Eosinophilic Esophagitis (EoE) Clinic

The Eosinophilic Esophagitis (EoE) Clinic at Nationwide Children’s Hospital provides expert diagnosis and care to children and adolescents with EoE. The multidisciplinary team at Nationwide Children’s combines a wide range of specialties to provide state-of-the-art care for the unique needs of children of all ages diagnosed with EoE.

US News Badge Gastroenterology

Nationwide Children's Hospital is ranked by U.S. News & World Report for Gastroenterology and GI Surgery.

What is Eosinophilic Esophagitis?

White blood cells are an important part of a healthy immune system, helping to fight off disease and infection. In some individuals, however, white blood cells can attack harmless substances that enter the body, including certain foods. This can cause inflammation and other allergy symptoms.

Eosinophilic esophagitis (EoE) is a chronic (long-term) allergic condition in which large numbers of eosinophils, a type of white blood cell, build up inside the esophagus and cause inflammation. EoE can occur anywhere between the mouth and the entrance to the stomach.

EoE is part of a group of diseases known as eosinophilic gastrointestinal (GI) disorders. Although these conditions are rare, EoE is the most common type.

Meet our Team

The EoE Clinic at Nationwide Children’s relies on a multidisciplinary team to provide expertise for eosinophilic esophagitis. Our team includes: 

  • Allergy and Immunology, which offers diagnosis, consultations, and treatment of allergic diseases, including those that may accompany EoE
  • Gastroenterology, Hepatology & Nutrition, which provides comprehensive patient care for a broad range of gastrointestinal and nutritional problems
  • Social work, which provides advocacy and emotional support to families and patients and helps link them to community resources, and works with families to identify and address barriers to wellness
  • Clinical Nutrition, which includes registered dieticians who provide consultation, assessment, and education to help aid patient nutrition, growth, and development
  • GI Psychology, which offers mental health care for patients with various GI disorders

Meet Our Team

Diagnosis & Treatment of EoE

EoE can affect children of all ages, but it is most often found in adolescents. Symptoms may differ depending on a child’s age. For example, young children may have feeding issues or failure to thrive. Adolescents are more likely to experience trouble swallowing or food getting stuck in the esophagus.

Symptoms that may indicate EoOE include:

  • Feeding issues
  • Difficulty swallowing, also known as dysphagia
  • Failure to thrive
  • Weight loss
  • Heartburn or chest pain
  • Abdominal pain
  • Food getting stuck in the throat
  • Vomiting or regurgitation

Untreated EoE can cause further complications, including scarring and narrowing of the esophagus. This can make symptoms worse and interfere with eating and nutrition.

EoE can be difficult to diagnose based only on symptoms. If a child’s symptoms suggest EoE, the pediatrician will refer you to a GI specialist.  Ann endoscopy is performed to help  make the diagnosis.

During an endoscopy, the patient is placed under full sedation. The physician inserts a camera attached to a long, thin tube into the mouth and throat. This allows the physician to get a closer look at the esophagus for signs of inflammation or injury. The physician may also perform biopsies by removing small samples of tissue from the esophagus. The samples are sent to a lab for study under a microscope.

There is currently no cure for EoE, but the condition can be treated to help control symptoms and prevent further damage and potential scarring to the esophagus.

Treatment and management for EoOE usually include:

  • Elimination diet to remove dietary triggers
  • Medications, such as proton pump inhibitors and steroids
  • Dilation of the esophagus (the patient’s esophagus is so narrow that food gets stuck, requiring stretching of the esophagus)

Any approach to managing EoE must be tailored to each family’s unique needs. Patients should be monitored regularly to determine the effects of any dietary changes or medication.

Transnasal Endoscopy (TNE) for Monitoring EoE

Nationwide Children’s offers transnasal endoscopy (TNE), a type of endoscopy that can be used for monitoring patients with EoE. TNE is only used after confirming an EoE diagnosis with traditional endoscopy.

TNE is an outpatient procedure in which the endoscope is inserted through the nose rather than the mouth. This method does not require sedation and can be completed faster than traditional endoscopy. This reduces the amount of time that patients spend in the hospital and the need for repeat sedation. Nationwide Children’s is one of only a few pediatric centers that currently offer TNE. This option will be available soon for children aged 8 years and older.

Meet Our Patients

DeMari's Story

Read DeMari's Story

Name: DeMari M.
Condition(s): Eosinophilic Esophagitis
Age Today: 11 Years

When DeMari was a baby she had constant trouble swallowing and would choke and gag on liquids and solids. It got to the point that she wouldn't eat. After multiple tests her family was told that DeMari had Eosinophilic Esophagitis.

Madeleine S

Read Madeleine's Story

Name: Madeleine S.
Condition(s): Allergic Inflammation, Eosinophilic Esophagitis
Age Today: 13 Years

Madeleine was born 10 weeks prematurely. The vomiting began as soon as she started eating, but she remained happy and growing. When she was 8 months old, the vomiting became worse. In fact, she started to avoid movement because it made her throw up.

What Research Is Being Done on EOE?

Experts at Nationwide Children’s are working to contribute to the scientific knowledge and discussion of EoE and other eosinophilic GI disorders. Here are a few of our publications: