William E. Smoyer, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Contact Information

Nephrology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4360
FX: (614) 722-6482
E-mail Me
Nephrology
700 Children's Drive
Columbus, Ohio 43205 [ map ]

Location Information for Patients

Main Campus

Biography

William Smoyer, MD, is a member of the Section of Nephrology at Nationwide Children’s Hospital, Vice President and Director for the Center for Clinical and Translational Research at The Research Institute at Nationwide Children’s Hospital and a Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Smoyer’s clinical interests include glomerulonephritis and nephrotic syndrome, pediatric dialysis and renal replacement therapy, and clinical and translational research therapies.

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Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • William Smoyer, MD, is a basic and clinical scientist with expertise in podocyte biology. He oversees a national clinical research network relating to chronic renal disease and also has a long-standing track record of NIH and other extramural funding.

Education and Training

Medical School

  • University of Florida College of Medicine
    Date Completed: 07/31/1986

Internship

  • University of Texas Medical Branch at Galveston
    Date Completed: 06/30/1987

Residency

  • University of Texas Medical Branch at Galveston
    Date Completed: 06/30/1989

Fellowship

  • Boston Children's Hospital
    Date Completed: 09/30/1992

Fellowship

  • Children's Hospital of Philadelphia
    Date Completed: 06/30/1993

Fellowship

  • University of Pennsylvania Medical Center
    Date Completed: 06/30/1993

Department:

  • Pediatrics

Section:

  • Nephrology

Specialty:

  • Pediatric Nephrology

Date of Appointment at Nationwide Children’s Hospital:

  • 03/02/2009

Professional Experience

2007–present

  • Director, Center for Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH

2007–present

  • C. Robert Kidder Endowed Chair in Clinical and Translational Research

2007–present

  • Vice President, Clinical and Translational Research, The Research Institute at Nationwide Children's Hospital, Columbus, OH

2005–2007

  • Associate Professor, College of Pharmacy, University of Michigan

2001–2007

  • Robert C. Kelsch Chair of Pediatric Nephrology

2001–2005

  • Director, Pediatric Nephrology Division, Department of Pediatrics, University of Michigan Health System

2000–2007

  • Associate Professor with Tenure, Department of Pediatrics, University of  Michigan Health System

1993–2000

  • Assistant Professor, Department of Pediatrics, University of Michigan  Medical Center

Publications

  • Byington,Carrie,L; Higgins,Sarah; Kaskel,Fredrick,J; Purucker,Mary; Davis,Jonathan,M; Smoyer,William,E. 2014. The CTSA Mentored Career Development Program: Supporting the Careers of Child Health Investigators.  Clinical and translational science. Vol. 7, no. 1. (February): 44-47.
  • Rheault,Michelle,N; Wei,Chang-Ching; Hains,David,S; Wang,Wei; Kerlin,Bryce,A; Smoyer,William,E. 2014. Increasing frequency of acute kidney injury amongst children hospitalized with nephrotic syndrome.  PEDIATRIC NEPHROLOGY. Vol. 29, no. 1. (January): 139-147.
  • Straatmann,Caroline; Ayoob,Rose; Gbadegesin,Rasheed; Gibson,Keisha; Rheault,Michelle,N; Srivastava,Tarak; Tran,Cheryl,L; Gipson,Debbie,S; Greenbaum,Larry,A; Smoyer,William,E; Vehaskari,V,Matti. 2013. Treatment outcome of late steroid-resistant nephrotic syndrome: a study by the Midwest Pediatric Nephrology Consortium.  PEDIATRIC NEPHROLOGY. Vol. 28, no. 8. (August): 1235-1241.
  • Mak,Robert,H; Smoyer,William,E. 2013. Genetic screening in steroid-resistant nephrotic syndrome.  NATURE REVIEWS NEPHROLOGY. Vol. 9, no. 7. (July): 379-381.
  • Kerlin, BA, Haworth, K, Smoyer, WS. 2013. Venous Thromboembolism in Pediatric Nephrotic Syndrome.  Pediatr Nephrol. Vol. 999, no. June: 999-999.
  • Kerlin,B; Smoyer,W; Tsai,J; Boulet,S. 2013. Venous thromboembolism dramatically increases healthcare utilization and mortality in childhood chronic kidney disease.  HAEMOPHILIA. Vol. 19, no. 3. (May): 467-468.
  • Gbadegesin,Rasheed,A; Winn,Michelle,P; Smoyer,William,E. 2013. Genetic testing in nephrotic syndrome-challenges and opportunities.  NATURE REVIEWS NEPHROLOGY. Vol. 9, no. 3. (March): 179-184.
  • Ferris,Maria; Norwood,Victoria; Radeva,Milena; Gassman,Jennifer,J; Al-Uzri,Amira; Askenazi,David; Matoo,Tej; Pinsk,Maury; Sharma,Amita; Smoyer,William; Stults,Jenna; Vyas,Shefali; Weiss,Robert; Gipson,Debbie; Kaskel,Frederick; Friedman,Aaron; Moxey-Mims,Marva; Trachtman,Howard. 2013. Patient Recruitment into a Multicenter Randomized Clinical Trial for Kidney Disease: Report of the Focal Segmental Glomerulosclerosis Clinical Trial (FSGS CT).  CTS-CLINICAL AND TRANSLATIONAL SCIENCE. Vol. 6, no. 1. (February): 13-20.
  • Guess,Adam,J; Ayoob,Rose; Chanley,Melinda; Manley,Joshua; Cajaiba,Mariana,M; Agrawal,Shipra; Pengal,Ruma; Pyle,Amy,L; Becknell,Brian; Kopp,Jeffrey,B; Ronkina,Natalia; Gaestel,Matthias; Benndorf,Rainer; Smoyer,William,E. 2013. Crucial Roles of the Protein Kinases MK2 and MK3 in a Mouse Model of Glomerulonephritis.  PLOS ONE. Vol. 8, no. 1. (January): ee54239.
  • Greenbaum,Larry,A; Benndorf,Rainer; Smoyer,William,E. 2012. Childhood nephrotic syndrome-current and future therapies.  NATURE REVIEWS NEPHROLOGY. Vol. 8, no. 8. (August): 445-458.
  • Ayoob,Rose,M; Hains,David,S; Smoyer,William,E. 2012. Trends in hospitalization characteristics for pediatric nephrotic syndrome in the USA.  CLINICAL NEPHROLOGY. Vol. 78, no. 2. (August): 106-111.
  • Kerlin,Bryce,A; Ayoob,Rose; Smoyer,William,E. 2012. Epidemiology and Pathophysiology of Nephrotic Syndrome-Associated Thromboembolic Disease.  CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. Vol. 7, no. 3. (March): 513-520.
  • Agrawal,Shipra; Guess,Adam,J; Benndorf,Rainer; Smoyer,William,E. 2011. Comparison of Direct Action of Thiazolidinediones and Glucocorticoids on Renal Podocytes: Protection from Injury and Molecular Effects.  MOLECULAR PHARMACOLOGY. Vol. 80, no. 3. (September): 389-399.
  • Pengal,Ruma; Guess,Adam,J; Agrawal,Shipra; Manley,Joshua; Ransom,Richard,F; Mourey,Robert,J; Benndorf,Rainer; Smoyer,William,E. 2011. Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.  AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. Vol. 301, no. 3. (September): F509-F519.
  • Hains,David,S; Reagan,Patricia,B; Smoyer,William,E. 2011. Do Declining Private Insurance Coverage Rates Influence Pediatric Hospital Charging Practices?.  CLINICAL PEDIATRICS. Vol. 50, no. 5. (May): 417-423.
  • Guess A; Agrawal S; Wei CC; Ransom RF; Benndorf R; Smoyer WE. 2010. Dose- and time-dependent glucocorticoid receptor signaling in podocytes.  American Journal Of Physiology. Renal Physiology. Vol. 299, no. 4. (October): F845-F853.
  • Guess,Adam; Agrawal,Shipra; Wei,Chang-Ching; Ransom,Richard,F; Benndorf,Rainer; Smoyer,William,E. 2010. Dose- and time-dependent glucocorticoid receptor signaling in podocytes.  AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. Vol. 299, no. 4. (October): F845-F853.
  • MacHardy,Nathaniel; Miles,Paul,V; Massengill,Susan,F; Smoyer,William,E; Mahan,John,D; Greenbaum,Larry; Massie,Sara; Yao,Lynne; Nagaraj,Shashi; Lin,Jen-Jar; Wigfall,Delbert; Trachtman,Howard; Hu,Yichun; Gipson,Debbie,S. 2009. Management patterns of childhood-onset nephrotic syndrome.  PEDIATRIC NEPHROLOGY. Vol. 24, no. 11. (November): 2193-2201.
  • Mueller BA; Smoyer WE. 2009. Challenges in developing evidence-based drug dosing guidelines for adults and children receiving renal replacement therapy.  Clinical Pharmacology And Therapeutics. Vol. 86, no. 5. (November): e479.
  • MacHardy N; Miles PV; Massengill SF; Smoyer WE; Mahan JD; Greenbaum L; Massie S; Yao L; Nagaraj S; Lin JJ; Wigfall D; Trachtman H; Hu Y; Gipson DS. 2009. Management patterns of childhood-onset nephrotic syndrome.  Pediatric Nephrology (Berlin, Germany). Vol. 24, no. 11. (November): e2193.
  • Mahan JD; Smoyer WE. 2009. The need for a children's oncology group-oriented approach to advance the care of children with Idiopathic nephrotic syndrome.  Clinical Journal Of The American Society Of Nephrology: CJASN. Vol. 4, no. 10. (October): e1549.
  • Gipson DS; Massengill SF; Yao L; Nagaraj S; Smoyer WE; Mahan JD; Wigfall D; Miles P; Powell L; Lin JJ; Trachtman H; Greenbaum LA. 2009. Management of childhood onset nephrotic syndrome.  Pediatrics. Vol. 124, no. 2. (August): e747.
  • Kerlin BA; Blatt NB; Fuh B; Zhao S; Lehman A; Blanchong C; Mahan JD; Smoyer WE. 2009. Epidemiology and risk factors for thromboembolic complications of childhood nephrotic syndrome: a Midwest Pediatric Nephrology Consortium (MWPNC) study.  The Journal Of Pediatrics. Vol. 155, no. 1. (July): e105.
  • Lin JJ; Mitsnefes MM; Smoyer WE; Valentini RP. 2009. Antihypertensive prescription in pediatric dialysis: a practitioner survey by the Midwest Pediatric Nephrology Consortium study.  Hemodialysis International. International Symposium On Home Hemodialysis. Vol. 13, no. 3. (July): e307.
  • Gbadegesin R; Zhao S; Charpie J; Brophy PD; Smoyer WE; Lin JJ. 2009. Significance of hemolysis on extracorporeal life support after cardiac surgery in children.  Pediatric Nephrology (Berlin, Germany). Vol. 24, no. 3. (March): e589.
  • Churchwell MD; Pasko DA; Smoyer WE; Mueller BA. 2009. Enhanced clearance of highly protein-bound drugs by albumin-supplemented dialysate during modeled continuous hemodialysis.  Nephrology, Dialysis, Transplantation: Official Publication Of The European Dialysis And Transplant Association - European Renal Association. Vol. 24, no. 1. (January): e231.
  • Gbadegesin R; Kudelka T; Gadegbeku CA; Brophy P; Smoyer WE; Lin JJ. 2008. Arterial compliance in adolescents and young adults receiving chronic hemodialysis.  Renal Failure. Vol. 30, no. 6. (January): e591.
  • Thompson M, Smoyer WE. 2008. Leadership. In Achieving Career Success in Oncology: A Practical Guide for Fellows & Junior Faculty. Unknown: American Society of Clinical Oncology.
  • Betrus C; Remenapp R; Charpie J; Kudelka T; Brophy P; Smoyer WE; Lin JJ. 2007. Enhanced hemolysis in pediatric patients requiring extracorporeal membrane oxygenation and continuous renal replacement therapy.  Annals Of Thoracic And Cardiovascular Surgery: Official Journal Of The Association Of Thoracic And Cardiovascular Surgeons Of Asia. Vol. 13, no. 6. (December): e378.
  • Cramer CH 2nd; Mills M; Valentini RP; Smoyer WE; Haftel H; Brophy PD. 2007. Clinical presentation and outcome in a cohort of paediatric patients with membranous lupus nephritis.  Nephrology, Dialysis, Transplantation: Official Publication Of The European Dialysis And Transplant Association - European Renal Association. Vol. 22, no. 12. (December): e3495.
  • Vega-Warner,V; Ransom,R,F; Vincent,A,M; Brosius,F,C; Smoyer,W,E. 2004. Induction of antioxidant enzymes in murine podocytes precedes injury by puromycin aminonucleoside.  KIDNEY INTERNATIONAL. Vol. 66, no. 5. (November): 1881-1889.
  • Siu,B; Wiggins,R,C; Smoyer,W,E; Delaney,C; Sullivan,K,A; Stevens,M,J; Brosius,F,C. 2001. Early loss of glomerular podocytes in rat models of diabetes.  DIABETES. Vol. 50, no. June: A64-A64.
  • Ransom,R,F; Smoyer,W,E. 1999. Protamine sulfate and oxidant stress cause similar changes in Hsp27 intracellular distribution in cultured podocytes.  PEDIATRIC RESEARCH. Vol. 45, no. 4. (April): 336A-336A.
  • Smoyer,W,E; Brouhard,B,H. 1989. ENHANCED GFR RESPONSE TO ORAL VS INTRAVENOUS (IV) ARGININE ADMINISTRATION.  CLINICAL RESEARCH. Vol. 37, no. 1. (January): A75-A75.
  • Smoyer,W,E; Brouhard,B,H. 1989. ENHANCED GFR RESPONSE TO ORAL VS INTRAVENOUS (IV) ARGININE ADMINISTRATION.  KIDNEY INTERNATIONAL. Vol. 35, no. 1. (January): 474-474.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000