Susan D. Reynolds, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Susan D. Reynolds, PhD

Susan D. Reynolds, PhD

Center for Perinatal Research
Principal Investigator

Contact Information

700 Children's Drive
Columbus, OH 43205 [ map ]
PH: (614) 355-6716
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Susan D. Reynolds, PhD's research focuses on tissue stem cells that maintain the conducting airway epithelium. Previous work identified a basal cell subtype that functioned as a tissue stem cell in mice. Current research translates these findings to human airways and seeks to use the tissue stem cell as therapy for lung disease, including Cystic Fibrosis.

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  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Susan D. Reynolds’ laboratory studies airway epithelial stem and progenitor cells. Her group’s goal is to use their knowledge of these cell types to treat chronic lung diseases that compromise airway function. This goal was facilitated by Dr. Reynolds’ move to Nationwide Children’s Hospital in January 2015 and development of collaborations with Don Hayes, Jr, M.D. and Daniel Malleske, M.D. Their Clinical-Basic Science Collaborative has given Dr. Reynolds’ group unprecedented access to human airway epithelial stem and progenitor cells from lung disease patients and normal controls. As a consequence, Dr. Reynolds’ group is now able to examine the signaling mechanisms that regulate human stem and progenitor cell function.

Education and Training

Graduate School

  • University of Rochester
    Date Completed: 06/05/1992


  • Center for Perinatal Research

Date of Appointment at Nationwide Children’s Hospital:

  • 01/01/2015


  • Ghosh, M, Ahmad, S, White, CW, Reynolds, SD. 2017. Transplantation of airway epithelial stem/progenitor cells: A future for cell-based therapy.  Am J Respir Cell Mol Biol. Vol. 56, no. January: 1-10.
  • Hayes, D, Jr, Reynolds, SD, Tumin, D. 2016. Outcomes of lung transplantation for primary ciliary dyskinesia and Kartagener syndrome.  Heart Lung Transplant. Vol. 35, no. November: 1377-1378.
  • Hayes, D, Joy, BF, Reynolds, SD, Tobias, JD, Tumin, D. 2016. Influence of graft ischemic time and geographic distance between donor and recipient on survival in children after lung transplantation.  J Heart Lung Transplant. Vol. 35, no. October: 1220-1226.
  • Huang, JT, Reynolds, SD, DiGiovanni Evans, B, Zimmermann, C, Joyce, CJ, Katz, JT, Buzney, E. 2016. Fine arts curriculum improves observational skills of dermatolgoy trainees: a pilot study.  Br J Dermatol. Vol. 175, no. October: 815-7.
  • Reynolds, SD, Rios, C, Wesolowsa-Andersen, A, Zhuang, Y, Pinter, M, Happoldt, C, Hill, CL, Lallier, SW, Cosgrove, GP, Solomon, GM, Nichols, DP, Seibold, MA. 2016. Airway progenitor clone formation is enhanced by Y-27632-Dependent changes in the transcriptome.  Am J Respir cell Mol Biol. Vol. 55, no. September: 323-36.
  • Hayes, D, Jr, Kopp, BT, Kirkby, SE, Reynolds, SD, Mansour, HM, Tobias, JD, Tumin, D. 2016. Impact of donor arterial partial pressure of oxygen on outcomes after lung transplantation in adult cystic fibrosis recipients.  Lung. Vol. 194, no. August: 547-53.
  • Chu, HW, Rios, C, Huang, C, Wesolowska-Andersen, A, Burchard, EG, O'Connor, BP, Fingerlin, TE, Nichols, D, Reynolds, SD, Seibold, MA. 2015. CRISPR-Cas9-mediated gene knockout in primary human airway epithelial cells reveals a proinflammatory role for MUC18.  Gene Ther. Vol. 22, no. October: 822-9.
  • Kutten, JC, McGovern, D, Hobson, CM, Luffy, SA, Nieponice, A, Tobita, K, Francis, RJ, Reynolds, SD, Isenberg, JS, Gilbert, TW. 2015. Decellularized tracheal extracellular matrix supports epithelial migration, differentiation, and function.  Tissue Eng Part A. Vol. 21, no. January: 75-84.
  • Brechbuhl, HM, Li, B, Smith, RW, Reynolds, SD. 2014. Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation.  Am J Physiol Lung Cell Mol Physiol. Vol. 307, no. November: L800-10.
  • Burke, MC, Li, FQ, Cyge, B, Arashiro, T, Brechbuhl, HM, Chen, X, Siller, SS, Weiss, MA, O'Connell, CB, Love, D, Westlake, CJ, Reynolds, SD, Kuriyama, R, Takemaru, K. 2014. Chibby promotes ciliary vesicle formation and basal body docking during airway cell dirrerentiation.  J Cell Biol. Vol. 207, no. October: 123-37.
  • Ghosh, M, Ahmad, S, Jian, A, Li, B, Smith, RW, Helm, KM, Seibold, MA, Groshong, SD, White, CW, Reynolds, SD. 2013. Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro.  Am J Respir Cell Mol Biol. Vol. 49, no. December: 1127-34.
  • Ghosh M1, Ahmad S, Jian A, Li B, Smith RW, Helm KM, Seibold MA, Groshong SD, White CW, Reynolds SD. Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro. Am J Respir Cell Mol Biol. 2013 Dec;49(6):1127-34. doi: 10.1165/rcmb.2013-0049OC. PubMed ID: 23927678
  • Ghosh M1, Smith RW, Runkle CM, Hicks DA, Helm KM, Reynolds SD. Regulation of trachebronchial tissue-specific stem cell pool size. Stem Cells. 2013 Dec;31(12):2767-78. doi: 10.1002/stem.1440. PubMed ID: 23712882
  • Seibold MA1, Smith RW, Urbanek C, Groshong SD, Cosgrove GP, Brown KK, Schwarz MI, Schwartz DA, Reynolds SD. The idiopathic pulmonary fibrosis honeycomb cyst contains a mucocilary pseudostratified epithelium. PLoS One. 2013;8(3):e58658. doi: 10.1371/journal.pone.0058658. Epub 2013 Mar 20. PubMed ID: 23527003
  • Brechbuhl HM1, Li B1, Smith RW1, Reynolds SD2. Epidermal growth factor receptor activity is necessary for mouse basal cell proliferation. Am J Physiol Lung Cell Mol Physiol. 2014 Nov 15;307(10):L800-10. doi: 10.1152/ajplung.00201.2014. Epub 2014 Sep 12. PubMed ID: 25217659
  • Smith MK1, Koch PJ, Reynolds SD. Direct and indirect roles for ß-catenin in facultative basal progenitor cell differentiation. Am J Physiol Lung Cell Mol Physiol. 2012 Mar 15;302(6):L580-94. doi: 10.1152/ajplung.00095.2011. Epub 2012 Jan 6. PubMed ID: 22227204
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