Zarife Sahenk, MD, PhD :: Nationwide Children’s Hospital, Columbus, Ohio

Zarife Sahenk, MD, PhD

Zarife Sahenk, MD, PhD Best Doctors 2011-2012

Contact Information

Neurology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-2203
FX: (614) 355-5247
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, OH 43205 [ map ]
PH: (614) 722.2203
FX: (614) 722.2203

Location Information for Patients

Main Campus
Westerville Surgery Center

Biography

Zarife Sahenk, MD, PhD, is an attending neurologist at Nationwide Children’s, Director of Clinical and Experimental Neuromuscular Pathology at The Research Institute at Nationwide Children’s and Professor of Pediatrics, Pathology and Neurology at The Ohio State University College of Medicine. Her laboratory plays an integral part in the preclinical studies and the gene therapy clinical trials that take place in the Center for Gene Therapy at Nationwide Children’s Hospital. She has provided valuable analysis of muscle derived from the first clinical gene trials for Duchenne and limb girdle muscular dystrophies. A primary goal of her research program is to gain a detailed understanding of the anatomical and molecular basis of nerve degeneration and impaired regeneration in hereditary peripheral neuropathies. Particular emphasis is placed on the role of trophic factors secreted by Schwann cells in regeneration-associated myelination. The role of neurotrophin-3 (NT-3) in nerve regeneration in animal models of Charcot-Marie-Tooth (CMT) is currently being investigated and a gene therapy paradigm is being developed using AAV1.NT-3. Dr. Sahenk is named among the “Best Doctors in America.”

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • A primary goal of Dr. Sahenk's research program is to gain a detailed understanding of the anatomical and molecular basis of hereditary peripheral neuropathies. Particular emphasis is placed on the role of trophic factors secreted by Schwann cells in regeneration-associated myelination. The role of neurotrophin-3 in nerve regeneration in patients and animal models of Charcot-Marie-Tooth (CMT) is currently being investigated. These studies are relevant to understanding the mechanism of axonal loss and impaired regeneration in CMT disorders and developing rational therapies to promote nerve repair.

Research Funding*:

  • Evaluating the Potential Efficacy of trkB, trkC Receptor Agonists and Their Combination in a Mouse Model of Charcot-Marie-Tooth Disease, Anonymous

Education and Training

Internship

  • Hacettepe University
    Date Completed: 06/30/1972

Medical School

  • Hacettepe University
    Date Completed: 07/31/1972

Residency

  • Hacettepe University
    Date Completed: 09/30/1972

Residency

  • Ohio State University Wexner Medical Center
    Date Completed: 06/30/1975

Fellowship

  • Ohio State University Wexner Medical Center
    Date Completed: 06/30/1978

Post Doctoral

  • The Ohio State University
    Date Completed: 06/30/1998

Department:

  • Pediatrics

Section:

  • Neurology

Specialty:

  • Neurology

Date of Appointment at Nationwide Children’s Hospital:

  • 06/30/2005

Professional Experience

2005–present

  • Professor of Neurology and Pediatrics, The Research Institute at Nationwide Children's Hospital, Neuromuscular Program, Director, Neuromuscular Pathology

1999–present

  • Professor of Neurology, Department of Neurology, Ohio State University College of Medicine

1999–2005

  • Director of the Clinical and Experimental Neuromuscular Disease Laboratories, Division of Neuromuscular Disease, Department of Neurology, Ohio State University Hospitals

1986–1987

  • Visiting Scientist, Bio-Architectonics Center, Case Western Reserve University, Cleveland, Ohio

1983–1999

  • Associate Professor or Neurology, Department of Neurology, Ohio State University College of Medicine

1978–1983

  • Assistant Professor, Department of Neurology, Ohio State University College of Medicine

Publications

  • Rodino-Klapac,Louise,R; Mendell,Jerry,R; Sahenk,Zarife. 2013. Update on the treatment of Duchenne muscular dystrophy.  Current neurology and neuroscience reports. Vol. 13, no. 3. (March): 332-?.
  • Findlay,Andrew,R; Lewis,Sarah; Sahenk,Zarife; Flanigan,Kevin,M. 2013. Camptocormia as a late presentation in a manifesting carrier of duchenne muscular dystrophy.  MUSCLE & NERVE. Vol. 47, no. 1. (January): 124-127.
  • Mendell,Jerry,R; Rodino-Klapac,Louise; Sahenk,Zarife; Malik,Vinod; Kaspar,Brian,K; Walker,Christopher,M; Clark,K,Reed. 2012. Gene therapy for muscular dystrophy: Lessons learned and path forward.  NEUROSCIENCE LETTERS. Vol. 527, no. 2. (October): 90-99.
  • Srivastava,Amit,K; Renusch,Samantha,R; Naiman,Nicole,E; Gu,Shuping; Sneh,Amita; Arnold,W,David; Sahenk,Zarife; Kolb,Stephen,J. 2012. Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.  NEUROBIOLOGY OF DISEASE. Vol. 47, no. 2. (August): 163-173.
  • Meadows,Eric; Kota,Janaiah; Lewis,Sarah; Sahenk,Zarife; Clark,Reed; Mendell,Jerry; Rodino-Klapac,Louise. 2012. Reducing Skeletal Muscle Fibrosis with AAV-Delivered miR-29.  NEUROLOGY. Vol. 78, no. April.
  • Lowes,Linda,Pax; Alfano,Lindsay; Viollet,Laurence; Rosales,Xiomara,Quintero; Sahenk,Zarife; Kaspar,Brian,K; Clark,K,Reed; Flanigan,Kevin,M; Mendell,Jerry,R; McDermott,Michael,P. 2012. Knee extensor strength exhibits potential to predict function in sporadic inclusion-body myositis.  MUSCLE & NERVE. Vol. 45, no. 2. (February): 163-168.
  • Szulc,Karolina; Borzuta,Karol; Lisiak,Dariusz; Buczynski,Janusz,T; Strzelecki,Jerzy; Grzeskowiak,Eugenia; Magda,Fabian; Lisiak,Beata. 2011. Influence of cross-breeding of native breed sows of Zlotnicka spotted with boars of Duroc and polish large white (PLW) breeds on the slaughter value fatteners.  AFRICAN JOURNAL OF BIOTECHNOLOGY. Vol. 10, no. 72. (November): 16402-16405.
  • Sahenk Z; Mendell JR. 2011. The muscular dystrophies: distinct pathogenic mechanisms invite novel therapeutic approaches.  Current Rheumatology Reports. Vol. 13, no. 3. (June): e199.
  • Kisanuki,Yasushi; Watanabe,Fumihiro; Ghodsizadeh,Odelia; Arnold,William; Hernandez,Anthony; Schumer,Mackenzie; Hammer,Robert; Sahenk,Zarife. 2011. Histopathologic and Electrophysiologic Characterization of the Rat Model for Hereditary Spastic Paraplegia.  NEUROLOGY. Vol. 76, no. 9. (March): A413-A413.
  • Mendell JR; Rodino-Klapac LR; Rosales XQ; Coley BD; Galloway G; Lewis S; Malik V; Shilling C; Byrne BJ; Conlon T; Campbell KJ; Bremer WG; Taylor LE; Flanigan KM; Gastier-Foster JM; Astbury C; Kota J; Sahenk Z; Walker CM; Clark KR. 2010. Sustained alpha-sarcoglycan gene expression after gene transfer in limb-girdle muscular dystrophy, type 2D.  Annals Of Neurology. Vol. 68, no. 5. (November): e629.
  • Gladman JT; Bebee TW; Edwards C; Wang X; Sahenk Z; Rich MM; Chandler DS. 2010. A humanized Smn gene containing the SMN2 nucleotide alteration in exon 7 mimics SMN2 splicing and the SMA disease phenotype.  Human Molecular Genetics. Vol. 19, no. 21. (November): e4239.
  • Mendell,Jerry,R; Campbell,Katherine; Rodino-Klapac,Louise; Sahenk,Zarife; Shilling,Chris; Lewis,Sarah; Bowles,Dawn; Gray,Steven; Li,Chengwen; Galloway,Gloria; Malik,Vinod; Coley,Brian; Clark,K,Reed; Li,Juan; Xiao,Xiao; Samulski,Jade; McPhee,Scott,W; Samulski,R,Jude; Walker,Christopher,M. 2010. Brief Report: Dystrophin Immunity in Duchenne's Muscular Dystrophy.  NEW ENGLAND JOURNAL OF MEDICINE. Vol. 363, no. 15. (October): 1429-1437.
  • Mendell JR; Campbell K; Rodino-Klapac L; Sahenk Z; Shilling C; Lewis S; Bowles D; Gray S; Li C; Galloway G; Malik V; Coley B; Clark KR; Li J; Xiao X; Samulski J; McPhee SW; Samulski RJ; Walker CM. 2010. Dystrophin immunity in Duchenne's muscular dystrophy.  The New England Journal Of Medicine. Vol. 363, no. 15. (October): e1429.
  • Sahenk Z; Galloway G; Edwards C; Malik V; Kaspar BK; Eagle A; Yetter B; Forgie A; Tsao D; Lin JC. 2010. TrkB and TrkC agonist antibodies improve function, electrophysiologic and pathologic features in Trembler J mice.  Experimental Neurology. Vol. 224, no. 2. (August): e495.
  • Collins MP; Periquet-Collins I; Sahenk Z; Kissel JT. 2010. Direct immunofluoresence in vasculitic neuropathy: specificity of vascular immune deposits.  Muscle & Nerve. Vol. 42, no. 1. (July): e62.
  • Rosales XQ; Gastier-Foster JM; Lewis S; Vinod M; Thrush DL; Astbury C; Pyatt R; Reshmi S; Sahenk Z; Mendell JR. 2010. Novel diagnostic features of dysferlinopathies.  Muscle & Nerve. Vol. 42, no. 1. (July): e14.
  • Malik V; Rodino-Klapac LR; Viollet L; Wall C; King W; Al-Dahhak R; Lewis S; Shilling CJ; Kota J; Serrano-Munuera C; Hayes J; Mahan JD; Campbell KJ; Banwell B; Dasouki M; Watts V; Sivakumar K; Bien-Willner R; Flanigan KM; Sahenk Z; Barohn RJ; Walker CM; Mendell JR. 2010. Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy.  Annals Of Neurology. Vol. 67, no. 6. (June): e771.
  • Rodino-Klapac LR; Montgomery CL; Bremer WG; Shontz KM; Malik V; Davis N; Sprinkle S; Campbell KJ; Sahenk Z; Clark KR; Walker CM; Mendell JR; Chicoine LG. 2010. Persistent expression of FLAG-tagged micro dystrophin in nonhuman primates following intramuscular and vascular delivery.  Molecular Therapy: The Journal Of The American Society Of Gene Therapy. Vol. 18, no. 1. (January): e109.
  • Kota J; Handy CR; Haidet AM; Montgomery CL; Eagle A; Rodino-Klapac LR; Tucker D; Shilling CJ; Therlfall WR; Walker CM; Weisbrode SE; Janssen PM; Clark KR; Sahenk Z; Mendell JR; Kaspar BK. 2009. Follistatin gene delivery enhances muscle growth and strength in nonhuman primates.  Science Translational Medicine. Vol. 1, no. 6. (November): e6ra15.
  • Mendell JR; Rodino-Klapac LR; Rosales-Quintero X; Kota J; Coley BD; Galloway G; Craenen JM; Lewis S; Malik V; Shilling C; Byrne BJ; Conlon T; Campbell KJ; Bremer WG; Viollet L; Walker CM; Sahenk Z; Clark KR. 2009. Limb-girdle muscular dystrophy type 2D gene therapy restores alpha-sarcoglycan and associated proteins.  Annals Of Neurology. Vol. 66, no. 3. (September): e290.
  • Tsao CY, Mendell J, Sahenk Z, Rusin J, Boue D. 2008. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings.  Semin Pediatr Neurol.. Vol. 15, no. 4. (December): 151-153.
  • Martin PT, Xu R, Rodino-Klapac LR, Oglesbay E, Camboni M, Montgomery CL, Shontz K, Chicoine L, Clark KR, Sahenk Z, Mendell JR, Janssen PM. 2008. Overexpression of Galgt2 in skeletal muscle prevents injury resulting from eccentric contractions in both mdx and wild type mice.  Am J Physiol Cell Physiol. Vol. 296, no. Epub. (December): C476-88.
  • Zhang X, Chow CY, Sahenk Z, Shy ME, Meisler MH, Li J. 2008. Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration.  Brain.. Vol. 131, no. Pt 8. (August): 1990-2001.
  • Sahenk Z, Oblinger J, Edwards C. 2008. Neurotrophin-3 deficient Schwann cells impair nerve regeneration.  Exp Neurol.. Vol. 221, no. 2. (August): 552-556.
  • Haidet AM, Rizo L, Handy C, Umapathi P, Eagle A, Shilling C, Boue D, Martin PT, Sahenk Z, Mendell JR, Kaspar BK. 2008. Long-term enhancement of skeletal muscle mass and strength by single gene administration of myostatin inhibitors.  Proc Natl Acad Sci USA.. Vol. 105, no. 11. (March): 4318-4322.
  • Li,Jun; Chow,Clement; Sahenk,Zarife; Shy,Michael; Meisler,Miriam; Zhang,Xuebao. 2008. Loss of function of Fig4 gene causes a neuronopathy and segmental demyelinaton.  NEUROLOGY. Vol. 70, no. 11. (March): A404-A404.
  • Edwards,Chris,J; Oblinger,Janet,L; Sahenk,Zarife. 2008. Neurotrophin 3 deficient Schwann cells are responsible for impaired nerve regeneration.  NEUROLOGY. Vol. 70, no. 11. (March): A339-A339.
  • Zhang,Xuebao; Chow,Clement; Sahenk,Zarife; Shy,Michael; Meisler,Miriam; Li,Jun. 2007. Of function of Fig4 gene causes a neuronopathy and segmental demyelinaton.  ANNALS OF NEUROLOGY. Vol. 62, no. 5. (November): 546-547.
  • Rodino-Klapac,Louise,R; Shilling,Chris,J; Sahenk,Zarife; Clark,K,Reed; Mendell,Jerry. 2007. Development of a potent viral based therapeutic for alpha-sarcoglycan deficiencies.  NEUROLOGY. Vol. 68, no. 12. (March): A305-A305.
  • Acharyya S, Villalta SA, Bakkar N, Bupha-Intr T, Janssen PM, Carathers M, Li ZW, Beg AA, Ghosh S, Sahenk Z, Weinstein M, Gardner KL, Rafael-Fortney JA, Karin M, Tidball JG, Baldwin AS, Guttridge DC. 2007. Interplay of IKK/NF-kappaB signaling in macrophages and myofibers promotes muscle degeneration in Duchenne muscular dystrophy.  Journal of Clinical Investigation. Vol. 117, no. 4. (January): 889-901.
  • Sahenk,Zarife. 2006. Emerging therapies in non-immune neuropathies.  NEUROMUSCULAR DISORDERS. Vol. 16, no. July: S101-S101.
  • Latov,Norman; Gorson,Kenneth,C; Brannagan,Thomas,H; Freeman,Roy,L; Apostolski,Slobodan; Berger,Alan,R; Bradley,Walter,G; Briani,Chiara; Bril,Vera; Busis,Neil,A; Cros,Didier,P; Dalakas,Marinos,C; Donofrio,Peter,D; Dyck,P,JamesB; England,John,D; Fisher,Morris,A; Herrmann,David,N; Menkes,Daniel,L; Sahenk,Zarife; Sander,Howard,W; Triggs,William,J; Vallat,Jean,Michel. 2006. Diagnosis and Treatment of Chronic Immune-mediated Neuropathies.  Journal of clinical neuromuscular disease. Vol. 7, no. 3. (March): 141-157.
  • Sahenk, Zarife. 2006. Neurotrophins and peripheral neuropathies.  Brain pathology (Zurich, Switzerland). Vol. 16, no. 4. (January): 311-9.
  • Sahenk, Z; Nagaraja, H, N; McCracken, B, S; King, W, M; Freimer, M, L; Cedarbaum, J, M; Mendell, J R. 2005. NT-3 promotes nerve regeneration and sensory improvement in CMT1A mouse models and in patients.  Neurology. Vol. 65, no. 5. (January): 681-9.
  • Acharyya, Swarnali; Butchbach, Matthew E, R; Sahenk, Zarife; Wang, Huating; Saji, Motoyasu; Carathers, Micheal; Ringel, Matthew, D; Skipworth, Richard J, E; Fearon, Kenneth C, H; Hollingsworth, Michael, A; Muscarella, Peter; Burghes, Arthur H, M; Rafael-Fortney, Jill, A; Guttridge, Denis C. 2005. Dystrophin glycoprotein complex dysfunction: a regulatory link between muscular dystrophy and cancer cachexia.  Cancer cell. Vol. 8, no. 5. (January): 421-32.
  • Mendell,J,R; Sahenk,Z. 2003. Painful sensory neuropathy - Reply.  NEW ENGLAND JOURNAL OF MEDICINE. Vol. 349, no. 3. (July): 306-307.
  • Mendell,J,R; Sahenk,Z. 2003. Painful sensory neuropathy.  NEW ENGLAND JOURNAL OF MEDICINE. Vol. 348, no. 13. (March): 1243-1255.
  • Collins, M, P; Periquet, M, I; Mendell, J, R; Sahenk, Z; Nagaraja, H, N; Kissel, J T. 2003. Nonsystemic vasculitic neuropathy: insights from a clinical cohort.  Neurology. Vol. 61, no. 5. (January): 623-30.
  • Sahenk, Zarife; Serrano-Munuera, Carmen; Chen, Lei; Kakabadze, Inga; Najagara, Haikady N. 2003. Evidence for impaired axonal regeneration in PMP22 duplication: studies in nerve xenografts.  Journal of the peripheral nervous system : JPNS. Vol. 8, no. 2. (January): 116-27.
  • Abrams, Charles, K; Freidin, Mona; Bukauskas, Feliksas; Dobrenis, Kostantin; Bargiello, Thaddeus, A; Verselis, Vytas, K; Bennett, Michael V, L; Chen, Lei; Sahenk, Zarife. 2003. Pathogenesis of X-linked Charcot-Marie-Tooth disease: differential effects of two mutations in connexin 32.  The Journal of neuroscience : the official journal of the Society for Neuroscience. Vol. 23, no. 33. (January): 10548-58.
  • Mendell, Jerry, R; Sahenk, Zarife. 2003. Clinical practice. Painful sensory neuropathy.  The New England journal of medicine. Vol. 348, no. 13. (January): 1243-55.
  • Sahenk,Z; Chen,L; Kakabadze,I. 2002. Impaired regeneration in trembler mice: Effects of neurotrophin-3 treatment.  NEUROLOGY. Vol. 58, no. 7. (April): A378-A378.
  • Sahenk,Z. 2001. Abnormal axon-Schwann cell interactions in CMT neuropathies: evidence for impaired axonal regeneration due to primary Schwann cell genetic defects.  NEUROMUSCULAR DISORDERS. Vol. 11, no. 6-7. (September): 643-643.
  • Novak, V; Freimer, M, L; Kissel, J, T; Sahenk, Z; Periquet, I, M; Nash, S, M; Collins, M, P; Mendell, J R. 2001. Autonomic impairment in painful neuropathy.  Neurology. Vol. 56, no. 7. (January): 861-8.
  • Murillo,F,M; Serrano-Munuera,C; Sahenk,Z. 2000. Xenograft studies in a case of familial spastic paraparesis.  NEUROLOGY. Vol. 54, no. 7. (April): A133-A133.
  • Sahenk,Z; Serrano-Munuera,C. 2000. Neurotrophin-3 rescues axons in CMT1A xenografts.  NEUROLOGY. Vol. 54, no. 7. (April): A214-A214.
  • Feng, B; Chen, L; Drmanovic, Z; Kakabadze, I; Mendell, J, R; Marzluf, G, A; Sahenk, Z. 2000. Intracellular processing and toxicity of the truncated androgen receptor: nuclear congophilia-associated cell death.  Journal of neuropathology and experimental neurology. Vol. 59, no. 8. (January): 652-63.
  • Collins, M, P; Mendell, J, R; Periquet, M, I; Sahenk, Z; Amato, A, A; Gronseth, G, S; Barohn, R, J; Jackson, C, E; Kissel, J T. 2000. Superficial peroneal nerve/peroneus brevis muscle biopsy in vasculitic neuropathy.  Neurology. Vol. 55, no. 5. (January): 636-43.
  • Novak,V; Periquet,I; Kissel,J; Freimer,M; Nash,S; Sahenk,Z; Collins,M; Mendell,J. 1999. The role of autonomic testing in painful sensory neuropathy.  NEUROLOGY. Vol. 52, no. 6. (April): A389-A389.
  • Haney, C, A; Sahenk, Z; Li, C; Lemmon, V, P; Roder, J; Trapp, B D. 1999. Heterophilic binding of L1 on unmyelinated sensory axons mediates Schwann cell adhesion and is required for axonal survival.  The Journal of cell biology. Vol. 146, no. 5. (January): 1173-84.
  • Sahenk, Z; Mendell, J R. 1999. Alterations in nodes of Ranvier and Schmidt-Lanterman incisures in Charcot-Marie-Tooth neuropathies.  Annals of the New York Academy of Sciences. Vol. 883, no. January: 508-12.
  • Sahenk, Z. 1999. Abnormal Schwann cell-axon interactions in CMT neuropathies. The effects of mutant Schwann cells on the axonal cytoskeleton and regeneration-associated myelination.  Annals of the New York Academy of Sciences. Vol. 883, no. January: 415-26.
  • Sahenk,Z. 1999. Abnormal Schwann cell-axon interactions in CMT neuropathies - The effects of mutant Schwann cells on the axonal cytoskeleton and regeneration-associated myelination. In 3rd International Conference on Charcot-Marie-Tooth Disorders
  • Periquet, M, I; Novak, V; Collins, M, P; Nagaraja, H, N; Erdem, S; Nash, S, M; Freimer, M, L; Sahenk, Z; Kissel, J, T; Mendell, J R. 1999. Painful sensory neuropathy: prospective evaluation using skin biopsy.  Neurology. Vol. 53, no. 8. (January): 1641-7.
  • Sahenk, Z; Chen, L; Mendell, J R. 1999. Effects of PMP22 duplication and deletions on the axonal cytoskeleton.  Annals of neurology. Vol. 45, no. 1. (January): 16-24.
  • Chen,L; Freimer,F; Sahenk,Z. 1998. A novel Val30Met PMP22 mutation causes HNPP.  NEUROLOGY. Vol. 50, no. 4. (April): A72-A73.
  • Kakabadze,I; Mendell,J,R; Sahenk,Z. 1998. Alterations in nodes of Ranvier and Schmidt-Lanterman Incisures in Charcot-Marie-Tooth neuropathies.  NEUROLOGY. Vol. 50, no. 4. (April): A74-A75.
  • Sahenk,Z; Erdem,S; Mendell,J,R. 1998. Fate of Schwann cells in CMT1A: Evidence for apoptosis.  NEUROLOGY. Vol. 50, no. 4. (April): A75-A75.
  • Erdem, S; Mendell, J, R; Sahenk, Z. 1998. Fate of Schwann cells in CMT1A and HNPP: evidence for apoptosis.  Journal of neuropathology and experimental neurology. Vol. 57, no. 6. (January): 635-42.
  • Working, P, K; Newman, M, S; Sullivan, T; Brunner, M; Podell, M; Sahenk, Z; Turner, N. 1998. Comparative intravenous toxicity of cisplatin solution and cisplatin encapsulated in long-circulating, pegylated liposomes in cynomolgus monkeys.  Toxicological sciences : an official journal of the Society of Toxicology. Vol. 46, no. 1. (January): 155-65.
  • Sahenk, Z; Chen, L; Freimer, M. 1998. A novel PMP22 point mutation causing HNPP phenotype: studies on nerve xenografts.  Neurology. Vol. 51, no. 3. (January): 702-7.
  • Mendell, J, T; Panicker, S, G; Tsao, C, Y; Feng, B; Sahenk, Z; Marzluf, G, A; Mendell, J R. 1998. Novel compound heterozygous laminina2-chain gene (LAMA2) mutations in congenital muscular dystrophy. Mutations in brief no. 159. Online.  Human mutation. Vol. 12, no. 2. (January): e135.
  • Sahenk, Z; Chen, L. 1998. Abnormalities in the axonal cytoskeleton induced by a connexin32 mutation in nerve xenografts.  Journal of neuroscience research. Vol. 51, no. 2. (January): 174-84.
  • Collins,M,P; Mendell,J,R; Periquet,M,I; Sahenk,Z; Amato,A,A; Kissel,J,T. 1997. Immunostaining in vasculitic neuropathy: Sensitivity and specificity of findings.  ANNALS OF NEUROLOGY. Vol. 42, no. 3. (September): M90-M90.
  • Sahenk,Z; Chen,L; Monani,U; Mendell,J,R. 1997. Studies on the effect of PMP22 duplication and deletion on axonal cytoskeleton using nerve xenograft model.  NEUROLOGY. Vol. 48, no. 3. (March): 59004-59004.
  • Mendell,J,T; Feng,B; Sahenk,Z; Marzluf,G,A; Amato,A,A; Mendell,J,R. 1997. Novel laminin alpha 2 mutations in congenital muscular dystrophy.  NEUROLOGY. Vol. 48, no. 3. (March): 3135-3135.
  • Sahenk,Z; Goel,A; BARNETT,D; Mendell,J,R. 1996. Molecular genetic defect in muscle AMP deaminase deficiency: Relationship phenotype.  ANNALS OF NEUROLOGY. Vol. 40, no. 3. (September): M88-M88.
  • Lotz,B; Brooks,B; Sanjak,M; Weasler,C; Roelke,K; Parnell,J; Neville,H; Ringel,S; Brinkmann,J; Singh,K; Burns,D; Pestronk,A; Lopate,G; Florence,J; Blume,G; ELIOTT,J; Mitsumoto,H; Levin,K; SZIRONY,K; Caldwell,M; Bosch,P; Smith,B; Verheijde,J; Carr,S; Engel,W,K; Velazquez,L; Miller,J; Graves,M; SEPULVEDA,L; GARCIA,S; Smith,R; Licht,J; GILLIE,E; Silverman,L; Olney,R; Yuen,E; Melnick,M; Mass,J; Bradley,W; Sharma,K; Hurtak,L; Mayor,L; Olanow,C,W; Hauser,R; Malapira,T; Olanow,E; Hopkins,L; Weissman,J; Pianta,T; Polak,M; Siddique,T; Sufit,R; Casey,P; Roos,R; SALAZARGRUESO,E; Richman,J; Kasarskis,E; English,T; Bottoms,B; Shefner,J; Logigian,E; Odaka,B; Corwin,C; Kuncl,R; Rothstein,J; Clawson,L; Chaudhry,V; Cornblath,D; Corse,A; Bromberg,M; Wald,J; Forshew,D; Litchy,W; Windebank,A; Buss,J; Campion,J; Daube,J,R; Subramony,S,H; Vedanarayanan,V; Weaver,R; Crosswhite,T; Kula,R; Anselmi,G; Riha,T; Sorrentino,C; Holmlund,T; Warner,C; Camann,M; Millard,C; Donnenfeld,H; Kleinman,A; Sivak,M; ALAMPUR,U; Hoehl,J; BRATTON,J; Jubelt,B; CARY,G; Barry,J; Drucker,J; Samaha,F; Sams,L; Clarke,A; Schwiederman,D; Mendell,J; Sahenk,Z; King,W; Downing,K; Bird,S; Scherer,S; Beale,J; Pfohl,D; HEIMANPATTERSON,T; Shy,M; Suh,Y; Giuliani,M; Lacomis,D; DeCesare,S; Holbach,S; Fenichel,G; Howard,J; Robison,J; Tandan,R; Peet,P; CUSIMANO,S; Krusinski,P; Hillel,A; Sumi,M; Veale,M; Konikow,N; Brooke,M; Cwik,V; BURDEN,N; Boyd,C; DaSilva,B; Strong,M; Rowe,A; Findlater,K; Cashman,N; Antel,J; FINCH,L; Brissette,J; Fisher,M,R; Cook,T; deMets,D; Bechhofer,R; Yoshihara,D; Wittes,J; McKhann,G; Ellenberg,J; Griggs,R,C; Lowenthal,D; Levine,R; Stambler,N; Charatan,M; Cedarbaum,J,M. 1996. A double-blind placebo-controlled clinical trial of subcutaneous recombinant human ciliary neurotrophic factor (rHCNTF) in amyotrophic lateral sclerosis.  NEUROLOGY. Vol. 46, no. 5. (May): 1244-1249.
  • Tan,E; Lynn,D,J; Amato,A,A; Kissel,J,T; Rammohan,K,W; Sahenk,Z; WARMOLTS,J,R; Jackson,C,E; Barohn,R,J; Mendell,J,R. 1995. IMMUNOSUPPRESSIVE TREATMENT OF MOTOR-NEURON SYNDROMES - REPLY.  ARCHIVES OF NEUROLOGY. Vol. 52, no. 3. (March): 230-231.
  • Barohn, R, J; Amato, A, A; Sahenk, Z; Kissel, J, T; Mendell, J R. 1995. Inclusion body myositis: explanation for poor response to immunosuppressive therapy.  Neurology. Vol. 45, no. 7. (January): 1302-4.
  • Mendell, J, R; Sahenk, Z; Prior, T W. 1995. The childhood muscular dystrophies: diseases sharing a common pathogenesis of membrane instability.  Journal of child neurology. Vol. 10, no. 2. (January): 150-9.
  • Mendell, J, R; Kissel, J, T; Amato, A, A; King, W; Signore, L; Prior, T, W; Sahenk, Z; Benson, S; McAndrew, P, E; Rice, R. 1995. Myoblast transfer in the treatment of Duchenne's muscular dystrophy.  The New England journal of medicine. Vol. 333, no. 13. (January): 832-8.
  • SEHARASYON,J; Sahenk,Z; Mendell,J,R; Burghes,A,HM. 1994. DELIVERY OF ADENOVIRUS-BASED GENE CONSTRUCTS IN SPINAL MOTOR-NEURONS VIA RETROGRADE AXONAL-TRANSPORT.  NEUROLOGY. Vol. 44, no. 4. (April): A221-A222.
  • Sahenk,Z; SAHARSEYON,J; Mendell,J,R. 1994. CILIARY NEUROTROPHIC FACTOR (CNTF) POTENTIATES PERIPHERAL-NERVE REGENERATION.  NEUROLOGY. Vol. 44, no. 4. (April): A283-A283.
  • Amato,A,A; Barohn,R; Kissel,J,T; Sahenk,Z. 1994. INCLUSION-BODY MYOPATHY - TREATMENT WITH INTRAVENOUS IMMUNOGLOBULIN.  NEUROLOGY. Vol. 44, no. 4. (April): A130-A130.
  • Coovert,D,D; McAndrew,P,E; Sahenk,Z; Mendell,J,R; Burghes,A,HM. 1994. ADENOVIRAL MEDIATED TRANSFER OF BETA-GALACTOSIDASE AND DYSTROPHIN CONSTRUCTS TO MUSCLE.  NEUROLOGY. Vol. 44, no. 4. (April): A267-A267.
  • Sahenk, Z; Seharaseyon, J; Mendell, J R. 1994. CNTF potentiates peripheral nerve regeneration.  Brain research. Vol. 655, no. 1-2. (January): 246-50.
  • Sahenk, Z; Barohn, R; New, P; Mendell, J R. 1994. Taxol neuropathy. Electrodiagnostic and sural nerve biopsy findings.  Archives of neurology. Vol. 51, no. 7. (January): 726-9.
  • Amato, A, A; Barohn, R, J; Jackson, C, E; Pappert, E, J; Sahenk, Z; Kissel, J T. 1994. Inclusion body myositis: treatment with intravenous immunoglobulin.  Neurology. Vol. 44, no. 8. (January): 1516-8.
  • Tan, E; Lynn, D, J; Amato, A, A; Kissel, J, T; Rammohan, K, W; Sahenk, Z; Warmolts, J, R; Jackson, C, E; Barohn, R, J; Mendell, J R. 1994. Immunosuppressive treatment of motor neuron syndromes. Attempts to distinguish a treatable disorder.  Archives of neurology. Vol. 51, no. 2. (January): 194-200.
  • Sahenk, Z; Seharaseyon, J; Mendell, J, R; Burghes, A H. 1993. Gene delivery to spinal motor neurons.  Brain research. Vol. 606, no. 1. (January): 126-9.
  • Amato, A, A; Barohn, R, J; Sahenk, Z; Tutschka, P, J; Mendell, J R. 1993. Polyneuropathy complicating bone marrow and solid organ transplantation.  Neurology. Vol. 43, no. 8. (January): 1513-8.
  • Sahenk, Z; Mendell, J R. 1992. Alterations in slow transport kinetics induced by estramustine phosphate, an agent binding to microtubule-associated proteins.  Journal of neuroscience research. Vol. 32, no. 4. (January): 481-93.
  • Mendell, J, R; Sahenk, Z. 1992. Inclusion body myositis.  Neurology. Vol. 42, no. 11. (January): 2231-2.
  • Mendell, J, R; Sahenk, Z; Gales, T; Paul, L. 1991. Amyloid filaments in inclusion body myositis. Novel findings provide insight into nature of filaments.  Archives of neurology. Vol. 48, no. 12. (January): 1229-34.
  • Sahenk, Z; Brown, A. 1991. Weak-base amines inhibit the anterograde-to-retrograde conversion of axonally transported vesicles in nerve terminals.  Journal of neurocytology. Vol. 20, no. 5. (January): 365-75.
  • Barohn, R, J; Sahenk, Z; Warmolts, J, R; Mendell, J R. 1991. The Bruns-Garland syndrome (diabetic amyotrophy). Revisited 100 years later.  Archives of neurology. Vol. 48, no. 11. (January): 1130-5.
  • Barohn, R, J; Clanton, T; Sahenk, Z; Mendell, J R. 1990. Recurrent respiratory insufficiency and depressed ventilatory drive complicating mitochondrial myopathies.  Neurology. Vol. 40, no. 1. (January): 103-6.
  • Sahenk, Z; Whitaker, J, N; Mendell, J R. 1990. Immunocytochemical evidence for the retrograde transport of intraaxonal cathepsin D: possible relevance to the dying-back process.  Brain research. Vol. 510, no. 1. (January): 1-6.
  • Sahenk, Z. 1990. Distal terminal axonopathy produced by 2,4-dithiobiuret: effects of long-term intoxication in rats.  Acta neuropathologica. Vol. 81, no. 2. (January): 141-7.
  • Ross, J, F; Sahenk, Z; Hyser, C; Mendell, J, R; Alden, C L. 1988. Characterization of a murine model for human bismuth encephalopathy.  Neurotoxicology. Vol. 9, no. 4. (January): 581-6.
  • Sahenk, Z; Lasek, R J. 1988. Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.  Brain research. Vol. 460, no. 1. (January): 199-203.
  • Sahenk, Z; Brady, S, T; Mendell, J R. 1987. Studies on the pathogenesis of vincristine-induced neuropathy.  Muscle & nerve. Vol. 10, no. 1. (January): 80-4.
  • Sahenk, Z; Brady, S T. 1987. Axonal tubulin and microtubules: morphologic evidence for stable regions on axonal microtubules.  Cell motility and the cytoskeleton. Vol. 8, no. 2. (January): 155-64.
  • Pappolla, M; Penton, R; Weiss, H, S; Miller, C H Jr; Sahenk, Z; Autilio-Gambetti, L; Gambetti, P. 1987. Carbon disulfide axonopathy. Another experimental model characterized by acceleration of neurofilament transport and distinct changes of axonal size.  Brain research. Vol. 424, no. 2. (January): 272-80.
  • Sahenk, Z. 1987. Toxic neuropathies.  Seminars in neurology. Vol. 7, no. 1. (January): 9-17.
  • Sahenk,Z; Mendell,J; Brady,S. 1986. STUDIES ON THE PATHOGENESIS OF VINCRISTINE NEUROPATHY.  MUSCLE & NERVE. Vol. 9, no. 5. (January): 116-116.
  • Mendell, J, R; Kissel, J, T; Kennedy, M, S; Sahenk, Z; Grinvalsky, H, T; Pittman, G, L; Kyler, R, S; Roelofs, R, I; Whitaker, J, N; Bertorini, T E. 1985. Plasma exchange and prednisone in Guillain-Barre syndrome: a controlled randomized trial.  Neurology. Vol. 35, no. 11. (January): 1551-5.
  • Mendell, J, R; Sahenk, Z; Whitaker, J, N; Trapp, B, D; Yates, A, J; Griggs, R, C; Quarles, R H. 1985. Polyneuropathy and IgM monoclonal gammopathy: studies on the pathogenetic role of anti-myelin-associated glycoprotein antibody.  Annals of neurology. Vol. 17, no. 3. (January): 243-54.
  • Mendell, J, R; Kissel, J, T; Kennedy, M, S; Sahenk, Z; Grinvalsky, H, T; Pittman, G, L; Kyler, R, S; Roelofs, R, I; Whitaker, J, N; Bertorini, T E. 1985. Plasma exchange and prednisone in acute inflammatory polyradiculoneuropathy: a controlled randomized trial.  Journal of clinical apheresis. Vol. 2, no. 4. (January): 332-42.
  • Ortman, J, A; Sahenk, Z; Mendell, J R. 1983. The experimental production of Renaut bodies.  Journal of the neurological sciences. Vol. 62, no. 1-3. (January): 233-41.
  • Sahenk, Z; Mendell, J R. 1983. Studies on the morphologic alterations of axonal membraneous organelles in neurofilamentous neuropathies.  Brain research. Vol. 268, no. 2. (January): 239-47.
  • Whitaker, J, N; Dodd, S, P; Sahenk, Z; Mendell, J R. 1983. Changes in sciatic nerve cathepsin D after ligation or exposure to neurotoxins.  Journal of neuropathology and experimental neurology. Vol. 42, no. 1. (January): 87-98.
  • Sahenk, Z; Mendell, J R. 1981. Acrylamide and 2,5-hexanedione neuropathies: abnormal bidirectional transport rate in distal axons.  Brain research. Vol. 219, no. 2. (January): 397-405.
  • Mendell, J, R; Sahenk, Z; Warmolts, J, R; Marshall, J, K; Thibert, P. 1981. The spontaneously diabetic BB Wistar rat. Morphologic and physiologic studies of peripheral nerve.  Journal of the neurological sciences. Vol. 52, no. 1. (January): 103-15.
  • Sahenk, Z; Mendell, J R. 1980. Axoplasmic transport in zinc pyridinethione neuropathy: evidence for an abnormality in distal turn-around.  Brain research. Vol. 186, no. 2. (January): 343-53.
  • DiMauro, S; Mendell, J, R; Sahenk, Z; Bachman, D; Scarpa, A; Scofield, R, M; Reiner, C. 1980. Fatal infantile mitochondrial myopathy and renal dysfunction due to cytochrome-c-oxidase deficiency.  Neurology. Vol. 30, no. 8. (January): 795-804.
  • Sahenk, Z; Mendell, J R. 1979. Ultrastructural study of zinc pyridinethione-induced peripheral neuropathy.  Journal of neuropathology and experimental neurology. Vol. 38, no. 5. (January): 532-50.
  • Sahenk, Z; Mendell, J R. 1979. Analysis of fast axoplasmic transport in nerve ligation and adriamycin-induced neuronal perikaryon lesions.  Brain research. Vol. 171, no. 1. (January): 41-53.
  • Mendell, J, R; Higgins, R; Sahenk, Z; Cosmos, E. 1979. Relevance of genetic animal models of muscular dystrophy to human muscular dystrophies.  Annals of the New York Academy of Sciences. Vol. 317, no. January: 409-30.
  • Sahenk, Z; Mendell, J, R; Couri, D; Nachtman, J. 1978. Polyneuropathy from inhalation of N2O cartridges through a whipped-cream dispenser.  Neurology. Vol. 28, no. 5. (January): 485-7.
  • Saida, K; Mendell, J, R; Sahenk, Z. 1977. Peripheral nerve changes induced by local application of bee venom.  Journal of neuropathology and experimental neurology. Vol. 36, no. 5. (January): 783-96.
  • Sahenk, Z; Mendell, J, R; Rossio, J, L; Hurtubise, P. 1977. Polyradiculoneuropathy accompanying procainamide-induced lupus erythematosus: evidence for drug-induced enhanced sensitization to peripheral nerve myelin.  Annals of neurology. Vol. 1, no. 4. (January): 378-84.
  • Mendell, J, R; Sahenk, Z; Saida, K; Weiss, H, S; Savage, R; Couri, D. 1977. Alterations of fast axoplasmic transport in experimental methyl n-butyl ketone neuropathy.  Brain research. Vol. 133, no. 1. (January): 107-18.
  • Silverman, L, M; Mendell, J, R; Sahenk, Z; Fontana, M B. 1976. Significance of creatine phosphokinase isoenzymes in Duchenne dystrophy.  Neurology. Vol. 26, no. 6 PT 1. (January): 561-4.

Awards, Honors and Organizations

  • Listed, “Best Doctors in America”
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