Catherine E. Cottrell, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Catherine E. Cottrell, PhD

Catherine E. Cottrell, PhD

Clinical Pathology
Director, Institute for Genomic Medicine Clinical Laboratory

Pathology and Laboratory Medicine
Clinical Pathology Team

Pathology Fellowship

Contact Information

700 Children's Drive
Columbus, OH 43205 [ map ]
PH: (614) 722-2866


Catherine E. Cottrell, PhD, is a clinical laboratory director within the Institute for Genomic Medicine. She is dual certified by the American Board of Medical Genetics and Genomics in the specialties of Clinical Cytogenetics and Clinical Molecular Genetics. She completed her fellowship training at The Ohio State University and Nationwide Children’s Hospital in Columbus, Ohio. She then directed clinical laboratory operations in next-generation sequencing, cytogenetics and molecular pathology at Washington University in Saint Louis, MO. Dr. Cottrell returns to Nationwide Children's with an interest in the development of new clinical diagnostic tests, with particular concentration on sequencing assays. She is skilled in the clinical interpretation of complex laboratory tests including cytogenetic and molecular assays. She has focus on quality assurance and quality compliance in the clinical laboratory. Her research and clinical interests include genetic variant interpretation, as well as defining the etiology of somatic disease.


  • Female

Languages Spoken:

  • English

Education and Training

Undergraduate School

  • The Ohio State University
    Date Completed: 06/08/2001

Graduate School

  • The Ohio State University
    Date Completed: 12/09/2007


  • Nationwide Children's Hospital
    Date Completed: 12/10/2010


  • Clinical Pathology

Date of Appointment at Nationwide Children’s Hospital:

  • 11/14/2016

Professional Experience


  • Nationwide Children's Hospital, Director, Clinical Laboratory, Institute for Genomic Medicine


  • Washington University School of Medicine Assistant Professor of Pathology and Immunology, Assistant Professor of Genetics, Director, Cytogenetics and Molecular Pathology, Medical Director of Genomics and Pathology Services


  • Olfson E1, Cottrell CE2, Davidson NO3, Gurnett CA4, Heusel JW5, Stitziel NO6, Chen LS1, Hartz S1, Nagarajan R7, Saccone NL8, Bierut LJ1. Identification of Medically Actionable Secondary Findings in the 1000 Genomes. PLoS One. 2015 Sep 2;10(9):e0135193. doi: 10.1371/journal.pone.0135193. eCollection 2015. PubMed ID: 26332594
  • Zhang B1, Willing M2, Grange DK2, Shinawi M2, Manwaring L2, Vineyard M2, Kulkarni S1, Cottrell CE1. Multigenerational autosomal dominant inheritance of 5p chromosomal deletions. Am J Med Genet A. 2016 Mar;170(3):583-93. doi: 10.1002/ajmg.a.37445. Epub 2015 Nov 24 PubMed ID: 26601658
  • Cottrell CE1, Al-Kateb H2, Bredemeyer AJ1, Duncavage EJ1, Spencer DH1, Abel HJ3, Lockwood CM1, Hagemann IS1, O'Guin SM3, Burcea LC3, Sawyer CS3, Oschwald DM3, Stratman JL1, Sher DA1, Johnson MR3, Brown JT3, Cliften PF3, George B1, McIntosh LD1, Shrivastava S1, Nguyen TT1, Payton JE1, Watson MA1, Crosby SD3, Head RD3, Mitra RD3, Nagarajan R1, Kulkarni S4, Seibert K1, Virgin HW 4th1, Milbrandt J3, Pfeifer JD1. Validation of a next-generation sequencing assay for clinical molecular oncology. J Mol Diagn. 2014 Jan;16(1):89-105. doi: 10.1016/j.jmoldx.2013.10.002. Epub 2013 Nov 6. PubMed ID: 24211365
  • Hucthagowder V1, Shenoy A1, Corliss M1, Vigh-Conrad KA2, Storer C2, Grange DK3, Cottrell CE1,2. Utility of clinical high-depth next generation sequencing for somatic variant detection in the PIK3CA-related overgrowth spectrum. Clin Genet. 2017 Jan;91(1):79-85. doi: 10.1111/cge.12819. Epub 2016 Jul 26. PubMed ID: 27307077
  • Hagemann IS1, Devarakonda S, Lockwood CM, Spencer DH, Guebert K, Bredemeyer AJ, Al-Kateb H, Nguyen TT, Duncavage EJ, Cottrell CE, Kulkarni S, Nagarajan R, Seibert K, Baggstrom M, Waqar SN, Pfeifer JD, Morgensztern D, Govindan R. Clinical next-generation sequencing in patients with non-small cell lung cancer. Cancer. 2015 Feb 15;121(4):631-9. doi: 10.1002/cncr.29089. Epub 2014 Oct 24. PubMed ID: 25345567

Awards, Honors and Organizations

  • Member, Association of Molecular Pathology, 2013-Present
  • Fellow, American College of Medical Genetics and Genomics, 2011-Present
  • Diplomate, American Board of Medical Genetics and Genomics, 2011-Present
  • Member, American Society of Human Genetics, 2002-Present
  • Member, Association of Molecular Pathology, 2013-Present
  • Member, American College of Medical Genetics and Genomics, 2010-2011
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000