John David Spencer, MD :: Nationwide Children's Hospital, Columbus, Ohio
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700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4360
FX: (614) 722-6482

Location Information for Patients

Main Campus


John David Spencer, MD, is a Pediatric Nephrologist and a Principal Investigator in the Center for Clinical and Translational Research in The Research Institute at Nationwide Children's Hospital and an Assistant Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Spencer's NIH-funded research focuses on defining the molecular mechanisms that regulate and prevent infections in the kidney and urinary tract, with an emphasis on the role that antimicrobial peptides play in maintaining sterility in the urinary tract.


  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. Spencer's research focus is attempting to understand the mechanisms operational in maintaining sterility and preventing infection in the kidney and urinary tract. Specifically, he and his team are interested in defining how antimicrobial peptides, a ubiquitous component of the innate immune system, maintain urinary tract sterility. His long-term goals are to determine the precise role that antimicrobial peptides play in the regulation and prevention of urinary tract infections.

Education and Training

Medical School

  • Indiana University School of Medicine
    Date Completed: 07/30/2006


  • LeBonheur Children's Hospital
    Date Completed: 06/30/2009


  • Nationwide Children's Hospital
    Date Completed: 06/30/2012


  • Pediatrics


  • Nephrology


  • Pediatric Nephrology
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2012


  • Schwaderer AL, Wang H, Kim S, Kline JM, Liang D, Brophy PD, McHugh KM, Tseng GC, Saxena V, Barr-Beare E, Pierce KR, Shaikh N, Manak JR, Cohen DM, Becknell B, Spencer JD, Baker PB, Yu CY, Hains DS. 2016. Polymorphisms in a-Defensin-Encoding DEFA1A3 Associate with Urinary Tract Infection Risk in Children with Vesicoureteral Reflux.  Journal of the American Society of Nephrology. Vol. Epub, no. March: eEpub.
  • Watson J, Hains DS, Cohen D, Spencer JD, Kline J, Yin H, Schwaderer AL. 2016. Evaluation of Novel Urinary Tract Infection Biomarkers in Children.  Peds Res. Vol. Epub, no. February: eEpub.
  • Becknell,Brian; Spencer,John,David. 2016. A Review of Ribonuclease 7's Structure, Regulation, and Contributions to Host Defense.  International journal of molecular sciences. Vol. 17, no. 3. (January): e423.
  • Spencer,John,David; Jackson,Ashley,R; Li,Birong; Ching,Christina,B; Vonau,Martin; Easterling,Robert,S; Schwaderer,Andrew,L; McHugh,Kirk,M; Becknell,Brian. 2015. Expression and Significance of the HIP/PAP and RegIII gamma Antimicrobial Peptides during Mammalian Urinary Tract Infection.  PLOS ONE. Vol. 10, no. 12. (December): ee0144024.
  • Becknell,Brian; Schwaderer,Andrew; Hains,David,S; Spencer,John,David. 2015. Amplifying renal immunity: the role of antimicrobial peptides in pyelonephritis.  NATURE REVIEWS NEPHROLOGY. Vol. 11, no. 11. (November): 642-655.
  • Spencer, John David, Hains, David S. 2015. Chapter 51: Use of Urinalysis and Urine Culture in Screening. In AAP Textbook of Pediatric Care (6th Revised Edition). Edited by T. McInerny, H. Adam, D. Campbell, D. Kamat, K. Kelleher. Columbus: American Academy of Pediatrics.
  • Korbel,Lindsey; Spencer,John,David. 2015. Diabetes mellitus and infection: an evaluation of hospital utilization and management costs in the United States.  JOURNAL OF DIABETES AND ITS COMPLICATIONS. Vol. 29, no. 2. (March): 192-195.
  • Schnaper HW, Schubert K, Perlman SA, Clark SL, Hains DS, Roach JL, Skversky AL, Spencer JD, Springel T, Swartz SJ, Norwood VF, Satlin LM. 2015. Training the next generation of pediatric nephrology advocates: the john e. Lewy foundation advocacy scholars program.  J Pediatr. Vol. 166, no. 2. (February): 218-219.
  • Becknell,Brian; Schober,Megan; Korbel,Lindsey; Spencer,John,David. 2015. The diagnosis, evaluation and treatment of acute and recurrent pediatric urinary tract infections.  EXPERT REVIEW OF ANTI-INFECTIVE THERAPY. Vol. 13, no. 1. (January): 81-90.
  • Becknell,Brian; Eichler,Tad,E; Beceiro,Susana; Li,Birong; Easterling,Robert,S; Carpenter,Ashley,R; James,Cindy,L; McHugh,Kirk,M; Hains,David,S; Partida-Sanchez,Santiago; Spencer,John,D. 2015. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract.  KIDNEY INTERNATIONAL. Vol. 87, no. 1. (January): 151-161.
  • Skandarajan, A, Spencer JD, Cohen D, Kline J, Hains DS, Schwaderer, AL. 2014. Urinary Tract Infections, Familial Occurrence and Association with Other Infections.  J of Clin Ped Nephrol.. Vol. 2, no. 1. (June): 49-52.
  • Spencer JD, Schwaderer AL, Eichler T, Wang H, Kline J, Cohen D, Hains DS. 2014. Endogenous Ribonuclease Inhibitor Regulates the Antimicrobial Activity of Ribonuclease 7 in the Human Urinary Tract.  Kidney Int.. Vol. 85, no. 5. (May): 1179-1191.
  • Becknell,Brian; Spencer,John,David; Carpenter,Ashley,R; Chen,Xi; Singh,Aspinder; Ploeger,Suzanne; Kline,Jennifer; Ellsworth,Patrick; Li,Birong; Proksch,Ehrhardt; Schwaderer,Andrew,L; Hains,David,S; Justice,Sheryl,S; McHugh,Kirk,M. 2013. Expression and Antimicrobial Function of Beta-Defensin 1 in the Lower Urinary Tract.  PLOS ONE. Vol. 8, no. 10. (October): e10.1371.
  • Spencer JD, Schwaderer AL, Becknell B, Watson J, Hains DS. 2013. The innate immune response during urinary tract infection and pyelonephritis.  Pediatric Nephrology. Vol. NA, no. June: ePMID: 23732397.
  • Spencer JD, Schwaderer AL, Wang H, Bartz J, Kline J, Eichler T, Desouza KR, Sims-Lucas S, Baker P, Hains DS. 2013. Ribonuclease 7, an antimicrobial peptide up-regulated during infection, contributes to microbial defense of the human urinary tract.  Kidney International. Vol. 83, no. 4. (April): 615-625.
  • Wang,Huanyu; Schwaderer,Andrew,L; Kline,Jennifer; Spencer,John,David; Kline,David; Hains,David,S. 2013. Contribution of Structural Domains to the Activity of Ribonuclease 7 against Uropathogenic Bacteria.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. Vol. 57, no. 2. (February): 766-774.
  • Becknell,Brian; Hains,David,S; Schwaderer,Andrew,L; VanderBrink,Brian,A; Spencer,John,David; Reagan,Patricia,B; McHugh,Kirk,M. 2012. Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy.  JOURNAL OF PEDIATRIC UROLOGY. Vol. 8, no. 5. (October): 470-476.
  • Spencer JD, Hastings MC, Wyatt RJ, Ault BH. 2012. Has the incidence of childhood steroid sensitive nephrotic syndrome changed?.  Clin Nephrol.. Vol. 78, no. 2. (August): 112-115.
  • Spencer JD, Hastings MC, Wyatt RJ, Ault BH. 2012. Has the Incidence of Steroid Sensitive Nephrotic Syndrome Changed?.  Clin Nephrol. Vol. 78, no. 2. (August): 112-005.
  • Spencer,John,David; Bates,Carlton,M; Mahan,John,D; Niland,Mary-Lynn; Staker,Shannon,R; Hains,David,S; Schwaderer,Andrew,L. 2012. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection.  JOURNAL OF PEDIATRIC UROLOGY. Vol. 8, no. 1. (February): 72-76.
  • Spencer,John,David; Hains,David,S; Porter,Edith; Bevins,Charles,L; DiRosario,Julianne; Becknell,Brian; Wang,Huanyu; Schwaderer,Andrew,L. 2012. Human Alpha Defensin 5 Expression in the Human Kidney and Urinary Tract.  PLOS ONE. Vol. 7, no. 2. (February): ee31712.
  • Spencer,John,David; Schwaderer,Andrew; Mchugh,Kirk; VanderBrink,Brian; Becknell,Brian; Hains,David,S. 2011. The demographics and costs of inpatient vesicoureteral reflux management in the USA.  PEDIATRIC NEPHROLOGY. Vol. 26, no. 11. (November): 1995-2001.
  • Janjua, H, Ayoob, R, Spencer JD. 2011. Hypertension in a Toddler with Bell’s Palsy.  Consultant for Pediatrics. Vol. 10, no. 6. (October): e203.
  • Spencer,John,D; Schwaderer,Andrew,L; Dirosario,Julianne,D; McHugh,Kirk,M; McGillivary,Glen; Justice,Sheryl,S; Carpenter,Ashley,R; Baker,Peter,B; Harder,Juergen; Hains,David,S. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  KIDNEY INTERNATIONAL. Vol. 80, no. 2. (July): 175-181.
  • Spencer,John,D; Schwaderer,Andrew,L; Dirosario,Julianne,D; McHugh,Kirk,M; McGillivary,Glen; Justice,Sheryl,S; Carpenter,Ashley,R; Baker,Peter,B; Harder,Jürgen; Hains,David,S. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  Kidney international. Vol. 80, no. 2. (July): 174-180.
  • Spencer,John,D; Schwaderer,Andrew,L; Dirosario,Julianne,D; McHugh,Kirk,M; McGillivary,Glen; Justice,Sheryl,S; Carpenter,Ashley,R; Baker,Peter,B; Harder,Juergen; Hains,David,S. 2011. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract.  KIDNEY INTERNATIONAL. Vol. 80, no. 2. (July): 175-181.
  • Spencer,John,David; Schwaderer,Andrew; Mchugh,Kirk; Hains,David,S. 2010. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA.  PEDIATRIC NEPHROLOGY. Vol. 25, no. 12. (December): 2469-2475.
  • Spencer,John,D; Schwaderer,Andrew; Mchugh,Kirk; Hains,David. 2010. RNase 7 Expression in the Human Kidney and Urinary Tract.  PEDIATRIC RESEARCH. Vol. 68, no. 4. (October): 356-356.
  • Spencer JD, Sanders JT, Ault BH. 2009. Two cases of hematuria with hemoglobin C trait.  Pediatr Nephrol. Vol. 24, no. 12. (December): 2455-2457.
  • Spencer JD, Hastings MC, Rye AK, English BK, Ault BH. 2008. Gastroenteritis caused by Edwardsiella tarda in a pediatric renal transplant recipient.  Pediatr Transplant. Vol. 12, no. 2. (March): 238-241.
  • Watson J, Hains D, Cogen D, Spencer JD, Schwaderer A. Urinary Tract Infection and Antimicrobial Stewardship in the Emergency Department.  Ped Emergency Care.
  • Eichler T, Becknell B, Easterling R, Ingraham S, Cohen D, Schwaderer S, Hains D, Li B, Cohen A, Metheny J, Tridandapani S, Spencer JD. Insulin and the PI3K/AKT Signaling Pathway Regulate Ribonuclease 7 Expression in the Human Urinary Tract.  Kidney International.
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700 Children's Drive Columbus, Ohio 43205 614.722.2000