Vidu Garg, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Vidu Garg, MD

Vidu Garg, MD

22q Center
Physician Team

Cardiology Fellowship

Center for Cardiovascular Research

Heart Center
Physician Team

Vidu Garg Lab
Principal Investigator

Contact Information

700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-2530
FX: (614) 722-2549
Email Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722-4988

Location Information for Patients

Main Campus


Vidu Garg, MD, is Director of Translational Research, The Heart Center and the Center for Cardiovascular Research at The Research Institute at Nationwide Children’s Hospital. Dr. Garg completed his pediatric residency at Nationwide Children’s Hospital in 1997 after which he spent five years at University of Texas Southwestern completing his pediatric cardiology training and a post-doctoral research fellowship in cardiac development and cardiovascular genetics. Subsequently, he joined the faculty at University of Texas Southwestern before returning to Nationwide Children’s. Dr. Garg’s research laboratory focuses on molecular pathways controlling cardiac development and the genetics of congenital heart disease. He is board certified in pediatrics.

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  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • The laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development. We have identified familial cases of congenital heart disease and used traditional linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease. Lab Web Site:

Education and Training

Undergraduate School

  • The Pennsylvania State University
    Date Completed: 06/30/1992

Medical School

  • Jefferson Medical College
    Date Completed: 06/10/1994


  • Nationwide Children's Hospital
    Date Completed: 06/30/1997


  • Children's Medical Center of Dallas
    Date Completed: 06/30/2000


  • University of Texas Southwestern Medical Center
    Date Completed: 06/30/2002


  • Pediatrics


  • Cardiology


  • Pediatric Cardiology

Date of Appointment at Nationwide Children’s Hospital:

  • 07/31/2009

Professional Experience


  • Associate Professor, Department of Pediatrics, The Ohio State University, Columbus, Ohio


  • Director of Translational Research, The Heart Center & Center for Cardiovascular Research, Nationwide Children’s Hospital, Columbus, Ohio


  • Associate Professor, Department of Molecular Genetics, The Ohio State University


  • Assistant Professor, McDermott Center of Human Growth and Development, University of Texas Southwestern Medical Center, Dallas, Texas


  • Assistant Professor, Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas


  • Assistant Professor, Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas


  • Assistant Instructor, Department of Pediatrics, Division of Pediatric Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas


  • Clinical Instructor, Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio


  • Horne TE, VandeKopple M, Sauls K, Koenig SN, Anstine LJ, Garg V, Norris RA, Lincoln J. 2015. Dynamic heterogeneity of the heart valve interstitial cell population in health and disease.”.  J CARDIOVASC DEVELOPMENT DIS. Vol. 2, no. 3. (August): 214-232.
  • Backes CH, Huang H, Cua C, Garg V, Galantowicz M, Bauer JA, Hoffman TH. 2015. Umbilical Cord Clamping in Infants with Congenital Heart Disease.  J PERINATOLOGY. Vol. 35, no. 10. (July): 826-31.
  • Hinton RB, McBride KL, Bleyl SB, Bowles NE, Border WL, Garg V, Smolarek TA, Lalani SR, Ware SM. 2015. Rationale for the Cytogenetic of Cardiovascular Malformations Consortium: a Phenotype Intensive Registry Based Approach.  J CARDIOVASC DEVELOPMENT DIS. Vol. 2, no. 2. (May): 76-92.
  • Fitzgerald-Butt S, Bodine A, Klima J, Fry KM, Ash J, Zaidi AN, Garg V, Gerhardt CA, McBride KL. 2015. Measuring Genetic Knowledge: Validation of a Brief Survey Instrument for Adolescents and Adults.  CLIN GENET. Vol. doi:, no. May: e10.1111/cge.12618.
  • Koenig, SN, Bosse K, Nadorlik HA, Lilly B, Garg V. 2015. Mouse model for bicuspid aortic valve-associated ascending aortic aneurysms.  J CARDIOVASC DEVELOPMENT DIS. Vol. 2, no. 1. (April): 17-30.
  • Fry,Kevin,M; Gerhardt,Cynthia,A; Ash,Jerry; Zaidi,Ali,N; Garg,Vidu; McBride,Kim,L; Fitzgerald-Butt,Sara,M. 2015. Lifetime Prevalence of Sexual Intercourse and Contraception Use at Last Sex Among Adolescents and Young Adults With Congenital Heart Disease.  JOURNAL OF ADOLESCENT HEALTH. Vol. 56, no. 4. (April): 396-401.
  • Zhao, N, Koenig, SN, Trask, AJ, Lin, CH, Hans, CP, Lucchesi, PA, Garg, V, Lilly, B. 2015. miR-145 regulates TGFBR2 expression and matrix synthesis in vascular smooth muscle cells.  CIRCULATION RESEARCH. Vol. 116, no. January: 23-24.
  • Cheng,Jeeyun; Koenig,Sara,N; Kuivaniemi,Helena,S; Garg,Vidu; Hans,Chetan,P. 2014. Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model.  JOURNAL OF THE AMERICAN HEART ASSOCIATION. Vol. 3, no. 6. (December): ee001064.
  • Misra,Chaitali; Chang,Sheng-Wei; Basu,Madhumita; Huang,Nianyuan; Garg,Vidu. 2014. Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation.  HUMAN MOLECULAR GENETICS. Vol. 23, no. 19. (October): 5025-5035.
  • Bonachea,Elizabeth,M; Zender,Gloria; White,Peter; Corsmeier,Don; Newsom,David; Fitzgerald-Butt,Sara; Garg,Vidu; McBride,Kim,L. 2014. Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve.  BMC MEDICAL GENOMICS. Vol. 7, no. September: e56.
  • Lincoln,Joy; Garg,Vidu. 2014. Etiology of Valvular Heart Disease - Genetic and Developmental Origins.  CIRCULATION JOURNAL. Vol. 78, no. 8. (August): 1801-1807.
  • Bonachea,Elizabeth,M; Chang,Sheng-Wei; Zender,Gloria; Lahaye,Stephanie; Fitzgerald-Butt,Sara; McBride,Kim,L; Garg,Vidu. 2014. Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve.  PEDIATRIC RESEARCH. Vol. 76, no. 2. (August): 211-216.
  • Hu,Hao; Roach,Jared,C; Coon,Hilary; Guthery,Stephen,L; Voelkerding,Karl,V; Margraf,Rebecca,L; Durtschi,Jacob,D; Tavtigian,Sean,V; Shankaracharya,; Wu,Wilfred; Scheet,Paul; Wang,Shuoguo; Xing,Jinchuan; Glusman,Gustavo; Hubley,Robert; Li,Hong; Garg,Vidu; Moore,Barry; Hood,Leroy; Galas,David,J; Srivastava,Deepak; Reese,Martin,G; Jorde,Lynn,B; Yandell,Mark; Huff,Chad,D. 2014. A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data.  NATURE BIOTECHNOLOGY. Vol. 32, no. 7. (July): 663-?.
  • LaHaye,Stephanie; Lincoln,Joy; Garg,Vidu. 2014. Genetics of valvular heart disease.  CURRENT CARDIOLOGY REPORTS. Vol. 16, no. 6. (June): 487-?.
  • Garg,Vidu; Basu,Madhumita. 2014. Beyond genetics: focusing on maternal environment for congenital heart disease prevention.  EVIDENCE-BASED MEDICINE. Vol. 19, no. 2. (April): ee8.
  • Lincoln,Joy; Garg,Vidu. 2014. Etiology of valvular heart disease.  Circulation journal. Vol. 78, no. 8. (January): 1801-1807.
  • Chang SW, Mislankar M, Misra C, Huang N, Dajusta DG, Harrison SM, McBride KL, Baker LA, Garg V. 2013. Genetic Abnormalities in FOXP1 Are Associated with Congenital Heart Defects.  HUMAN MUTATION. Vol. 34, no. 9. (September): 1226-30.
  • Chang,Sheng-Wei; Mislankar,Mona; Misra,Chaitali; Huang,Nianyuan; DaJusta,Daniel,G; Harrison,Steven,M; McBride,Kim,L; Baker,Linda,A; Garg,Vidu. 2013. Genetic Abnormalities in FOXP1 Are Associated with Congenital Heart Defects.  HUMAN MUTATION. Vol. 34, no. 9. (September): 1226-1230.
  • Bosse K, Hans CP, Zhao N, Koenig SN, Huang N, Guggilam A, Lahaye S, Tao G, Lucchesi PA, Lincoln J, Lilly B, Garg V. 2013. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.  J MOL CELL CARDIOL. Vol. 60, no. July: 27-35.
  • Pediatric Cardiac Genomics Consortium, et al. 2013. The Congenital Heart Disease Genetic Network Study: rationale, design, and early results.  CIRC RES. Vol. 112, no. 4. (February): 698-706.
  • Gelb,Bruce; Brueckner,Martina; Chung,Wendy; Goldmuntz,Elizabeth; Kaltman,Jonathan; Kaski,Juan,Pablo; Kim,Richard; Kline,Jennie; Mercer-Rosa,Laura; Porter,George; Roberts,Amy; Rosenberg,Ellen; Seiden,Howard; Seidman,Christine; Sleeper,Lynn; Tennstedt,Sharon; Kaltman,Jonathan; Schramm,Charlene; Burns,Kristin; Pearson,Gail; Rosenberg,Ellen; Newburger,Jane; Breitbart,Roger; Colan,Steven; Geva,Judith; Monafo,Angela; Roberts,Amy; Stryker,Janice; Seidman,Christine; McDonough,Barbara; Seidman,Jonathan; Goldmuntz,Elizabeth; Edman,Sharon; Garbarini,Jennifer; Hakonarson,Hakon; Mercer-Rosa,Laura; Mitchell,Laura; Tusi,Jessica; White,Peter; Woyciechowski,Stacy; Chung,Wendy; Warburton,Dorothy; Awad,Danielle; Celia,Katrina; Etwaru,Davina; Sond,Jaswinder,Kaur; Kline,Jennie; Korsin,Rosalind; Lanz,Alyssa; Marquez,Emma; Williams,Ismee; Wilpers,Abigail; Yee,Roslyn; Guevara,Denise; Julian,Ariel; Mac Neal,Meghan; Mintz,Cassie; Peter,Inga; Sachidanandam,Ravi; Seiden,Howard; Romano-Adesman,Angela; Gruber,Dorota; Stellato,Nancy; Brueckner,Martina; Lifton,Richard; Cross,Nancy; Deanfield,John; Giardini,Alessandro; Flack,Karen; Porter,George; Taillie,Eileen; Kim,Richard; Nhu Tran,N; Tennstedt,Sharon; Breitbart,Roger; Dandreo,Kimberly; Gallagher,Dianne; Lu,Minmin; Sleeper,Lynn; Berlin,Dorit; Beiswanger,Christine; Lifton,Richard; Seidman,Jonathan; Hakonarson,Hakon; White,Peter; Italia,Mike; Chung,Wendy; Seidman,Christine; Brooks,Maria; Olive,Michelle; Botkin,Jeffrey; Dupuis,Josee; Garg,Vidu; Watson,Mike; Bristow,James; Evans,Todd; Kendziorski,Christina; Mardis,Elaine; Murray,Jeffrey; Saltz,Joel; Wong,Hector. 2013. The Congenital Heart Disease Genetic Network Study Rationale, Design, and Early Results.  CIRCULATION RESEARCH. Vol. 112, no. 4. (February): 698-706.
  • Misra,Chaitali; Garg,Vidu. 2013. Compacting the heart with Notch.  NATURE MEDICINE. Vol. 19, no. 2. (February): 133-134.
  • Hans,Chetan,P; Koenig,Sara,N; Huang,Nianyuan; Cheng,Jeeyun; Beceiro,Susana; Guggilam,Anuradha; Kuivaniemi,Helena; Partida-Sanchez,Santiago; Garg,Vidu. 2012. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation.  ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. Vol. 32, no. 12. (December): 3012-23.
  • Garg, V. 2012. The Molecular Basis of Cardiac Development and Congenital Heart Disease. In Translational Cardiology. Edited by Patterson C and Willis MS. New York: Springer-Humana Press.
  • Payne,Ashleigh,R; Chang,Sheng-Wei; Koenig,Sara,N; Zinn,Andrew,R; Garg,Vidu. 2012. Submicroscopic Chromosomal Copy Number Variations Identified in Children With Hypoplastic Left Heart Syndrome.  PEDIATRIC CARDIOLOGY. Vol. 33, no. 5. (June): 757-763.
  • Misra,Chaitali; Sachan,Nita; McNally,Caryn,Rothrock; Koenig,Sara,N; Nichols,Haley,A; Guggilam,Anuradha; Lucchesi,Pamela,A; Pu,William,T; Srivastava,Deepak; Garg,Vidu. 2012. Congenital heart disease-causing gata4 mutation displays functional deficits in vivo.  PLoS GENETICS. Vol. 8, no. 5. (May): ee1002690.
  • Bhoj,Elizabeth,J; Ramos,Purita; Baker,Linda,A; Garg,Vidu; Cost,Nicholas; Nordenskjoeld,Agneta; Elder,Frederick,F; Bleyl,Steven,B; Bowles,Neil,E; Arrington,Cammon,B; Delhomme,Brigitte; Vanhoutteghem,Amandine; Djian,Philippe; Zinn,Andrew,R. 2012. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development (vol 20, pg 249, 2012).  EUROPEAN JOURNAL OF HUMAN GENETICS. Vol. 20, no. 2. (February): 249-249.
  • Garg, V. 2011. Growth of the Normal Human Heart. In Handbook of Growth and Growth Monitoring in Health and Disease. Edited by Victor R. Preedy. New York: Springer.
  • Garg, V. 2011. Growth of the Normal Human Heart. In Handbook of Growth and Growth Monitoring in Health and Disease. Edited by Preedy, VR. New York: Springer.
  • Acharya,Asha; Hans,Chetan,P; Koenig,Sara,N; Nichols,Haley,A; Galindo,Cristi,L; Garner,Harold,R; Merrill,Walter,H; Hinton,Robert,B; Garg,Vidu. 2011. Inhibitory Role of Notch1 in Calcific Aortic Valve Disease.  PLOS ONE. Vol. 6, no. 11. (November): ee27743.
  • Roach,Jared,C; Glusman,Gustavo; Hubley,Robert; Montsaroff,Stephen,Z; Holloway,Alisha,K; Mauldin,Denise,E; Srivastava,Deepak; Garg,Vidu; Pollard,Katherine,S; Galas,David,J; Hood,Leroy; Smit,Arian,FA. 2011. Chromosomal Haplotypes by Genetic Phasing of Human Families.  AMERICAN JOURNAL OF HUMAN GENETICS. Vol. 89, no. 3. (September): 382-397.
  • McBride,Kim,L; Garg,Vidu. 2011. Heredity of bicuspid aortic valve: is family screening indicated?.  HEART. Vol. 97, no. 15. (August): 1193-1195.
  • Yu,Shibin; Poe,Bryan; Schwarz,Margaret; Elliot,Sarah,A; Albertine,Kurt,H; Fenton,Stephen; Garg,Vidu; Moon,Anne,M. 2010. Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development.  DEVELOPMENTAL BIOLOGY. Vol. 347, no. 1. (November): 92-108.
  • Maitra,Meenaksh; Koenig,Sara,N; Srivastava,Deepak; Garg,Vidu. 2010. Identification of GATA6 Sequence Variants in Patients With Congenital Heart Defects.  PEDIATRIC RESEARCH. Vol. 68, no. 4. (October): 281-285.
  • Richards A and Garg V. 2010. Genetics of congenital heart disease.  CURRENT CARDIOLOGY REVIEWS. Vol. 6, no. 2. (May): 91-97.
  • McBride,Kim,L; Garg,Vidu. 2010. Impact of Mendelian inheritance in cardiovascular disease.  ANN N Y ACAD SCI. Vol. 1214, no. January: 122-137.
  • Pan,Hubert; Richards,Ashleigh,A; Zhu,Xiaohui; Jogtar,Jose,A; Yin,Helen,L; Garg,Vidu. 2009. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death.  HEART RHYTHM. Vol. 6, no. 5. (May): 707-710.
  • Maitra,Meenakshi; Schluterman,Marie,K; Nichols,Haley,A; Richardson,James,A; Lo,Cecilia,W; Srivastava,Deepak; Garg,Vidu. 2009. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development.  DEVELOPMENTAL BIOLOGY. Vol. 326, no. 2. (February): 368-377.
  • Ransom,Joshua,F; King,Isabelle,N; Garg,Vidu; Srivastava,Deepak. 2008. A Rare Human Sequence Variant Reveals Myocardin Autoinhibition.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 283, no. 51. (December): 35845-35852.
  • Richards,Ashleigh,A; Santos,Lane,Jaeckle; Nichols,Haley,A; Crider,Bill,P; Elder,Frederick,F; Hauser,Natalie,S; Zinn,Andrew,R; Garg,Vidu. 2008. Cryptic chromosomal abnormalities identified in children with congenital heart disease.  PEDIATRIC RESEARCH. Vol. 64, no. 4. (October): 358-363.
  • Tomita-Mitchell,A; Maslen,C,L; Morris,C,D; Garg,V; Goldmuntz,E. 2007. GATA4 sequence variants in patients with congenital heart disease.  JOURNAL OF MEDICAL GENETICS. Vol. 44, no. 12. (December): 779-783.
  • Rajagopal,Satish,K; Ma,Qing; Obler,Dita; Shen,Ji; Manichaikul,Am; Tomita-Mitchell,Aoy; Boardman,Kari; Briggs,Christine; Garg,Vidu; Srivastava,Deepak; Goldmuntz,Elizabeth; Broman,Karl,W; Benson,D,Woodrow; Smoot,Leslie,B; Pu,William,T. 2007. Spectrum of heart disease associated with murine and human GATA4 mutation.  JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. Vol. 43, no. 6. (December): 677-685.
  • Schluterman,Marie,K; Krysiak,Amanda,E; Kathiriya,Irfan,S; Abate,Nicola; Chandalia,Manisha; Srivastava,Deepak; Garg,Vidu. 2007. Screening and biochemical analysis of GATA4 sequence variations identified in patients with congenital heart disease.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 143A, no. 8. (April): 817-823.
  • Garg,V. 2006. Insights into the genetic basis of congenital heart disease.  CELLULAR AND MOLECULAR LIFE SCIENCES. Vol. 63, no. 10. (May): 1141-1148.
  • Garg,Vidu. 2006. Molecular genetics of aortic valve disease.  CURRENT OPINION IN CARDIOLOGY. Vol. 21, no. 3. (May): 180-184.
  • Garg,V; Muth,A,N; Ransom,J,F; Schluterman,M,K; Barnes,R; King,I,N; Grossfeld,P,D; Srivastava,D. 2005. Mutations in NOTCH1 cause aortic valve disease.  NATURE. Vol. 437, no. 7056. (September): 270-274.
  • Garg, V. and Srivastava, D. 2005. Genetic Underpinnings of Cardiogenesis and Congenital Heart Disease. In Principles of Molecular Cardiology. Edited by C. Patterson and M. Runge. New York: Springer-Verlag.
  • Garg,V; Kathiriyra,I,S; Barnes,R; Schluterman,M,K; King,I,N; Butler,C,A; Rothrock,C,R; Eapen,R,S; Hirayama-Yamada,K; Joo,K; Matsuoka,R; Cohen,J,C; Srivastava,D. 2003. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5.  NATURE. Vol. 424, no. 6947. (July): 443-447.
  • Garg V; Srivastava D. 2002. Cardiac Development and congenital heart disease. In American College of Cardiology Self Assessment Program V. Edited by Fishman, M. Bethesda: American College of Cardiology.
  • Kunte,A; Ivey,K; Yamagishi,C; Garg,V; Yamagishi,H; Srivastava,D. 2001. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L.  MECHANISMS OF DEVELOPMENT. Vol. 108, no. 1-2. (October): 81-92.
  • Garg,V; Yamagishi,C; Hu,T,H; Kathiriya,I,S; Yamagishi,H; Srivastava,D. 2001. Tbx1, a DiGeorge syndrome candidate gene, is regulated by Sonic hedgehog during pharyngeal arch development.  DEVELOPMENTAL BIOLOGY. Vol. 235, no. 1. (July): 62-73.
  • Garg V; Srivastava D. 2001. 22q11 deletion syndrome.  Pediatric Society of Greater Dallas Newsletter.
  • Srivastava D; Garg V. 2001. Potential for fetal gene therapy in congenital heart disease.  FRONTIERS IN FETAL HEALTH. Vol. 3, no. 7. (January): 211-212.
  • Yamagishi,H; Garg,V; Matsuoka,R; Thomas,T; Srivastava,D. 1999. A molecular pathway revealing a genetic basis for human cardiac and craniofacial defects.  SCIENCE. Vol. 283, no. 5405. (February): 1158-1161.
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