Timothy P. Cripe, MD, PhD :: Nationwide Children's Hospital, Columbus, Ohio
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Contact Information

Hematology & Oncology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3552
FX: (614) 722-3699

Location Information for Patients

Main Campus

Biography

Dr. Cripe’s clinical interests include gene and viral therapies for solid tumors in children, including brain tumors, neuroblastoma, and bone and soft tissue sarcomas. His current research focuses on developing and testing new, targeted therapies for pediatric solid tumors and translating those findings into clinical studies. He was among the first in the country to launch clinical trials of attenuated oncolytic viruses in children. Dr. Cripe completed his degrees in medicine and philosophy and received his pediatric residency training at the University of Iowa. He was a fellow in pediatric hematology/oncology at the Children’s Hospital and the Dana-Farber Cancer Institute in Boston, and at the Children’s Hospital and University of Colorado Health Sciences Center in Denver. He has been on faculty at the University of Wisconsin-Madison and at Cincinnati Children’s Hospital Medical Center, where he was the founding director of the comprehensive sarcoma program and the medical director of the Translational Research Trials Office. Dr. Cripe is voted among the “Best Doctors in America”.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Education and Training

Undergraduate School

  • Princeton University
    Date Completed: 05/01/1982

Graduate School

  • University of Iowa
    Date Completed: 05/06/1989

Medical School

  • University of Iowa
    Date Completed: 05/06/1989

Residency

  • University of Iowa Hospitals and Clinics
    Date Completed: 07/01/1992

Fellowship

  • Boston Children's Hospital
    Date Completed: 06/30/1993

Fellowship

  • The Children's Hospital - University of Colorado
    Date Completed: 06/30/1995

Department:

  • Pediatrics

Section:

  • Hematology & Oncology

Specialty:

  • Pediatric Hematology Oncology

Date of Appointment at Nationwide Children’s Hospital:

  • 01/27/2012

Publications

  • Wu,J; Patmore,D,M; Jousma,E; Eaves,D,W; Breving,K; Patel,A,V; Schwartz,E,B; Fuchs,J,R; Cripe,T,P; Stemmer-Rachamimov,A,O; Ratner,N. 2014. EGFR-STAT3 signaling promotes formation of malignant peripheral nerve sheath tumors.  ONCOGENE. Vol. 33, no. 2. (January): 173-180.
  • Stehn,Justine,R; Haass,Nikolas,K; Bonello,Teresa; Desouza,Melissa; Kottyan,Gregg; Treutlein,Herbert; Zeng,Jun; Nascimento,Paula,RBB; Sequeira,Vanessa,B; Butler,Tanya,L; Allanson,Munif; Fath,Thomas; Hill,Timothy,A; McCluskey,Adam; Schevzov,Galina; Palmer,Stephen,J; Hardeman,Edna,C; Winlaw,David; Reeve,Vivienne,E; Dixon,Ian; Weninger,Wolfgang; Cripe,Timothy,P; Gunning,Peter,W. 2013. A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells.  CANCER RESEARCH. Vol. 73, no. 16. (August): 5169-5182.
  • Wang PY, Currier MA, Hansford L, Kaplan D, Chiocca EA, Uchida H, Goins WF, Cohen JB, Glorioso JC, van Kuppevelt TH, Mo X, Cripe TP. 2013. Expression of HSV-1 receptors in EBV-associated lymphoproliferative disease determines susceptibility to oncolytic HSV.  Gene Therapy. Vol. 20, no. July: 761-9.
  • Currier,Mark,A; Eshun,Francis,K; Sholl,Allyson; Chernoguz,Artur; Crawford,Kelly; Divanovic,Senad; Boon,Louis; Goins,William,F; Frischer,Jason,S; Collins,Margaret,H; Leddon,Jennifer,L; Baird,William,H; Haseley,Amy; Streby,Keri,A; Wang,Pin-Yi; Hendrickson,Brett,W; Brekken,Rolf,A; Kaur,Balveen; Hildeman,David; Cripe,Timothy,P. 2013. VEGF Blockade Enables Oncolytic Cancer Virotherapy in Part by Modulating Intratumoral Myeloid Cells.  MOLECULAR THERAPY. Vol. 21, no. 5. (May): 1014-1023.
  • Jessen,Walter,J; Miller,Shyra,J; Jousma,Edwin; Wu,Jianqiang; Rizvi,Tilat,A; Brundage,Meghan,E; Eaves,David; Widemann,Brigitte; Kim,Mi-Ok; Dombi,Eva; Sabo,Jessica; Dudley,Atira,Hardiman; Niwa-Kawakita,Michiko; Page,Grier,P; Giovannini,Marco; Aronow,Bruce,J; Cripe,Timothy,P; Ratner,Nancy. 2013. MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 123, no. 1. (January): 340-347.
  • Patmore,Deanna,M; Welch,Sara; Fulkerson,Patricia,C; Wu,Jianqiang; Choi,Kwangmin; Eaves,David; Kordich,Jennifer,J; Collins,Margaret,H; Cripe,Timothy,P; Ratner,Nancy. 2012. In Vivo Regulation of TGF-beta by R-Ras2 Revealed through Loss of the RasGAP Protein NF1.  CANCER RESEARCH. Vol. 72, no. 20. (October): 5317-5327.
  • Cripe, TP. 2012. Differing approaches to experimental therapeutics: Are we a world apart?.  Molecular Therapy. Vol. 20, no. September: 1649-1650.
  • Patel,Ami,V; Eaves,David; Jessen,Walter,J; Rizvi,Tilat,A; Ecsedy,Jeffrey,A; Qian,Mark,G; Aronow,Bruce,J; Perentesis,John,P; Serra,Eduard; Cripe,Timothy,P; Miller,Shyra,J; Ratner,Nancy. 2012. Ras-Driven Transcriptome Analysis Identifies Aurora Kinase A as a Potential Malignant Peripheral Nerve Sheath Tumor Therapeutic Target.  CLINICAL CANCER RESEARCH. Vol. 18, no. 18. (September): 5020-5030.
  • Kaur,Balveen; Chiocca,E,Antonio; Cripe,Timothy,P. 2012. Oncolytic HSV-1 Virotherapy: Clinical Experience and Opportunities for Progress.  CURRENT PHARMACEUTICAL BIOTECHNOLOGY. Vol. 13, no. 9. (July): 1842-1851.
  • Chernoguz,Artur; Crawford,Kelly; Donovan,Eileen; Vandersall,Abbey; Berglund,Caroline; Cripe,Timothy,P; Frischer,Jason,S. 2012. EGFR Inhibition Fails to Suppress Vascular Proliferation and Tumor Growth in a Ewing's Sarcoma Model.  JOURNAL OF SURGICAL RESEARCH. Vol. 173, no. 1. (March): 1-9.
  • Wu,Jianqiang; Dombi,Eva; Jousma,Edwin; Dunn,R,Scott; Lindquist,Diana; Schnell,Beverly,M; Kim,Mi-Ok; Kim,AeRang; Widemann,Brigitte,C; Cripe,Timothy,P; Ratner,Nancy. 2012. Preclincial testing of Sorafenib and RAD001 in the Nfflox/flox;DhhCre mouse model of plexiform neurofibroma using magnetic resonance imaging.  PEDIATRIC BLOOD & CANCER. Vol. 58, no. 2. (February): 173-180.
  • Kaimal,Vinod; Chu,Zhengtao; Mahller,Yonatan,Y; Papahadjopoulos-Sternberg,Brigitte; Cripe,Timothy,P; Holland,Scott,K; Qi,Xiaoyang. 2011. Saposin C Coupled Lipid Nanovesicles Enable Cancer-Selective Optical and Magnetic Resonance Imaging.  MOLECULAR IMAGING AND BIOLOGY. Vol. 13, no. 5. (October): 886-897.
  • Browne,Andrew,W; Leddon,Jennifer,L; Currier,Mark,A; Williams,Jon,P; Frischer,Jason,S; Collins,Margaret,H; Ahn,Chong,H; Cripe,Timothy,P. 2011. Cancer Screening by Systemic Administration of a Gene Delivery Vector Encoding Tumor-Selective Secretable Biomarker Expression.  PLOS ONE. Vol. 6, no. 5. (May): ee19530.
  • Dmitrieva,Nina; Yu,Lianbo; Viapiano,Mariano; Cripe,Timothy,P; Chiocca,E,Antonio; Glorioso,Joseph,C; Kaur,Balveen. 2011. Chondroitinase ABC I-Mediated Enhancement of Oncolytic Virus Spread and Antitumor Efficacy.  CLINICAL CANCER RESEARCH. Vol. 17, no. 6. (March): 1362-1372.
  • Browne,Andrew,W; Ramasamy,Lakshminarayanan; Cripe,Timothy,P; Ahn,Chong,H. 2011. A lab-on-a-chip for rapid blood separation and quantification of hematocrit and serum analytes.  LAB ON A CHIP. Vol. 11, no. 14. (January): 2440-2446.
  • Liu,Chunyan; Cripe-,Timothy,P; Kim,Mi-Ok. 2010. Statistical Issues in Longitudinal Data Analysis for Treatment Efficacy Studies in the Biomedical Sciences.  MOLECULAR THERAPY. Vol. 18, no. 9. (September): 1724-1730.
  • Eshun,F,K; Currier,M,A; Gillespie,R,A; Fitzpatrick,J,L; Baird,W,H; Cripe,T,P. 2010. VEGF blockade decreases the tumor uptake of systemic oncolytic herpes virus but enhances therapeutic efficacy when given after virotherapy.  GENE THERAPY. Vol. 17, no. 7. (July): 922-929.
  • Maldonado,Arturo,R; Klanke,Chuck; Jegga,Anil,G; Aronow,Bruce,J; Mahller,Yonatan,Y; Cripe,Timothy,P; Crombleholme,Timothy,M. 2010. Molecular engineering and validation of an oncolytic herpes simplex virus type transcriptionally targeted to midkine-positive tumors.  JOURNAL OF GENE MEDICINE. Vol. 12, no. 7. (July): 613-623.
  • Miller,S,J; Lan,Z,D; Hardiman,A; Wu,J; Kordich,J,J; Patmore,D,M; Hegde,R,S; Cripe,T,P; Cancelas,J,A; Collins,M,H; Ratner,N. 2010. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.  ONCOGENE. Vol. 29, no. 3. (January): 368-379.
  • Kaur,Balveen; Cripe,Timothy,P; Chiocca,E,Antonio. 2009. "Buy One Get One Free": Armed Viruses for the Treatment of Cancer Cells and their Microenvironment.  CURRENT GENE THERAPY. Vol. 9, no. 5. (October): 341-355.
  • Cripe,Timothy,P; Wang,Pin-Yi; Marcato,Paola; Mahller,Yonatan,Y; Lee,Patrick,WK. 2009. Targeting Cancer-initiating Cells With Oncolytic Viruses.  MOLECULAR THERAPY. Vol. 17, no. 10. (October): 1677-1682.
  • Qi,Xiaoyang; Chu,Zhengtao; Mahller,Yonatan,Y; Stringer,Keith,F; Witte,David,P; Cripe,Timothy,P. 2009. Cancer-Selective Targeting and Cytotoxicity by Liposomal-Coupled Lysosomal Saposin C Protein.  CLINICAL CANCER RESEARCH. Vol. 15, no. 18. (September): 5840-5851.
  • Wise-Draper,Trisha,M; Mintz-Cole,Rachael,A; Morris,Teresa,A; Simpson,David,S; Wikenheiser-Brokamp,Kathryn,A; Currier,Mark,A; Cripe,Timothy,P; Grosveld,Gerard,C; Wells,Susanne,I. 2009. Overexpression of the Cellular DEK Protein Promotes Epithelial Transformation In vitro and In vivo.  CANCER RESEARCH. Vol. 69, no. 5. (March): 1792-1799.
  • Mahller,Yonatan,Y; Williams,Jon,P; Baird,William,H; Mitton,Bryan; Grossheim,Jonathan; Saeki,Yoshinaga; Cancelas,Jose,A; Ratner,Nancy; Cripe,Timothy,P. 2009. Neuroblastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytic Virus.  PLOS ONE. Vol. 4, no. 1. (January): ee4235.
  • Mahller,Y,Y; Sakthivel,B; Baird,W,H; Aronow,B,J; Hsu,Y-H; Cripe,T,P; Mehrian-Shai,R. 2008. Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication.  CANCER GENE THERAPY. Vol. 15, no. 11. (November): 733-741.
  • Currier,Mark,A; Gillespie,Rebecca,A; Sawtell,Nancy,M; Mahller,Yonatan,Y; Stroup,Greg; Collins,Margaret,H; Kambara,Hirokazu; Chiocca,E,Antonio; Cripe,Timothy,P. 2008. Efficacy and safety of the oncolytic herpes simplex virus rRp450 alone and combined with cyclophosphamide.  MOLECULAR THERAPY. Vol. 16, no. 5. (May): 879-885.
  • Johansson,Gunnar; Mahller,Yonatan,Y; Collins,Margaret,H; Kim,Mi-Ok; Nobukuni,Takahiro; Perentesis,John; Cripe,Timothy,P; Lane,Heidi,A; Kozma,Sara,C; Thomas,George; Ratner,Nancy. 2008. Effective in vivo targeting of the mammalian target of rapamycin pathway in malignant peripheral nerve sheath tumors.  MOLECULAR CANCER THERAPEUTICS. Vol. 7, no. 5. (May): 1237-1245.
  • Mahller,Yonatan,Y; Vaikunth,Sachin,S; Ripberger,Maria,C; Baird,William,H; Saeki,Yoshinaga; Cancelas,Jose,A; Crombleholme,Timothy,M; Cripe,Timothy,P. 2008. Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors.  CANCER RESEARCH. Vol. 68, no. 4. (February): 1170-1179.
  • Mahller,Yonatan,Y; Vaikunth,Sachin,S; Currier,Mark,A; Miller,Shyra,J; Ripberger,Maria,C; Hsu,Ya-Hsuan; Mehrian-Shai,Ruty; Collins,Margaret,H; Crombleholme,Timothy,M; Ratner,Nancy; Cripe,Timothy,P. 2007. Oncolytic HSV and erlotinib inhibit tumor growth and angiogenesis in a novel malignant peripheral nerve sheath tumor xenograft model.  MOLECULAR THERAPY. Vol. 15, no. 2. (February): 279-286.
  • Toretsky,Jeffrey,A; Erkizan,Verda; Levenson,Amy; Abaan,Ogan,D; Parvin,Jeffrey,D; Cripe,Timothy,P; Rice,Anna,M; Lee,Sean,Bong; Uren,Aykut. 2006. Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A.  CANCER RESEARCH. Vol. 66, no. 11. (June): 5574-5581.
  • Mahller,Y,Y; Rangwala,F; Ratner,N; Cripe,T,P. 2006. Malignant peripheral nerve sheath tumors with high and low Ras-GTP are permissive for oncolytic herpes simplex virus mutants.  PEDIATRIC BLOOD & CANCER. Vol. 46, no. 7. (June): 745-754.
  • Parikh,N,S; Currier,M,A; Mahller,Y,Y; Adams,L,C; Di Pasquale,B; Collins,M,H; Cripe,T,P. 2005. Oncolytic herpes simplex virus mutants are more efficacious than wild-type adenovirus type 5 for the treatment of high-risk neuroblastomas in preclinical models.  PEDIATRIC BLOOD & CANCER. Vol. 44, no. 5. (May): 469-478.
  • Currier,M,A; Adams,L,C; Mahller,Y,Y; Cripe,T,P. 2005. Widespread intratumoral virus distribution with fractionated injection enables local control of large human rhabdomyosarcoma xenografts by oncolytic herpes simplex viruses.  CANCER GENE THERAPY. Vol. 12, no. 4. (April): 407-416.
  • Parikh,N,S; Hoyer,J,D; Cripe,T,P. 2005. A young girl with hemolytic anemia and elevated hemoglobin F.  PEDIATRIC BLOOD & CANCER. Vol. 44, no. 3. (March): 264-266.
  • Currier,M,A; Mahller,Y,H; Adams,L,C; Horsburgh,B; Tufaro,F; Cripe,T,P. 2004. Widespread intratumoral viral distribution enables local control of large human sarcoma xenografts by oncolytic herpes simplex viruses.  MOLECULAR THERAPY. Vol. 9, no. May: S237-S237.
  • Parikh,N,S; Currier,M,A; Adams,L,C; Collins,M,H; Cripe,T,P. 2004. Herpes simplex virus mediated oncolysis is an effective intratumoral therapy in high-risk neuroblastoma tumor models.  MOLECULAR THERAPY. Vol. 9, no. May: S112-S113.
  • Parikh,N,S; Currier,M,A; Adams,L,C; Cripe,T,P. 2004. Herpes simplex virus mediated oncolysis is an effective intratumoral therapy in high-risk neuroblastoma tumor models.  PEDIATRIC RESEARCH. Vol. 55, no. 4. (April): 285A-285A.
  • Halsted,M,J; Perry,L,A; Cripe,T,P; Collins,M,H; Jakobovits,R; Benton,C; Halsted,D,G. 2004. Computers in radiology - Improving patient Care: The use of a digital teaching file to enhance clinicians' access to the intellectual capital of interdepartmental conferences.  AMERICAN JOURNAL OF ROENTGENOLOGY. Vol. 182, no. 2. (February): 307-309.
  • Halsted,Mark,J; Perry,Laurie,A; Cripe,Timothy,P; Collins,Margaret,H; Jakobovits,Rex; Benton,Corning; Halsted,David,G. 2004. Improving patient care: the use of a digital teaching file to enhance clinicians' access to the intellectual capital of interdepartmental conferences.  AJR. American journal of roentgenology. Vol. 182, no. 2. (February): 307-309.
  • Dickens,D,S; Cripe,T,P. 2003. Effect of combined cyclooxygenase-2 and matrix metalloproteinase inhibition on human sarcoma xenografts.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 25, no. 9. (September): 709-714.
  • Dickens,D,S; Kozielski,R; Leavey,P,J; Timmons,C; Cripe,T,P. 2003. Cyclooxygenase-2 expression does not correlate with outcome in osteosarcoma or rhabdomyosarcoma.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 25, no. 4. (April): 282-285.
  • Currier,M,A; Adams,L,C; Horsburgh,B; Tufaro,F; Cripe,T,P. 2003. Local control of large human rhabdomyosarcoma xenograft tumors by fractionated multiple direct intratumoral injections of oncolytic herpes simplex viruses.  PEDIATRIC RESEARCH. Vol. 53, no. 4. (April): 269A-269A.
  • Rice,A,M; Currier,M,A; Adams,L,C; Bharatan,N,S; Collins,M,H; Snyder,J,D; Khan,J; Cripe,T,P. 2002. Ewing sarcoma family of tumors express adenovirus receptors and are susceptible to adenovirus-mediated oncolysis.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 24, no. 7. (October): 527-533.
  • Bharatan,N,S; Currier,M,A; Cripe,T,P. 2002. Differential susceptibility of pediatric sarcoma cells to oncolysis by conditionally replication-competent herpes simplex viruses.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 24, no. 6. (August): 447-453.
  • Dickens,D,S; Kozielski,R; Khan,J; Forus,A; Cripe,T,P. 2002. Cyclooxygenase-2 expression in pediatric sarcomas.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 5, no. 4. (July): 356-364.
  • Cripe,T,P; Dunphy,E,J; Holub,A,D; Saini,A; Vasi,N,H; Mahller,Y,Y; Collins,M,H; Snyder,J,D; Krasnykh,V; Curiel,D,T; Wickham,T,J; DeGregori,J; Bergelson,J,M; Currier,M,A. 2001. Fiber knob modifications overcome low, heterogeneous expression of the coxsackievirus-adenovirus receptor that limits adenovirus gene transfer and oncolysis for human rhabdomyosarcoma cells.  CANCER RESEARCH. Vol. 61, no. 7. (April): 2953-2960.
  • Maxwell,I,H; Cripe,T,P. 1999. Transcriptional targeting.  TUMOR TARGETING. Vol. 4, no. 4. (December): 189-209.
  • Dunphy,E,J; Redman,R,A; Herweijer,H; Cripe,T,P. 1999. Reciprocal enhancement of gene transfer by combinatorial adenovirus transduction and plasmid DNA transfection in vitro and in vivo.  HUMAN GENE THERAPY. Vol. 10, no. 14. (September): 2407-2417.
  • Massuda,E,S; Dunphy,E,J; Redman,R,A; Schreiber,J,J; Nauta,L,E; Barr,F,G; Maxwell,I,H; Cripe,T,P. 1997. Regulated expression of the diphtheria toxin A chain by a tumor-specific chimeric transcription factor results in selective toxicity for alveolar rhabdomyosarcoma cells.  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 94, no. 26. (December): 14701-14706.

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