Yusen Liu, Ph.D.

Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection. His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Areas of Interest:

• My laboratory is interested in the signal transduction pathways that control the innate immunity. Specifically, we are studying the signaling pathways that regulate the production of inflammatory cytokines. We have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. We hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the anti-inflammatory mechanism of triptolide, a compound isolated from an anti-rheumatic herb used for centuries in traditional Chinese medicine. The long term goals of these research projects are to understand the regulation of inflammation and to develop novel treatments for inflammatory diseases.

Undergraduate

• Zhejiang University
  Date Completed: 06/30/1983

Graduate School

• Dalian Institute of Technology
  Date Completed: 06/30/1986

Doctorate

• Hiroshima University
  Date Completed: 06/30/1991

Post Doctoral

• National Institutes of Health
  Date Completed: 06/30/1996

2010–present

• Professor of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH “

2003–present

• Principal Investigator, The Research Institute at Nationwide Children's Hospital, Columbus, OH.

2006–2010

• Associate Professor, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH

2003–2006

• Assistant Professor, Center for Developmental Pharmacology and Toxicology, Children's Research Institute, Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH

1996–2003

• Tenure-track Investigator, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1995–1996

• Visiting Associate, Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1992–1995

• Visiting Fellow, Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1991–1992

• Assistant Professor, Department of Fermentation Technology, Hiroshima University , Japan

1986–1987

• Research Associate, Department of Chemical Engineering, Dalian Institute of Technology

• Wancket, L.M., Frazier, W.J., and Liu, Y. 2012. Mitogen-activated protein kinase (MKP)-1 in immunology, physiology, and disease.  Life Sci.. Vol. 90. : 237-248.
• Zhang, T., Lu, X., Arnold, P., Liu, Y., and Feng, Q. 2012. Mitogen-activated protein kinase phosphatase-1 inhibits myocardial tumor necrosis factor-alpha expression and improves cardiac function during endotoxemia.  Cardiovascular Res.. (Formally Accepted)
• Zhang, Y., Leung, D.Y.M., Richers, B.N., Liu, Y., Remigio, L.K., Riches, D.W., and Goleva E. 2012. Vitamin D inhibits monocyte/macrophage pro-inflammatory 1 cytokine production by targeting mitogen-activated protein kinase phosphatase 1.  J. Immunol.. (Formally Accepted)
• Yan. J., Meng, X., Wancket, L.M., Lintner, K., Nelin, L.D., Chen, B., Francis, K.P., Smith, C.V., Rogers, L.K., Liu, Y. 2012. Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.  J. Immunol.. (Formally Accepted)
• Gu B; Zhang J; Wu Y; Zhang X; Tan Z; Lin Y; Huang X; Chen L; Yao K; Zhang M. 2011. Proteomic analyses reveal common promiscuous patterns of cell surface proteins on human embryonic stem cells and sperms.  Plos One. Vol. 6, no. 5. (May 3): e19386.
• Chicione LG; Stenger MR; Cui H; Calvert A; Evans RJ; English BK; Liu Y; Nelin LD. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 300, no. 4. (April 1): L596.
• Rastogi R; Du W; Ju D; Pirockinaite G; Liu Y; Nunez G; Samavati L. 2011. Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells.  American Journal Of Respiratory And Critical Care Medicine. Vol. 183, no. 4. (February 15): 500.
• Gu B; Zhang J; Wang W; Mo L; Zhou Y; Chen L; Liu Y; Zhang M. 2010. Global expression of cell surface proteins in embryonic stem cells.  Plos One. Vol. 5, no. 12. (December 29): e15795.
• Farrell MR; Rogers LK; Liu Y; Welty SE; Tipple TE. 2010. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.  Free Radical Biology & Medicine. Vol. 49, no. 9. (November 15): 1361.
• Chang J; Voorhees TJ; Liu Y; Zhao Y; Chang CH. 2010. Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 107, no. 18. (May 4): 8340.
• Jin Y; Calvert TJ; Chen B; Chicoine LG; Joshi M; Bauer JA; Liu Y; Nelin LD. 2010. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 298, no. 5. (May 1): H1518.
• Shen. J., Chandrasekharan, U.M., Ashraf, M.Z., Long, E., Morton, R.E., Liu, Y., Smith, J.D., Dicorleto, P.E. Lack of MAP kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.  Circ Res.. (IF: 10) (In press)
• Gu, B., Zhang, J., Chen, Q., Tao, B., Wang, W., Zhou, Z., Chen, R., Liu, Y., Zhang, M. Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells.  Biochem. Biophys. Res. Commun.. (In press)
• Jin, J., Calvert, T., Chen, B., Chicoine, L., Joshi, M., Bauer, J., Liu, Y., and Nelin, L.D. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  Am. J. Physiol.- Heart Circ. Physiol.. (In press)
• Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 183, no. 11. (December 1): 7411.
• Frazier WJ, Wang X, Wancket LM, Li XA, Meng X, Nelin LD, Cato AC, Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  J Immunol.. Vol. 183, no. 11. (December 1): 7411-7419.
• Wang X, Zhao Q, Matta R, Meng X, Liu X, Liu CG, Nelin LD, Liu Y. 2009. Inducible nitric oxide synthase expression is regulated by MAP kinase phosphatase-1.  J Biol Chem. Vol. 284, no. 40. (October 2): 27123-27134. http://www.jbc.org/cgi/reprint/M109.051235v1?view=long&pmid=19651781.
• Matta R, Wang X, Ge H, Nelin LD, Liu Y. 2009. Triptolide induces an anti-inflammatory cellular response.  Am J Translational Res. Vol. 1, no. 3. (March 5): 267-282.
• Li L, Chen S-F, Liu Y. 2009. MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.  Int J Cell Exp Med. Vol. 2, no. 1. (February 15): 48-67.
• Liu Y and Shanley TP. 2009. MAP kinase phosphatase-1 and septic shock.  Journal of Organ Dysfunction. Vol. 5, no. 2: 66-78. http://www.informaworld.com/10.1080/17471060701200444.
• W. Joshua Frazier, Xianxi Wang, Xiaomei Meng, Leif D. Nelin, Yusen Liu. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice [Abstract]. Abstract book, 2009 AAI meeting (Published)
• Frazier, WJ, Wang, X., Wancket, L.M., Meng, X., Nelin, L.D., and Liu, Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after Gram-negative sepsis in Mkp-1 deficient mice [Abstract]. Abstract book, The 13th Asian Pacific Congress of Pediatrics and 3rd Asian Pacific Congress of Pediatric Nursing (Published)
• Ranyia Matta, John Barnard, Lyn M. Wancket, Jessica Grieves, Qingqing Wang, Yi Jin, Leif, D. Nelin, and Yusen Liu. 2009. ROLE OF MKP-1 IN AN IL-10 KNOCKOUT MURINE MODEL OF INFLAMMATORY [Abstract]. Abstract book, The 13th Asian Pacific Congress of Pediatrics and 3rd Asian Pacific Congress of Pediatric Nursing (Published)
• Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. 2008. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes.  Mol Cell Biol.. Vol. 28, no. 18. (September): 5785-5794. (IF: 6.42)
• Ichikawa T, Zhang J, Chen K, Liu Y, Schopfer FJ, Baker PR, Freeman BA, Chen YE, Cui T. 2008. Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.  Endocrinology. Vol. 149, no. 8. (August): 4086-4094. (IF: 5.045)
• Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li JJ. 2008. Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation.  J Biol Chem.. Vol. 283, no. 30. (July): 21011-21023. (IF: 5.581)
• Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2008. Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.  Am J Physiol Heart Circ Physiol.. Vol. 294, no. 4. (April): H1621-H1629. (IF: 3.973)
• Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB. 2008. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.  Proc Natl Acad Sci USA. Vol. 105, no. 14. (April): 5620-5625. (IF: 9.598)
• Wang X, Nelin LD, Kuhlman JR, Meng X, Welty SE, Liu Y. 2008. The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.  Life Sci.. Vol. 83, no. 19-20: 671-680. (IF: 2.257)
• Shen, J., Chandrasekharan, U.M., Liu, Y., Smith, J.D., and DiCorleto, P.E. 2008. MAP kinase phosphatase-1 (MKP-1) deficiency leads to reduced atherosclerotic lesion formation in ApoE-null mice [Abstract]. Abstract book, 2008 Annual meeting of Experimental Biology (Published)
• Liu, Y., Zhao Q., Wang, X., Nelin, L.D. 2008. MKP-1 inhibits iNOS expression during the innate immune response to LPS. [Abstract]. Abstract, 2008 Annual meeting of Experimental Biology (Published)
• Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. 2008. Cytokine-induced arginase activity in pulmonary endothelial cells in dependent on Src family tyrosine kinase activity.  Am J Physiol Lung Cell Mol Physiol. Vol. 295, no. 4: L688-697. http://ajplung.physiology.org/cgi/content/full/295/4/L688. (IF: 4.214)
• Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y. 2007. MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock. [Abstract]. Abstract book, 2007 American Association of Immunologists Annual Meeting (Published)
• Hu JH, Chen T, Zhuang ZH, Kong L, Yu MC, Liu Y, Zang JW, Ge BX. 2007. Feedback control of MKP-1 expression by p38.  Cellular Signaling. Vol. 19, no. 2: 393-400.
• Wang X, Meng X, Kuhlman JR, Nelin LD, Nicol KK, English BK, Liu Y. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.  Journal of Immunology. Vol. 178, no. 8: 5312-5320.
• Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y. 2007. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.  American Journal of Physiology - Cell Physiology. Vol. 293, no. 2: C632-C640.
• Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K., Liu, Y. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria. [Abstract]. Abstract book, 2007 Society for leukocyte Biology Annual Meeting (Published)
• Liu Y, Shepherd EG, Nelin LD. 2007. MAPK phosphatases-regulating the immune response.  Nature Reviews Immunology. Vol. 7, no. 3: 202-212. (IF: 30.01)
• Wang, X., Nelin, L.D., Kuhlman, J.R., Meng, X., Welty, S.E., and Liu, Y. 2007. MAP kinase phosphatase-1 plays a pivotal role in the protective effect of dexamethasone against endotoxic shock. [Abstract]. Abstract book, 2007 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Liu, Y. Wang, X., Meng, X., Kuhlman, J.R., Nelin, L.D., English, B.K. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to Gram-positive bacteria. [Abstract]. Abstract book, 2007 American Association of Immunologists Annual Meeting (Published)
• Wang X, Liu Y. 2007. Regulation of innate immune response by MAP kinase phosphatase-1.  Cellular Signaling. Vol. 19, no. 7: 1372-1382.
• Sweeney MC, Wang X, Park J, Liu Y, Pei D. 2006. Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library.  Biochemistry. Vol. 45, no. 49. (December 12): 14740-14748.
• Wang X, Matta R, Shen G, Nelin LD, Pei D, Liu Y. 2006. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.  J Mol Med. Vol. 84, no. 5. (May): 405-415.
• Zhao Q, Chen P, Manson ME, Liu Y. 2006. Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells.  Protein Expr Purif. Vol. 46, no. 2. (April): 468-474.
• Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin LD. 2006. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.  Am J Physiol Lung Cell Mol Physiol. Vol. 290, no. 2. (February): L298-L306.
• Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y. 2006. MAP kinase phosphatase-1 controls innate immune responses and suppresses endotoxic shock. [Abstract]. Abstract book, 2006 ASBMB annual meeting (Published)
• Zhao, Q., Wang, X., Nelin, L.D., Meng, X., Smith, C.V., Bauer, J.A., and Liu, Y. 2006. MKP-1 restrains innate immune responses and protects host from endotoxic shock. [Abstract]. Abstract book, 2006 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhou JY, Liu Y, Wu GS. 2006. The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death.  Cancer Res. Vol. 66: 4888-4894.
• Yao Y, Xu Q, Kown MJ, Matta R, Liu Y, Hong SC, Chang CH. 2006. ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.  J Immunol. Vol. 177: 70-76.
• Lin, T.K., Barnard, J.A., Liu, Y. 2006. The Role of Mitogen-activated Protein Kinase Phosphatase-1 in a Mouse Model of Inflammatory Bowel Disease. [Abstract]. Abstract book, Annual meeting of the American Gastroenterological Association (AGA), 2006 (Published)
• Kuhlman, J.R., Wang, X., Zhao, Q., Nelin, L.D., and Liu, Y. 2006. Regulation of acute-phase response by MKP-1. [Abstract]. Abstract book, 2006 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Wang Z; Xu J; Zhou J-Y; Liu Y; Wu GS. 2006. Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance.  Cancer Research. Vol. 66, no. 17: 8870-8877.
• Wang, X., Kuhlman, K., Meng, X., and Liu, Y. 2006. MAP kinase phosphatase (MKP)-1 plays an important role in the anti-inflammatory action of glucocorticoids. [Abstract]. Abstract book, 2006 Society for Leukocyte Biology annual meeting. (Published)
• Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X, Smith CV, Bauer JA, Chang CH, Liu Y. 2006. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.  J Exp Med. Vol. 203, no. 1. (January): 131-140. (IF: 13.6)
• Wang, X., Meng, X., Nelin, L.D., and Liu, Y. 2006. Knockout of Mkp-1 sensitizes mice to multiple organ failure elicited by peptidoglycan and lipoteichoic acid. [Abstract]. Abstract book, 2006 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. 2005. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.  Am J Respir Cell Mol Biol. Vol. 33, no. 4. (October): 394-401.
• Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y. 2005. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.  J Biol Chem. Vol. 280, no. 9. (March 4): 8101-8108.
• Chicoine, L.G., Rieger-Fackeldey, E., Young, T.L., Liu, Y., and Nelin, N.D. 2005. Cytokine-induced nitric oxide is due mainly to inducible nitric oxide synthase in bovine pulmonary arterial endothelial cells. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhao, Q., Shepherd, E.G., Manson, M.E., Nelin, L.D., Sorokin, A., and Liu, Y. 2005. Feedback control of MAP kinases and proinflammatory cytokine biosynthesis by MKP-1 in LPS-stimulated alveolar macrophages. [Abstract]. Abstract book, 2005 ASBMB Annual Meeting in conjunction with Experimental Biology meeting (Published)
• Wang, X., Matta, R., Shen, G., Pei, D., and Liu, Y. 2005. The hydroxyl group at position 14 is essential for the anti-cancer and anti-inflammatory activities of triptolide. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhao, Q., Chen, P., and Liu, Y. 2005. Production of active recombinant MAP kinases through transient transfection of 293T cells. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Manson, M.E., Zhao, Q., Shepherd, E.G., Nelin, L.D., Sorokin, A., and Liu, Y. 2005. MKP-1 plays an important role in the attenuation of MAP kinase activation and TNF-? production induced by LPS in alveolar macrophages. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhao, Q., Shepherd, E.G., Nelin, L.D., and Liu, Y. 2005. Regulation of innate immune responses to LPS by mitogen-activated protein kinase phosphatase-1. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Nowicki, P.T., Liu, Y., and Wang, X. 2005. Lipopolysaccharide up regulates endothelin ETA receptora and downregulates ETB receptors in piglet intestine. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Shepherd, E.G., Zhao, Q., and Liu, Y. 2005. Regulation of pro-inflammatory MAP kinase pathways by MKP-1 and oxidative stress in macrophages. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Su, B.Y., Liu, Y., and Nowicki, P.T. 2005. The anti-apoptotic protein Bcl-2 inhibits apoptosis of vascular smooth muscle cells induced by mechanical stretch. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhao, Q., Nelin, L.D., Manson, M.E., Shepherd, E.E., and Liu, Y. 2005. MKP-1, a Footbrake of the Innate Immune Responses. [Abstract]. Abstract book, 2005 Annual meeting of the International Society for Inteferon and Cytokine Research. (Published)
• Young, T.L., English, B.K., Chicoine, L.G., Liu, Y., and Nelin, L. 2005. Epidermal growth factor receptor tyrosine kinase regulates cytokine-induced arginase expression in bovine pulmonary arterial endothelial cells. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Liu, Y., Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V. 2005. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages. [Abstract]. Abstract book, The 2005 ASBMB Annual Meeting in conjunction with Experimental Biology meeting (Published)
• Matta, R., Shepherd, E.G., Nelin, L.D., English, B.K., and Liu, Y. 2005. Triptolide potently inhibits the macrophage expression of inflammatory cytokines stimulated by bacterial components. [Abstract]. Abstract book, 2005 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Shepherd EG, Zhao Q, Welty SE, Hansen TN, Smith CV, Liu Y. 2004. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.  J Biol Chem. Vol. 279, no. 52. (December): 54023-54031.
• Zhao, Q., Shepherd, E.G., and Liu, Y. 2004. The role of MKP-1 as a negative regulator of map kinases in LPS-stimulated alveolar macrophages. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Nelin, L.D., Young, T.L., Smith, C.V., and Liu, Y. 2004. The effect of stable transfection of MKP-1 on LPS-induced nitric oxide and urea production in RAW264.7 cells. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Zhao, Q., Shepherd, E.G., and Liu, Y. 2004. Induction of mitogen-activated protein kinase phosphatase-1 by anti-inflammatory corticosteroids in macrophages. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Young, T.L., Chicoine , L.G., Liu, Y., and Nelin, L.D. 2004. Genistein inhibits cytokine-induced arginase expression and urea production in pulmonary arterial endothelial cells. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting, (Published)
• Liu, Y., Li, J., Gorospe, M., and Barnes, J. 2004. Tumor promoter arsenite stimulates histone H3 phosphoacetylation at c-fos and c-jun in normal human diploid fibroblasts. [Abstract]. Abstract book, 2004 Society of Toxicology Meeting, (Published)
• Liu, Y., Zhao, Q., Shepherd, E.G., Chen, P., and Kokkonen, GC. 2004. Regulation of proinflammatory cytokine production by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. [Abstract]. Abstract book, The 2004 ASMBM annual meeting and 8th IUBMB (Published)
• Shepherd, E.G., Zhao, Q., Welty, S.E., Hansen, T.N., Smith, C.V. and Liu, Y. 2004. Modulation of inflammatory signals by MAP kinase phosphatase-1 in peptidoglycan-stimulated macrophages. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Meng, X., Manson. M.E., Rogers, L.K., Shepherd, E.G., Smith, C.V., and Liu, Y. 2004. Overdose of acetaminophen activates c-Jun N-terminal kinases. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Liu, L., Su, S.Y., Nowicki, P.N., Wang, X.T., and Liu, Y. 2004. Triptolide inhibits the PI3-kinase/Akt pathway and induces apoptosis of human tumor cells. [Abstract]. Abstract book, 2004 American Pediatric Society/Society for Pediatric Research Annual Meeting (Published)
• Li J, Gorospe M, Barnes J, Liu Y. 2003. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.  J Biol Chem. Vol. 278, no. 15. (April): 13183-13191.
• Manson, M.E., Rogers, L.K., Smith, C.V., and Liu, Y. 2003. Overdose of acetaminophen activates c-Jun N-terminal kinases. [Abstract]. Abstract book, 2003 Annual Meeting of Society of Toxicology Ohio Valley chapter (Published)
• Liu, Y., Miller, B.A., and Barnes, B. 2003. Interferon-gamma augments p38 and JNK MAP kinases through blocking MKP-1 induction in lipopolysaccharide-stimulated macrophages. [Abstract]. Abstract book 2003 American Pediatric Society/Society for Pediatric Research Annual Meeting [Peer Reviewed] (Published)
• Chen, P., Li, J., Barnes, J., Kokkonen, G.C., Lee, J.C., and Liu, Y. 2003. Restraint of pro-inflammatory cytokine biosynthesis by MKP-1 in lipopolysaccharide-stimulated macrophages. [Abstract]. Abstract book of 6th International Congress for Inflammation. (Published)
• Liu, Y., Li, J., Lorenzini, A., Sinogeeva, N., Chen, P., Gorospe, M., and Cristofalo, V.J. 2003. Constitutively active Raf induces growth arrest in WI-38 normal human lung fibroblasts: The effects of active Raf on chromosomal structure and gene expression profiles. [Abstract]. Meeting abstract (Published)
• Li J, Chen P, Sinogeeva N, Gorospe M, Wersto RP, Chrest FJ, Barnes J, Liu Y. 2002. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells.  J Biol Chem. Vol. 277, no. 51. (December 20): 49504-10-49510.
• Chen P, Li J, Barnes J, Kokkonen GC, Lee JC, Liu Y. 2002. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.  J Immunol. Vol. 169, no. 11. (December 1): 6408-6416.
• Chen P, Hutter D, Liu P, Liu Y. 2002. A mammalian expression system for rapid production and purification of active MAP kinase phosphatases.  Protein Expr Purif.. Vol. 24, no. 3. (April): 481-488.
• Hutter D, Chen P, Li J, Barnes J, Liu Y. 2002. The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity.  Mol Cell Biochem. Vol. 233, no. 1-2. (April): 107-117.
• Rong R; He Q; Liu Y; Sheikh MS; Huang Y. 2002. TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway.  Oncogene. Vol. 21, no. 7. (February 7): 1062-1070.
• Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y. 2001. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.  Mol Cell Biol. Vol. 21, no. 23. (December 21): 8213-8224.
• Tong T; Fan W; Zhao H; Jin S; Fan F; Blanck P; Alomo I; Rajasekaran B; Liu Y; Holbrook NJ; Zhan Q. 2001. Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation.  Experimental Cell Research. Vol. 269, no. 1. (September 10): 64-72.
• Chen P; Hutter D; Yang X; Gorospe M; Davis RJ; Liu Y. 2001. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.  The Journal Of Biological Chemistry. Vol. 276, no. 31. (August 3): 29440-29449.
• Liu, Y. and Holbrook, N.J. 2001. Mitogen-activated protein kinase signaling pathways and aging. In Handbook of the Biology of Aging. 5th ed. Edited by E. J. Masoro & S. Austad. San Diego, CA, USA: Academic Press. 179-206.
• Hutter D, Chen P, Barnes J, Liu Y. 2000. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.  Biochem J. Vol. 352, no. Part 1. (November 15): 155-163.
• Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL. 2000. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.  Molecular And Cellular Biology. Vol. 20, no. 18. (September 1): 6945-6957.
• Huang Y; Hutter D; Liu Y; Wang X; Sheikh MS; Chan AM; Holbrook NJ. 2000. Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities.  The Journal Of Biological Chemistry. Vol. 275, no. 24. (June 16): 18234-18242.
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