Santiago Partida-Sanchez, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Santiago Partida-Sanchez, Ph.D.

Santiago  Partida-Sanchez, Ph.D.

Center for Microbial Pathogenesis
Principal Investigator

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722.4092
FX: (614) 722.2818
Email Me

Biography

Santiago Partida-Sanchez, PhD is a Principal Investigator at The Research Institute at Nationwide Children’s Hospital. He is an Associate Professor of Pediatrics at the Ohio State University College of Medicine. Dr. Partida-Sanchez’s NIH funded research program focuses on identifying mechanisms of activation of calcium cellular signals via TRP type ion channels. His team's goal is to elucidate how those pathways impact on the functions of innate immune cells, such as macrophages and dendritic cells. Dr. Partida-Sanchez's research will provide insights into how inflammatory cells are recruited during infection or inflammation, and will help to develop cellular migration inhibitors with therapeutic potential.

View CV »

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • My laboratory is interested in the study of immune cell recruitment induced by infection and/or inflammation. Our research projects are focused on molecular analyses of chemokine receptor-mediated G-protein-linked signaling and calcium influx in neutrophils and DCs. We are conducting experiments to study regulation of calcium influx mediated by CD38-catalyzed metabolites and the ADPR-activated calcium channel TRPM2 in inflammatory cells. We would like to assess whether CD38 inhibiting drugs, CD38-derived antagonists, and/or TRPM2 channel inhibitors, have potential therapeutic use to block undesired chronic inflammatory responses, or harmful T cell responses leading to autoimmunity. This knowledge could allow us to design new strategies for clinical intervention in several immunological disorders, as well as inflammatory and infectious diseases.

Education and Training

Post Doctoral

  • National Polytechnic Institute
    Date Completed: 06/30/1998

Fellowship

  • The Trudeau Institute
    Date Completed: 06/30/2003

Professional Experience

2004–present

  • Graduate Faculty Member, Integrated Biomedical Science Graduate Program and Molecular, Cellular and Development Biology Program, The Ohio State University, College of Medicine and Public Health, Columbus, OH.

2004–present

  • Assistant Professor of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University, College of Medicine and Public Health, Columbus, OH.

2003–2004

  • Research Scientist, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund.

1998–2003

  • Post-Doctoral Fellow, The Trudeau Institute, Saranac Lake, NY. PI. Dr. Frances E. Lund.

Publications

  • Petrovic-Djergovic D, Popovic M, Chittiprol S, Cortado H, Ransom RF, Partida-Sánchez S. 2015. CXCL10 induces the recruitment of monocyte derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis.  Clinical & Experimental Immunology. Vol. 180, no. 2. (May): 305-15.
  • Becknell B, Eichler T, Beceiro S, Li B, Easterling R, Carpenter A, Partida-Sánchez S, Spencer JD. 2014. A comparison of the expression and antimicrobial function of ribonuclease 6 and ribonuclease 7 in the mammalian urinary tract.  Kidney International. Vol. 87, no. 1. (July): 151-61.
  • Beceiro S, Cortado H, Partida-Sanchez S. 2013. Novel CX3CR1+hi monocyte-derived dendritic cell subtype with inflammatory properties.  Journal of Immunology. Vol. 190, no. May: 115-18.
  • Partida-Sanchez S, Cortado H, Horvath D, Li R, Flano E, Justice S. 2013. Nonclassical monocyte-derived macrophages are essential for preventing pyelonephritis upon urinary tract infection in mice.  Journal of Immunology. Vol. 190, no. May: 130-4.
  • McNally B, Willette M, Ye F, Partida-Sanchez S, Flano E. 2012. Intranasal administration of dsRNA analog poly(I:C) induces interferon-alpha receptor-dependent accumulation of antigen axperienced T cells in the airways.  PLoS One. Vol. 7, no. 12. (December): ee51351.
  • Hans CP, Koenig SN, Huang N, Cheng J, Beceiro S, Guggilam A, Kuivaniemi H, Partida-Sanchez S, Garg V. 2012. Inhibition of Notch1 signaling reduces abdominal aortic aneurysm in mice by attenuating macrophage-mediated inflammation.  Arteriosclerosis, Thrombosis and Vascular Biology. Vol. 32, no. 12. (December): 3012-23.
  • Partida-Sanchez S, Horvath D, Cortado H, Li B, Flano E, Justice S. 2012. Monocyte-derived inflammatory dendritic cells expressing CX3CR1hi control urinary tract infection in mice.  Journal of Immunology. Vol. 188, no. May: e120.25.
  • Bolton M, Horvath DJ, Li B, Cortado H, Newsom D, White P, Partida-Sanchez S, JusticeSS. 2012. Intrauterine growth restriction is a direct consequence of localized maternal eropathogenic Escherichia coli cystitis.  PloS One. Vol. 7, no. 3. (March): ee33897.
  • Sumoza-Toledo A, Lange I, Cortado H, Bhagat H, Mori Y, Fleig A, Penner R, Partida-Sanchez S. 2011. Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release.  FASEB Journal. Vol. 25, no. 10. (October): 3529-3542.
  • Horvath DJ, Li Rollin, Casper, T, Partida-Sanchez S, Hustad DA, Hultgren SJ and Justice SS. 2011. Morphological plasticity promotes resistance to phagocyte killing of uropathogenic Escherichia coli.  Microbes and Infection. Vol. 13, no. 5. (January): 426-437.
  • Lund FE, Randall TD, Partida-Sanchez S. 2010. Sm38 nucleic acid molecules.  Official Gazette of the United States Patent and Trademark.
  • Partida-Sanchez S,, Sumoza-Toledo, A., Bhagat, H., Lange, I., Penner, R., and Fleig, A. 2010. Azole derivative drugs inhibit neutrophil chemotaxis by blocking the Calcium permeant channel TRPM2. In J. Immunol. Proceedings of the 97th AAI Meeting in Baltimore, MD.
  • Sumoza-Toledo A, Lange I, Bhagat H, Cortado H, Mori Y, Penner R, Fleig A, Partida-Sanchez S,. 2010. Transient Receptor Potential Melastatin 2 (TRPM2) is a Calcium Release Channel Essential for Chemotaxis of Dendritic Cells. In J Immunol. Proceddings of the 97th AAI Meeting in Baltimore, MD.
  • Lange I, Yamamoto S, Partida-Sanchez S, Mori Y, Fleig A, Penner R. 2009. TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.  Science Signaling. Vol. 2, no. 71. (January): eArticle No.: ra23.
  • Randolph GJ, Ochando J and Partida-Sánchez S. 2008. Migration of dendritic cell subsets and their precursors.  Annual Review of Immunology. Vol. 26, no. April: 293-331.
  • Novotny LA, Partida-Sanchez S, Munson RS Jr, Bakaletz LO. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.  Infection and Immunity. Vol. 76, no. 3. (January): 967-977.
  • Randolph GJ, Ochando J, Partida-Sanchez S. 2008. Migration of dendritic cell subsets and their precursors.  Annual Review of Immunology. Vol. 26, no. January: 293-316.
  • Siebrands, C.C., Dammermann, W., Fliegert, R., Partida-Sanchez, S., Walseth, T.F., Lund, F.E., and Lonati, C. 2007. 8Br-ADPR: A Novel Antagonist of TRPM2 Channels. In Fall Meeting German Society of Biochemistry and Molecular Biology
  • Partida-Sanchez S, Nava-Rivero L, Shi G, Lund FE. 2007. CD38 an ecto-enzyme at the crossroads of innate and adaptive immune response.  Advances in Experimental Medicine and Biology. Vol. 590, no. January: 171-183.
  • Partida-Sanchez S, Gasser A, Fliegert R, Siebrands CC, Dammermann W, Shi G, Mousseau BJ, Sumoza-Toledo A, Bhagat H, Walseth TF, Guse AH, Lund FE. 2007. Chemotaxis of mouse bone marrow neutrophils and dendritic cells is controlled by Adp-ribose, the major product generated by the Cd38 enzyme reaction.  Journal of Immunology. Vol. 179, no. 11. (January): 7827-7839.
  • Partida-Sanchez,Santiago; Rivero-Nava,Laura; Shi,Guixiu; Lund,Frances,E. 2007. CD38: An ecto-enzyme at the crossroads of innate and adaptive immune responses. In 1st Conference on Crossroads Between Innate and Adaptive Immunity
  • Shi G, Partida-Sanchez S, Misra RS, Tighe M, Borchers MT, Lee JJ, Simon MI, Lund FE. 2007. Identification of an alternative G alpha(q)-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes.  Journal of Experimental Medicine. Vol. 204, no. 11. (January): 2705-2718.
  • Partida-Sanchez S, Rivero-Nava L, Shi G, Lund FE. 2007. CD38: An ecto-enzyme at the crossroads of innate and adaptive immune responses.  Crossroads Between Innate and Adaptive Immunity. Vol. 590, no. January: 171-183.
  • Partida-Sánchez S, Nava-Rivero L, Shi G, and Lund FE. 2007. CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. In Crossroads between Innate and Adaptive Immunity, Advances in Experimental Medicine and Biology. Edited by Katsikis Peter D, Pulendran Bali, Schoenberger Steven P. New York, NY: Springer US.
  • Partida-Sánchez, S., Fliegert R., Gasser A., Bhagat H., Guse AH., Walseth TF., Guse AH., and Lund FE. 2006. Regulation of Ca2+ signaling and chemotaxis in phagocytes by ADPR, a novel second messenger in immune cells. In The AAI meeting 2006
  • Partida-Sanchez S, Fliegert R, Gasser A, Bhagat H, Walseth TF, Guse AH, Lund FE. 2006. Regulation of Ca2+ signaling and chemotaxis in phagocytes by ADPR, a novel second messenger in immune cells.  Journal of Immunology. Vol. 176, no. April: S40-S40.
  • Partida-Sanchez, S., Gasser,A., Fliegert R, Sumoza-Toledo A , B. H., Shi, G., Walseth T.F., Guse A.H., Lund F.E. 2006. CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels. In Molecular Medicine
  • Lund FE, Muller-Steffner H, Romero-Ramirez H, Moreno-Garcia ME, Partida-Sanchez S, Makris M, Oppenheimer NJ, Santos-Argumedo L, Schuber F. 2006. CD38 induces apoptosis of a murine pro-b leukemic cell line by a tyrosine kinase-dependent but ADP-ribosyl cyclase- and NAD glycohydrolase-independent mechanism.  International Immunology. Vol. 18, no. 7. (January): 1029-1042.
  • Massullo P, Sumoza-Toledo A, Bhagat H, Partida-Sanchez S. 2006. TRPM channels, calcium and redox sensors during innate immune responses.  Seminars in Cell & Developmental Biology. Vol. 17, no. 6. (January): 654-666.
  • Khader SA, Partida-Sanchez S, Bell G, Jelley-Gibbs DM, Swain S, Pearl JE, Ghilardi N, deSauvage FJ, Lund FE, Cooper AM. 2006. Interleukin 12p40 is required for dendritic cell migration and T cell priming after Mycobacterium tuberculosis infection.  Journal of Experimental Medicine. Vol. 203, no. 7. (January): 1805-1815.
  • Randall TD, Rivero-Nava LE, Guedes AGP, Partida-Sanchez S, Kannan MS, Lund FE. 2006. Regulation of allergic airway disease by CD38: Roles for CD38 in T cell priming, Th2 effector cell generation and airway hyperresponsiveness.  Molecular Medicine. Vol. 12, no. January: S21-S21.
  • Partida-Sanchez S, Gasser A, Fliegert R, Sumoza-Toledo A, Bhagat H, Shi G, Walseth TF, Guse AH, Lund FE. 2006. CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels.  Molecular Medicine. Vol. 12, no. January: S19-S19.
  • Randall , T.D., Rivero-Nava L.E., Guedes A.G.P., Partida-Sánchez, S., Kannan, M.S., Lund, F.E. 2006. Regulation of allergic airway disease by CD38: Roles for CD38 in T cell priming, Th2 effector cell generation and airway hyperresponsiveness. In Molecular Medicine
  • Partida-Sánchez, S., Goodrich, SP., Kusser, K., Oppenheimer, N., Randall, TD. Lund, FE. 2004. Regulation of dendritic cell trafficking by the ADP-Ribosyl cyclase CD38: impact on the development of humoral immunity. In The 12th International Congress of Immunology
  • Rivero-Nava, L. Partida-Sánchez, S., Randall, TD. Lund, FE.,. 2004. CD38 Regulates Trafficking of TNF-alpha-Producing Dendritic Cells after Listeria monocytogenes Infection. In The 12th International Congress of Immunology
  • Partida-Sanchez S, Iribarren P, Moreno-Garcia ME, Gao JL, Murphy PM, Oppenheimer N, Wang JM, Lund FE. 2004. Chemotaxis and calcium responses of phagocytes to formyl peptide receptor ligands is differentially regulated by cyclic ADP ribose.  Journal of Immunology. Vol. 172, no. 3. (January): 1896-1906.
  • Partida-Sanchez S, Goodrich S, Kusser KL, Oppenheimer N, Randall TD, Lund FE. 2004. Regulation of dendritic cell trafficking by the ADP-ribosyl cyclase CD38: Impact on the development of humoral immunity.  Immunity. Vol. 20, no. January: 279-291.
  • Moreno-Garcia ME, Partida-Sanchez S, Primack J, Sumoza-Toledo A, Muller-Steffner H, Schuber F, Oppenheimer N, Lund FE, Santos-Argumedo L. 2004. CD38 is expressed as noncovalently associated homodimers on the surface of murine B lymphocytes.  European Journal of Biochemistry. Vol. 271, no. 5. (January): 1025-1034.
  • Partida-Sánchez, S., Fliegert, R., Gasser, A., Bhagat, H., Walseth, T. F., Guse, A. H., Lund, F. E. 2003. CD38 initiates allergic airway inflammation by regulating T cell priming. In FASEB Journal
  • Rivero-Nava L, Partida-Sanchez S, Randall T, Lund FE. 2003. CD38 initiates allergic airway inflammation by regulating T cell priming.  FASEB Journal. Vol. 17, no. 7. (April): C14-C14.
  • Partida-Sanchez S, Randall TD, Lund FE. 2003. Innate immunity is regulated by CD38, an ecto-enzyme with ADP-ribosyl cyclase activity.  Microbes and Infection. Vol. 5, no. 1. (January): 49-58.
  • Partida-Sánchez, S., Randall, T.D. and Lund, F.E. 2002. CD38 regulates immune responses by modulating T cell priming by antigen-presenting cells. In The FASEB Experimental Biology Meeting 2002
  • Partida-Sanchez S, Randall TD, Lund FE. 2002. CD38 regulates immune responses by modulating T cell priming by antigen-presenting cells.  FASEB Journal. Vol. 16, no. 5. (March): A1227-A1227.
  • Lund FE, Randall TD, Partida-Sánchez S. 2002. Regulation of Immune Responses by and cADPR. In Cyclic ADP-ribose and NAADP: Structures, Metabolism and Functions. 1st ed. Edited by Lee, HC. Boston, MA: Kluwer Academic Publishers.
  • Lund FE, Partida-Sanchez S, Lee BO, Kusser KL, Hartson L, Hogan RJ, Woodland DL, Randall TD. 2002. Lymphotoxin-alpha-deficient mice make delayed, but effective, T and B cell responses to influenza.  Journal of Immunology. Vol. 169, no. 9. (January): 5236-5243.
  • Moyron-Quiroz JE, Partida-Sanchez S, Donis-Hernandez R, Sandoval-Montes C, Santos-Argumedo L. 2002. Expression and function of CD22, a B-cell restricted molecule.  Scandinavian Journal of Immunology. Vol. 55, no. 4. (January): 343-351.
  • Lund FE. Randall TD, Partida-Sanchez S. 2002. Does neutrophil CD38 have a role in calcium signaling triggered beta2 integrin?.  Nature Medicine. Vol. 8, no. 4. (January): 307-308.
  • Partida-Sánchez, S., Cockayne, D., Jacobson, E., Garvy, B., Harmsen, A., Randall, T.D., and Lund, F.E. 2001. Production of cADPR by CD38 controls capacitative calcium influx and neutrophil chemotaxis to bacterial chemoattractants and is required for bacterial clearance. In The 11th International Congress of Immunology
  • Partida-Sanchez, S., Cockayne, D., Monard, S., Jacobson, E.L., Garvy, B., Randall, T., Lund, F.E. 2001. CD38 catalyzed cADPR controls neutrophil chemotaxis, calcium influx and bacterial clearance. In FASEB Journal
  • Partida-Sanchez S, Cockayne DA, Monard S, Jacobson EL, Oppenheimer N, Garvy B, Kusser K, Goodrich S, Howard M, Harmsen A, Randall TD, Lund FE. 2001. Cyclic ADP-ribose production by CD38 regulates intracellular calcium release, extracellular calcium influx and chemotaxis in neutrophils and is required for bacterial clearance in vivo.  Nature Medicine. Vol. 7, no. 11. (January): 1209-1216.
  • Partida-Sánchez, S., Harmsen, A., Garvy ,B., Randall,T., Lund, F.E. 2000. A new emergent role for CD38 during innate immune responses. In FASEB Journal
  • Randall T.D., Kusser, K., Primack, J., Partida-Sanchez, S., Lee, B.O., Harmsen, A., and Lund, F.E. 2000. B cell responses to influenza develop more rapidly in the lung than in systemic sites. In FASEB Journal
  • Partida-Sanchez S, Harmsen A, Garvy B, Randall T, Lund FE. 2000. A new emergent role for CD38 during innate immune responses.  FASEB Journal. Vol. 14, no. 6. (April): A1151-A1151.
  • Partida-Sanchez S, Garibay-Escobar A, Frixione E, Parkhouse RME, Santos-Argumedo L. 2000. CD45r, CD44 and MHC class Ii are signaling molecules for the cytoskeleton-dependent induction of dendrites and motility in activated B cells.  European Journal of Immunology. Vol. 30, no. 9. (January): 2722-2728.
  • Partida-Sanchez S, Favila-Castillo L, Pedraza-Sanchez S, Gomez-Melgar M, Saul A, Estrada-Parra S, Estrada-Garcia I. 1998. IgG antibody subclasses, tumor necrosis factor and Ifn-gamma levels in patients with type Ii lepra reaction on thalidomide treatment.  International Archives of Allergy and Immunology. Vol. 116, no. 1. (January): 60-66.
  • Santos-Argumedo L, Kincade PW, Partida-Sanchez S, Parkhouse RME. 1997. CD44-stimulated dendrite formation ('spreading') in activated B cells.  Immunology. Vol. 90, no. 1. (January): 147-153.
  • Partida-Sánchez, S, Favila L, Pedraza S, Estrada-Parra S, Estrada-Garcia I and Saul A. 1993. Tumor Necrosis Factor (TNF) in leprosy patients with type II reaction. In The 14th International Leprosy Congress
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