Lauren O. Bakaletz, PhD
Contact Information
- Call us at: (614)722-2915
- Fax us at: (614)722-2818
-
The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, OH 43205 (map)
Biography
Lauren O. Bakaletz, PhD, is a principal investigator in and the director of the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital. She is a professor in the Departments of Pediatrics and of Otolaryngology at The Ohio State University College of Medicine. The research program of the Bakaletz Lab is focused on determining the molecular mechanisms that underlie polymicrobial infections of the respiratory tract, with a primary emphasis on otitis media or middle ear infections, a highly prevalent pediatric disease worldwide.
Academic and Clinical Areas
-
Center for Microbial Pathogenesis
Director -
The Research Institute
Vice President -
Infectious Diseases Fellowship
Faculty -
Primary Section
Center for Microbial Pathogenesis
Awards, Honors & Organizations
- College of Medicine Distinguished Professor, The Ohio State University, 2013 - Present
- Director, Executive Committee, International Society for Otitis Media (ISOM), 2012 - Present
- National Deafness and Other Communication Disorders Advisory Council, National Institutes of Health, 2010 - 2014
- Editorial Board, Infection and Immunity, 2008 - 2016
- Tillie E. Coleman Endowed Chair in Pediatric Research, Nationwide Children's Hospital, 2006 - Present
Research
The Bakaletz Lab's research focus is attempting to understand the pathogenic mechanisms operational in the highly prevalent pediatric disease, otitis media (OM) (or middle ear infection). Specifically, we are interested in elucidating how upper respiratory tract viruses predispose the middle ear to invasion by any of the three predominant bacterial pathogens of OM (nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae). We are also interested in understanding how bacterial biofilms contribute to the recurrence and chronicity of OM, chronic rhinosinusitis, bronchitis, chronic cough and exacerbations of both COPD and CF. With this enhanced understanding, we then attempt to identify potential molecular targets for the design, development and pre-clinical testing of novel vaccine candidates or therapeutics using an animal model of viral-bacterial superinfection that closely mimics the polymicrobial nature of OM in children. Our long-term goal is to develop novel methods to more effectively treat or preferably, to prevent, otitis media and other respiratory tract infections where there is a biofilm component to the disease course.
Publications
- Freire M, Young A, Devaraj A, Downey JS, Navarro J, Chen C, Bakaletz LO, Zadeh H, Goodman SD. 2017. A bacterial biofilm induced oral osteolytic infection can be successfully treated by immuno-targeting an extracellular nucleoid associated protein. Mol Oral Microbiol. Vol. 32, no. 1. (February): 74-88.
- Navarro JB, Mashburn-Warren L, Bakaletz LO, Goodman SD. 2017. Enhanced probiotic potential of Lactobacillus reuteri when delivered as a biofilm on dextranomer microspheres that contain beneficial cargo. Front Microbiol. Vol. 8, no. March: e489.
- Novotny LA, Clements JD, Goodman SD, Bakaletz LO. 2017. Transcutaneous immunization with a bandaid prevents experimental otitis media in a polymicrobial model. Clin Vaccine Immunol. Vol. 24, no. 6. (April): doi: 10.1128/CVI.00563-16.
- Pettigrew MM, Alderson MR, Bakaletz LO, Barenkamp SJ, Hakansson AP, Mason KM, Nokso-Koivisto J, Patel J, Pelton SI, Murphy TF. 2017. Panel 6: Vaccines. Otolaryngol Head Neck Surg. Vol. 156, no. 4_supp. (April): S76-S87.
- Rocco CJ, Davey ME, Bakaletz LO, Goodman SD. 2017. Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics. Mol Oral Microbiol. Vol. 32, no. 2. (April): 118-130.
- 2017. Natural antigenic differences in the functionally equivalent extracellular DNABII proteins of bacterial biofilms provide a means for targeted biofilm therapeutics. Molecular oral microbiology. Vol. 32, no. 2. (April 1).
- Bakaletz LO. 2017. Viral-bacterial co-infection in the respiratory tract. Curr Opin Microbiol. Vol. 35, no. February 1: 30-35-30-35.
- Bakaletz LO. 2017. Viral-bacterial co-infection in the respiratory tract. Curr Opin Microbiol. Vol. 35, no. February: 30-35.
- Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz, LO. 2016. ModA2 phasevarion wwitching in nontypeable Haemophilus influenzae increases the severity of experimental otitis media. J Infect Dis. Vol. 214, no. 5. (September 1): 817-824-817-824.
- Brockman KL, Jurcisek JA, Atack JM, Srikhanta YN, Jennings MP, Bakaletz, LO. 2016. ModA2 phasevarion wwitching in nontypeable Haemophilus influenzae increases the severity of experimental otitis media. J Infect Dis. Vol. 214, no. 5. (September): 817-824.
- Dagan R, Pelton SI, Bakaletz LO, Cohen R. 2016. Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease. Lancet Infect Dis. Vol. 16, no. April 1: 480-492-480-492.
- Dagan R, Pelton SI, Bakaletz LO, Cohen R. 2016. Prevention of early episodes of otitis media by pneumococcal vaccines might reduce progression to complex disease. Lancet Infect Dis. Vol. 16, no. April: 480-492.
- Gunn JS, Bakaletz LO, Wozniak DJ. 2016. What is on the outside matters: the role of the extracellular polymeric substance of Gram-negative biofilms in evading host immunity and as a target for therapeutic intervention. J Biol Chem. Vol. 291, no. 24. (June): 12538-12546.
- Idicula W, Jurcisek JA, Cass ND, Syed A, Goodman SD, Elmaraghy CA, Jatana K, Bakaletz LO. 2016. Identification of biofilms in post-tympanostomy tube otorrhea. Laryngoscope. Vol. 126, no. 8. (January 1): 1946-1951-1946-1951.
- Idicula W, Jurcisek JA, Cass ND, Syed A, Goodman SD, Elmaraghy CA, Jatana K, Bakaletz LO. 2016. Identification of biofilms in post-tympanostomy tube otorrhea. Laryngoscope. Vol. 126, no. 8. (January): 1946-1951.
- Mokrzan EM, Ward MO Jr, Bakaletz LO. 2016. Type IV pilus expression is upregulated in nontypeable Haemophilus influenzae biofilms formed at the temperature of the human nasopharynx. J Bacteriol. Vol. 198, no. 19. (April 1): 2169-2630-2169-2630.
- Mokrzan EM, Ward MO Jr, Bakaletz LO. 2016. Type IV pilus expression is upregulated in nontypeable Haemophilus influenzae biofilms formed at the temperature of the human nasopharynx. J Bacteriol. Vol. 198, no. 19. (April): 2169-2630.
- Novotny LA, Bakaletz LO. 2016. Intercellular adhesion molecule 1 serves as a primary cognate receptor for the type IV pilus of nontypeable Haemophilus influenzae. Cell Microbiol. Vol. 18, no. 8. (February 1): 1043-1055-1043-1055.
- Novotny LA, Bakaletz LO. 2016. Intercellular adhesion molecule 1 serves as a primary cognate receptor for the type IV pilus of nontypeable Haemophilus influenzae. Cell Microbiol. Vol. 18, no. 8. (February): 1043-1055.
- Novotny LA, Jurcisek JA, Goodman SD, Bakaletz LO. 2016. Monoclonal antibodies against the DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo. eBioMedicine. Vol. 10, no. August: 33-44.
- Shimoyama M, Smith JR, DePons J, Tutaj M, Khampang P, Hong W, Erbe C, Ehrlich G, Bakaletz LO, Kerschner J. 2016. Next-gen chinchilla – resource for an otolaryngology disease model. Database. Vol. doi: 10.1093/database/baw073, no. May: edoi: 10.1093/database/baw073.
- 2016. A Bacterial Biofilm Induced Oral Osteolytic Infection Can be Successfully Treated by Immuno-Targeting an Extracellular Nucleoid Associated Protein. Molecular oral microbiology.
- 2016. Monoclonal antibodies against DNA-binding tips of DNABII proteins disrupt biofilms in vitro and induce bacterial clearance in vivo. EBioMedicine. Vol. 10, no. August 1.
- 2016. The Chinchilla Research Resource Database: resource for an otolaryngology disease model. Database : the journal of biological databases and curation. Vol. 2016, no. January 1.
- 2016. What's on the Outside Matters: The Role of the Extracellular Polymeric Substance of Gram-negative Biofilms in Evading Host Immunity and as a Target for Therapeutic Intervention. JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 291, no. 24. (June 10).
- Cho C, Chande A, Gakhar L, Bakaletz LO, Jurcisek JA, Ketterer M., Shao J, Gotoh K, Hunt J, O'Brien E, Apicella MA. 2015. Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms. Infect Immun. Vol. 83, no. 3. (March): 950-957.
- Devaraj A, Justice SS, Bakaletz LO, Goodman SD. 2015. DNABII proteins play a central role in UPEC biofilm structure. Mol Microbiol. Vol. 96, no. 6. (June 1): 1119-1135-1119-1135.
- Devaraj A, Justice SS, Bakaletz LO, Goodman SD. 2015. DNABII proteins play a central role in UPEC biofilm structure. Mol Microbiol. Vol. 96, no. 6. (June): 1119-1135.
- Novotny LA, Clements JD, Bakaletz LO. 2015. Therapeutic transcutaneous immunization with a bandaid vaccine resolves experimental otitis media. Clin Vaccine Immunol. Vol. 22, no. 8. (May 1): 867-874-867-874.
- Novotny LA, Clements JD, Bakaletz LO. 2015. Therapeutic transcutaneous immunization with a bandaid vaccine resolves experimental otitis media. Clin Vaccine Immunol. Vol. 22, no. 8. (May): 867-874.
- Novotny LA, Jurcisek JA, Ward MO, Jordan ZB, Goodman SD, Bakaletz LO. 2015. Antibodies against the majority subunit of type IV pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media. Mol Microbiol. Vol. 96, no. 2. (April): 276-292.
- 2015. A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in non-typeable Haemophilus influenzae. NATURE COMMUNICATIONS. Vol. 6, no. July 1.
- 2015. Antibodies against the majority subunit of type IV Pili disperse nontypeable Haemophilus influenzae biofilms in a LuxS-dependent manner and confer therapeutic resolution of experimental otitis media. Molecular microbiology. Vol. 96, no. 2. (April 1).
- 2015. Role of the nuclease of nontypeable Haemophilus influenzae in dispersal of organisms from biofilms. Infection and immunity. Vol. 83, no. 3. (March 1).
- Atack JM, Srikhanta YN, Fox KL, Jurcisek JA, Clark TA, Boitano M, Power PM, Jen FEC, McEwan AG, Grimmond SM, Smith AL, Barenkamp SJ, Korlach J, Bakaletz LO, Jennings MP. 2015. A biphasic epigenetic switch controls immunoevasion, virulence and niche adaptation in nontypeable Haemophilus influenzae. Nat Commun. Vol. 6, no. July: e7828.
- Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP. 2015. Selection and counterselection of Hia expression reveals a key role for phase-variable expression of Hia in infection caused by nontypeable Haemophilus influenzae. J Infect Dis. Vol. 212, no. 4. (February 1): 645-653-645-653.
- Atack JM, Winter LE, Jurcisek JA, Bakaletz LO, Barenkamp SJ, Jennings MP. 2015. Selection and counterselection of Hia expression reveals a key role for phase-variable expression of Hia in infection caused by nontypeable Haemophilus influenzae. J Infect Dis. Vol. 212, no. 4. (February): 645-653.
- Blakeway LV, Power PM, Jen FE-C, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL. 2014. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media. FASEB J. Vol. 28, no. 12. (December 1): 5197-5207-5197-5207.
- Blakeway LV, Power PM, Jen FE-C, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL. 2014. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media. FASEB J. Vol. 28, no. 12. (December): 5197-5207.
- Blakeway LV, Power PM, Jen FEC, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL. 2014. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media. FASEB J. Vol. 28, no. 12. (December 1): 5197-5207-5197-5207.
- Blakeway LV, Power PM, Jen FEC, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL. 2014. ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media. FASEB J. Vol. 28, no. 12. (December): 5197-5207.
- Brockson ME, Novotny LA, Mokrzan EM, Malhotra S, Jurcisek JA, Akbar R, Devaraj A, Goodman SD, Bakaletz LO. 2014. Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms. Mol Microbiol. Vol. 93, no. 6. (September): 1246-1258.
- Das S, Rosas LE, Jurcisek JA, Novotny LA, Bakaletz LO. 2014. Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis. Laryngoscope. Vol. 124, no. 3. (March): 605-615.
- Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP. 2014. Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients. PLoS One. Vol. 9, no. 2. (February 1): e90505-e90505.
- Fox KL, Atack JM, Srikhanta YN, Eckert A, Novotny LA, Bakaletz LO, Jennings MP. 2014. Selection for Phase Variation of LOS Biosynthetic Genes Frequently Occurs in Progression of Non-Typeable Haemophilus influenzae Infection from the Nasopharynx to the Middle Ear of Human Patients. PLoS One. Vol. 9, no. 2. (February): ee90505.
- Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO. 2014. Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone Children. PLoS One. Vol. 9, no. 5. (May 1): e98269-e98269.
- Jones EA, Kananurak A, Bevins CL, Hollox EJ, Bakaletz LO. 2014. Copy Number Variation of the Beta Defensin Gene Cluster on Chromosome 8p Influences the Bacterial Microbiota within the Nasopharynx of Otitis-Prone Children. PLoS One. Vol. 9, no. 5. (May): ee98269.
- 2014. Evaluation of the kinetics and mechanism of action of anti-integration host factor-mediated disruption of bacterial biofilms. Molecular microbiology. Vol. 93, no. 6. (September 1).
- 2014. Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis. Laryngoscope. Vol. 124, no. 3. (March 1).
- Brandstetter KA, Jurcisek JA, Goodman SD, Bakaletz LO, Das S. 2013. Antibodies directed against integration host factor mediate biofilm clearance from nasopore. Laryngoscope. Vol. 123, no. 11. (May 1): 2626-2623-2626-2623.
- Brandstetter KA, Jurcisek JA, Goodman SD, Bakaletz LO, Das S. 2013. Antibodies directed against integration host factor mediate biofilm clearance from nasopore. Laryngoscope. Vol. 123, no. 11. (May): 2626-2623.
- Caye-Thomasen P, Hermansson A, Bakaletz LO, Hellstrom S, Kanzaki S, Kerschner J, Lim D, Lin J, Mason K, Spratley J. 2013. Panel 3: Recent Advances in Anatomy, Pathology, and Cell Biology in Relation to Otitis Media Pathogenesis. Otolaryngol Head Neck Surg. Vol. 148, no. April 1: E37-E51-E37-E51.
- Caye-Thomasen P, Hermansson A, Bakaletz LO, Hellstrom S, Kanzaki S, Kerschner J, Lim D, Lin J, Mason K, Spratley J. 2013. Panel 3: Recent Advances in Anatomy, Pathology, and Cell Biology in Relation to Otitis Media Pathogenesis. Otolaryngol Head Neck Surg. Vol. 148, no. April: E37-E51.
- Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, DeOliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. 2013. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. PNAS. Vol. 110, no. 24. (June 1): E2209-18-E2209-18.
- Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, DeOliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. 2013. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens. PNAS. Vol. 110, no. 24. (June): E2209-18.
- Dagan R, Leibovitz E, Greenberg D, Bakaletz LO, Givon-Lavi N. 2013. Mixed pneumococcal - nontypeable Haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution. J Infect Dis. Vol. 208, no. 7. (July 1): 1152-1160-1152-1160.
- Dagan R, Leibovitz E, Greenberg D, Bakaletz LO, Givon-Lavi N. 2013. Mixed pneumococcal - nontypeable Haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution. J Infect Dis. Vol. 208, no. 7. (July): 1152-1160.
- Gustave JE, Jurcisek JA, McCoy KS, Goodman SD, Bakaletz LO. 2013. Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis. J Cystic Fibrosis. Vol. 12, no. 4. (July 1): 384-389-384-389.
- Gustave JE, Jurcisek JA, McCoy KS, Goodman SD, Bakaletz LO. 2013. Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis. J Cystic Fibrosis. Vol. 12, no. 4. (July): 384-389.
- Jones EA, McGillivary G, Bakaletz LO. 2013. Extracellular DNA within a Nontypeable Haemophilus influenzae-Induced Biofilm Binds Human Beta Defensin-3 and Reduces Its Antimicrobial Activity. J Innate Immun. Vol. 5, no. 1. (January 1): 24-38-24-38.
- Jones EA, McGillivary G, Bakaletz LO. 2013. Extracellular DNA within a Nontypeable Haemophilus influenzae-Induced Biofilm Binds Human Beta Defensin-3 and Reduces Its Antimicrobial Activity. J Innate Immun. Vol. 5, no. 1. (January): 24-38.
- Kunthalert D, Novotny LA, Massa HM, Ulett GC, Bakaletz LO, Kyd JM, Cripps AW. 2013. Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26. Hum Vaccin Immunother. Vol. 9, no. 3. (March 1): 625-635-625-635.
- Kunthalert D, Novotny LA, Massa HM, Ulett GC, Bakaletz LO, Kyd JM, Cripps AW. 2013. Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26. Hum Vaccin Immunother. Vol. 9, no. 3. (March): 625-635.
- Li J-D, Hermansson A, Ryan A, Bakaletz LO, Brown SD, Cheeseman MT, Juhn SK, Jung TTK, Lim DJ, Lim JH, Lin J, Moon S-K, Post JC. 2013. Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models. Otolaryngol Head Neck Surg. Vol. 148, no. April: E52-E63.
- McGillivary G, Jordan ZB, Peeples ME, Bakaletz LO. 2013. Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin. J Innate Immun. Vol. 5, no. 1. (January 1): 60-71-60-71.
- McGillivary G, Jordan ZB, Peeples ME, Bakaletz LO. 2013. Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin. J Innate Immun. Vol. 5, no. 1. (January): 60-71.
- Novotny LA, Amer AO, Brockson ME, Goodman SD, Bakaletz LO. 2013. Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein. PLoS One. Vol. 8, no. 6. (January 1): e67629-e67629.
- Novotny LA, Amer AO, Brockson ME, Goodman SD, Bakaletz LO. 2013. Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein. PLoS One. Vol. 8, no. 6. (January): ee67629.
- Novotny LA, Clements, JD, Bakaletz LO. 2013. Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization. Vaccine. Vol. 31, no. July 1: 3417-3426-3417-3426.
- Novotny LA, Clements, JD, Bakaletz LO. 2013. Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization. Vaccine. Vol. 31, no. July: 3417-3426.
- Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak A, Bakaletz LO. 2013. Panel 6: Vaccines. Otolaryngol Head Neck Surg. Vol. 148, no. April 1: E90-E101-E90-E101.
- Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak A, Bakaletz LO. 2013. Panel 6: Vaccines. Otolaryngol Head Neck Surg. Vol. 148, no. April: E90-E101.
- Taneja N-K, Ganguly T, Bakaletz LO, Dubey P, Poole L, Deora R. 2013. D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes cellular adherence and resistance to antimicrobial peptides and PMN-mediated killing. J Bacteriol. Vol. 195, no. 22. (November 1): 5102-5111-5102-5111.
- Taneja N-K, Ganguly T, Bakaletz LO, Dubey P, Poole L, Deora R. 2013. D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes cellular adherence and resistance to antimicrobial peptides and PMN-mediated killing. J Bacteriol. Vol. 195, no. 22. (November): 5102-5111.
- 2013. Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages. Frontiers in cellular and infection microbiology. Vol. 3, no. December 1.
- 2013. Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models. OTOLARYNGOLOGY-HEAD AND NECK SURGERY. Vol. 148, no. April 1.
- Abu Khweek A, Fernández Dávila NS, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H, Novotny LA, Bakaletz LO, Amer AO. 2013. Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages. Front Cell Infect Microbiol. Vol. 3, no. May: e18.
- Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO. 2012. Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media. PLoS One. Vol. 7, no. 6. (June 1): e40088-e40088.
- Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO. 2012. Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media. PLoS One. Vol. 7, no. 6. (June): ee40088.
- Carruthers MD, Tracy EN, Dickson AC, Ganser K, Munson Jr RS, Bakaletz LO. 2012. Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons. J Bacteriol. Vol. 194, no. 8. (February 1): 1927-1933-1927-1933.
- Carruthers MD, Tracy EN, Dickson AC, Ganser K, Munson Jr RS, Bakaletz LO. 2012. Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons. J Bacteriol. Vol. 194, no. 8. (February): 1927-1933.
- Carruthers MD; Tracy EN; Dickson AD; Ganser K; Munson Jr RS; Bakaletz LO. 2012. Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons. J Bacteriol.
- Harrison A, Bakaletz LO, Munson Jr, RS. 2012. Haemophilus influenzae and oxidative stress. Front Cell Inf Microbio. Vol. 2, no. 40. (March 1): doi: 10.3389/fcimb.2012.00040-doi: 10.3389/fcimb.2012.00040.
- Harrison A, Bakaletz LO, Munson Jr, RS. 2012. Haemophilus influenzae and oxidative stress. Front Cell Inf Microbio. Vol. 2, no. 40. (March): edoi: 10.3389/fcimb.2012.00040.
- Harrison, A; Bakaletz, LO; Munson Jr, RS. 2012. Haemophilus influenzae and oxidative stress. Front Cell Inf Microbio. Vol. 2, no. March: edoi: 10.3389/fcimb.2012.00040.
- Hoopman T, Liu W, Joslin S, Pybus C, Sedillo J, Labandeira-Rey M, Laurence C, Wang W, Richardson J, Bakaletz LO, Hansen E. 2012. Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis. Infect Immun. Vol. 80, no. 3. (March 1): 982-982.
- Hoopman T, Liu W, Joslin S, Pybus C, Sedillo J, Labandeira-Rey M, Laurence C, Wang W, Richardson J, Bakaletz LO, Hansen E. 2012. Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis. Infect Immun. Vol. 80, no. 3. (March): e982.
- Kolappan S, Tracy EN, Bakaletz LO, Munson Jr RS, Craig L. 2012. Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus. Acta Crystallographica. Vol. F68, no. March 1: 284-284.
- Kolappan S, Tracy EN, Bakaletz LO, Munson Jr RS, Craig L. 2012. Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus. Acta Crystallographica. Vol. F68, no. March: e284.
- 2012. Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus. Acta Crystallogr Sect F Struct Biol Cryst Commun. Vol. 68, no. Pt 3. (March 1).
- 2012. Haemophilus influenzae and oxidative stress. Front Cell Infect Microbiol. Vol. 2, no. January 1.
- Bakaletz LO. 2012. Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment. Paediatr Respir Rev.
- Bakaletz, LO. 2012. Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment. Paediatr Respir Rev. Vol. 13, no. 3. (April 1): 154-159-154-159.
- Bakaletz, LO. 2012. Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment. Paediatr Respir Rev. Vol. 13, no. 3. (April): 154-159.
Professional Experience
2008 - Present The Research Institute at Nationwide Children's Hospital, The Ohio State University Professor, Dept. of Otolaryngology
2007 - Present The Research Institute at Nationwide Children's Hospital, The Ohio State University Professor, Dept. of Pediatrics
2007 - Present The Research Institute at Nationwide Children's Hospital Vice President for Basic Science Research
2006 - 2007 Vice President for Basic Science Research Columbus Children's Research Institute
2000 - 2007 Children's Research Institute, The Ohio State University Professor, Dept. of Pediatrics
1998 - 2000 Children's Research Institute, The Ohio State University Associate Professor, Dept. of Pediatrics
1993 - 1998 The Ohio State University Associate Professor, Dept. of Otolaryngology
1985 - 1986 The Ohio State University Post-doctoral Researcher, Dept. of Otolaryngology
Contact Information
- Call us at: (614)722-2915
- Fax us at: (614)722-2818
-
The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, OH 43205 (map)