Shalini C Reshmi, PhD :: Nationwide Children's Hospital, Columbus, Ohio
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Shalini C Reshmi, PhD

Shalini C Reshmi, PhD

Clinical Pathology
Associate Director, Cytogenetic & Molecular Genetics Laboratory

Pathology and Laboratory Medicine
Clinical Pathology Team

Pathology Fellowship

Contact Information

Laboratory Medicine/ Anatomic Pathology
700 Children's Dr.
Columbus, OH 43205 [ map ]
PH: (614) 722-5779
FX: (614) 722-5471
Email Me


Dr. Reshmi received her doctoral degree from the University of Pittsburgh, Graduate School of Public Health. She completed her Clinical Genetics fellowships at the University of Chicago, Pritzker School of Medicine. She is board certified in both Clinical Cytogenetics and Clinical Molecular Genetics. Her areas of responsibility at Nationwide Children's Hospital include the Clinical Cytogenetics and Molecular Genetics laboratories and the Nationwide Children's Oncology Group (COG) reference laboratories for Acute Lymphoblastic Leukemia, Neuroblastoma, and Wilms Tumor. She is also a Assistant Professor (Clinical) of Pathology at The Ohio State University.

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  • Female

Languages Spoken:

  • English

Education and Training

Undergraduate School

  • The Catholic University of America
    Date Completed: 05/30/1992

Graduate School

  • University of Pittsburgh
    Date Completed: 05/30/1996

Graduate School

  • University of Pittsburgh
    Date Completed: 05/30/2005


  • University of Chicago
    Date Completed: 11/30/2008


  • Clinical Pathology

Date of Appointment at Nationwide Children’s Hospital:

  • 12/01/2008

Professional Experience


  • Assistant Professor,(Clinical)Pathology, The Ohio State University


  • Assistant Director of the Cytogenetics and Molecular Genetics Laboratories, Nationwide Children's Hospital, Department of Laboratory Medicine


  • Assistant Director of the Children's Oncology Group Reference Laboratory, The Research Institute at Nationwide Children's Hospital


  • Clinical Cytogenetics and Molecular Genetics Fellow


  • Graduate Student Researcher, Cancer Cytogenetics; The University of Pittsburgh


  • Supervisor, Cytogenetics Facility; University of Pittsburgh Cancer Institute and Center for Human Genetics and Integrative Biology


  • Cytogenetic Technologist, Allegheny General Hospital


  • Polan MB, Pastore MT, Steingass K, Hashimoto S, Thrush DL, Pyatt R, Reshmi S, Gastier-Foster JM, Astbury C, McBride KL. 2014. Neurodevelopmental disorders among individuals with duplication of 4p13 to 4p12 containing a GABA(A) receptor subunit gene cluster.  EUROPEAN JOURNAL OF HUMAN GENETICS. Vol. 22, no. 1. (January): 105-109.
  • Repnikova EA, Rosenfeld JA, Bailes A, Weber C, Erdman L, McKinney A, Ramsey S, Hashimoto S, Thrush DL, Astbury C, Reshmi SC, Shaffer LG, Gastier-Foster JM, Pyatt RE. 2013. Characterization of copy number variation in genomic regions containing STR loci using array comparative genomic hybridization.  FORENSIC SCIENCE INTERNATIONAL-GENETICS. Vol. 7, no. 5. (September): 475-481.
  • Hickey SE, Thrush DL, Walters-Sen L, Reshmi SC, Astbury C, Gastier-Foster JM, Atkin J. 2013. A case of an atypically large proximal 15q deletion as cause for Prader-Willi syndrome arising from a de novo unbalanced translocation.  EUROPEAN JOURNAL OF MEDICAL GENETICS. Vol. 56, no. 9. (September): 510-514.
  • Rosales XQ, Malik V, Sneh A, Chen L, Lewis S, Kota J, Gastier-Foster JM, Astbury C, Pyatt R, Reshmi S, Rodino-Klapac LR, Clark KR, Mendell JR, Sahenk Z. 2013. Impaired regeneration in LGMD2A supported by increased PAX7-positive satellite cell content and muscle-specific microrna dysregulation.  MUSCLE & NERVE. Vol. 47, no. 5. (May): 731-739.
  • Alyaqoub F, Pyatt RE, Bailes A, Brock A, Deeg C, McKinney A, Astbury C, Reshmi S, Shane KP, Thrush DL, Sommer A, Gastier-Foster JM. 2012. 12q14 microdeletion associated with HMGA2 gene disruption and growth restriction.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 158A, no. 11. (November): 2925-2930.
  • Repnikova EA, Astbury C, Reshmi SC, Ramsey SN, Atkin JF, Thrush DL, Mitchell AL, Pyatt RE, Reber K, Slavin T, Gastier-Foster JM. 2012. Microarray comparative genomic hybridization and cytogenetic characterization of tissue-specific mosaicism in three patients.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 158A, no. 8. (August): 1924-1933.
  • Chen IM, Harvey RC, Mullighan CG, Gastier-Foster J, Wharton W, Kang H, Borowitz MJ, Camitta BM, Carroll AJ, Devidas M, Pullen DJ, Payne-Turner D, Tasian SK, Reshmi S, Cottrell CE, Reaman GH, Bowman WP, Carroll WL, Loh ML, Winick NJ, Hunger SP, Willman CL. 2012. Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pediatric acute lymphoblastic leukemia: a Children's Oncology Group Study.  BLOOD. Vol. 119, no. 15. (April): 3512-3522.
  • Reshmi SC, Miller JL, Deplewski D, Close C, Henderson LJ, Littlejohn E, Schwartz S, Waggoner DJ. 2011. Evidence of a mechanism for isodicentric chromosome Y formation in a 45,X/46,X,idic(Y)(p11.31)/46,X,del(Y)(p11.31) mosaic karyotype.  EUROPEAN JOURNAL OF MEDICAL GENETICS. Vol. 54, no. 2. (March): 161-164.
  • Cottrell CE, Prior TW, Pyatt R, Astbury C, Reshmi S, Bartholomew D, Atkin J, Manickam K, Thrush DL, Pastore M, Mendell J, Tsao CY, Al-Dahhak R, Newmeyer A, Gastier-Foster JM. 2010. Unexpected detection of dystrophin gene deletions by array comparative genomic hybridization.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 152A, no. 9. (September): 2301-2307.
  • Rosales XQ, Gastier-Foster JM, Lewis S, Malik V, Thrush DL, Astbury C, Pyatt R, Reshmi S, Sahenk Z, Mendell JR. 2010. Novel diagnostic features of dysferlinopathies.  MUSCLE & NERVE. Vol. 42, no. 1. (July): 14-21.
  • Qian Z, Joslin JM, Tennant TR, Reshmi SC, Young DJ, Stoddart A, Larson RA, Le Beau MM. 2010. Cytogenetic and genetic pathways in therapy-related acute myeloid leukemia.  CHEMICO-BIOLOGICAL INTERACTIONS. Vol. 184, no. 1-2. (March): 50-57.
  • Martin CL, Reshmi SC, Ried T, Gottberg W, Wilson JW, Reddy JK, Khanna P, Johnson JT, Myers EN, Gollin SM. 2008. Chromosomal imbalances in oral squamous cell carcinoma: Examination of 31 cell lines and review of the literature.  ORAL ONCOLOGY. Vol. 44, no. 4. (April): 369-382.
  • Reshmi SC, Huang X, Schoppy DW, Black RC, Saunders WS, Smith DI, Gollin SM. 2007. Relationship between FRA11F and 11q13 gene amplification in oral cancer.  GENES CHROMOSOMES & CANCER. Vol. 46, no. 2. (February): 143-154.
  • Reshmi SC, Roychoudhury S, Yu Z, Feingold E, Potter D, Saunders WS, Gollin SM. 2007. Inverted duplication pattern in anaphase bridges confirms the breakage-fusion-bridge (BFB) cycle model for 11q13 amplification.  CYTOGENETIC AND GENOME RESEARCH. Vol. 116, no. 1-2. (January): 46-52.
  • Wittschieben JP, Reshmi SC, Gollin SM, Wood RD. 2006. Loss of DNA polymerase zeta causes chromosomal instability in mammalian cells.  CANCER RESEARCH. Vol. 66, no. 1. (January): 134-142.
  • Cook JR, Aguilera NI, Reshmi S, Huang X, Yu ZS, Gollin SM, Abbondanzo SL, Swerdlow SH. 2005. Deletion 6q is not a characteristic marker of nodal lymphoplasmacytic lymphoma.  CANCER GENETICS AND CYTOGENETICS. Vol. 162, no. 1. (October): 85-88.
  • Reshmi SC, Gollin SM. 2005. Chromosomal instability in oral cancer cells.  JOURNAL OF DENTAL RESEARCH. Vol. 84, no. 2. (February): 107-117.
  • Reshmi SC, Saunders WS, Kudla DM, Ragin CR, Gollin SM. 2004. Chromosomal instability and marker chromosome evolution in oral squamous cell carcinoma.  GENES CHROMOSOMES & CANCER. Vol. 41, no. 1. (September): 38-46.
  • Ragin CR, Reshmi SC, Gollin SM. 2004. Mapping and analysis of HPV16 integration sites in a head and neck cancer cell line.  INTERNATIONAL JOURNAL OF CANCER. Vol. 110, no. 5. (July): 701-709.
  • Cook JR, Aguilera NI, Reshmi-Skarja SC, Huang X, Yu ZS, Gollin SM, Abbondanzo SL, Swerdlow SH. 2004. Lack of PAX5 rearrangements in lymphoplasmacytic lymphomas: Reassessing the reported association with t(9;14).  HUMAN PATHOLOGY. Vol. 35, no. 4. (April): 447-454.
  • Cook JR, Aguilera NI, Reshmi-Skarja S, Huang X, Yu Z, Gollin SM, Abbondanzo SL, and Swerdlow SH. 2004. Lack of PAX5 Rearrangements in lymphoplasmacytic lymphomas: reassessing the reported association with t(9;14).  Hum Pathol. Vol. 35, no. January: 1-8.
  • Reshmi-Skarja S, Huebner A, Handschug K, Finegold DN, Clark AL, Gollin SM. 2003. Chromosomal fragility in patients with triple A syndrome.  AMERICAN JOURNAL OF MEDICAL GENETICS PART A. Vol. 117A, no. 1. (February): 30-36.
  • Cook JR, Aguilera NI, Reshmi-Skarja SC, Gollin SM, Huang X, Abbondanzo SL, Swerdlow SH. 2003. Absence of PAX5 rearrangements in lymphoplasmacytic lymphomas by interphase FISH.  MODERN PATHOLOGY. Vol. 16, no. 1. (January): 229A-229A.
  • Reshmi Skarja S, Huebner A, Handschug K, Finegold DN, Clark AJL and Gollin SM. 2003. Chromosomal fragility in patients with triple A syndrome.  Am J Med Genet. Vol. 117A, no. January: 30-36.
  • Cook JR, Aguilera NI, Reshmi-Skarja SC, Gollin SM, Huang X, Abbondanzo SL, Swerdlow SH. 2003. Absence of PAX5 rearrangements in lymphoplasmacytic lymphomas by interphase FISH.  LABORATORY INVESTIGATION. Vol. 83, no. 1. (January): 229A-229A.
  • Martinez-Climent JA, Comes AM, Vizcarra E, Reshmi S, Benet I, Marugan I, Tormo M, Terol MJ, Solano C, Arbona C, Prosper F, Barragan E, Bolufer P, Rowley JD, Garcia-Conde J. 1999. Variant three-way translocation of inversion 16 in AML-M4Eo confirmed by fluorescence in situ hybridization analysis.  CANCER GENETICS AND CYTOGENETICS. Vol. 110, no. 2. (April): 111-114.
  • Rowley JD, Reshmi S, Carlson K, Roulston D. 1999. Spectral karyotype analysis of T-cell acute leukemia.  BLOOD. Vol. 93, no. 6. (March): 2038-2042.
  • Fleischman EW, Reshmi S, Frenkel MA, Konovalova WI, Guleva GP, Kulagina OE, Konstantinova LN, Tupitsyn NN, Rowley JD. 1999. MLL is involved in a t(2;11)(p21;q23) in a patient with acute myeloblastic leukemia.  GENES CHROMOSOMES & CANCER. Vol. 24, no. 2. (February): 151-155.
  • Fleischman EW, Reshmi S, Sokova OI, Kirichenko OP, Konstantinova LN, Kulagina OE, Frenkel MA, Rowley JD. 1999. Increased karyotype precision using fluorescence in situ hybridization and spectral karyotyping in patients with myeloid malignancies.  CANCER GENETICS AND CYTOGENETICS. Vol. 108, no. 2. (January): 166-170.
  • Sato Y, Bohlander SK, Kobayashi H, Reshmi S, Suto Y, Davis EM,Espinosa R, Hoopes R, Montgomery KT, Kucherlapati RS, Lebeau MM, Rowley JD. 1997. Heterogeneity in the breakpoints in balanced rearrangements involving band 12p13 in hematologic malignancies identified by fluorescence in situ hybridization: TEL (ETV6) is involved in only one half.  BLOOD. Vol. 90, no. 12. (December): 4886-4893.
  • Super HG, Strissel PL, Sobulo OM, Burian D, Reshmi SC, Roe B, Zeleznikle NJ, Diaz MO, Rowley JD. 1997. Identification of complex genomic breakpoint junctions in the t(9;11) MLL-AF9 fusion gene in acute leukemia.  GENES CHROMOSOMES & CANCER. Vol. 20, no. 2. (October): 185-195.
  • Sobulo OM, Borrow J, Tomek R, Reshmi S, Harden A, Schlegelberger B, Housman D, Doggett NA, Rowley JD, Zeleznikle NJ. 1997. MLL is fused to CBP, a histone acetyltransferase, in therapy-related acute myeloid leukemia with a t(11;16)(q23;p13.3).  PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. Vol. 94, no. 16. (August): 8732-8737.
  • Rowley JD, Reshmi S, Sobulo O, Musvee T, Anastasi J, Raimondi S, Schneider NR, Barredo JC, Cantu ES, Schlegelberger B, Behm F, Doggett NA, Borrow J, Zeleznikle N. 1997. All patients with the T(11;16)(q23;p13.3) that involves MLL and CBP have treatment-related hematologic disorders.  BLOOD. Vol. 90, no. 2. (July): 535-541.
  • Rathod PK, Reshmi S. 1994. Susceptibility of plasmodium-falciparum to a combination of thymidine and ICI D1694, A quinazoline antifolate directed at thymidylate synthase.  ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. Vol. 38, no. 3. (March): 476-480.

Awards, Honors and Organizations

  • Invited participant, 3rd Annual St. Jude National Graduate Student Symposium, St. Jude Children's Research Hospital, Memphis, TN, 2004
  • American Society of Human Genetics, Member, 1994 - Present
  • Public Health Dean's Scholarship Recipient, Outstanding Doctoral Student, University of Pittsburgh, 2004
  • Children's Oncology Group, Member, 2008 - Present
  • Certified Molecular Pathology and Cytogenetics CAP Inspector, 2011 - Present
  • Association for Molecular Pathology, Member, 2008 - Present
  • American College of Medical Genetics, Member, 2007 - Present
  • Best doctoral dissertation, Human Genetics, Delta Omega National Honor Society, Omicron Chapter Pittsburgh, PA, 2005
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000