Yusen Liu, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Yusen Liu, Ph.D.

Yusen  Liu, Ph.D.

Center for Perinatal Research
Principal Investigator

Neonatology
Principal Investigator

Neonatology Fellowship
Faculty

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus , Ohio 43205 [ map ]
PH: (614) 722.2700
E-mail Me

Biography

Yusen Liu, PhD, is a Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Liu’s NIH-funded research program focuses on the role of MAP kinase phosphatases in host defense against microbial infection. His research has established MAP kinase phosphatase (MKP)-1 as one of the most important negative regulators of inflammation and a potential target for a variety of inflammatory diseases.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • My laboratory is interested in the signal transduction pathways that control the innate immunity. Specifically, we are studying the signaling pathways that regulate the production of inflammatory cytokines. We have found that MAP kinase phosphatase (MKP)-1 plays a pivotal role in the restraint of the inflammatory responses in innate immune cells-by dephosphorylating p38 and JNK, MKP-1 deactivates the stress-activated MAP kinases and inhibits the production of pro-inflammatory cytokines. We hypothesize that defects in MKP-1 gene may sensitize host to inflammatory diseases. Currently, animal models are developed to test this hypothesis using genetics, biochemistry, and molecular biology techniques. Another research project in the laboratory is to understand the anti-inflammatory mechanism of triptolide, a compound isolated from an anti-rheumatic herb used for centuries in traditional Chinese medicine. The long term goals of these research projects are to understand the regulation of inflammation and to develop novel treatments for inflammatory diseases.

Education and Training

Undergraduate School

  • Zhejiang University
    Date Completed: 06/30/1983

Graduate School

  • Dalian Institute of Technology
    Date Completed: 06/30/1986

Doctorate

  • Hiroshima University
    Date Completed: 06/30/1991

Post Doctoral

  • National Institutes of Health
    Date Completed: 06/30/1996

Professional Experience

2010–present

  • Professor of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH “

2003–present

  • Principal Investigator, The Research Institute at Nationwide Children's Hospital, Columbus, OH.

2006–2010

  • Associate Professor, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH

2003–2006

  • Assistant Professor, Center for Developmental Pharmacology and Toxicology, Children's Research Institute, Children's Hospital, Department of Pediatrics, The Ohio State University, Columbus, OH

1996–2003

  • Tenure-track Investigator, Laboratory of Cellular and Molecular Biology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1995–1996

  • Visiting Associate, Laboratory of Cellular and Molecula Biology, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1992–1995

  • Visiting Fellow, Laboratory of Molecular Genetics, Gerontology Research Center, National Institute on Aging, NIH, Baltimore, MD

1991–1992

  • Assistant Professor, Department of Fermentation Technology, Hiroshima University , Japan

1986–1987

  • Research Associate, Department of Chemical Engineering, Dalian Institute of Technology

Publications

  • Turner-Ivey B, Manevich Y, Schulte J, Kistner-Griffin E, Jezierska-Drutel A, Liu Y, and Neumann CA. 2013. Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.  Oncogene. Vol. 32, no. November: 5302-5314.
  • Rastogi, R., Jiang Z., Rosati R., Liu, Y., Beuret L., Charron J., and Samavati L. 2013. Rapamycin induces MKP-1 expression through activation of AKT and MEK/ ERK pathways.  J. Biol. Chem.. Vol. 288, no. November: 33966-33977.
  • Lian, W., Upadhyaya, P., Liu, Y., and Pei, D. 2013. Screening bicyclic peptide libraries for protein-protein interaction inhibitors: Discovery of a tumor necrosis factor-alpha antagonist.  J. Am. Chem. Soc.. Vol. 135, no. August: 11990-11995.
  • Yan, J., Ralston, M.M., Meng, X.; Bongiovanni, K.D., Jones, A., Benndorf, R., Nelin, L.D., Rogers, L.K., Smith, C.V., and Liu, Y. 2013. Glutathione reductase is essential for host defense against bacterial infection.  Free Radical Biol. Med. Vol. 61C, no. April: 320-332.
  • Jin,Yi; Chen,Bernadette; Calvert,Thomas,J; Chicoine,Louis,G; Liu,Yusen; Nelin,Leif,D. 2013. Chronic hypoxia decreases arterial and venous compliance in isolated perfused rat lungs: an effect that is reversed by exogenous L-arginine.  AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. Vol. 304, no. 2. (January): H195-H205.
  • Wancket,Lyn,M; Meng,Xiaomei; Rogers,Lynette,K; Liu,Yusen. 2012. Mitogen-activated protein kinase phosphatase (Mkp)-1 protects mice against acetaminophen-induced hepatic injury.  Toxicologic pathology. Vol. 40, no. 8. (December): 1095-1105.
  • Frazier,W,Joshua; Xue,Jianjing; Luce,Wendy,A; Liu,Yusen. 2012. MAPK Signaling Drives Inflammation in LPS-Stimulated Cardiomyocytes: The Route of Crosstalk to G-Protein-Coupled Receptors.  PLOS ONE. Vol. 7, no. 11. (November): ee50071.
  • Vandevyver,Sofie; Dejager,Lien; Van Bogaert,Tom; Kleyman,Anna; Liu,Yusen; Tuckermann,Jan; Libert,Claude. 2012. Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 122, no. 6. (June): 2130-2140.
  • Matta, R., Barnard, J.A., Wancket, L.M., Yan, J., Grieves, J., Frazier, W.J., Nelin, L.D., Cato, A.C.B., and Liu, Y. 2012. Knockout of Mkp-1 exacerbates colitis in Il-10-deficient mice.  Am. J. Physiol.-Gastr. L. Physiol.. Vol. 302, no. 11. (June): G1322-G1335.
  • Wancket, L.M., Frazier, W.J., and Liu, Y. 2012. Mitogen-activated protein kinase (MKP)-1 in immunology, physiology, and disease.  Life Sci.. Vol. 90, no. January: 237-248.
  • Zhang, T., Lu, X., Arnold, P., Liu, Y., and Feng, Q. Mitogen-activated protein kinase phosphatase-1 inhibits myocardial tumor necrosis factor-alpha expression and improves cardiac function during endotoxemia.  Cardiovascular Res..
  • Zhang, Y., Leung, D.Y.M., Richers, B.N., Liu, Y., Remigio, L.K., Riches, D.W., and Goleva E. Vitamin D inhibits monocyte/macrophage pro-inflammatory 1 cytokine production by targeting mitogen-activated protein kinase phosphatase 1.  J. Immunol..
  • Yan. J., Meng, X., Wancket, L.M., Lintner, K., Nelin, L.D., Chen, B., Francis, K.P., Smith, C.V., Rogers, L.K., Liu, Y. Glutathione reductase facilitates host defense by sustaining phagocytic oxidative burst and promoting the development of neutrophil extracellular traps.  J. Immunol..
  • Chicione,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 300, no. 4. (April): L596-L604.
  • Chicione LG; Stenger MR; Cui H; Calvert A; Evans RJ; English BK; Liu Y; Nelin LD. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  American Journal Of Physiology. Lung Cellular And Molecular Physiology. Vol. 300, no. 4. (April): eL596.
  • Rastogi R; Du W; Ju D; Pirockinaite G; Liu Y; Nunez G; Samavati L. 2011. Dysregulation of p38 and MKP-1 in response to NOD1/TLR4 stimulation in sarcoid bronchoalveolar cells.  American Journal Of Respiratory And Critical Care Medicine. Vol. 183, no. 4. (February): e500.
  • Gu B; Zhang J; Wang W; Mo L; Zhou Y; Chen L; Liu Y; Zhang M. 2010. Global expression of cell surface proteins in embryonic stem cells.  Plos One. Vol. 5, no. 12. (December): ee15795.
  • Farrell MR; Rogers LK; Liu Y; Welty SE; Tipple TE. 2010. Thioredoxin-interacting protein inhibits hypoxia-inducible factor transcriptional activity.  Free Radical Biology & Medicine. Vol. 49, no. 9. (November): e1361.
  • Chang J; Voorhees TJ; Liu Y; Zhao Y; Chang CH. 2010. Interleukin-23 production in dendritic cells is negatively regulated by protein phosphatase 2A.  Proceedings Of The National Academy Of Sciences Of The United States Of America. Vol. 107, no. 18. (May): e8340.
  • Jin Y; Calvert TJ; Chen B; Chicoine LG; Joshi M; Bauer JA; Liu Y; Nelin LD. 2010. Mice deficient in Mkp-1 develop more severe pulmonary hypertension and greater lung protein levels of arginase in response to chronic hypoxia.  American Journal Of Physiology. Heart And Circulatory Physiology. Vol. 298, no. 5. (May): eH1518.
  • Shen. J., Chandrasekharan, U.M., Ashraf, M.Z., Long, E., Morton, R.E., Liu, Y., Smith, J.D., Dicorleto, P.E. Lack of MAP kinase phosphatase-1 protects ApoE-null mice against atherosclerosis.  Circ Res..
  • Gu, B., Zhang, J., Chen, Q., Tao, B., Wang, W., Zhou, Z., Chen, R., Liu, Y., Zhang, M. Aire regulates the expression of differentiation-associated genes and self-renewal of embryonic stem cells.  Biochem. Biophys. Res. Commun..
  • Frazier WJ; Wang X; Wancket LM; Li XA; Meng X; Nelin LD; Cato AC; Liu Y. 2009. Increased inflammation, impaired bacterial clearance, and metabolic disruption after gram-negative sepsis in Mkp-1-deficient mice.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 183, no. 11. (December): e7411.
  • Wang X, Zhao Q, Matta R, Meng X, Liu X, Liu CG, Nelin LD, Liu Y. 2009. Inducible nitric oxide synthase expression is regulated by MAP kinase phosphatase-1.  J Biol Chem. Vol. 284, no. 40. (October): 27123-27134.
  • Matta R, Wang X, Ge H, Nelin LD, Liu Y. 2009. Triptolide induces an anti-inflammatory cellular response.  Am J Translational Res. Vol. 1, no. 3. (March): 267-282.
  • Li L, Chen S-F, Liu Y. 2009. MAP kinase phosphatase-1, a critical negative regulator of the innate immune response.  Int J Cell Exp Med. Vol. 2, no. 1. (February): 48-67.
  • Matta,Ranyia; Wang,Xianxi; Ge,Hui; Ray,William; Nelin,Leif,D; Liu,Yusen. 2009. Triptolide induces anti-inflammatory cellular responses.  AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH. Vol. 1, no. 3. (January): 267-282.
  • Liu Y and Shanley TP. 2009. MAP kinase phosphatase-1 and septic shock.  Journal of Organ Dysfunction. Vol. 5, no. 2. (January): 66-78.
  • Lu TC, Wang Z, Feng X, Chuang P, Fang W, Chen Y, Neves S, Maayan A, Xiong H, Liu Y, Iyengar R, Klotman PE, He JC. 2008. Retinoic acid utilizes CREB and USF1 in a transcriptional feed-forward loop in order to stimulate MKP1 expression in human immunodeficiency virus-infected podocytes.  Mol Cell Biol.. Vol. 28, no. 18. (September): 5785-5794.
  • Ichikawa T, Zhang J, Chen K, Liu Y, Schopfer FJ, Baker PR, Freeman BA, Chen YE, Cui T. 2008. Nitroalkenes suppress lipopolysaccharide-induced signal transducer and activator of transcription signaling in macrophages: a critical role of mitogen-activated protein kinase phosphatase 1.  Endocrinology. Vol. 149, no. 8. (August): 4086-4094.
  • Wang Z, Cao N, Nantajit D, Fan M, Liu Y, Li JJ. 2008. Mitogen-activated protein kinase phosphatase-1 represses c-Jun NH2-terminal kinase-mediated apoptosis via NF-kappaB regulation.  J Biol Chem.. Vol. 283, no. 30. (July): 21011-21023.
  • Calvert TJ, Chicoine LG, Liu Y, Nelin LD. 2008. Deficiency of mitogen-activated protein kinase phosphatase-1 results in iNOS-mediated hypotension in response to low-dose endotoxin.  Am J Physiol Heart Circ Physiol.. Vol. 294, no. 4. (April): H1621-H1629.
  • Zhou X, Ferraris JD, Dmitrieva NI, Liu Y, Burg MB. 2008. MKP-1 inhibits high NaCl-induced activation of p38 but does not inhibit the activation of TonEBP/OREBP: opposite roles of p38alpha and p38delta.  Proc Natl Acad Sci USA. Vol. 105, no. 14. (April): 5620-5625.
  • Wang X, Nelin LD, Kuhlman JR, Meng X, Welty SE, Liu Y. 2008. The role of MAP kinase phosphatase-1 in the protective mechanism of dexamethasone against endotoxemia.  Life Sci.. Vol. 83, no. 19-20. (January): 671-680.
  • Chang R, Chicoine LG, Cui H, Kanagy NL, Walker BR, Liu Y, English BK, Nelin LD. 2008. Cytokine-induced arginase activity in pulmonary endothelial cells in dependent on Src family tyrosine kinase activity.  Am J Physiol Lung Cell Mol Physiol. Vol. 295, no. 4. (January): L688-697.
  • Nelin LD, Wang X, Zhao Q, Chicoine LG, Young TL, Hatch DM, English BK, Liu Y. 2007. MKP-1 switches arginine metabolism from nitric oxide synthase to arginase following endotoxin challenge.  American Journal of Physiology - Cell Physiology. Vol. 293, no. 2. (January): C632-C640.
  • Wang X, Liu Y. 2007. Regulation of innate immune response by MAP kinase phosphatase-1.  Cellular Signaling. Vol. 19, no. 7. (January): 1372-1382.
  • Wang X, Meng X, Kuhlman JR, Nelin LD, Nicol KK, English BK, Liu Y. 2007. Knockout of Mkp-1 enhances the host inflammatory responses to gram-positive bacteria.  Journal of Immunology. Vol. 178, no. 8. (January): 5312-5320.
  • Hu JH, Chen T, Zhuang ZH, Kong L, Yu MC, Liu Y, Zang JW, Ge BX. 2007. Feedback control of MKP-1 expression by p38.  Cellular Signaling. Vol. 19, no. 2. (January): 393-400.
  • Liu Y, Shepherd EG, Nelin LD. 2007. MAPK phosphatases-regulating the immune response.  Nature Reviews Immunology. Vol. 7, no. 3. (January): 202-212.
  • Sweeney MC, Wang X, Park J, Liu Y, Pei D. 2006. Determination of the sequence specificity of XIAP BIR domains by screening a combinatorial peptide library.  Biochemistry. Vol. 45, no. 49. (December): 14740-14748.
  • Wang X, Matta R, Shen G, Nelin LD, Pei D, Liu Y. 2006. Mechanism of triptolide-induced apoptosis: Effect on caspase activation and Bid cleavage and essentiality of the hydroxyl group of triptolide.  J Mol Med. Vol. 84, no. 5. (May): 405-415.
  • Zhao Q, Chen P, Manson ME, Liu Y. 2006. Production of active recombinant mitogen-activated protein kinases through transient transfection of 293T cells.  Protein Expr Purif. Vol. 46, no. 2. (April): 468-474.
  • Stanley KP, Chicoine LG, Young TL, Reber KM, Lyons CR, Liu Y, Nelin LD. 2006. Gene transfer with inducible nitric oxide synthase decreases production of urea by arginase in pulmonary arterial endothelial cells.  Am J Physiol Lung Cell Mol Physiol. Vol. 290, no. 2. (February): L298-L306.
  • Zhao Q, Wang X, Nelin LD, Yao Y, Matta R, Manson ME, Baliga RS, Meng X, Smith CV, Bauer JA, Chang CH, Liu Y. 2006. MAP kinase phosphatase 1 controls innate immune responses and suppresses endotoxic shock.  J Exp Med. Vol. 203, no. 1. (January): 131-140.
  • Zhou JY, Liu Y, Wu GS. 2006. The role of mitogen-activated protein kinase phosphatase-1 in oxidative damage-induced cell death.  Cancer Res. Vol. 66, no. January: 4888-4894.
  • Yao Y, Xu Q, Kown MJ, Matta R, Liu Y, Hong SC, Chang CH. 2006. ERK and p38 MAPK signaling pathways negatively regulate CIITA gene expression in dendritic cells and macrophages.  J Immunol. Vol. 177, no. January: 70-76.
  • Wang Z; Xu J; Zhou J-Y; Liu Y; Wu GS. 2006. Mitogen-activated protein kinase phosphatase-1 is required for cisplatin resistance.  Cancer Research. Vol. 66, no. 17. (January): 8870-8877.
  • Nelin LD, Chicoine LG, Reber KM, English BK, Young TL, Liu Y. 2005. Cytokine-induced endothelial arginase expression is dependent on epidermal growth factor receptor.  Am J Respir Cell Mol Biol. Vol. 33, no. 4. (October): 394-401.
  • Zhao Q, Shepherd EG, Manson ME, Nelin LD, Sorokin A, Liu Y. 2005. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide: attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.  J Biol Chem. Vol. 280, no. 9. (March): 8101-8108.
  • Shepherd EG, Zhao Q, Welty SE, Hansen TN, Smith CV, Liu Y. 2004. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.  J Biol Chem. Vol. 279, no. 52. (December): 54023-54031.
  • Li J, Gorospe M, Barnes J, Liu Y. 2003. Tumor promoter arsenite stimulates histone H3 phosphoacetylation of proto-oncogenes c-fos and c-jun chromatin in human diploid fibroblasts.  J Biol Chem. Vol. 278, no. 15. (April): 13183-13191.
  • Li J, Chen P, Sinogeeva N, Gorospe M, Wersto RP, Chrest FJ, Barnes J, Liu Y. 2002. Arsenic trioxide promotes histone H3 phosphoacetylation at the chromatin of CASPASE-10 in acute promyelocytic leukemia cells.  J Biol Chem. Vol. 277, no. 51. (December): 49504-10.
  • Chen P, Li J, Barnes J, Kokkonen GC, Lee JC, Liu Y. 2002. Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages.  J Immunol. Vol. 169, no. 11. (December): 6408-6416.
  • Chen P, Hutter D, Liu P, Liu Y. 2002. A mammalian expression system for rapid production and purification of active MAP kinase phosphatases.  Protein Expr Purif.. Vol. 24, no. 3. (April): 481-488.
  • Hutter D, Chen P, Li J, Barnes J, Liu Y. 2002. The carboxyl-terminal domains of MKP-1 and MKP-2 have inhibitory effects on their phosphatase activity.  Mol Cell Biochem. Vol. 233, no. 1-2. (April): 107-117.
  • Rong R; He Q; Liu Y; Sheikh MS; Huang Y. 2002. TC21 mediates transformation and cell survival via activation of phosphatidylinositol 3-kinase/Akt and NF-kappaB signaling pathway.  Oncogene. Vol. 21, no. 7. (February): 1062-1070.
  • Li J, Gorospe M, Hutter D, Barnes J, Keyse SM, Liu Y. 2001. Transcriptional induction of MKP-1 in response to stress is associated with histone H3 phosphorylation-acetylation.  Mol Cell Biol. Vol. 21, no. 23. (December): 8213-8224.
  • Tong T; Fan W; Zhao H; Jin S; Fan F; Blanck P; Alomo I; Rajasekaran B; Liu Y; Holbrook NJ; Zhan Q. 2001. Involvement of the MAP kinase pathways in induction of GADD45 following UV radiation.  Experimental Cell Research. Vol. 269, no. 1. (September): 64-72.
  • Chen P; Hutter D; Yang X; Gorospe M; Davis RJ; Liu Y. 2001. Discordance between the binding affinity of mitogen-activated protein kinase subfamily members for MAP kinase phosphatase-2 and their ability to activate the phosphatase catalytically.  The Journal Of Biological Chemistry. Vol. 276, no. 31. (August): 29440-29449.
  • Liu, Y. and Holbrook, N.J. 2001. Mitogen-activated protein kinase signaling pathways and aging. In Handbook of the Biology of Aging. 5th ed. Edited by E. J. Masoro & S. Austad. San Diego, CA: Academic Press.
  • Hutter D, Chen P, Barnes J, Liu Y. 2000. Catalytic activation of mitogen-activated protein (MAP) kinase phosphatase-1 by binding to p38 MAP kinase: critical role of the p38 C-terminal domain in its negative regulation.  Biochem J. Vol. 352, no. Part 1. (November): 155-163.
  • Shan X; Czar MJ; Bunnell SC; Liu P; Liu Y; Schwartzberg PL; Wange RL. 2000. Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.  Molecular And Cellular Biology. Vol. 20, no. 18. (September): 6945-6957.
  • Huang Y; Hutter D; Liu Y; Wang X; Sheikh MS; Chan AM; Holbrook NJ. 2000. Transforming growth factor-beta 1 suppresses serum deprivation-induced death of A549 cells through differential effects on c-Jun and JNK activities.  The Journal Of Biological Chemistry. Vol. 275, no. 24. (June): 18234-18242.
  • Hutter D; Yo Y; Chen W; Liu P; Holbrook NJ; Roth GS; Liu Y. 2000. Age-related decline in Ras/ERK mitogen-activated protein kinase cascade is linked to a reduced association between Shc and EGF receptor.  The Journals Of Gerontology. Series A, Biological Sciences And Medical Sciences. Vol. 55, no. 3. (March): B125-B134.
  • Wang W; Furneaux H; Cheng H; Caldwell MC; Hutter D; Liu Y; Holbrook N; Gorospe M. 2000. HuR regulates p21 mRNA stabilization by UV light.  Molecular And Cellular Biology. Vol. 20, no. 3. (February): 760-769.
  • Chen W; Martindale JL; Holbrook NJ; Liu Y. 1998. Tumor promoter arsenite activates extracellular signal-regulated kinase through a signaling pathway mediated by epidermal growth factor receptor and Shc.  Molecular And Cellular Biology. Vol. 18, no. 9. (September): 5178-5188.
  • Guyton KZ; Gorospe M; Wang X; Mock YD; Kokkonen GC; Liu Y; Roth GS; Holbrook NJ. 1998. Age-related changes in activation of mitogen-activated protein kinase cascades by oxidative stress.  The Journal Of Investigative Dermatology. Symposium Proceedings / The Society For Investigative Dermatology, Inc. [And] European Society For Dermatological Research. Vol. 3, no. 1. (August): 23-27.
  • Wang X; Martindale JL; Liu Y; Holbrook NJ. 1998. The cellular response to oxidative stress: influences of mitogen-activated protein kinase signalling pathways on cell survival.  The Biochemical Journal. Vol. 333 ( Pt 2), no. July: 291-300.
  • Liu Y; Gorospe M; Kokkonen GC; Boluyt MO; Younes A; Mock YD; Wang X; Roth GS; Holbrook NJ. 1998. Impairments in both p70 S6 kinase and extracellular signal-regulated kinase signaling pathways contribute to the decline in proliferative capacity of aged hepatocytes.  Experimental Cell Research. Vol. 240, no. 1. (April): 40-48.
  • Liu, Y., Gorospe, M., Holbrook, N.J., and Anderson, C. 1998. Post-translational mechanisms leading to mammalian gene activation in response to genotoxic stress. In DNA Damage and Repair, Vol. 2: DNA Repair in Higher Eukaryotes. Edited by Hoekstra, M.F. and Nickoloff, J.A. Totowa, NJ: Humana Press.
  • Liu, Y., Holbrook, N.J., Kokkonen, G.C., and Roth, G.S. 1998. Intracellular signal transduction and receptor activity in stimulated hepatocyte DNA synthesis. In Methods in Aging Research. Edited by Yu, B.P.. Boston, MA: CRC Press.
  • Xu Q; Fawcett TW; Gorospe M; Guyton KZ; Liu Y; Holbrook NJ. 1997. Induction of mitogen-activated protein kinase phosphatase-1 during acute hypertension.  Hypertension. Vol. 30, no. 1 Pt 1. (July): 106-111.
  • Huang Y; Chan AM; Liu Y; Wang X; Holbrook NJ. 1997. Serum withdrawal and etoposide induce apoptosis in human lung carcinoma cell line A549 via distinct pathways.  Apoptosis: An International Journal On Programmed Cell Death. Vol. 2, no. 2. (January): 199-206.
  • Sheikh MS; Garcia M; Zhan Q; Liu Y; Fornace AJ Jr. 1996. Cell cycle-independent regulation of p21Waf1/Cip1 and retinoblastoma protein during okadaic acid-induced apoptosis is coupled with induction of Bax protein in human breast carcinoma cells.  Cell Growth & Differentiation: The Molecular Biology Journal Of The American Association For Cancer Research. Vol. 7, no. 12. (December): 1599-1608.
  • Gorospe M; Liu Y; Xu Q; Chrest FJ; Holbrook NJ. 1996. Inhibition of G1 cyclin-dependent kinase activity during growth arrest of human breast carcinoma cells by prostaglandin A2.  Molecular And Cellular Biology. Vol. 16, no. 3. (March): 762-770.
  • Liu Y; Guyton KZ; Gorospe M; Xu Q; Kokkonen GC; Mock YD; Roth GS; Holbrook NJ. 1996. Age-related decline in mitogen-activated protein kinase activity in epidermal growth factor-stimulated rat hepatocytes.  The Journal Of Biological Chemistry. Vol. 271, no. 7. (February): 3604-3607.
  • Guyton KZ; Liu Y; Gorospe M; Xu Q; Holbrook NJ. 1996. Activation of mitogen-activated protein kinase by H2O2. Role in cell survival following oxidant injury.  The Journal Of Biological Chemistry. Vol. 271, no. 8. (February): 4138-4142.
  • Xu Q; Liu Y; Gorospe M; Udelsman R; Holbrook NJ. 1996. Acute hypertension activates mitogen-activated protein kinases in arterial wall.  J Clin Invest. Vol. 97, no. 2. (January): 508-514.
  • Liu Y; Martindale JL; Gorospe M; Holbrook NJ. 1996. Regulation of p21WAF1/CIP1 expression through mitogen-activated protein kinase signaling pathway.  Cancer Research. Vol. 56, no. 1. (January): 31-35.
  • Holbrook, N.J., Liu, Y., and Fornace, Jr., A.J. 1996. Signalling events controlling the molecular response to genotoxic stress. In Stress-induced cellular responses.. Edited by Feige U., Morimoto, R.I., Yahara, I., and Polla B.S.. Basel: Birkhauser Verlag.
  • Liu Y, Guyton KZ, Gorospe M, Xu Q, Lee JC, Holbrook NJ. 1996. Differential activation of ERK, JNK/SAPK and P38/CSBP/RK map kinase family members during the cellular response to arsenite.  Free Radic Biol Med. Vol. 21, no. 6. (January): 771-781.
  • Nakamura T; Namba H; Ohmoto T; Liu Y; Hirata D; Miyakawa T. 1995. Cloning and characterization of the Saccharomyces cerevisiae SVS1 gene which encodes a serine- and threonine-rich protein required for vanadate resistance.  Gene. Vol. 165, no. 1. (November): 25-29.
  • Liu Y; Gorospe M; Yang C; Holbrook NJ. 1995. Role of mitogen-activated protein kinase phosphatase during the cellular response to genotoxic stress. Inhibition of c-Jun N-terminal kinase activity and AP-1-dependent gene activation.  The Journal Of Biological Chemistry. Vol. 270, no. 15. (April): 8377-8380.
  • Nakamura T; Liu Y; Hirata D; Namba H; Harada S; Hirokawa T; Miyakawa T. 1993. Protein phosphatase type 2B (calcineurin)-mediated, FK506-sensitive regulation of intracellular ions in yeast is an important determinant for adaptation to high salt stress conditions.  The EMBO Journal. Vol. 12, no. 11. (November): 4063-4071.
  • Nakamura,T; Liu,Y,S; Hirata,D; Namba,H; Harada,S; Hirokawa,T; Miyakawa,T. 1993. PROTEIN PHOSPHATASE TYPE-2B (CALCINEURIN)-MEDIATED, FK506-SENSITIVE REGULATION OF INTRACELLULAR IONS IN YEAST IS AN IMPORTANT DETERMINANT FOR ADAPTATION TO HIGH-SALT STRESS CONDITIONS.  EMBO JOURNAL. Vol. 12, no. 11. (November): 4063-4071.
  • Nakamura,T; Tsutsumi,H; Mukai,H; Kuno,T; Miyakawa,T. 1992. CA2+/CALMODULIN-ACTIVATED PROTEIN PHOSPHATASE (PP2B) OF SACCHAROMYCES-CEREVISIAE - PP2B ACTIVITY IS NOT ESSENTIAL FOR GROWTH.  FEBS LETTERS. Vol. 309, no. 1. (August): 103-106.
  • Cui Z; Mochizuki D; Matsuno Y; Nakamura T; Liu Y; Hatano T; Fukui S; Miyakawa T. 1992. Cloning and molecular analysis of cDNA encoding a carboxymethylcellulase of the yeast Cryptococcus flavus.  Bioscience, Biotechnology, And Biochemistry. Vol. 56, no. 8. (August): 1230-1235.
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