Santiago Partida-Sanchez, Ph.D.

Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital. He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells. Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

View CV »

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Microbial Pathogenesis

Areas of Interest:

• My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

Post Doctoral

• National Polytechnic Institute
  Date Completed: 06/30/1998

Fellowship

• The Trudeau Institute
  Date Completed: 06/30/2003

2004–present

• Graduate Faculty Member, Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Columbus, OH.

2004–present

• Assistant Professor of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, College of Medicine and Public Health, Columbus, OH.

2003–2004

• Research Scientist, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund.

1998–2003

• Post-Doctoral Fellow, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund.

• Horvath DJ, Li Rollin, Casper, T, Partida-Sanchez S, Hustad DA, Hultgren SJ and Justice SS. 2010. Morphological Plasticity Promotes Resistance to Phagocyte Killing of Uropathogenic Escherichia coli..  Microbes and Infection. (December 21) (Formally Accepted)
• Lund FE, Randall TD, Partida-Sanchez S. 2010. Sm38 nucleic acid molecules.  Official Gazette of the United States Patent and Trademark. (March 14)
• Lund FE, Randall TD, Partida-Sanchez S. 2010. Sm38 nucleic acid molecules.. Vol. Official Gazette of the United States Patent and Trademark Office Patents. Alexandria, VA, USA: United States Patent and Trademark Office. [Peer Reviewed]
• Lange, Ingo; Yamamoto, Shinichiro; Partida-Sanchez, Santiago; Mori, Yasuo; Fleig, Andrea; Penner, Reinhold. 2009. Trpm2 Functions as a Lysosomal Ca2+-release Channel in beta Cells.  Science Signaling. Vol. 2, no. 71: Article No.: ra23. (IF: 30)
• Randolph GJ, Ochando J and Partida-Sánchez S. 2008. Migration of dendritic cell subsets and their precursors. Review of Dendritic Cells. Annual Review of Immunology. Vol. 26: Annual Reviews. (April): 293-331. (47.23) [Peer Reviewed] (Published)
• Novotny, Laura A.; Partida-Sanchez, Santiago; Munson, Robert S., Jr.; Bakaletz, Lauren O. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.  Infection and Immunity. Vol. 76, no. 3: 967-977.
• Randolph, Gwendalyn J.; Ochando, Jordi; Partida-Sanchez, Santiago. 2008. Migration of dendritic cell subsets and their precursors.  Annual Review of Immunology. Vol. 26: 293-316. (IF: 47.23)
• Partida-Sanchez, S., Nava-Rivero L, Shi G, and Lund FE. 2007. Cd38 an ecto-enzyme at the crossroads of innate and adaptive immune response.  Adv Exp Med Biol. Vol. 590: 171-183. (IF: 1.67)
• Partida-Sánchez S, Nava-Rivero L, Shi G, and Lund FE. 2007. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. In Crossroads between Innate and Adaptive Immunity, Advances in Experimental Medicine and Biology. Vol. 590. Edited by Katsikis Peter D, Pulendran Bali, Schoenberger Steven P. New York, NY, United States: Springer US. 171-183.
• Shi, Guixiu; Partida-Sanchez, Santiago; Misra, Ravi S.; Tighe, Michael; Borchers, Michael T.; Lee, James J.; Simon, Melvin I.; Lund, Frances E. 2007. Identification of an alternative G alpha(q)-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.  Journal of Experimental Medicine. Vol. 204, no. 11: 2705-2718. (IF: 15.21)
• Partida-Sanchez, Santiago; Gasser, Andreas; Fliegert, Ralf; Siebrands, Cornelia C.; Dammermann, Werner; Shi, Guixiu; Mousseau, Betty J.; Sumoza-Toledo, Adriana; Bhagat, Harivadan; Walseth, Timothy F.; Guse, Andreas H.; Lund, Frances E. 2007. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by Adp-ribose, the major product generated by the Cd38 enzyme reaction.  Journal of Immunology. Vol. 179, no. 11: 7827-7839. (IF: 6.29)
• Lund, Frances E.; Muller-Steffner, Helene; Romero-Ramirez, Hector; Moreno-Garcia, Miguel E.; Partida-Sanchez, Santiago.; Makris, Melissa; Oppenheimer, Norman J.; Santos-Argumedo, Leopoldo; Schuber, Francis. 2006. Cd38 induces apoptosis of a murine pro-b leukemic cell line by a tyrosine kinase-dependent but Adp-ribosyl cyclase- and Nad glycohydrolase-independent mechanism.  International Immunology. Vol. 18, no. 7: 1029-1042. (IF: 3.18)
• Khader, Shabaana A.; Partida-Sanchez, Santiago; Bell, Guy; Jelley-Gibbs, Dawn M.; Swain, Susan; Pearl, John E.; Ghilardi, Nico; deSauvage, Frederic J.; Lund, Frances E.; Cooper, Andrea M. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection.  Journal of Experimental Medicine. Vol. 203, no. 7: 1805-1815. (IF: 15.21)
• Massullo, Pam; Sumoza-Toledo, Adriana; Bhagat, Harivadan; Partida-Sanchez, Santiago. 2006. Trpm channels, calcium and redox sensors during innate immune responses.  Seminars in Cell & Developmental Biology. Vol. 17, no. 6: 654-666. (IF: 8.67)
• Lund FE, Randall TD, Partida-Sanchez S. 2005. Methods for identifying compounds that inhibit CD38 activity. Vol. Official Gazette of the United States Patent and Trademark Office Patents. Alexandria, VA, USA: United States Patent and Trademark Office. [Peer Reviewed]
• Moreno-Garcia, Miguel E.; Partida-Sanchez, Santiago; Primack, Julie; Sumoza-Toledo, Adriana; Muller-Steffner, Helene; Schuber, Francis; Oppenheimer, Norman; Lund, Frances E.; Santos-Argumedo, Leopoldo. 2004. Cd38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes.  European Journal of Biochemistry (FEBS J). Vol. 271, no. 5: 1025-1034. (IF: 3.57)
• Partida-Sanchez, S, Goodrich S, Kusser KL, Oppenheimer N, Randall TD and Lund FE. 2004. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity.  Immunity. Vol. 20: 279-291. (IF: 20.57)
• Partida-Sanchez, S; Iribarren, Pablo; Moreno-Garcia, Miguel E.; Gao, Ji-Liang; Murphy, Philip M.; Oppenheimer, Norman; Wang, Ji Ming; Lund, Frances E. 2004. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic Adp ribose.  Journal of Immunology. Vol. 172, no. 3: 1896-1906. (IF: 6.29)
• Partida-Sanchez, Santiago; Randall, Troy D.; Lund, Frances E. 2003. Innate immunity is regulated by Cd38, an ecto-enzyme with Adp-ribosyl cyclase activity.  Microbes and Infection. Vol. 5, no. 1: 49-58. (IF: 3.12)
• Lund, Frances E.; Randall, Troy D.; Partida-Sanchez, Santiago. 2002. Does Neutrophil CD38 have a role in Calcium signaling triggered beta2 Integrin?.  Nature Medicine. Vol. 8, no. 4. : 307-308. (IF: 28.58)
• Lund, Frances E.; Partida-Sanchez, S.; Lee, Byung O.; Kusser, Kimberly L.; Hartson, Louise; Hogan, Robert J.; Woodland, David L.; Randall, Troy D. 2002. Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza.  Journal of Immunology. Vol. 169, no. 9: 5236-5243. (IF: 6.29)
• Moyron-Quiroz, J. E.; Partida-Sanchez, S.; Donis-Hernandez, R.; Sandoval-Montes, C.; Santos-Argumedo, L. 2002. Expression and function of Cd22, a B-cell restricted molecule.  Scandinavian Journal of Immunology. Vol. 55, no. 4: 343-351. (IF: 2.18)
• Lund FE, Randall TD, Partida-Sánchez S. 2002. Regulation of Immune Responses by and cADPR. In Cyclic ADP-ribose and NAADP: Structures, Metabolism and Functions. 1st ed. Edited by Lee, HC. Boston, MA, United States: Kluwer Academic Publishers. 217-240.
• Partida-Sanchez, S.; Cockayne, Debra A.; Monard, Simon; Jacobson, Elaine L.; Oppenheimer, Norman; Garvy, Beth; Kusser, Kim; Goodrich, Stephen; Howard, Maureen; Harmsen, Allen; Randall, Troy D.; Lund, Frances E. 2001. Cyclic Adp-ribose production by Cd38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.  Nature Medicine. Vol. 7, no. 11: 1209-1216. (IF: 28.58)
• Partida-Sanchez, S.; Garibay-Escobar, Adriana; Frixione, Eugenio; Parkhouse, R. M. E.; Santos-Argumedo, Leopoldo. 2000. Cd45r, Cd44 and Mhc class Ii are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells.  European Journal of Immunology. Vol. 30, no. 9: 2722-2728. (IF: 4.86)
• Partida-Sanchez, S.; Favila-Castillo, L.; Pedraza-Sanchez, S.; Gomez-Melgar, M.; Saul, A.; Estrada-Parra, S.; Estrada-Garcia, I. 1998. IgG antibody subclasses, tumor necrosis factor and Ifn-gamma levels in patients with type Ii lepra reaction on thalidomide treatment.  International Archives of Allergy and Immunology. Vol. 116, no. 1: 60-66. (IF: 2.52)
• Santos-Argumedo, L.; Kincade, P. W.; Partida-Sanchez, S.; Parkhouse, R. M. E. 1997. Cd44-stimulated dendrite formation ('spreading') in activated B cells.  Immunology. Vol. 90, no. 1: 147-153. (IF: 3.67)
• Frances E. Lund, Troy D. Randall, and Santiago Partida-Sanchez, Inventor. filed February 15, 2005 and issued April 13, 2010. SM38 NUCLEIC ACID MOLECULES. patent no. US 7,695,933 B2. www.uspto.gov/web/patents/patog/week15/OG/html/1353-2/US07695933-20100413.html.
• Partida-Sanchez, Santiago, Robert Peterson. filed 2010. (patent pending) Tissue Disaggregator. patent no. B2312-282.
• Lund, Frances E, Randall, Troy D, Partida-Sanchez, Santiago, Inventor. filed 2005 and issued April 12, 2008. CD38 Modulated Chemotaxis. patent no. WO2006088951. WIPO. http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2006088951&F=0.
• Lund, Frances E., Partida-Sanchez, Santiago, Walseth, Tim, Inventor. filed October 1, 2007. (patent pending) TRPM2-Specific Inhibitors. patent no. WO2007082053. WIPO. http://v3.espacenet.com/textdoc?DB=EPODOC&IDX=WO2007082053&F=0.
• Lund, Frances E, Randall, Troy D, and Partida-Sanchez, Santiago, Inventor. filed October 17, 2001 and issued October 18, 2005. Methods for Identifying compounds that inhibit CD38 activity. patent no. U.S. Patent 6,955,884. U.S Patent office. http://ptft.uspto.gov/netacgi/nph-Parser?patentnumber=6%2c955%2c884.