Warren D. Lo, MD

Warren D. Lo, MD, is attending pediatric neurologist at Nationwide Children’s and Associate Professor of Clinical Pediatrics and Neurology at The Ohio State University College of Medicine. His clinical and research interests center on stroke in infants and children. This emphasis led to the development of the Stroke and Vascular Anomalies Clinic at Nationwide Children’s, where he serves as director. His clinical research examines the social and cognitive impairments that result from stroke, and the improvement of recovery. Dr. Lo is named among the “Best Doctors in America.” Together with Dr. Roach and Dr. Heyer, Dr. Lo authored the book "Pediatric Stroke and Cerebrovascular Disorders.”

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Hospital-Based Research Faculty

Medical School

• Northwestern University Hospital
  Date Completed: 06/30/1977

Internship

• University of Minnesota Hospitals and Clinics
  Date Completed: 06/30/1980

Residency

• University of California Medical Center Parnassus
  Date Completed: 06/30/1983

Fellowship

• University of Michigan
  Date Completed: 06/30/1985

Department:

• Pediatrics

Section:

• Neurology

Speciality:

• Child Neurology
  
• Neurology
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 12/17/1985

• Lo WD, Hajek C, Pappa C, Wang W, Zumberge N. 2013. Outcomes in children with.  JAMA Neurol. Vol. 70, no. January: 66-71.
• Dowling MM, Hynan LS, Lo W, Licht DJ, McClure C, Yager JY, Dlamini N, Kirkham. 2012. International Paediatric Stroke Study: stroke associated with cardiac disorders.  Int J Stroke. Vol. Epub ahead of, no. December: eEpub ahead of.
• Lo W. 2012. Pediatric Stroke. In Manual of Pediatric Neurology. Hackensack: World Scientific Publishing, Inc.
• Lo WD, Ichord RN, Dowling MM, Rafay M, Templeton J, Halperin A, Smith SE,. 2012. The Pediatric Stroke Recurrence and Recovery Questionnaire:.  Neurology. Vol. 79, no. 9. (August): 964-70.
• Tate,Elizabeth,D; Pranzatelli,Michael,R; Verhulst,Steven,J; Markwell,Stephen,J; Franz,David,Neal; Graf,William,D; Joseph,S,Anne; Khakoo,Yasmin,N; Lo,Warren,D; Mitchell,Wendy,G; Sivaswamy,Lalitha. 2012. Active Comparator-Controlled, Rater-Blinded Study of Corticotropin-Based Immunotherapies for Opsoclonus-Myoclonus Syndrome.  JOURNAL OF CHILD NEUROLOGY. Vol. 27, no. 7. (July): 875-884.
• Saver,Jeffrey,L; Warach,Steven; Janis,Scott; Odenkirchen,Joanne; Becker,Kyra; Benavente,Oscar; Broderick,Joseph; Dromerick,Alexander,W; Duncan,Pamela; Elkind,Mitchell,SV; Johnston,Karen; Kidwell,Chelsea,S; Meschia,James,F; Schwamm,Lee. 2012. Standardizing the Structure of Stroke Clinical and Epidemiologic Research Data The National Institute of Neurological Disorders and Stroke (NINDS) Stroke Common Data Element (CDE) Project.  STROKE. Vol. 43, no. 4. (April): 967-U108.
• Lo,Warren; Marchuk,Douglas,A; Ball,Karen,L; Juhasz,Csaba; Jordan,Lori,C; Ewen,Joshua,B; Comi,Anne. 2012. Updates and future horizons on the understanding, diagnosis, and treatment of Sturge-Weber syndrome brain involvement.  DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY. Vol. 54, no. 3. (March): 214-223.
• Bernard,Timothy,J; Manco-Johnson,Marilyn,J; Lo,Warren; Mackay,Mark,T; Ganesan,Vijeya; DeVeber,Gabrielle; Goldenberg,Neil,A; Armstrong-Wells,Jennifer; Dowling,Michael,M; Roach,E,Steve; Tripputi,Mark; Fullerton,Heather,J; Furie,Karen,L; Benseler,Susanne,M; Jordan,Lori,C; Kirton,Adam; Ichord,Rebecca. 2012. Towards a Consensus-Based Classification of Childhood Arterial Ischemic Stroke.  STROKE. Vol. 43, no. 2. (February): 371-377.
• Beslow,Lauren,A; Kasner,Scott,E; Smith,Sabrina,E; Mullen,Michael,T; Kirschen,Matthew,P; Bastian,Rachel,A; Dowling,Michael,M; Lo,Warren; Jordan,Lori,C; Bernard,Timothy,J; Friedman,Neil; DeVeber,Gabrielle; Kirton,Adam; Abraham,Lisa; Licht,Daniel,J; Jawad,Abbas,F; Ellenberg,Jonas,H; Lautenbach,Ebbing; Ichord,Rebecca,N. 2012. Concurrent Validity and Reliability of Retrospective Scoring of the Pediatric National Institutes of Health Stroke Scale.  STROKE. Vol. 43, no. 2. (February): 341-345.
• Lo WD, Heyer GL, Roach ES. 2012. Cerebrovascular Disorders in Children. In Textbook of Clinical Pediatrics. Edited by A. Elzouki. New York: Springer.
• Roach ES, Lo WD, Heyer GL. 2012. Pediatric Stroke and Cerebrovasular Disorders. 3rd ed. New York: Demos Medical Publishers, Inc.
• Turney,Colin,M; Wang,Wei; Seiber,Eric; Lo,Warren. 2011. Acute Pediatric Stroke Contributors to Institutional Cost.  STROKE. Vol. 42, no. 11. (November): 3219-U471.
• Lo,Warren,D. 2011. Childhood Hemorrhagic Stroke: An Important but Understudied Problem.  JOURNAL OF CHILD NEUROLOGY. Vol. 26, no. 9. (September): 1174-1185.
• Mackay MT, Wiznitzer M, Benedict SL, Lee KJ, Deveber GA, Ganesan V;. 2011. International Pediatric Stroke Study Group. Arterial Iscchemic Stroke Risk Factors: The International Pediatric Stroke Study.  Ann Neurol. Vol. 1, no. 69. (January): 130-140.
• Lo W, Marchuk D, Ball K et al. 2011.
• Lo,W. 2011.
• Ichord RN, Bastian R, Abraham L, Askalan R, Benedict S, Bernard TJ, Beslow L, Deveber G, Dowling M, Friedman N, Fullerton H, Jordan L, Kan L, Kirton A, Amlie-Lefond C, Licht D, Lo W, McClure C, Pavlakis S, Smith SE, Tan M, Kasner S, Jawad AF. 2011. Interrater reliability of the Pediatric National Institutes of Health Stroke Scale (PedNIHSS) in a multicenter study.  Stroke. Vol. 42, no. 3. (January): 613-617.
• Stevens J, Harman J, Pakalnis A, Lo W, Prescod J. 2010. Sociodemographic Differences in Diagnosis and Treatment of Pediatric Headache.  J Child Neurol. Vol. 4, no. 25. (April): 435-440.
• Jordan LC, Rafay MF, Smith SE, Askalan R, Zamel KM, Deveber G, Ashwal S, et al. 2010. Antithrombotic Treatment in Neonatal Cerebral Sinovenous Thrombosis: For the Internation Pediatric Stroke Study Group.  J Pediatri. Vol. 5, no. 156. (January): 704-710.
• Goldenbert NA, Bernard TJ, Fullerton HJ, et al. 2009. Anti-thrombotic Treatments, Outcomes, and Prognostic Factors in Acute Childhood-Onset Arterial Ischemic Stroke: Internatinal Pediatric Stroke Study Findings.  Lancet Neurol. Vol. 12, no. 8. (December): 1120-1127.
• Amlie-Lefond,Catherine; DeVeber,Gabrielle; Chan,Anthony,K; Benedict,Susan; Bernard,Timothy; Carpenter,Jessica; Dowling,Michael,M; Fullerton,Heather; Hovinga,Collin; Kirton,Adam; Lo,Warren; Zamel,Khaled; Ichord,Rebecca. 2009. Use of alteplase in childhood arterial ischaemic stroke: a multicentre, observational, cohort study.  LANCET NEUROLOGY. Vol. 8, no. 6. (June): 530-536.
• Amlie-Lefond,Catherine; Bernard,Timothy,J; Sebire,Guillaume; Friedman,Neil,R; Heyer,Geoffrey,L; Lerner,Norma,B; de Veber,Gabrielle; Fullerton,Heather,J. 2009. Predictors of Cerebral Arteriopathy in Children With Arterial Ischemic Stroke Results of the International Pediatric Stroke Study.  CIRCULATION. Vol. 119, no. 10. (March): 1417-U110.
• Lo WD, Stephens J, Fernandez S. 2009. Pediatric Stroke in the United States and the Impact of Risk Factors.  J Child Neurol. Vol. 2, no. 24. (February): 194-203.
• Golomb MR, fullerton JH, Nowak-Gottl U, et al. 2009. Male Predominance in Childhood Ischemic Stroke. Findings from the International Pediatric Stroke Study.  Stroke. Vol. 1, no. 40. (January): 52-57.
• Lefond K, Bernard T, Sebire G, et al. 2009. Predictors of Cerebral Arteriopathy in Children with Arterial Ischemic Stroke: Results of the International Pediatric Stroke Study.  Circulation. Vol. 119, no. January: 1417-1423.
• Amlie-Lefond C, deVeber G, Chan A, et al. 2009. Use of tPA in Childhood Arterial Ischemic Stroke.  Lancet Neurol. Vol. 8, no. January: 530-536.
• Perkins E, Stephens J, Xiang H, Lo WD. 2009. The Cost of Pediatric Stroke Acute Care in the United States.  Stroke. Vol. 40, no. January: 2820-2827.
• Lo WD, Lee J, Perkins E, Rusin J, Roach ES. 2008. Intracranial Hemorrhage in Children: An Evolving Spectrum.  Arch Neurol. Vol. 12, no. 65. (December): 1629-1633.
• Lo W, Zamel K, Ponnappa K, Allen A, Chisolm D, Tang M, Kerlin B, Yeates KO. 2008. The Cost of Pediatric Stroke Care and Rehabilitation.  Stroke. Vol. 39, no. January: 161-165.
• Tsao CY, et al. 2007. Islated Neurosarcoidosis presenting as Headache and Multiple Brain and Spinal Cord Leisons Mimicking Central Nervous Ssytem Metastases.  Brain Dev. Vol. 29, no. January: 514-518.
• Raju T, Nelson K, Ferriero D, Lynch J, et al. 2007. Ischemic Perinatal Stroke: summary of a Workshop Sponsored by the National Institute of Child Health and Human Development and the National Institute of Neurological Disorders and Stroke.  Pediatrics. Vol. 3, no. 120. (January): 609-616.
• Lo WD, Roach ES. 2007. The degree of risk: multiple factors promote perinatal stroke.  Pediatric Neurology. Vol. 2, no. 37. (January): 152-153.
• Jiang Y, Lo W, Akhmametyeva E, Chang L-S. 2006. Over-expression of p73 Results sin Apoptiotic Death of Postmitotic hNT Neurons.  J Neurol Sci. Vol. 240, no. January: 1-6.
• Tsao CY, Lo WD. 2005. Acute Head Injury in Children. In Conn's Current Therapy. Edited by Rakel RE, Bope ET. New York: Elsevier.
• Tallian KB, Nahata MC, Lo WD, Tsao CY. 2004. Pharmacokinetics of Gabapentin in Paediatric Patients with Uncontrolled Seizures.  Journal of Clinical Pharmacy and Therapeutics. Vol. 29, no. January: 511-515.
• Tsao CY, Herman G, Boue DR, Prior TW, Lo WD, ATkin JF, Rusin J. 2003. Leigh Disease with Mitchondrial DNA A8344G Mutation: Case Report and Brief review.  J Child Neurol. Vol. 1-2, no. 113. (May): 1-12.
• Cereghino JJ, Cloyd JC, Kuzniecky RI, et al. 2002. Rectal Diazepam Gel for Treatment of Acute Repetitive Seizures in Adults.  Arch Neurol. Vol. 12, no. 59. (December): 1915-1920.
• Tsao,C,Y; Mendell,J,R; Lo,W,D; Luquette,M; Rusin,J. 2000. Mitochondrial respiratory-chain defects presenting as nonspecific features in children.  JOURNAL OF CHILD NEUROLOGY. Vol. 15, no. 7. (July): 445-448.
• Sferra TJ, Qu G, McNeely D, Rennard R, Clark KR, Lo WD, Johnson PR. 2000. Recombinant Adeno-associated Virus-mediated Correction of Lysosomal Storage Within the Central Nervous System of the Adult Mucopolysaccharidosis Type VII Mouse.  Hum Gene Ther. Vol. 4, no. 11. (March): 507-519.
• Tsao CY, Mendell JR, Lo WD, Luquette M, Rennebohm R. 2000. Myasthenia Gravis and Associated Autoimmune Diseases in Children.  J Child Neurol. Vol. 11, no. 15. (January): 767-769.
• Lo WD, Qu G, Sferra T, Clark KR, Chen R, Johnson PR. 1999. Adeno-associated virus mediated gene transfer to the brain: duration and modulation of expression.  Human Gene Therapy. Vol. 10, no. 2. (January): 201-213.
• Whalen MJ, Carlos TM, Kochanek PM, et al. 1999. Neutrophils do not mediate blood-brain barrier permeability early after controlled cortical impact in rats.  J Neurotrauma. Vol. 7, no. 16. (January): 583-594.
• Clark KR, Sferra TJ, Lo WD, Qu G, Chen R, Johnson PR. 1999. Gene transfer into the CNS using recombinant adeno-associated virus: analysis of vector DNA forms resulting in substained expression.  J Drug Target. Vol. 4, no. 7. (January): 269-283.
• Kriel RL, Cloyd JC, Pellock JM, Mitchell WG, Cereghino JJ, Rosman NP. 1999. Rectal diazepam gel for treatment of acute repetitive seizures. The North American Diastat Study Group.  Pediatr Neurol. Vol. 4, no. 20. (January): 282-288.
• Mitchell WG, Conry JA, Crumrine PK, Kriel RL, Cereghino JJ, Rosenfeld WE, Groves L and the North American Diastat Study Group. 1999. Safety and efficacy of diazepam rectal gel (Diastat) when administered repeatedly: an open-label study.  Epilepsia.
• Lo WD, Chen R, Boue D, Stokes BT. 1998. Effect of neutrophil depletion in acute cerebritis.  Brain Res.
• Cerehino JJ, Mitchell WG, Murphy J, Kriel RL, Rosenfeld WE, Trevathan E, and the North American Diastat Study Group. 1998. Treating repetitive seizures with a rectal diazepam formulation: a randomized study.  Neurology. Vol. 5, no. 51. (January): 1274-1282.
• Dreifuss FE, Kuzniecky RI, Pellock JM, Cloyd JC, Lo WD, Rosman NP, Matsuo F, Sharp GB, Conry JA, Bergen DC, Bell WE. 1998. A comparison of rectal diazepam gel and placebo for acute repetitive seizures.  New Engl J Med.
• Tallian KB, Nahata MC, Lo WD, Tsao CY. 1996. Gabapentin Associated with Agressive Behavior in Pediatric Patients with Seizures.  Epilepsia. Vol. 37, no. 5. (January): 501-502.
• Tsao CY, Lo WD, Mendell JR, Batley RJ. 1995. Critical illness polyneuropathy in a 2-year old girl with hemorrhagic shock encephalopathy syndrome.  J Child Neurol.
• Tsao CY, Romshe CA, Lo WD, Wright FS, Sommer A. 1994. Familial adrenal insuffciency, achalasia, alacrima, peripheral neuropathy, microcephaly, normal plasma very long chain fatty acids and normal muscle mitochodrial respiratory chain enzymes.  J Child Neurol.
• Donat JF, Lo WD. 1994. Asymmetrical hypsarrhythmia and infantile spasms in West syndrome.  J Child Neurol.
• Lo WD, Wolny A, Boesel C. 1994. Blood-brain barrier permeability in staphylococcal cerebritis and early brain abscess.  J Neurosurgery.
• Griffin AC, Lo WD, Wolny AC, Whitacre CC. 1993. Suppression of experimental autoimmune encephalomyelitis (EAE) by restraint stress: sex differences.  J Neuroimmunology.
• Lo, WD, Wolny A, Timan C, Shin D, Kinkle G. 1993. Blood-brain barrier permeability and the brain extracellular space in acute cerebral inflammation.  J Neurological Sciences.
• LO WD, Sloan HR, Sotos JF, Klinger RJ. 1993. Late clinical presentation of partial carbamyl phosphate synthetase I deficiency.  AJDC.
• Tsao CY, Lo WD, Craenen J. 1992. Congestive heart failure and cardiac thrombus as first presentations of Friedreich Ataxia.  Pediatric Neurology. Vol. 8, no. 4. (January): 313-314.
• Mortensen ME, Cecalupo AJ, Lo WD, Egorin MJ, Batley R. 1992. Inadvertent intrathecal injection of daunorubicin with fatal outcome.  Med Ped Oncol.
• Lo WD, Kadlecek T, Packman S. 1991. Biotin transport in the rat central nervous system.  J of Nutrition and Vitaminology.
• Lo WD, McNeely DL, Boesel CW. 1991. Blood-brain barrier permeability in an experimental model of bacterial cerebritis.  Neurosurgery. Vol. 6, no. 29. (January): 1-5.
• Lo WD, Donat JF, Wright FS. 1991. Tonic and myoclonic seizures in Lennox-Gastaut syndrome mistaken as complex partial seizures.  J Epilepsy.
• Lo WD, Barohn RJ, Bobulski RJ, Kean J, Mendell JR. 1990. Centronuclear myopathy and type I hypotrophy without central nuclei: Distinct nosologic entities?.  Arch Neurol.
• Lo WD, Sloan HR, Fahey BP, et al. 1990. Tangier disease in a black male: Unusual clinical presentation.  Am J Med.
• Sollinger-Applegate M and Lo WD. 1989. Febrile seizures: Current concepts on prognosis and clinical management.  J Fam Pract.
• LO WD, Ennis SR, Goldstein GW, McNeely D, Betz AL. 1987. The effects of galactosamine-induced hepatic failure upon blood-brain barrier permeability.  Hepatology.
• Lo WD, Betz AL, Schielke GP, Hoff JT. 1987. Transport of sodium from blood to brain in ischemic brain edema.  Stroke.
• Lo WD, Betz AL. 1986. Oxygen free radical reduction of brain capillary endothelial cell rubidium uptake.  J Neurochem.
• LO WD, Matthay K, Kushner J. 1985. Spinal cord compression in a child with acute lymphoblastic leukemia.  Am J Pediatr Hematol Oncol.
• Lo WD, Sander JF, Koenigsberger MR. 1985. Similarity of the brain CT scan appearance in spongy degeneration to subacute necrotizing encephalomyelopathy.  Ann Neurol.
• Koch TK, Lo WD, Berg BO. 1985. Variability of serial CT scans in subacute necrotizing encephalomyelopathy (Leigh disease).  Pediatr Neurol.
• Lo WD, Packman S, Nash S, et al. 1984. Curious neurological sequelae in galactosemia.  Pediatrics.
• Wilson-Davis SL, Lo WD, Filly RA. 1983. Limitations of ultra-sound in detecting cerebral ischemic lesions in the neonate.  Ann Neurol. Vol. 2, no. 14. (January): 249-251.
• Disterhoft JF, Kwan HH, Lo WD. 1977. Nictitating membrane conditioning to tone in the mobilized albino rabbit.  Brain Res.
• Lo WD, Hajek C, Pappa C, Wang W, Zumberge N. Outcomes in Children with Hemorrhagic Stroke.  Arch Neurol.
• Dowling MM, Hyman L, Lo W, et al. International Pediatric Stroke Study: Stroke Associated with Cardiac Disorders.  Int J Stroke.
• Lo W, Ichord R, Dowling MM. The Pediatric Stroke Recurrence and Recovery Questionnaire: Validation in a Prospective Cohort.  Neurology.

• Member, Child Neurology Society
• Member, Child Neurology Society Executive Committee, 2009-2011
• Councilor, Child Neurology Section, American Academy of Neurology, 2008-2010
• Editorial Board Journal of Child Neurology, 2008-present
• Editorial Board, Pediatric Neurology 2008-present
• Elected member of the American Neurological Association
• Listed, "Best Doctors in America"