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Patient-Derived Embryonic Stem Cells Help Deliver Good Genes in a Model of Inherited Blood Disorder
Researchers at Nationwide Children’s Hospital report a gene therapy strategy that improves the condition of a mouse model of an inherited blood disorder, Beta Thalassemia. The gene correction involves using unfertilized eggs from afflicted mice to produce a batch of embryonic stem cell lines.
News
Nationwide Childrens Hospital Joins Statewide Health Information Exchange
Nationwide Children’s Hospital is the first hospital in Central Ohio to join the new statewide health information exchange (HIE) that will allow sharing of patient health information among medical professionals across the state.
News
The Torch Relay for Childrens Miracle Network Hospitals Comes Through Columbus
Columbus residents will join upwards of 10,000 participants from 22 cities for an 11th annual coast-to-coast event: The Torch Relay for Children’s Miracle Network Hospitals, a charity that raises funds for children’s hospitals. The Columbus event will take place on Sunday, Oct.
News
Nationwide Children’s Becomes Certified Site for CAR-T Cell Therapy
Nationwide Children’s Hospital has been designated a certified treatment center for the FDA-approved Novartis CAR-T cell therapy Kymriah™ (tisagenlecleucel) and can now offer the therapy to patients.
News
Investigators Develop Technique to Effectively Edit NK Cells to Target Specific Cancer Cells
Originally, NK cells seemed promising for a natural therapy to fight cancer due to their innate ability to recognize any cells expressing stress or signs of infection. But investigators quickly realized they faced three key challenges: first, it was difficult to grow a large enough number of NK cells in the lab to offer useful infusions at a reasonable cost; second, an ideal universal donor solution was needed to make NK cell products faster, more reliably and with off-the-shelf availability; and third, NK cells were resistant to genetic modifications that might help them better target specific types of cancer cells. Nationwide Children’s Hospital investigators and their collaborators painstakingly solved the first two problems over the past decade. Now, they’ve conquered the third.
News
Justice Stores Third Annual National Fundraising Campaign to Benefit Nationwide Childrens Hospital Begins Feb. 26
For the third-consecutive year, tween retailer Justice (an Ascena Retail Group, Inc. company) will launch a national fundraising effort in their stores to benefit Nationwide Children’s Hospital. The “Give Hope” campaign will begin Feb.
News
Oligodendrocytes Induce Motor Neuron Death in ALS
A first-of-its-kind oligodendrocyte in vitro model shows that human cells normally supportive of motor neuron function play an active role in amyotrophic lateral sclerosis pathogenesis – and this discovery may point the way toward therapeutic timing and targets.
News
Christina and Ryan Day Encourage Students to Take a “Day Time Break” for Mental Health as Part of On Our Sleeves Movement
Christina and Ryan Day are partnering with the On Our Sleeves™ movement to launch an interactive school-based program to help break stigmas, start important conversations and improve mental health awareness for students in more than 200 middle and high schools in Franklin and surrounding counties.
News
Jaimie D. Nathan, MD, Achieves Surgical Milestone: 100th TPIAT Procedure
Nationwide Children’s Hospital congratulates Jaimie D. Nathan, MD, on a significant milestone in an advanced procedure known as a total pancreatectomy with islet autotransplantation (TPIAT). Dr. Nathan performed his 100th TPIAT on September 19, 2023.
Blog
Scleroderma: What Parents Need to Know
Each person’s skin is unique, so scleroderma looks different for every patient. A child or young adult may start out with a small area of affected skin that changes in texture. Some people describe the skin as becoming tighter, firmer, more stretched, or thickened. The affected area may lighten, darken, or develop a red border.