTGF) in fibrotic diseases, which are characterized by excessive production and deposition of insoluble collagen matrix, resulting in loss of tissue structure and organ dysfunction. Our main research efforts are currently focussed on liver and pancreatic fibrosis but we have collaborative efforts that focus on other organ systems such as the lung, intestine, heart and skin. Using molecular, cellular and biochemical approches, both in vitro and in vivo, our goals are to understand the mechanisms by which CTGF stimulates collagen production by fibrogenic cells types. In this manner, we will determine the therapeutic value of targetting pathways of CTGF biosynthesis or action to treat a variety of fibrotic disorders.

Publications

2008 - Present Division of Pediatric Surgery, The Ohio State University College of Medicine, Professor of Surgery

1993 - Present Molecular, Cellular, and Developmental Biology Program, The Ohio State University, Member

1991 - Present The Research Institute at Nationwide Children's Hospital, Principal Investigator

1991 - Present Pediatric Surgery Research Laboratory, Ohio State University College of Medicine, Director

1997 - 2008 Division of Pediatric Surgery, The Ohio State University College of Medicine, Associate Professor of Surgery

1991 - 1997 Division of Pediatric Surgery, The Ohio State University College of Medicine, Assistant Professor of Surgery

1988 - 1991 Department of Surgery, Harvard Medical School and Children's Hospital (Boston, MA), Post-doctoral Research Fellow

1984 - 1988 Institute of Animal Physiology and Cambridge University, Graduate Student