Sarah H. O'Brien, MD

Sarah O’Brien, MD, MSc, is a pediatric hematologist in the Nationwide Children’s Hospital Hemostasis and Thrombosis Center, an investigator in the Center for Innovation in Pediatric Practice at Nationwide Children’s Research Institute and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She also leads a multi-disciplinary hematology and adolescent gynecology clinic at Nationwide Children’s Hospital. Her clinical and research interests include pediatric thrombosis and thromboprophylaxis, the evaluation and diagnosis of mild bleeding disorders, and the intersections between hematology and women’s health. As a health services researcher, Dr. O’Brien has a particular interest in the use of large administrative databases, as well as decision analysis and cost-effectiveness analysis.

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Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Innovation in Pediatric Practice

Areas of Interest:

• DVT Prevention in Pediatric and Adolescent Trauma Patients: Safety & Costs. In this study, we seek to identify which, if any, young trauma patients may truly benefit from the thromboprophylaxis strategies that have become standard of care in adults. The research will give clinicians a tool to identify young trauma patients who would benefit from LMWH prophylaxis. The results will be used to create child and adolescent-specific guidelines, thereby allowing clinicians to maximize patient safety and minimize costs when considering LMWH prophylaxis for a young trauma patient. AHRQ Small Research Grant Program (O'Brien) 09/07 - 09/09
• Menorrhagia in adolescents
• Iron deficiency in adolescent females
• Dr. O'Brien is a pediatric hematologist whose research interests involve the application of health services research techniques to the field of pediatric thrombosis. Her current research focuses on the development of a decision analysis model to address the health effects and costs of universal screening for hereditary thrombophilia in children with a first episode of deep venous thrombosis (DVT).
• Quality of care in sickle cell anemia
• New anticoagulants in pediatrics
• Thrombophilia Screening in Children with Venous Thromboembolism: A Cost-Effectiveness Analysis. Dr. O'Brien received the 2006 Wallace H. Coulter Foundation Scholar, awarded to the recipient of an ASH Scholar Award with the highest scored clinical/translational research application. The research involves the development of a decision analysis model to address the health effects and costs of universal screening for hereditary thrombophilia in children with a first episode of deep venous thrombosis (DVT).
• Management of pediatric ITP
• Thromboprophylaxis Evaluation and diagnosis of mild bleeding disorders

Research Funding*:

• American Society of Hematology Fellow Scholar Award, American Society of Hematology
• DVT Prevention in Pediatric and Adolescent Trauma Patients: Safety and Costs, Agency for Healthcare Research and Quality
• Thrombophilia Screening in Children with Venous Thromboembolism: Cost-Effectiveness Analysis, American Society of Hematology

Medical School

• University of Pittsburgh School of Medicine
  Date Completed: 05/31/2000

Residency

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/2003

Graduate School

• University of Pittsburgh
  Date Completed: 06/30/2006

Fellowship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 07/31/2006

Department:

• Pediatrics

Section:

• Hematology/Oncology

Speciality:

• Pediatric Hematology Oncology, Certified
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 09/29/2006

2006–present

• Assistant Professor, Department of Pediatrics, Division of Hematology/Oncology, The Ohio State University

2006–present

• Investigator, Center for Innovation in Pediatric Practice, Columbus Children's Research Institute

2003–2006

• Pediatric Hematology/Oncology Fellowship, Children's Hospital of Pittsburgh

2000–2003

• Pediatric Residency, Children's Hospital of Pittsburgh

• O'Brien SH, Candrilli SD. 2011. In the absence of a central venous catheter, risk ofvenous thromboembolism is low in critically injured children, adolescents, andyoung adults: evidence from the National Trauma Data Bank.  Pediatric Critical Care Medicine. Vol. 12, no. 3. (May): 251-256. (IF: 2.376)
• Marcus PD, Nire KG, Grooms L, Klima J, O'Brien SH. 2011. The power of a standardized bleeding score in diagnosing pediatric type 1 Von Willebrand disease and platelet function defects.  Haemophilia. Vol. 17, no. 2. (March): 223-227. (IF: 2.505)
• Candrilli SD, O'Brien SH, Ware RE, Nahata MC, Seiber EE, Balkrishnan RB. 2011. Hydroxyurea Adherence and Associated Outcomes in Medicaid Enrollees with Sickle Cell Disease.  American Journal of Hematology. Vol. 86, no. 3. (March): 273-277. (IF: 2.61)
• O'Brien SH, Klima J, Reed S, Chisolm D, Schwarz EB, Kelleher KJ. 2011. Hormonal contraception use and pregnancy in adolescents with sickle cell disease: analysis of Michigan Medicaid claims.  Contraception. Vol. 83, no. 2. (February): 134-137. (IF: 2.369)
• Young G, Yee DL, O'Brien SH, Khanna R, Barbour A, Nugent DJ. 2011. FondaKIDS: A prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age.  Pediatric Blood & Cancer. (February) (IF: 2.134) (Formally Accepted)
• Bollinger LM, Nire KG, Rhodes M, Chisolm D, O'Brien SH. 2011. Caregivers' perspectives on barriers to transcranial doppler screening in children with sickle cell disease.  Pediatric Blood & Cancer. Vol. 56, no. 1. (January): 99-102.
• Bollinger LM; Nire KG; Rhodes MM; Chisolm DJ; O'Brien SH. 2011. Caregivers' perspectives on barriers to transcranial Doppler screening in children with sickle-cell disease.  Pediatric Blood & Cancer. Vol. 56, no. 1. (January 1): 99. (Formally Accepted)
• Bollinger LM, Nire KG, Rhodes MM, Chisolm DJ, O'Brien SH. 2011. Caregivers' Perspectives on Barriers to Transcranial Doppler Screening in Children with Sickle Cell Disease.  Pediatr Blood Cancer. (January) (IF: 2.134)
• Grooms L, O?Brien SH, Holland-Hall C, Walsh M, Casto L. 2010. A new approach for a new generation. [Abstract]. the 62nd Annual Meeting of the National Hemophilia Foundation, New Orleans, LA. (November) (Published)
• Reed S, Klima J, Schwarz EB, O?Brien SH. 2010. Prescription Contraception Use in Adolescents and YoungAdults with Sickle Cell Disease: Analysis of Michigan Medicaid Claims. [Abstract]. The 23rd annual meeting of the American Society of Pediatric Hematology/Oncology. Montréal, Quebec, Canada. (April 7) [Peer Reviewed] (Unspecified)
• Cavo M, Wang W, O'Brien SH. 2010. Use of low molecular weight heparin for thromboprophylaxis in a pediatric inpatient population: reasons for use and incidence of bleeding complications.  Thrombosis Research. Vol. 125, no. 4. (April): 370-372. (IF: 2.406)
• O'Brien SH; Fan L; Kelleher KJ. 2010. Inpatient use of laxatives during opioid administration in children with sickle cell disease.  Pediatric Blood & Cancer. Vol. 54, no. 4. (April 1): 559.
• O'Brien SH, Fan L, Kelleher KJ. 2010. Inpatient use of laxatives during opioid administration in children with sickle cell disease.  Pediatric Blood & Cancer. Vol. 54, no. 4. (April): 559-562. (IF: 2.394)
• Setty B, O?Brien SH, Kerlin BA. 2010. Pediatric venous thromboembolism: redefining epidemiology. [Abstract]. The National Conference on Blood Disorders in Public Health. Atlanta, GA. (March) [Peer Reviewed] (Unspecified)
• O'Brien SH, Klima J, Reed S, Chisolm D, Schwarz EB, Kelleher KJ. Hormonal contraception use and pregnancy in adolescents with sickle cell disease: analysis of Michigan Medicaid claims.  Contraception. (In press)
• Candrill SD, O?Brien SH, Ware RE, Balkrishnan R. 2009. Hydroxyurea adherence and associated outcomes in Medicaid enrollees with sickle cell disease. [Abstract]. The 51st American Society of Hematology Annual Meeting. New Orleans, LA. (December) [Peer Reviewed] (Published)
• Bollinger LM, Rhodes MM, Nire KG, Chisolm DJ, O?Brien SH. 2009. Caregivers? perspectives on barriers to transcranial Doppler screening in children with sickle cell disease. [Abstract]. The 51st American Society of Hematology Annual Meeting. New Orleans, LA. (December) [Peer Reviewed] (Published)
• Marcus PD, Nire KG, Grooms L, Klima J, O?Brien SH. 2009. The power of a standardized bleeding score in diagnosing pediatric type 1 von Willebrand disease. [Abstract]. The 51st American Society of Hematology Annual Meeting. New Orleans, LA. (December) [Peer Reviewed] (Unspecified)
• O'Brien SH, Hankins JS. 2009. Decision analysis of treatment strategies in children with severe sickle cell disease.  Journal Of Pediatric Hematology/Oncology. Vol. 31, no. 11. (November): 873-878.
• Candrilli SD, Balkrishnan R, O'Brien SH. 2009. Changes in rates of sickle cell disease-related inpatient stays and associated resource use among African Americans in the United States following approval of hydroxyurea. [Abstract]. The ISPOR 12th Annual European Congress, October 2009 at Le Palais des Congrès de Paris in Paris, France.. (October) [Peer Reviewed] (In press)
• Candrilli SD, Balkrishnan R, O'Brien SH. 2009. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients.  Pediatric Critical Care Medicine. Vol. 10, no. 5. (September): 554-557.
• Candrilli SD, Balkrishnan R, O?Brien SH. 2009. Effect of injury severity on the incidence and resource utilization-related outcomes of deep vein thrombosis among pediatric trauma admissions in the United States.  Pediatric Critical Care Medicine. Vol. 5, no. 10. (September): 554-557. (IF: 2.33)
• O'Brien SH; Smith KJ. 2009. Using thrombophilia testing to determine anticoagulation duration in pediatric thrombosis is not cost-effective.  Journal Of Pediatrics. Vol. 155, no. 1. (July): 100-104.
• O'Brien SH, Smith KJ. 2009. Using Thrombophilia testing to determine anticoagulation duration in pediatric thrombosis is not cost-effective.  Journal of Pediatrics. Vol. 155, no. 1. (July): 100-104. (IF: 4.122)
• O?Brien SH. 2009. Secondary data demonstrate safety of splenectomy in spherocytosis.  Pediatr Blood Cancer. Vol. 52, no. 7. (July): 753-754. (IF: 2.394)
• O'Brien SH. 2009. Secondary data demonstrate safety of splenectomy in spherocytosis.  Pediatric Blood & Cancer. Vol. 52, no. 7. (July): 753-754.
• Cavo M, Wang W, O'Brien SH. 2009. Use of low molecular weight heparin for thromboprophylaxis in a pediatric inpatient population: reasons for use and incidence of bleeding complications.  Thrombosis Research. Vol. 124, no. Epub ahead of print. (April). (IF: 2.449)
• Hyatt SA, Wang W, Kerlin BA, O'Brien SH. 2009. Applying diagnostic criteria for Type 1 von Willebrand Disease to a Pediatric Population.  Pediatric Blood & Cancer. Vol. 1, no. 52. (January): 102-107. (IF: 2.394)
• O'Brien SH, Klima J, Gaines BA, Betz S, Zenati MS. 2009. Low molecular weight heparin for thromboprophylaxis in young trauma patients: Patterns of drug utilization and incidence of bleeding complications.  Pharmacoepidemiol Drug Saf. (First submission)
• O?Brien SH, Hankins JS. Decision analysis of treatment strategies in children with severe sickle cell disease.  Journal of Pediatric Hematology & Oncology. (IF: 1.176) (In press)
• Marcus PD, Nire K, Grooms L, Klima J, O'Brien SH. 2009. The power of a standardized bleeding score in diagnosing pediatric type 1 Von willebrand disease.  J Thromb Haemost. (First submission)
• Hyatt SA, Wang W, Kerlin BA, O'Brien SH. 2009. Applying diagnostic criteria for type 1 von Willebrand disease to a pediatric population.  Pediatric Blood & Cancer. Vol. 52, no. 1. (January): 102-107.
• Powell KK, Wang W, Kelleher KJ, Bridge JA, O'Brien SH. 2009. Use of SSRIs not associated with increased bleeding in Michigan Children insured by Medicaid.  Pharmacoepidemiol Drug Saf.. (First submission)
• Standridge SM, O'Brien SH. 2008. Idiopathic intracranial hypertension in a pediatric population: a retrospective analysis of the initial imaging evaluation.  Journal of Child Neurology. Vol. 23, no. 11. (November): 1308-1311. (IF: 1.24)
• Standridge SM, O'Brien SH. 2008. Idiopathic intracranial hypertension in a pediatric population: a retrospective analysis of the initial imaging evaluation.  Journal Of Child Neurology. Vol. 23, no. 11. (November): 1308-1311.
• O'Brien SH, Kaizar EE, Gold MA, Kelleher KJ. 2008. Trends in prescribing patterns of hormonal contraceptives for adolescents.  Contraception. Vol. 77, no. 4. (April): 264-269. (IF: 2.262)
• O'Brien SH; Kaizar EE; Gold MA; Kelleher KJ. 2008. Trends in prescribing patterns of hormonal contraceptives for adolescents.  Contraception. Vol. 77, no. 4. (April 1): 264.
• O'Brien SH, Haley K, Kelleher KJ, Wang W, McKenna C, Gaines BA. 2008. Variation in DVT prophylaxis for adolescent trauma patients: a survey of the Society of Trauma Nurses.  Journal of Trauma Nursing. Vol. 15, no. 2. (April): 53-57.
• O'Brien SH. 2008. Decision analysis in pediatric hematology. Review.  Pediatric Clinics of North America. Vol. 55, no. 2. (April): 287-304, vii. (IF: 1.27)
• O'Brien SH. 2008. Decision analysis in pediatric hematology.  Pediatric Clinics Of North America. Vol. 55, no. 2. (April): 287-304.
• Gaines BA, O'Brien S, Rodeberg D, McKenna C, Miller M, Sippey M, Dickson J, Ritchey AK. 2008. Management of children at risk for deep venous thrombosis: results of a clinical guideline. [Abstract]. The 67th Annual Meeting of the American Association for the Surgery of Trauma, Maui, HI. Maui, HI [Peer Reviewed] (Unspecified)
• O'Brien SH, Haley K, Kelleher KJ, Wang W, McKenna C, Gaines BA. 2008. Variation in DVT prophylaxis for adolescent trauma patients: a survey of the Society of Trauma Nurses.  Journal Of Trauma Nursing. Vol. 15, no. 2. : 53-57.
• Fernandez KS, O'Brien SH. 2008. Physician knowledge and attitudes regarding contraception and DVT risk in adolescents. [Abstract]. The 4th Annual Hemophilia and Thrombosis Research Society Scientific Symposium,Chicago, IL,. Chicago, IL [Peer Reviewed] (Unspecified)
• Powell KK, Wang W, Kelleher KJ, O'Brien SH. 2008. Use of SSRIs not associated with increased bleeding events in children: an analysis of the Michigan Medicaid database from 2000-2003. [Abstract]. Abstract 2389. Vol. 112, no. 11: Blood: 832-832. [Peer Reviewed] (Published)
• O'Brien SH, Lee H, Ritchey AK. 2007. Once-daily enoxaparin in pediatric thromboembolism: a dose finding and pharmacodynamics/pharmacokinetics study.  Journal Of Thrombosis And Haemostasis. Vol. 5, no. 9. (September): 1985-1987.
• Lampel HP, Patel N, Boyse K, O'Brien SH, Zirwas MJ. 2007. Prevalence of hand dermatitis in inpatient nurses at a United States hospital.  Dermatitis. Vol. 18, no. 3. (September): 140-142.
• Lee PL; Lemos B; O'Brien SH; English JC 3rd; Zirwas MJ. 2007. Cutaneous diphtheroid infection and review of other cutaneous Gram-positive Bacillus infections.  Cutis; Cutaneous Medicine For The Practitioner. Vol. 79, no. 5. (May 1): 371.
• O'Brien SH; Ritchey AK; Smith KJ. 2007. A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP).  Pediatric Blood & Cancer. Vol. 48, no. 2. (February 1): 173.
• O'Brien SH; Ritchey AK; Ragni MV. 2007. Combined clotting factor deficiencies: experience at a single hemophilia treatment center.  Haemophilia: The Official Journal Of The World Federation Of Hemophilia. Vol. 13, no. 1. (January 1): 26.
• Lee PL, Lemos B, O?Brien SH, English JC, Zirwas MJ. 2007. Cutaneous diphtheroid infection and review of other cutaneous gram-positive bacillus infections.  Dermatitis. Vol. 79, no. 5. : 371-377. (IF: 1.197)
• O'Brien SH, Ritchey AK, Ragni MV. 2007. Combined clotting factor deficiencies: experience at a single hemophilia treatment center.  Haemophilia. Vol. 13, no. 1. : 26-29. (IF: 1.947)
• Lampel HP, Patel N, Boyse K, O?Brien SH, Zirwas MJ. 2007. Prevalence of hand dermatitis in inpatient nurses in a United States hospital.  Cutis. Vol. 18, no. 3: 140-142. (IF: 0.615)
• O'Brien SH, Ritchey AK, Smith KJ. 2007. A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP).  Pediatric Blood & Cancer. Vol. 48, no. 2. : 173-180. (IF: 2.164)
• O'Brien SH, Lee H, Ritchey AK. 2007. Once-daily enoxaparin in pediatric thromboembolism: a dose finding and pharmacodynamics/pharmacokinetics study.  Journal of Thrombosis and Haemostasis. Vol. 5, no. 9: 1985-1987. (IF: 5.947)
• O'Brien SH, Holubkov R, Reis EC. 2004. Identification, evaluation, and management of obesity in an academic primary care center.  Pediatrics. Vol. 114, no. 2. (August): e154-e159.
• O'Brien SH, Reis EC. 2004. Identification, evaluation, and management of obesity in an academic primary care center.  Pediatrics. Vol. 114, no. 2: e154-e159. (IF: 3.903)
• Reis EC, O'Brien S. 1998. Young children and parents experience greater distress iwth multiple immunization injections. [Abstract]. The American Pediatric Association Program and Abstracts [Peer Reviewed] (Unspecified)