Cell Line and Serum Banking Core

The Cell Line and Serum Banking Core aims to further muscular dystrophy research by collecting and sharing samples with investigators within the muscular dystrophy research community. The Core holds cell lines from >200 patients, including >100 with Duchenne muscular dystrophy. Cell lines include fibroblasts, myoblasts and peripheral blood mononuclear cells (PBMCs). The core has extensive expertise immortalizing and transdifferentiating fibroblasts into myoblasts through inducible MyoD expression, as well as generating induced pluripotent stem cells (iPSCs). The core has also established partnerships to develop 3D culture models using these cells. The Core supports the activities of all 3 MRSDC projects, as well as several other labs within Nationwide Children's. The Core has also distributed Cell lines to academic and industry collaborators nationally and internationally.