Sarah H. O'Brien, MD

Sarah O’Brien, MD, MSc, is a pediatric hematologist in the Nationwide Children’s Hospital Hemostasis and Thrombosis Center, an investigator in the Center for Innovation in Pediatric Practice at Nationwide Children’s Research Institute and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. She also leads a multi-disciplinary hematology and adolescent gynecology clinic at Nationwide Children’s Hospital. Her clinical and research interests include pediatric thrombosis and thromboprophylaxis, the evaluation and diagnosis of mild bleeding disorders, and the intersections between hematology and women’s health. As a health services researcher, Dr. O’Brien has a particular interest in the use of large administrative databases, as well as decision analysis and cost-effectiveness analysis.

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Gender:

• Female

Languages Spoken:

• English

Research Center:

• Center for Innovation in Pediatric Practice

Areas of Interest:

• DVT Prevention in Pediatric and Adolescent Trauma Patients: Safety & Costs. In this study, we seek to identify which, if any, young trauma patients may truly benefit from the thromboprophylaxis strategies that have become standard of care in adults. The research will give clinicians a tool to identify young trauma patients who would benefit from LMWH prophylaxis. The results will be used to create child and adolescent-specific guidelines, thereby allowing clinicians to maximize patient safety and minimize costs when considering LMWH prophylaxis for a young trauma patient. AHRQ Small Research Grant Program (O'Brien) 09/07 - 09/09
• Menorrhagia in adolescents
• Iron deficiency in adolescent females
• Dr. O'Brien is a pediatric hematologist whose research interests involve the application of health services research techniques to the field of pediatric thrombosis. Her current research focuses on the development of a decision analysis model to address the health effects and costs of universal screening for hereditary thrombophilia in children with a first episode of deep venous thrombosis (DVT).
• Quality of care in sickle cell anemia
• New anticoagulants in pediatrics
• Thrombophilia Screening in Children with Venous Thromboembolism: A Cost-Effectiveness Analysis. Dr. O'Brien received the 2006 Wallace H. Coulter Foundation Scholar, awarded to the recipient of an ASH Scholar Award with the highest scored clinical/translational research application. The research involves the development of a decision analysis model to address the health effects and costs of universal screening for hereditary thrombophilia in children with a first episode of deep venous thrombosis (DVT).
• Management of pediatric ITP
• Thromboprophylaxis Evaluation and diagnosis of mild bleeding disorders

Research Funding*:

• American Society of Hematology Fellow Scholar Award, American Society of Hematology
• DVT Prevention in Pediatric and Adolescent Trauma Patients: Safety and Costs, Agency for Healthcare Research and Quality
• Thrombophilia Screening in Children with Venous Thromboembolism: Cost-Effectiveness Analysis, American Society of Hematology

Medical School

• University of Pittsburgh School of Medicine
  Date Completed: 05/31/2000

Residency

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/2003

Graduate School

• University of Pittsburgh
  Date Completed: 06/30/2006

Fellowship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 07/31/2006

Department:

• Pediatrics

Section:

• Hematology/Oncology

Speciality:

• Pediatric Hematology Oncology
  

Date of Appointment at Nationwide Children’s Hospital:

• 09/29/2006

2006–present

• Assistant Professor, Department of Pediatrics, Division of Hematology/Oncology, The Ohio State University

2006–present

• Investigator, Center for Innovation in Pediatric Practice, Columbus Children's Research Institute

2003–2006

• Pediatric Hematology/Oncology Fellowship, Children's Hospital of Pittsburgh

2000–2003

• Pediatric Residency, Children's Hospital of Pittsburgh

• O'Brien SH. 0. Bleeding scores: are they really useful?. In American Society of Hematology Annual Meeting
• O'Brien SH. 2012. Recognition and management of pediatric venous thromboembolism in the emergency department.  Clin Pediatr Emerg Med. Vol. 12, no. 3. (September): 185-190.
• Setty B, O'Brien SH, Kerlin BA. 2012. Pediatric venous thromboembolism in the United States: a tertiary care complication of chronic diseases.  Pediatr Blood Cancer. Vol. 59, no. 2. (August): 258-64.
• SLADKY,J,L; Klima,J; Grooms,L; Kerlin,B,A; O'Brien,S,H. 2012. The PFA-100 (R) does not predict delta-granule platelet storage pool deficiencies.  HAEMOPHILIA. Vol. 18, no. 4. (July): 626-629.
• O'Brien SH, Klima J, Termuhlen AM, Kelleher KJ. 2012. Venous thromboembolism and adolescent and young adult oncology inpatients in US children's hospitals, 2001 to 2008.  J Pediatr. Vol. 159, no. 1. (July): 133-7.
• Pillai,Prasanth; Bonny,Andrea; O'Brien,Sarah. 2012. CONTRACEPTION-RELATED VENOUS THROMBOEMBOLISM IN A PEDIATRIC INSTITUTION.  PEDIATRIC BLOOD & CANCER. Vol. 58, no. 7. (July): 1033-1034.
• Sladky JL, Klima J, Grooms L, Kerlin BA, O'Brien SH. 2012. The PFA-100 does not predict delta-granule platelet storage pool deficiencies.  Haemophilia. Vol. 18, no. 4. (July): 626-9.
• O'Brien,Sarah,H. 2012. An update on pediatric bleeding disorders: Bleeding scores, benign joint hypermobility, and platelet function testing in the evaluation of the child with bleeding symptoms.  AMERICAN JOURNAL OF HEMATOLOGY. Vol. 87, no. May: S40-S44.
• Askegard-Giesmann JR, O'Brien SH, Wang W, Kenney BD. 2012. Increased utilization for enoxaparin in pediatric trauma patients.  J Pediatr Surg. Vol. 47, no. 5. (May): 980-3.
• Askegard-Giesmann,Johanna,R; O'Brien,Sarah,H; Wang,Wei; Kenney,Brian,D. 2012. Increased use of enoxaparin in pediatric trauma patients. In 43rd Annual Meeting of the Canadian-Association-of-Paediatric-Surgeons (CAPS)
• Dickerson AK, Klima J, Rhodes MM, O'Brien SH. 2012. Young adult with SCD in US children's hospitals: are they different from adolescents?.  Pediatr Blood Cancer. Vol. 58, no. 5. (May): 741-5.
• O'Brien SH, Klima J, Gaines BA, Betz S, Zenati MS. 2012. Utilization of low molecular weight heparin prophylaxis in pediatric and adolescent trauma patients.  J Trauma Nurs.. Vol. 19, no. 2. (February): 117-21.
• Young,Guy; Yee,Donald,L; O'Brien,Sarah,H; Khanna,Rachna; Barbour,April; Nugent,Diane,J. 2011. FondaKIDS: A Prospective Pharmacokinetic and Safety Study of Fondaparinux in Children Between 1 and 18 Years of Age.  PEDIATRIC BLOOD & CANCER. Vol. 57, no. 6. (December): 1049-1054.
• Young G, Yee DL, O'Brien SH, Khanna R, et al. 2011. FondaKIDS: A prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age.  Pediatr Blood Cancer. Vol. 57, no. 6. (December): 1049-1054.
• O'Brien,Sarah,H; Candrilli,Sean,D. 2011. In the absence of a central venous catheter, risk of venous thromboembolism is low in critically injured children, adolescents, and young adults: Evidence from the National Trauma Data Bank.  PEDIATRIC CRITICAL CARE MEDICINE. Vol. 12, no. 3. (May): 251-256.
• O'Brien SH, Candrilli SD. 2011. In the absence of a central venous catheter, risk ofvenous thromboembolism is low in critically injured children, adolescents, andyoung adults: evidence from the National Trauma Data Bank.  Pediatric Critical Care Medicine. Vol. 12, no. 3. (May): 251-256.
• Candrilli,Sean,D; O'Brien,Sarah,H; Ware,Russell,E; Nahata,Milap,C; Seiber,Eric,E; Balkrishnan,Rajesh. 2011. Hydroxyurea adherence and associated outcomes among Medicaid enrollees with sickle cell disease.  AMERICAN JOURNAL OF HEMATOLOGY. Vol. 86, no. 3. (March): 273-277.
• Candrilli SD, O'Brien SH, Ware RE, Nahata MC, Seiber EE, Balkrishnan RB. 2011. Hydroxyurea Adherence and Associated Outcomes in Medicaid Enrollees with Sickle Cell Disease.  American Journal of Hematology. Vol. 86, no. 3. (March): 273-277.
• Marcus,P,D; Nire,K,G; Grooms,L; Klima,J; O'Brien,S,H. 2011. The power of a standardized bleeding score in diagnosing paediatric type 1 von Willebrand's disease and platelet function defects.  HAEMOPHILIA. Vol. 17, no. 2. (March): 223-227.
• Marcus PD, Nire KG, Grooms L, Klima J, O'Brien SH. 2011. The power of a standardized bleeding score in diagnosing pediatric type 1 Von Willebrand disease and platelet function defects.  Haemophilia. Vol. 17, no. 2. (March): 223-227.
• O'Brien,Sarah,H; Klima,Jennifer; Reed,Suzanne; Chisolm,Deena; Schwarz,Eleanor,B; Kelleher,Kelly,J. 2011. Hormonal contraception use and pregnancy in adolescents with sickle cell disease: analysis of Michigan Medicaid claims.  CONTRACEPTION. Vol. 83, no. 2. (February): 134-137.
• Young G, Yee DL, O'Brien SH, Khanna R, Barbour A, Nugent DJ. 2011. FondaKIDS: A prospective pharmacokinetic and safety study of fondaparinux in children between 1 and 18 years of age.  Pediatric Blood & Cancer.
• O'Brien SH, Klima J, Reed S, Chisolm D, Schwarz EB, Kelleher KJ. 2011. Hormonal contraception use and pregnancy in adolescents with sickle cell disease: analysis of Michigan Medicaid claims.  Contraception. Vol. 83, no. 2. (February): 134-137.
• Bollinger,Lindsay,M; Nire,Kidan,G; Rhodes,Melissa,M; Chisolm,Deena,J; O'Brien,Sarah,H. 2011. Caregivers' Perspectives on Barriers to Transcranial Doppler Screening in Children With Sickle-Cell Disease.  PEDIATRIC BLOOD & CANCER. Vol. 56, no. 1. (January): 99-102.
• Bollinger LM, Nire KG, Rhodes M, Chisolm D, O'Brien SH. 2011. Caregivers' perspectives on barriers to transcranial doppler screening in children with sickle cell disease.  Pediatric Blood & Cancer. Vol. 56, no. 1. (January): 99-102.
• O'Brien,Sarah,H; Cavo,Matthew; Wang,Wei. 2010. Use of low molecular weight heparin for thromboprophylaxis in a pediatric inpatient population: Reasons for use and incidence of bleeding complications.  THROMBOSIS RESEARCH. Vol. 125, no. 4. (April): 370-372.
• O'Brien SH, Fan L, Kelleher KJ. 2010. Inpatient use of laxatives during opioid administration in children with sickle cell disease.  Pediatric Blood & Cancer. Vol. 54, no. 4. (April): 559-562.
• Cavo M, Wang W, O'Brien SH. 2010. Use of low molecular weight heparin for thromboprophylaxis in a pediatric inpatient population: reasons for use and incidence of bleeding complications.  Thrombosis Research. Vol. 125, no. 4. (April): 370-372.
• O'Brien,Sarah,H; Fan,Ling; Kelleher,Kelly,J. 2010. Inpatient Use of Laxatives During Opioid Administration in Children With Sickle Cell Disease.  PEDIATRIC BLOOD & CANCER. Vol. 54, no. 4. (April): 559-562.
• O'Brien,Sarah,H; Hankins,Jane,S. 2009. Decision Analysis of Treatment Strategies in Children With Severe Sickle Cell Disease.  JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY. Vol. 31, no. 11. (November): 873-878.
• Candrilli,Sean,D; O'Brien,Sarah; Ware,Russell,E; Balkrishnan,Rajesh. 2009. Hydroxyurea Adherence and Associated Outcomes in Medicaid Enrollees with Sickle Cell Disease. In 51st Annual Meeting and Exposition of the American-Society-of-Hematology
• O'Brien SH, Hankins JS. 2009. Decision analysis of treatment strategies in children with severe sickle cell disease.  Journal Of Pediatric Hematology/Oncology. Vol. 31, no. 11. (November): 873-878.
• Candrilli,S,D; Davis,K,L; Balkrishnan,R; O'Brien,S. 2009. CHANGES IN RATES OF SICKLE CELL DISEASE-RELATED INPATIENT STAYS AND ASSOCIATED RESOURCE USE AMONG AFRICAN AMERICANS IN THE UNITED STATES FOLLOWING APPROVAL OF HYDROXYUREA.
• Candrilli,Sean,D; Balkrishnan,Rajesh; O'Brien,Sarah,H. 2009. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients. In 13th Annual International Meeting of the International-Society-of-Pharmacoeconomics-and-Outcomes-Research
• Candrilli,Sean,D; Balkrishnan,Rajesh; O'Brien,Sarah,H. 2009. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients. In 13th Annual International Meeting of the International-Society-of-Pharmacoeconomics-and-Outcomes-Research
• Candrilli,Sean,D; Balkrishnan,Rajesh; O'Brien,Sarah,H. 2009. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients.  PEDIATRIC CRITICAL CARE MEDICINE. Vol. 10, no. 5. (September): 554-557.
• Candrilli SD, Balkrishnan R, O'Brien SH. 2009. Effect of injury severity on the incidence and utilization-related outcomes of venous thromboembolism in pediatric trauma inpatients.  Pediatric Critical Care Medicine. Vol. 10, no. 5. (September): 554-557.
• O'Brien,Sarah,H. 2009. Secondary Data Demonstrate Safety of Splenectomy in Spherocytosis.  PEDIATRIC BLOOD & CANCER. Vol. 52, no. 7. (July): 753-754.
• O'Brien,Sarah,H; Smith,Kenneth,J. 2009. Using Thrombophilia Testing to Determine Anticoagulation Duration in Pediatric Thrombosis is not Cost-Effective.  JOURNAL OF PEDIATRICS. Vol. 155, no. 1. (July): 100-104.
• O'Brien SH. 2009. Secondary data demonstrate safety of splenectomy in spherocytosis.  Pediatric Blood & Cancer. Vol. 52, no. 7. (July): 753-754.
• O'Brien SH; Smith KJ. 2009. Using thrombophilia testing to determine anticoagulation duration in pediatric thrombosis is not cost-effective.  Journal Of Pediatrics. Vol. 155, no. 1. (July): 100-104.
• O'Brien,Sarah,H; Smith,Kenneth,J. 2009. Using Thrombophilia Testing to Determine Anticoagulation Duration in Pediatric Thrombosis is not Cost-Effective. In 49th Annual Meeting of the American-Society-of-Hematology
• Ritchey AK, Keller FG, O'Brien SH. 2009. Hematologic Manifestations of Childhood Illness. In Hematology: Basic Principles and Practice, 5th Edition. Edited by Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silverstein LE, McGlave P. New York: Elsevier, Churchill Livingstone.
• Hyatt SA, Wang W, Kerlin BA, O'Brien SH. 2009. Applying diagnostic criteria for type 1 von Willebrand disease to a pediatric population.  Pediatric Blood & Cancer. Vol. 52, no. 1. (January): 102-107.
• Hyatt,Sarah,A; Wang,Wei; Kerlin,Bryce,A; O'Brien,Sarah,H. 2009. Applying Diagnostic Criteria for Type 1 von Willebrand Disease to a Pediatric Population.  PEDIATRIC BLOOD & CANCER. Vol. 52, no. 1. (January): 102-107.
• Standridge,Shannon,M; O'Brien,Sarah,H. 2008. Idiopathic Intracranial Hypertension in a Pediatric Population: A Retrospective Analysis of the Initial Imaging Evaluation.  JOURNAL OF CHILD NEUROLOGY. Vol. 23, no. 11. (November): 1308-1311.
• Standridge SM, O'Brien SH. 2008. Idiopathic intracranial hypertension in a pediatric population: a retrospective analysis of the initial imaging evaluation.  Journal Of Child Neurology. Vol. 23, no. 11. (November): 1308-1311.
• Candrilli,S,D; Balkrishnan,R; O'Brien,S. 2008. The effect of injury severity on the incidence and resource utilization-related outcomes of deep vein thrombosis among pediatric trauma admissions in the United States.
• O'Brien SH. 2008. Decision analysis in pediatric hematology.  Pediatric Clinics Of North America. Vol. 55, no. 2. (April): 287-304.
• O'Brien,Sarah,H; Haley,Kathy; Kelleher,Kelly,J; Wang,Wei; McKenna,Christine; Gaines,Barbara,A. 2008. Variation in DVT prophylaxis for adolescent trauma patients: a survey of the Society of Trauma Nurses.  Journal of trauma nursing : the official journal of the Society of Trauma Nurses. Vol. 15, no. 2. (April): 53-57.
• O'Brien,Sarah,H; Kaizar,Eloise,E; Gold,Melanie,A; Kelleher,Kelly,J. 2008. Trends in prescribing patterns of hormonal contraceptives for adolescents.  CONTRACEPTION. Vol. 77, no. 4. (April): 264-269.
• O'Brien SH, Kaizar EE, Gold MA, Kelleher KJ. 2008. Trends in prescribing patterns of hormonal contraceptives for adolescents.  Contraception. Vol. 77, no. 4. (April): 264-269.
• O'Brien,Sarah,H. 2008. Decision analysis in pediatric hematology.  PEDIATRIC CLINICS OF NORTH AMERICA. Vol. 55, no. 2. (April): 287-?.
• O'Brien SH, Haley K, Kelleher KJ, Wang W, McKenna C, Gaines BA. 2008. Variation in DVT prophylaxis for adolescent trauma patients: a survey of the Society of Trauma Nurses.  Journal Of Trauma Nursing. Vol. 15, no. 2. (January): 53-57.
• O'Brien,Sarah,H; Smith,Kenneth,J. 2007. Universal thrombophilia screening not cost-effective for determining duration of anticoagulation in pediatric patients. In 49th Annual Meeting of the American-Society-of-Hematology
• O'Brien SH, Lee H, Ritchey AK. 2007. Once-daily enoxaparin in pediatric thromboembolism: a dose finding and pharmacodynamics/pharmacokinetics study.  Journal Of Thrombosis And Haemostasis. Vol. 5, no. 9. (September): 1985-1987.
• O Brien,S,H; LEE,H; Ritchey,A,K. 2007. Once-daily enoxaparin in pediatric thromboembolism: a dose finding and pharmacodynamics/pharmacokinetics study(1).  JOURNAL OF THROMBOSIS AND HAEMOSTASIS. Vol. 5, no. 9. (September): 1985-1987.
• Lampel,Heather,P; Patel,Nisha; Boyse,Kathryn; O'Brien,Sarah,H; Zirwas,Matthew,J. 2007. Prevalence of hand dermatitis in inpatient nurses at a United States hospital.  DERMATITIS. Vol. 18, no. 3. (September): 140-142.
• Lampel HP, Patel N, Boyse K, O'Brien SH, Zirwas MJ. 2007. Prevalence of hand dermatitis in inpatient nurses at a United States hospital.  Dermatitis. Vol. 18, no. 3. (September): 140-142.
• Lee,Peggy,Lin; Lemos,Bianca; O'Brien,Sarah,H; English,Joseph,C; Zirwas,Matthew,J. 2007. Cutaneous diphtheroid infection and review of other cutaneous Gram-positive Bacillus infections.  Dermatitis. Vol. 79, no. 5. (May): 371-377.
• O'Brien,Sarah,H; Ritchey,A,Kim; Smith,Kenneth,J. 2007. A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP).  PEDIATRIC BLOOD & CANCER. Vol. 48, no. 2. (February): 173-180.
• O'Brien SH, Ritchey AK, Smith KJ. 2007. A cost-utility analysis of treatment for acute childhood idiopathic thrombocytopenic purpura (ITP).  Pediatric Blood & Cancer. Vol. 48, no. 2. (January): 173-180.
• Lee PL, Lemos B, O’Brien SH, English JC, Zirwas MJ. 2007. Cutaneous diphtheroid infection and review of other cutaneous gram-positive bacillus infections.  Dermatitis. Vol. 79, no. 5. (January): 371-377.
• O'Brien,S,H; Ritchey,A,K; Ragni,M,V. 2007. Combined clotting factor deficiencies: experience at a single hemophilia treatment center.  HAEMOPHILIA. Vol. 13, no. 1. (January): 26-29.
• O'Brien SH, Ritchey AK, Ragni MV. 2007. Combined clotting factor deficiencies: experience at a single hemophilia treatment center.  Haemophilia. Vol. 13, no. 1. (January): 26-29.
• O'Brien SH, Holubkov R, Reis EC. 2004. Identification, evaluation, and management of obesity in an academic primary care center.  Pediatrics. Vol. 114, no. 2. (August): e154-e159.
• O'Brien,Sarah,Harvey; Holubkov,Richard; Reis,Evelyn,Cohen. 2004. Identification, evaluation, and management of obesity in an academic primary care center.  Pediatrics. Vol. 114, no. 2. (August): e154-9.
• O'Brien S, Holtzer K. 2003. Hematology/Oncology. In Pediatrics in a Page. Edited by Kahan S, DeAntonis K.. Oxford: Blackwell Publishing.
• Vo KT, Grooms L, Klima J, Holland-Hall C, O'Brien SH. Menstrual bleeding patterns and prevalence of bleeding disorders in a multidisciplinary adolescent hematology clinic.  Haemophilia.
• Audino AN, Yeager ND, Asti L, Miao Y, O'Brien SH. Length of stay and treatment-related complications are similar in pediatric and AYA patients with bone sarcoma in United States children's hospitals.  Pediatr Blood Cancer.
• O'Brien SH. Common management issues in pediatric patients with mild bleeding disorders.  Semin Thromb Hemost.
• Kelly C, Rivard L, Salvi S, Hayani A, Hopkins W, O'Brien SH, et al. Surveillance following head, neck and chest radiotherapy: thyroid ultrasound monitoring for secondary thyroid malignancy.  Pediatr Blood Cancer.
• Ragni MV, O'Brien SH. 0. Women's Health Issues in Hematology. In American Society of Hematology Self Assessment Program 5th Edition.