Vidu Garg, MD

Vidu Garg, MD, is Director of Translational Research, The Heart Center and Center for Cardiovascular and Pulmonary Research, Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. He is board certified in pediatrics.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Cardiovascular and Pulmonary Research

Areas of Interest:

• The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease. Lab Web Site: http://www.nationwidechildrens.org/garg-lab

Undergraduate

• The Pennsylvania State University
  Date Completed: 06/30/1992

Medical School

• Jefferson Medical College
  Date Completed: 06/10/1994

Residency

• Nationwide Children's Hospital
  Date Completed: 06/30/1997

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/1997

Fellowship

• Children's Medical Center of Dallas
  Date Completed: 06/30/2000

Fellowship

• University of Texas Southwestern Medical Center
  Date Completed: 06/30/2002

Department:

• Pediatrics

Section:

• Cardiology

Speciality:

• Pediatric Cardiology, Certified
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 07/31/2009

2009–present

• Associate Professor, Department of Pediatrics, The Ohio State University, Columbus, Ohio

2009–present

• Director of Translational Research, Heart Center & Center for Cardiovascular and Pulmonary Research, Nationwide Children’s Hospital, Columbus, Ohio
  

2005–2009

• Assistant Professor, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas

2005–2009

• Assistant Professor, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas

2002–2009

• Assistant Professor, Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas

2000–2002

• Assistant Instructor, Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas

1994–1997

• Clinical Instructor, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio

• Acharya A, Hans CP, Koenig SN, Nichols HA, Galindo C, Garner HR, Merrill WH, Hinton RB, Garg, V. 2011. Inhibitory role of Notch1 in calcific aortic valve disease is mediated by Sox9.  PLoS One. Vol. 6, no. 11. : e27743.
• Roach JC, Glusman G, Hubley R, Montsaroff SZ, Holloway AK, Mauldin DE, Srivastava D, Garg V, Pollard KS, Galas DJ, Hood L, Smit AF. 2011. Chromosomal haplotypes by genetic phasing of human families.  Am J Hum Genet. Vol. 89, no. 3. : 382-397.
• McBride KL and Garg V. 2011. Heredity of Bicuspid Aortic Valve: Is Family Screening Indicated?.  Heart. Vol. 97, no. 15. : 1193-1195.
• McBride KL; Garg V. 2010. Impact of Mendelian inheritance in cardiovascular disease.  Annals Of The New York Academy Of Sciences. Vol. 1214. (December 1): 122.
• Yu S; Poe B; Schwarz M; Elliot SA; Albertine KH; Fenton S; Garg V; Moon AM. 2010. Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.  Developmental Biology. Vol. 347, no. 1. (November 1): 92.
• Maitra M; Koenig SN; Srivastava D; Garg V. 2010. Identification of GATA6 sequence variants in patients with congenital heart defects.  Pediatric Research. Vol. 68, no. 4. (October 1): 281.
• Richards AA; Garg V. 2010. Genetics of Congenital Heart Disease.  Current Cardiology Reviews. Vol. 6, no. 2. : 91-97.
• Maitra M; Koenig S; Srivastava D; Garg V. 2010. GATA6 sequence variations in human congenital heart disease.  Pediatric Research. Vol. 68. : 281-285.
• Yu, S., Poe, B., Schwarz, M., Elliot, S., Albertine, K.H., Fenton, S., Garg, V., and Moon, A.M. 2010. Fetal and post-natal lung defects reveal a novel and required role for Fgf8 in lung development.  Developmental Biology. Vol. 347. : 92-108.
• McBride, K.L. and Garg, V. 2010. Impact of Mendelian Genetics in Cardiovascular Disease.  Annals of New Yor Acad Sci. Vol. 1214. : 122-137.
• Garg, V. Growth of the Normal Human Heart. In Handbook of Growth and Growth Monitoring in Health and Disease. Edited by Victor R. Preedy. New York: Springer. (In press)
• Pan H; Richards AA; Zhu X; Joglar JA; Yin HL; Garg V. 2009. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death.  Heart Rhythm: The Official Journal Of The Heart Rhythm Society. Vol. 6, no. 5 (May 1): 707.
• Maitra M; Schluterman MK; Nichols HA; Richardson JA; Lo CW; Srivastava D; Garg V. 2009. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.  Developmental Biology. Vol. 326, no. 2 (February 15): 368.
• Ransom JF; King IN; Garg V; Srivastava D. 2008. A rare human sequence variant reveals myocardin autoinhibition.  The Journal Of Biological Chemistry. Vol. 283, no. 51 (December 19): 35845.
• Richards AA; Santos LJ; Nichols HA; Crider BP; Elder FF; Hauser NS; Zinn AR; Garg V. 2008. Cryptic chromosomal abnormalities identified in children with congenital heart disease.  Pediatric Research. Vol. 64, no. 4 (October 1): 358.
• Rajagopal SK; Ma Q; Obler D; Shen J; Manichaikul A; Tomita-Mitchell A; Boardman K; Briggs C; Garg V; Srivastava D; Goldmuntz E; Broman KW; Benson DW; Smoot LB; Pu WT. 2007. Spectrum of heart disease associated with murine and human GATA4 mutation.  Journal Of Molecular And Cellular Cardiology. Vol. 43, no. 6 (December 1): 677.
• Tomita-Mitchell A; Maslen CL; Morris CD; Garg V; Goldmuntz E. 2007. GATA4 sequence variants in patients with congenital heart disease.  Journal Of Medical Genetics. Vol. 44, no. 12 (December 1): 779.
• Schluterman MK; Krysiak AE; Kathiriya IS; Abate N; Chandalia M; Srivastava D; Garg V. 2007. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.  American Journal Of Medical Genetics. Part A. Vol. 143A, no. 8 (April 15): 817.
• Garg V. 2006. Insights into the genetic basis of congenital heart disease.  Cellular And Molecular Life Sciences: CMLS. Vol. 63, no. 10 (May 1): 1141.
• Garg V. 2006. Molecular genetics of aortic valve disease.  Current Opinion In Cardiology. Vol. 21, no. 3 (May 1): 180.
• Garg V; Muth AN; Ransom JF; Schluterman MK; Barnes R; King IN; Grossfeld PD; Srivastava D. 2005. Mutations in NOTCH1 cause aortic valve disease.  Nature. Vol. 437, no. 7056 (September 8): 270.
• Garg, V. and Srivastava, D. 2005. Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease. In Principles of Molecular Cardiology. Edited by C. Patterson and M. Runge. New York: Springer-Verlag.
• Garg V; Kathiriya IS; Barnes R; Schluterman MK; King IN; Butler CA; Rothrock CR; Eapen RS; Hirayama-Yamada K; Joo K; Matsuoka R; Cohen JC; Srivastava D. 2003. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.  Nature. Vol. 424, no. 6947 (July 24): 443.
• Kunte A; Ivey K; Yamagishi C; Garg V; Yamagishi H; Srivastava D. 2001. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L.  Mechanisms Of Development. Vol. 108, no. 1-2 (October 1): 81.
• Garg V; Yamagishi C; Hu T; Kathiriya IS; Yamagishi H; Srivastava D. 2001. Tbx1, a DiGeorge syndrome candidate gene, is regulated by sonic hedgehog during pharyngeal arch development.  Developmental Biology. Vol. 235, no. 1 (July 1): 62.
• Yamagishi H; Garg V; Matsuoka R; Thomas T; Srivastava D. 1999. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.  Science (New York, N.Y.). Vol. 283, no. 5405 (February 19): 1158.