New Guidelines for Nausea, Stomach Pain and Other Problems Help Physicians Better Diagnose, Treat Kids

May 31, 2016
A child feels nauseated all the time, but no medical test can find what is wrong. Or a child vomits regularly, but there’s no illness or eating disorder to explain it. These, and other stomach and bowel-related problems with no obvious causes, are called functional gastrointestinal disorders.
Because there are no clear causes, diagnosis and treatment can be difficult for these disorders, which also include irritable bowel syndrome and functional constipation. The disorders may even be unintentionally dismissed by parents or doctors as not existing at all. However, international guidelines about the disorders, developed with leadership from Nationwide Children’s Hospital, aim to make diagnosis and treatment easier.
The guidelines, called the Rome IV criteria, are the fourth version of the criteria produced by the international Rome Foundation. The criteria cover all age groups. The six-person committee that developed the criteria for children and adolescents was chaired by Carlo Di Lorenzo, MD, chief of Gastroenterology, Hepatology and Nutrition at Nationwide Children’s. Miguel Saps, MD, director of research for the Motility Center at Nationwide Children's, was also one of the international committee members.
“I compare these disorders to headaches,” Dr. Di Lorenzo said. “If you have a headache, it doesn’t mean you have a brain tumor or meningitis. In the same way, people may have a bellyache, but they don’t have a blockage or an ulcer. They still are experiencing pain, though, and it is still affecting their lives, sometimes drastically.”
The guidelines allow physicians to more accurately diagnose and treat the following disorders, which affect an estimated 30-40% of children worldwide: 
  • Cyclic vomiting syndrome
  • Functional nausea and functional vomiting
  • Rumination syndrome
  • Aerophagia
  • Functional dyspepsia
  • Irritable bowel syndrome
  • Abdominal migraine
  • Functional abdominal pain – not otherwise specified
  • Functional constipation
  • Nonretentive fecal incontinence
Currently, functional constipation alone is experienced by 10-15% of all children and costs the health system more than $3 billion dollars a year. Experts say that’s just one reason faster and more accurate diagnoses could be a game-changer.
Past guidelines may have led doctors to order a battery of tests to rule out every possible disease before arriving at a functional GI disorder diagnosis, according to Dr. Di Lorenzo. That can be exasperating for patients, and add to anxiety they are already experiencing. The new criteria make clear that a diagnosis can be made without exhaustive tests.
“The patient’s history and a physical exam are key in making the diagnosis,” said Desale Yacob, MD, a gastroenterologist at Nationwide Children’s who treats functional GI disorders. “As we should with every patient who comes to see us, we need to listen to the history presented by the patient and the parents. This is not something that the child is imagining. These are real symptoms that impact the child’s life. They should be taken seriously and addressed promptly.”
While causes aren’t always obvious, the last decade of research has shed new light on factors that can lead to functional GI disorders. Physicians say there is a strong link between stress, depression and other psychological issues and the disorders – part of what they call the “brain-gut connection.” Medications can be effective for some disorders, but so can non-medical treatment options such as acupuncture, massage therapy, counseling and relaxation exercises.
“We are treating the whole person, not just the GI tract or a single organ,” said Dr. Di Lorenzo, who is also a professor of Clinical Pediatrics at The Ohio State University College of Medicine. “We work closely with psychologists, nutritionists, therapists and others to help the child get better.”   
A summary of the pediatric criteria was published this month in the journal Gastroenterology, with Dr. Di Lorenzo as co-lead author. A forthcoming book, Rome IV Pediatric Functional Gastrointestinal Disorders – Disorders of Gut-Brain Interaction, co-edited by Dr. Di Lorenzo, explores the criteria in depth.
Caroline Schueren is examined by Dr. Desale Yacob at Nationwide Children`s Hospital. Schueren was diagnosed with Rumination Syndrome - See more at:
Caroline Schueren is examined by Dr. Desale Yacob at Nationwide Children`s Hospital. Caroline was diagnosed with a functional gastrointestinal disorder called rumination syndrome.

About Nationwide Children's Hospital

Named to the Top 10 Honor Roll on U.S. News & World Report’s 2019-20 list of “Best Children’s Hospitals,” Nationwide Children’s Hospital is one of America’s largest not-for-profit freestanding pediatric health care systems providing wellness, preventive, diagnostic, treatment and rehabilitative care for infants, children and adolescents, as well as adult patients with congenital disease. Nationwide Children’s has a staff of more than 13,000 providing state-of-the-art pediatric care during more than 1.5 million patient visits annually. As home to the Department of Pediatrics of The Ohio State University College of Medicine, Nationwide Children’s physicians train the next generation of pediatricians and pediatric specialists. The Abigail Wexner Research Institute at Nationwide Children’s Hospital is one of the Top 10 National Institutes of Health-funded freestanding pediatric research facilities. More information is available at