Rodney D. Britt, PhD
Contact Information
Rodney D. Britt Jr, PhD, is a Principal Investigator at Nationwide Children’s Hospital and an Assistant Professor in the Department of Pediatrics at The Ohio State University. Dr. Britt earned his BS in Chemistry from North Carolina A&T State University and PhD in Biomedical Sciences from The Ohio State University. He completed his postdoctoral training at Mayo Clinic in Rochester, MN. His research training centered on understanding mechanisms in neonatal and pediatric airway diseases, most notably asthma and bronchopulmonary dysplasia.
Children with airway disease experience significant airflow obstruction, airway hyperresponsiveness, and chronic inflammation. Furthermore, development of airway disease as a child increases the risk having a chronic airway as an adult. Dr. Britt’s lab aims to advance understanding of mechanisms related to neonatal and pediatric airway disease, with emphasis on how airway inflammation affects airway structure and function in asthma.
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Center for Perinatal Research
Principal Investigator -
Primary Department
Center for Perinatal Research
- Member, American Heart Association, 2015 - Present
- Member, American Physiological Society, 2014 - Present
- Member, American Thoracic Society, 2009 - Present
Date of Appointment at Nationwide Children’s Hospital: 06/01/2018
| Postdoctoral Training | Mayo Clinic | Date Completed: 06/04/2018 |
|---|---|---|
| Graduate School | The Ohio State University | Date Completed: 12/16/2012 |
| Undergraduate School | North Carolina A&T State University | Date Completed: 05/15/2006 |
2018 - Present Nationwide Children's Hospital, Principal Investigator
2017 - 2018 Mayo Clinic, Associate Consultant I
2012 - 2017 Mayo Clinic, Postdoctoral Fellow
National Institutes of Health R01 HL155095
Airway Structural Cells and Corticosteroid Resistance in Asthma, Principal Investigator
The goal of this proposal is to investigate how Th1 cytokines, notably IFNγ, mediate corticosteroid resistance in severe allergic airway inflammation and primary human airway smooth muscle cells. These studies will integrate RNA-, ATAC-, and ChIP-seq analyses to assess changes in chromatin accessibility that may affect corticosteroid sensitivity.
National Institutes of Health R00 HL131682
Enhancing Corticosteroid Sensitivity in Neonatal and Pediatric Lung Diseases, Principal Investigator
The goal of this proposal is to provide the training necessary for transition to an independent research career. Studies will examine how inflammation disrupts glucocorticoid receptor signaling and assess potential therapeutic approaches to restore corticosteroid sensitivity in pediatric asthma.