Research News and Highlights :: The Research Institute at Nationwide Children's Hospital


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Dr. Besner discusses finding a cure for necrotizing enterocolitis at The Research Institute at Nationwide Children's Hospital
Gene Therapy Reveals Immunity in DMD
Dr. Jerry Mendell explains how being designated as a Wellstone Center will help muscular dystrophy research at Nationwide Children's
Drs. Pam Lucchesi and Vidu Garg discuss translational heart research at Nationwide Children's
Studies examines a genetic link in vesicoureteral reflux, a condition that can lead to chronic kidney disease in children
Dr. Jadcherla discusses his neonatal feeding disorders research
Jerry Mendell, MD, discusses ongoing muscular dystrophy research efforts at The Research Institute
Dr. Barnard discusses expansion plans for the Research Institute at Nationwide Children's Hospital.
See how patients' lives are impacted by the groundbreaking research that takes place at The Research Institute

Research News and Highlights

Research News Room

View the most recent research-related news releases that are available in our news room.  

Our Research Magazine Features

Click on the image below to view an interactive version of our latest research magazine.  

In this issue:

How to Bridge the Gap between Orphan Disease Drug Development and Big Pharma

Gene Therapy Drugs Safe for Use in Humans

Simplifying the Complex Process of Tumor Banking

Intellectual Property Outside the University

Analysis Pipeline Can Search a Genome for Disease in Hours

Additional Research Highlights

2/11/13 :: New Study Finds Increase in Dance-Related Injuries Among Children and Adolescents in the U.S.
A new study by researchers at the Center for Injury Research and Policy of The Research Institute at Nationwide Children’s Hospital examined dance-related injuries among children and adolescents 3 to 19 years of age from 1991 to 2007.

1/18/13 :: Study: Bariatric Surgery in Extremely Obese Adolescents
May Also Help Treat Previously Undiagnosed Cardiovascular Abnormalities

12/11/12 :: Infants with Severe RSV Disease May Be Immunosuppressed
Infants with severe lower respiratory tract infection caused by respiratory syncytial virus (RSV) may have a dysfunctional innate immune response that relates to the severity of their disease. These are the findings from a Nationwide Children’s Hospital study appearing in a recent issue of the Journal of Infectious Diseases.

11/12/12 :: Nationwide Children’s Hospital Biorespository Receives Accreditation from Prestigious College of American Pathologists
The Biopathology Center at Nationwide Children’s Hospital, the hospital’s long-standing biorepository, has received accreditation from the College of American Pathologists, confirming that the biorepository operates to ensure that high-quality biospecimens and related data are available for the purpose of supporting cutting-edge medical research.

10/31/12 :: Guidelines Developed for Extremely Premature Infants at Nationwide Children’s Hospital Proven to be Life-Changing
Small Baby Guidelines show improvement in the lives of premature infants 

10/29/12 :: Study Suggests New Way to Prevent Recurrent Ear Infections
Key may be in decreasing bacteria’s DNA-compromised covering to boost existing antimicrobial proteins

10/5/12 :: Exon-Skipping Shows Promise in Duchenne Muscular Dystrophy
Results from a Phase IIb extension trial of the drug eteplirsen show an increased ability to walk in boys with Duchenne muscular dystrophy.

8/21/12 :: Low Oxygen Levels May Decrease Life-Saving Protein in Spinal Muscular Atrophy
Investigators at Nationwide Children’s Hospital may have discovered a biological explanation for why low levels of oxygen advance spinal muscular atrophy (SMA) symptoms and why breathing treatments help SMA patients live longer.

7/9/12 :: New Gene Transfer Strategy Shows Promise for Limb Girdle and Other Muscular Dystrophies
The challenge of treating patients with genetic disorders in which a single mutated gene is simply too large to be replaced using traditional gene therapy techniques may soon be a thing of the past.

6/27/12 :: New Mouse Model Helps Explain Gene Discovery in Congenital Heart Disease
Scientists now have clues to how a gene mutation discovered in families affected with congenital heart disease leads to underdevelopment of the walls that separate the heart into four chambers.

6/6/12 :: Study: Why Hot, Humid Air Triggers Symptoms in Patients with Mild Asthma
Temperature increase may activate sensory nerves that induce coughing and airway constriction

5/14/12 :: New Study Examines Injuries Associated with Baby Bottles, Pacifiers and Sippy Cups in the U.S.
A new study by researchers in the Center for Biobehavioral Health and the Center for Injury Research and Policy at Nationwide Children’s Hospital examined pediatric injuries associated with baby bottles, pacifiers and sippy cups.

3/19/12 :: Newborn Screening for Duchenne Muscular Dystrophy Shows Promise as an International Model
Investigators at Nationwide Children’s Hospital, working with the DNA Sequencing Core Facility at the University of Utah, have developed an approach to newborn screening (NBS) for the life-threatening genetic disorder, Duchenne muscular dystrophy (DMD) and potentially other muscular dystrophies.

2/3/2012 :: Loss of Notch Signaling Linked to Calcification in Human Heart Valves
Researchers have demonstrated how a gene responsible for cell differentiation and its signaling pathway is linked to calcium deposits developing on the aortic valve in the human heart.

2/3/2012 :: Grant Provides Funding Toward Gene Therapy Clinical Trial to Replace the DMD Gene in all of the Leg Muscles of Duchenne Patients
Investigators from the Center for Gene Therapy are working toward an approach to replace the defective gene in Duchene muscular dystrophy (DMD) by treating all of the muscles in the leg, thanks to funding from Jesse’s Journey.

11/17/2011 :: Bacteria Responsible for Middle Ear Infections, Pink Eye and Sinusitis May Protect Themselves by Stealing Immune Molecules
Bacteria responsible for middle ear infections, pink eye and sinusitis protect themselves from further immune attack by transporting molecules meant to destroy them away from their inner membrane target.

11/8/2011 :: New NIH Grant Investigates Combined Effects of Obesity and Air Pollution on Cardiac Function
Loren E. Wold, PhD, FAHA, has received a five-year grant from the National Institutes of Health to study the combined effects obesity and air pollution have on cardiac function.  This R01 award totals nearly $1.6 million. 

11/8/2011 :: Study Refines Incidence Data of Venous Thromboembolism in Children
Infants and adolescents with complex chronic diseases are at risk for life-threatening artery blockages, regardless of whether they are treated at a community hospital or in a tertiary care setting.  These are the findings from a Nationwide Children’s Hospital study meant to refine the epidemiologic understanding of acute and chronic diseases associated with pediatric venous thromboembolism.

11/8/2011 :: Researchers Design A Viral Vector To Treat A Genetic Form Of Blindness
Researchers at Ohio State University Medical Center and Nationwide Children’s Hospital have developed a viral vector designed to deliver a gene into the eyes of people born with an inherited, progressive form of blindness that affects mainly males.

9/19/2011 :: Pediatric Liver Biopsies Done by Interventional Radiologists or Gastroenterologists are Equally Safe
Although gastroenterologists are most commonly trained to perform percutaneous liver biopsies in children, interventional radiologists can perform this procedure equally as safe, according to a study from Nationwide Children’s Hospital.

9/19/2011 :: Are Young Adults with Sickle Cell Disease in Children’s Hospitals Different from Adolescents?
Reasons for admission are similar between adolescents and young adults with sickle cell disease at pediatric hospitals and mortality for both groups is low, according to findings from Nationwide Children’s.

7/12/2011 :: Nonprofit Creativity Award Goes to Center for Injury Research and Policy
The award honors Ohio nonprofit groups who have utilized information technology creatively in any of eleven different categories and recognized Dr. Dawn Comstock’s innovative use of RIOTM.

6/14/2011 :: Nationwide Children’s Trainees Dominate Presentation Competition at International Otitis Media Symposium
Trainees from Nationwide Children’s Hospital received several awards during the 10th International Symposium on Recent Advances in Otitis Media, sweeping the competition.

5/17/2011 :: How the Anti-Inflammatory Drug, Celebrex, May Treat and Prevent Cancer
Celebrex, a drug currently marketed for its anti-inflammatory properties, may have anti-tumor and cancer prevention effects, particularly because it blocks STAT3 signaling, suggests new research.

5/17/2011 :: Assessment of Joint Pain in Children with IBD
About one quarter of children with inflammatory bowel disease (IBD) experience inflammatory symptoms beyond their intestinal tract, most commonly manifested as joint pain.  In an article appearing in Current Gastroenterology Reports, Nationwide Children’s faculty members describe the differential diagnosis of joint complaints in children, with a focus on IBD-related disease and rheumatic disease. 

4/8/2011 :: Chemical Found in Blood Plasma May be Linked to Pulmonary Hypertension in Down Syndrome Patients
Could Serve as a New Therapeutic Target and Biomarker for High Blood Pressure in This Population\

4/8/2011 :: E. Coli-Derived Probiotic Shows Promise in Halting Growth of UTI-Causing Bacteria, In Vitro
A non-disease-causing strain of E. coli found in an existing dietary supplement may halt the growth of many urinary-tract-infection-causing bacteria, according to laboratory studies.

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