Zongdi Feng, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Zongdi Feng, PhD

Zongdi  Feng, PhD

Center for Vaccines and Immunity
Principal Investigator

Contact Information

700 Children's Drive
Columbus, OH 43205 [ map ]
PH: (614) 355-2784
FX: (614) 722-3680
Email Me


Dr. Zongdi Feng became an Assistant Professor of Pediatrics at the Ohio State University and a member of the Center for Vaccines and Immunity at Nationwide Children’s Hospital Research Institute in 2014. Dr. Feng received his Ph.D. from the University of Illinois in 2008 and undertook post-doctoral training on the immune responses and pathogenesis associated with hepatitis viruses with Dr. Stan Lemon at the Lineberger Comprehensive Cancer Center at UNC-Chapel Hill.

Dr. Feng’s research mainly focuses on the life cycle and pathogenesis of hepatitis viruses. Previous studies by Dr. Feng have shown that hepatitis A virus (traditionally thought to be nonenveloped) hijacks host membranes to evade antibody response and facilitate its spread (Nature. 496: 367-71). A similar phenomenon exists for hepatitis E virus (Trends Microbiol. 22:59-64), an emerging agent that causes high mortality (up to 28%) in pregnant women and often develops into persistent infection in immunosuppressed individuals. These novel “quasi-enveloped” viruses create a new paradigm in virology and provide novel insights on vaccines and immunity. Projects focus on understanding how these “quasi-enveloped” viruses (1) structurally differ from their nonenveloped counterparts, (2) enter and exit the cells, (3) become neutralized by antibodies, and (4) interact with “non-permissive” cells.


  • Male

Languages Spoken:

  • English

Clinical Interests

  • Infectious Diseases

Research Interests

Research Center:

Areas of Interest:

  • Viral Pathogenesis
  • Host Immune Responses
  • Hepatitis Viruses

Education and Training

Undergraduate School

  • Wuhan University
    Date Completed: 06/30/1999

Graduate School

  • Wuhan Institute of Virology, Chinese Academy of Sciences
    Date Completed: 06/30/2002

Graduate School

  • University of Illinois
    Date Completed: 06/30/2008


  • Center for Vaccines and Immunity

Date of Appointment at Nationwide Children’s Hospital:

  • 06/30/2014

Professional Experience


  • Assistant Professor, Department of Pediatrics, The Ohio State University, Columbus, OH


  • Research Principal Investigator, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital, Columbus, OH


  • Research Associate, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC


  • Postdoctoral Research Associate, Stanley Lemon M.D. Laboratory, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC


  • Postdoctoral Fellow, Stanley Lemon M.D. Laboratory, Galveston National Laboratory, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX


  • Graduate Research Assistant, Department of Microbiology and Immunology, University of Illinois, Chicago, IL


  • Graduate Research Assistant, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China

Awards, Honors and Organizations

  • 3rd place - 3rd Annual Oliver Smithies Nobel Symposium Postdoctoral Researcher Poster Forum, UNC, Chapel Hill, 2013
  • 2013 Best Poster Award - Center of Gastrointestinal Biology and Disease Annual Retreat, UNC, Chapel Hill
  • 2001 Di'ao Graduate Fellowship, Chinese Academy of Sciences, China Practice
  • Member, American Society of Virology, 2012- present
  • 2009 Travel Award. American Association for the Study of Liver Diseases (AASLD). The Henry M. and Lillian Stratton Basic Research Single Topic Conference "Pattern Receptors and Innate Immune Signaling pathways in Liver Diseases", Atlanta, GA
  • Member, American Society of Microbiology, 2008 - present
  • 2014 Recipient, Lineberger Comprehensive Cancer Center Joseph S. Pagano Award. University of North Carolina, Chapel Hill, NC
  • 2012 Travel Award. 31st American Society of Virology Annual Meeting, Madison, WI
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000