Asthma Clinical Trials :: Nationwide Children's Hospital

Asthma Clinical Trials

Clinical researchers at Nationwide Children's are committed to identifying new approaches for the prevention, diagnosis and treatment of asthma, taking research discoveries from the lab to the patient's bedside.

Trials Currently Enrolling Participants: Browse asthma-related research studies currently enrolling at Nationwide Children’s

An Overview: Asthma-Related Clinical Trials at Nationwide Children's

SOYA Study
Scientists have made observations suggesting that diets rich in soy-based proteins provide some protection for individuals with asthma.  SOYA, as the study is named, focuses on difficult to control asthma comparing an oral soy supplement to placebo.  Monitoring includes lung function, asthma control day count and quality of life.  Our focus as the pediatric site for Asthma Clinical Research Center, ALA supported grant OSU-based study are those aged 12 and older.

STAN Study
We are examining the effect of using nasal steroids on asthma symptoms in a project titled the Study of Asthma and Nasal Steroids (STAN) is also supported by Asthma Clinical Research Center, ALA supported grant.  Like SOYA, we are the pediatric site for an OSU-based grant.  Patients with difficult to control asthma will be recruited and treated with either nasal steroids or placebo to determine if nasal steroids can significantly stabilize asthma symptoms.  Our target population is 6 years and older. 

STAN and SOYA Database
Participants in STAN and SOYA are also recruited to participate in a large database to determine if certain biomarkers are related to a better response to asthma treatments.  This type of knowledge helps us to select the best medical treatments for individual asthma patients and avoid less effective medical strategies.

Asthma-Related Education in Primary Care
In general, it is difficult to improve asthma care as new interventions come available and as guidelines change.  This is particularly true among private practitioners. In a program that spanned about three years, we approached private practices to allow us to supply an on-site asthma coordinator.  This effort was intended to improve asthma-related education among primary care colleagues.  During this program we had "active" (intervention) and "placebo" (observation) practices.  Midway through the program, the active and placebo practices crossed over.  We saw major improvements during the time the coordinator was there and for six months after the study period, in both groups.  These results were presented this fall at the European Respiratory Society in Amsterdam and a publication is now in preparation for submission.

Pre-Screening African American Children for Asthma
Several years ago, an unfortunate asthma-related death occurred in a young African American athlete in Columbus, OH.  As a result of this death, the community asked for a pre-season asthma screening. A team screened nearly 1,300 youth.  Alarmingly, 45 to 50 percent of these youth screened positively for asthma.  We know that hospitalizations and deaths among African Americans are significantly higher, but the prevalence of asthma in children is usually estimated at 9 to 10 percent. 

When we reviewed these alarming results, it was not clear if this was a fluke or related to social economic factors.  To follow up, Nationwide Children's pulmonologist Dr. Shahid Sheikh approached a suburban private school and an urban church, all exclusively African American.  The rate of positives among the children based upon questionnaire and pulmonary function testing was again about 50 percent in both settings. 

These findings indicate that even closer scrutiny for African American children is indicated and that every effort should be made to eliminate barriers to health care and improve education regarding symptoms, risks and treatments.

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