Samantha J. King, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Samantha J. King, PhD

Samantha J. King, PhD

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, OH 43205 [ map ]
PH: (614) 722-2912
FX: (614) 722-2818
Email Me


Samantha King, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis at Nationwide Children’s Hospital and an Associate Professor in the Department of Pediatrics at The Ohio State University College of Medicine. Dr. King’s research program focuses on the pathogenesis of alpha-hemolytic streptococci.

View CV »


  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Bacteria in the genus Streptococcus cause a wide range of human diseases including pneumonia, bacteremia, otitis media and endocarditis. These diseases are major causes of morbidity and mortality world-wide. Development of more effective vaccines and treatments will require a greater understanding of the pathogenic mechanisms utilized by these organisms. Glycans decorate all host surfaces and many host molecules, and as such can play a critical role in the disease process. Dr. King’s laboratory studies how alpha-hemolytic streptococci modify and interact with host glycans and how these interactions contribute to pathogenicity. Two major avenues of her work include; 1) defining how these bacteria can release carbohydrates from host glycans and utilize these free carbohydrates for growth, and 2) how interactions with host glycans can mediate bacterial binding to host surfaces.

Education and Training

Undergraduate School

  • University of Leicester, Leicester, UK
    Date Completed: 06/01/1994


  • University of Warwick, Coventry UK
    Date Completed: 10/01/1999

Post Doctoral

  • University of Warwick, Coventry, UK
    Date Completed: 10/01/2002

Post Doctoral

  • University of Pennsylvania, Philadelphia, PA
    Date Completed: 10/01/2005

Professional Experience


  • Associate Professor, Department of Pediatrics, The Ohio State University College of Medicine


  • Assistant Professor, Department of Pediatrics, The Ohio State University College of Medicine


  • Sundaram S., Rahman M.A., Mitra S., Woodiga S.A., King S.J. and Wewers M.D. 2016. I?B? regulates human monocyte-pro-inflammatory responses induced by Streptococcus pneumoniae.  PLoS One. Vol. 11, no. 9. (September): ee0161931.
  • Blanchette K.A., Shenoy A.T., Milner J.2nd, Gilley R.P., McClure E., Hinojosa C.A., Kumar N., Daughtery S.C., Tallon L.J., Ott S., King S.J., Ferreira D.M., Gordon S.B., Tettelin H., and Orihuela C.J. 2016. Neuraminidase: A exposed galactose promotes Streptococcus pneumoniae biofilm formation during colonization.  Infection And Immunity. Vol. Epub ahead of print, no. August: e..
  • Singh A.K., Osman A.S., Woodiga S.A., White P., Mahan J.D., and King S.J. 2016. Defining the role of pneumococcal neuraminidases and O-glycosidase in pneumococcal hemolytic uremic syndrome.  Journal of Medical Microbiology. Vol. Epub ahead of print, no. July.
  • Singh A.K., Pluvinage B., Higgins M.A., Dalia A.B., Woodiga S.A., Flynn M., Lloyd A.R., Wesier J.N., Stubbs K.A., Boraston A.B., and King S.J. 2014. Unravelling the multiple functions of the architecturally intricate Streptococcus pnumoniae beta-galactosidase, BgaA.  PLoS Pathogens. Vol. 10, no. 9. (September): ee1004364.
  • Ouyang K., Woodiga S., Dwivedi V., Marion C., Singh A., Binjawadagi B., Hiremath J., Manickam C., Schleappi R., Mahesh K., Wu J., King S., and Renukaradhya G.J. 2014. Pretreatment of epithelial cells with live Streptococcus pneumoniae has no detectable effect on influenza A virus replication in vitro.  PLoS One. Vol. 9, no. 3. (March): ee90066.
  • Linke C.M., Woodiga S.A., Meyers D.J., Buckwalter C.M., Salhi H.E. and King, S.J. 2013. ) The ABC transporter encoded at the pneumococcal fructooligosaccharides utilization locus correlates with the ability to utilize long and short chain fructooligosaccharides.  Journal of Bacteriology. Vol. 195, no. 5. (March): 1031-1041.
  • Link C.M., Woodiga S.A., Meyers D.J., Buckwalter C.M., Salhi H.E., and King S.J. 2013. The ABC Transporter Encoded at the Pneumococcal Fructooligosaccharide Utilization Locus Determines the Ability To Utilize Long- and Short-Chain Fructooligosaccharides.  Journal of Bacteriology. Vol. 195, no. 5. (March): 1031-1041.
  • Buckwalter C.M. and King S.J. 2012. Pneumococcal carbohydrate transport: food for thought.  Trends in Microbiology. Vol. 20, no. 11. (September): 517-522.
  • Marion C., Stewart J.M., Tazi M.F., Burnaugh A.M., Linke C.M., Woodiga S.A. and King S.J. 2012. Streptococcus pneumoniae can utilize multiple sources of hyaluronic acid for growth.  Infection and Immunity. Vol. 80, no. 4. (April): 1390-1398.
  • Marion C., Aten A.E., Woodiga S.A. and King S.J. 2011. Identification of an ATPase, MsmK, which energizes multiple carbohydrate ABC transporters in Streptococcus pneumoniae.  Infection and Immunity. Vol. 79, no. 10. (October): 4193-4200.
  • King, Samantha J. 2011. Advances in Vaccines for Streptococcus pneumoniae. In XIAPO Manual of Pediatric Otorhinolaryngology. Edited by Sih, T., Chinski, A., Eavey, R., and Goddino, R.. Sao Paulo: Editora e Grafica Vida & Consciencia.
  • Limoli D.H., Sladek J.A., Fuller L.A., Singh A.K. and King S.J. 2011. BgaA acts as an adhesin to mediate attachment of some pneumococcal strains to human epithelial cells.  Microbiology- SGM. Vol. 157, no. August: 2369-2381.
  • Chen G.Y., Chen X., King S.J., Cavassani K.A., Cheng J., Zheng X., Cao H., Yu H., Qu J., Fang D., Wu W., Bai X.F., Liu J.Q., Woodiga S.A., Chen C., Sun L., Hogaboam C.M., Kunkel S.L., Zheng P. and Liu Y. 2011. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction.  Nature Biotechnology. Vol. 29, no. 5. (May): 428-435.
  • Marion C., Burnaugh A.M., Woodiga S.A. and King S.J. 2011. Sialic acid transport contributes to pneumococcal colonization.  Infection and Immunity. Vol. 79, no. 3. (March): 1262-1269.
  • King S.J. 2010. Pneumococcal modification of host sugars: a major contributor to colonization of the human airway?.  Molecular Oral Biology. Vol. 25, no. 1. (February): 15-24.
  • Marion C., Limoli D.H., Bobulsky G.S., Abraham J.L., Burnaugh A.M. and King S.J. 2009. Identification of a pneumococcal glycosidase that modifies O-linked glycans.  Infection and Immunity. Vol. 77, no. 4. (April): 1389-1396.
  • Gut H., King S.J. and Walsh M.A. 2008. Structural and functional studies of Streptococcus pneumoniae neuraminidase B: An intramolecular trans-sialidase.  FEBS Letters. Vol. 582, no. 23-24. (October): 3348-3352.
  • Burnaugh A.M., Frantz L.J. and King S.J. 2008. Growth of Streptococcus pneumoniae on human glycoconjugates is dependent upon the sequential activity of bacterial exoglycosidases.  Journal of Bacteriology. Vol. 190, no. 1. (January): 221-230.
  • Roche A.M., King S.J. and Weiser J.N. 2007. Live attenuated Streptococcus pneumoniae strains induce serotype-independent mucosal and systemic protection in mice.  Infection and Immunity. Vol. 75, no. 5. (May): 2469-2475.
  • King S.J., Hippe K.R. and Weiser J.N. 2006. Deglycosylation of human glycoconjugates by the sequential activities of exoglycosidases expressed by Streptococcus pneumoniae.  Molecular Microbiology. Vol. 59, no. 3. (February): 961-974.
  • King S.J., Whatmore A.M. and Dowson C.G. 2005. NanA, a neuraminidase from Streptococcus pneumoniae, shows high levels of sequence diversity, at least in part through recombination with Streptococcus oralis.  Journal of Bacteriology. Vol. 187, no. 15. (August): 5376-5386.
  • King S.J., Hippe K.R., Gould J.M., Bae D., Peterson S., Cline R.T., Fasching C., Janoff E.N. and Weiser J.N. 2004. Phase variable desialylation of host proteins that bind to Streptococcus pneumoniae in vivo and protect the airway.  Molecular Microbiology. Vol. 54, no. 1. (October): 159-171.
  • King S.J., Allen A.G., Maskell D.J., Dowson C.G. and Whatmore A.M. 2004. Distribution, genetic diversity, and variable expression of the gene encoding hyaluronate lyase within the Streptococcus suis population.  Journal of Bacteriology. Vol. 186, no. 14. (July): 4740-4747.
  • Shakhnovich E.A., King S.J. and Weiser J.N. 2002. Neuraminidase expressed by Streptococcus pneumoniae desialylates the lipopolysaccharide of Neisseria meningitidis and Haemophilus influenzae: a paradigm for interbacterial competition among pathogens of the human respiratory tract.  Infection and Immunity. Vol. 70, no. 12. (December): 7161-7164.
  • King S.J., Leigh J.A., Heath P.J., Luque I., Tarradas C., Dowson C.G. and Whatmore A.M. 2002. Development of a multilocus sequence typing scheme for the pig pathogen Streptococcus suis: Identification of virulent clones and potential capsular serotype exchange.  Journal of Clinical Microbiology. Vol. 40, no. 10. (October): 3671-3680.
  • King S.J., Heath P.J., Luque I., Tarradas C., Dowson C.G. and Whatmore A.M. 2001. Distribution and genetic diversity of suilysin in Streptococcus suis isolated from different diseases of pigs and characterization of the genetic basis of suilysin absence.  Infection and Immunity. Vol. 69, no. 12. (December): 7572-7582.
  • Muller-Graf C.DM., Whatmore A.M., King S.J., Trzcinski K., Pickerill A.P., Doherty N., Paul J., Griffiths D., Crook D. and Dowson C.G. 1999. Population biology of Streptococcus pneumoniae isolated from oropharyngeal carriage and invasive disease.  Microbiology- SGM. Vol. 145, no. November: 3283-3293.
  • Whatmore A.M., King S.J., Doherty N.C., Sturgeon D., Chanter N. and Dowson C.G. 1999. Molecular characterization of equine isolates of Streptococcus pneumoniae: Natural disruption of genes encoding the virulence factors pneumolysin and autolysin.  Infection and Immunity. Vol. 67, no. 6. (June): 2776-2782.
  • Dowson C.G., Barcus V., King S.J., Pickerill P., Whatmore A. and Yeo M. 1997. Horizontal gene transfer and the evolution of resistance and virulence determinants in Streptococcus.  Journal of Applied Microbiology. Vol. 83, no. January: S42-S51.
  • Linke C.M., Woodiga S.A., Meyers D.J., Buckwalter C.M., Salhi H.E. and King S.J. The ABC transporter encoded at the pneumococcal fructooligosaccharides utilization locus correlates with the ability to utilize long and short chain fructooligosaccharides.  Journal of Bacteriology.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000