John David Spencer, MD

John David Spencer, MD, is a Pediatric Nephrologist and a Principal Investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's Hospital and an Assistant Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Spencer's NIH-funded research focuses on defining the molecular mechanisms that regulate and prevent infections in the kidney and urinary tract, with an emphasis on the role that antimicrobial peptides play in maintaining sterility in the urinary tract.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• Dr. Spencer's research focus is attempting to understand the mechanisms operational in maintaining sterility and preventing infection in the kidney and urinary tract. Specifically, he and his team are interested in defining how antimicrobial peptides, a ubiquitous component of the innate immune system, maintain urinary tract sterility. His long-term goals are to determine the precise role that antimicrobial peptides play in the regulation and prevention of urinary tract infections.

Medical School

• Indiana University School of Medicine
  Date Completed: 07/30/2006

Residency

• LeBonheur Children's Hospital
  Date Completed: 06/30/2009

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2012

Department:

• Pediatrics

Section:

• Nephrology

Speciality:

• Pediatric Nephrology
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 07/01/2012

• Spencer JD, Schwaderer AL, Wang H, Bartz J, Kline J, Eichler T, Desouza KR, Sims-Lucas S, Baker P, Hains DS. 2013. Ribonuclease 7, an antimicrobial peptide up-regulated during infection, contributes to microbial defense of the human urinary tract.  Kidney Int.. Vol. 83, no. 4. (April): 615-625.
• Wang,Huanyu; Schwaderer,Andrew,L; Kline,Jennifer; Spencer,John,David; Kline,David; Hains,David,S. 2013. Contribution of Structural Domains to the Activity of Ribonuclease 7 against Uropathogenic Bacteria.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. Vol. 57, no. 2. (February): 766-774.
• Becknell,Brian; Hains,David,S; Schwaderer,Andrew,L; VanderBrink,Brian,A; Spencer,John,David; Reagan,Patricia,B; McHugh,Kirk,M. 2012. Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy.  JOURNAL OF PEDIATRIC UROLOGY. Vol. 8, no. 5. (October): 470-476.
• Spencer JD, Hastings MC, Wyatt RJ, Ault BH. 2012. Has the Incidence of Steroid Sensitive Nephrotic Syndrome Changed?.  Clin Nephrol. Vol. 78, no. 2. (August): 112-005.
• Spencer,John,David; Bates,Carlton,M; Mahan,John,D; Niland,Mary-Lynn; Staker,Shannon,R; Hains,David,S; Schwaderer,Andrew,L. 2012. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection.  JOURNAL OF PEDIATRIC UROLOGY. Vol. 8, no. 1. (February): 72-76.
• Spencer,John,David; Hains,David,S; Porter,Edith; Bevins,Charles,L; DiRosario,Julianne; Becknell,Brian; Wang,Huanyu; Schwaderer,Andrew,L. 2012. Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract.  PLOS ONE. Vol. 7, no. 2. (February): ee31712.
• Spencer,John,David; Schwaderer,Andrew; Mchugh,Kirk; VanderBrink,Brian; Becknell,Brian; Hains,David,S. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  PEDIATRIC NEPHROLOGY. Vol. 26, no. 11. (November): 1995-2001.
• Janjua, H, Ayoob, R, Spencer JD. 2011. Hypertension in a Toddler with Bell’s Palsy.  Consultant for Pediatrics. Vol. 10, no. 6. (October): e203.
• Spencer,John,D; Schwaderer,Andrew,L; Dirosario,Julianne,D; McHugh,Kirk,M; McGillivary,Glen; Justice,Sheryl,S; Carpenter,Ashley,R; Baker,Peter,B; Harder,Juergen; Hains,David,S. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  KIDNEY INTERNATIONAL. Vol. 80, no. 2. (July): 175-181.
• Spencer,John,D; Schwaderer,Andrew,L; Dirosario,Julianne,D; McHugh,Kirk,M; McGillivary,Glen; Justice,Sheryl,S; Carpenter,Ashley,R; Baker,Peter,B; Harder,Jürgen; Hains,David,S. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  Kidney international. Vol. 80, no. 2. (July): 174-180.
• Spencer,John,David; Schwaderer,Andrew; Mchugh,Kirk; Hains,David,S. 2010. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.  PEDIATRIC NEPHROLOGY. Vol. 25, no. 12. (December): 2469-2475.
• Spencer,John,D; Schwaderer,Andrew; Mchugh,Kirk; Hains,David. 2010. RNase 7 Expression in the Human Kidney and Urinary Tract.  PEDIATRIC RESEARCH. Vol. 68, no. 4. (October): 356-356.
• Spencer JD, Sanders JT, Ault BH. 2009. Two cases of hematuria with hemoglobin C trait.  Pediatr Nephrol. Vol. 24, no. 12. (December): 2455-2457.
• Spencer JD, Hastings MC, Rye AK, English BK, Ault BH. 2008. Gastroenteritis caused by Edwardsiella tarda in a pediatric renal transplant recipient.  Pediatr Transplant. Vol. 12, no. 2. (March): 238-241.
• 1. Spencer JD, Schwaderer AL, Eichler T, Wang H, Kline J, Cohen D, Hains DS. Endogenous Ribonuclease Inhibitor Regulates the Antimicrobial Activity of Ribonuclease 7 in the Human Urinary Tract.  Kidney Int..