Ruoning Wang, PhD :: Nationwide Children's Hospital, Columbus, Ohio

Ruoning Wang, PhD

Ruoning  Wang, PhD

Contact Information

700 Children's Drive
Room WA5016
Columbus, Ohio 43205 [ map ]
PH: (614) 355-2980
FX: (614) 722-5895
Email Me


Ruoning Wang, PhD, is principal investigator in the Center for Childhood Cancer and Blood Diseases in The Research Institute at Nationwide Children’s Hospital, and Assistant Professor in the Department of Pediatrics at The Ohio State University College of Medicine.

View CV »


  • Male

Languages Spoken:

  • English
  • Chinese

Research Interests

Research Center:

Areas of Interest:

  • Our lab's fundamental interest is to understand how eukaryotic cells integrate various extracellular and intrinsic signals/cues to dictate cellular fate (cell proliferation, death, growth and differentiation). We address our questions in patho-physiological context such as tumorigenesis and immune response. In particular, we focus on understanding the impact of the interplay between cell metabolic programs and cell signaling programs on tumorigenesis and immunity. We apply various experimental models, each of which has unique scientific features, such as mouse models of human tumor and autoimmune disease (accessible for genetic and pharmacological modulations), frog oocytes (with defined cell cycle stage and accessible for direct intracellular injection of biological material), various primary cells from mouse (MEFs, T, B cell and macrophage), and human transformed cell lines (provide unique cellular tools to understand the potential cellular mechanisms that may mimic what happen in vivo).

Education and Training

Undergraduate School

  • China Pharmaceutical University
    Date Completed: 06/30/1996

Graduate School

  • Nanjing Medical University
    Date Completed: 06/01/2002

Graduate School

  • MD Anderson Cancer Center/GSBS
    Date Completed: 12/01/2007

Post Doctoral

  • St. Jude Children's Research Hospital
    Date Completed: 08/01/2013

Date of Appointment at Nationwide Children’s Hospital:

  • 08/12/2013

Professional Experience


  • Nanjing Medical University/Teacher


  • Jennifer Martinez, Katherine Verbist, Ruoning Wang, and Douglas Green. The Relationship between Metabolism and the Autophagy Machinery during the Innate Immune Response. Cell Metabolism. 2013 Jun 4, 17(6):895-900.
  • Verbist Katherin, Ruoning Wang and Douglas Green. T cell metabolism and the immune response. Seminars in Immunology. 2013 Jan (Review).
  • Ruoning Wang* and Douglas Green*. The metabolic checkpoint in activated T cells. Nature Immunology. 2012 Oct, 13(10):907-15 (Review). (*Corresponding author).
  • Zuqin Nie*, Gangqing Hu*, Gang Wei, Kairong Cui, Arito Yamane, Wolfgang Resch, Ruoning Wang, Douglas R. Green, Lino Tessarollo, Rafael Casellas, Keji Zhao, and David Levens. c-Myc is a universal amplifier of gene expression. Cell. 2012 Sep, (1):68-79. (*Contributed equally to this work).
  • Ruoning Wang and Douglas Green. The metabolic reprogramming and dependency in T cells. Immunological Review. 2012 Sep, 249(1):14-26 (Review).
  • Ruoning Wang, Christopher Dillon, Lewis Shi, Sandra Milasta, Robert Carter, Laura McCormick, Patrick Fitzgerald, Hongbo Chi, Joshua Munger and Douglas Green. The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation. Immunity. 2011 Dec 23, 35(6):871-82.
  • David Bedford, Lawryn Kasper, Ruoning Wang, Yunchao Chang, Douglas Green and Paul Brindle. Disrupting the CH1 domain structure in the acetyltransferases CBP and p300 results in lean mice with increased metabolic control. Cell Metabolism. 2011 Aug 3, 14(2):219-30.
  • Lewis Shi*, Ruoning Wang*, Gonghua Huang, Peter Vogel, Geoffrey Neale, Douglas Green and Hongbo Chi. HIF1-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med. 2011 Jul 4, 208(7):1367-76.(*Contributed equally to this work).
  • Ruoning Wang, Sungyun Jung, Chuanfen Wu, Jun Qin, Ryuji Kobayashi, Gary E Gallick, P. and Jian Kuang. Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. PNAS. 2010 Nov, 107(46):19885-90.
  • Douglas Green* and Ruoning Wang. Calcium and Energy: Making the Cake and Eating It too? Cell. 2010 Jul 23, 142(2):200-202 (Preview). (*Corresponding author).
  • Chuan Fen Wu, Ruoning Wang, Sung Yun Jung, Wenke Li, Cheryl L. Ashorn, Mayra Nelman-Gonzalez, Jun Qin, Sue-Hwa Lin and Jian Kuang. Dissecting the M phase-specific phosphorylation of S/T-P motifs. Mol Biol Cell. 2010 May, 21(9):1470-81.
  • Jinhua Yu, Huixia He, Chunbo Tang, Guangdong Zhang, Yuanfei Li, Ruoning Wang, Junnan Shi and Yan Jin. Differentiation potential of STRO-1+ dental pulp stem cells changes during cell passaging. BMC Cell Biology. 2010 May.
  • Shujuan Pan, Ruoning Wang, Xi Zhou, Malgorzata Kloc, Joe Corvera, Richard Sifers, Sue-Hwa Lin and Jian Kuang. Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J. 2008 Aug 6, 27(15):2077-90.
  • Yong Zhao, Oliveier Haccard, Ruoning Wang, JiangtaoYu, Jian Kuang, Catherine Jessus, Michael L. Goldberg. Roles of Greatwall. Kinase in the Regulation of Cdc25 Phosphatase. Mol Biol Cell. 2008 Apr, 19(4):1317-27.
  • Ruoning Wang, Guangan He, Mayra Nelman-Gonzalez, Cheryl L. Ashorn, P. Todd Stukenberg, Marc W. Kirschner and Jian Kuang. Regulation of Cdc25C by Erk-MAP kinase during the G2/M transition. Cell. 2007 Mar, 128:1119-32.
  • Shujuan Pan*, Ruoning Wang*, Xi Zhou, Guangan He, John Koomen, Ryuji Kobayashi, Gary E. Gallick, Le Sun, Joe Corvera and Jian Kuang. Involvement of the Conserved adaptor protein Alix in actin cytoskeleton assembly. J Biol Chem. 2006 Nov 10, 281(45):34640-50. (*Contributed equally to this work).
  • Jinhua Yu, Junnan Shi, Zhihong Deng, Heng Zhuang, Xin Nie, Ruoning Wang and Yan Jin. Cell pellets from dental papillae can reexhibit dental morphogenesis and dentinogenesis. Biochem Biophys Res Commun. 2006 Jul 21, 346(1):116-24.
  • Guangan He, Zahid H Siddik, Zaifeng Huang, Ruoning Wang, John Koomen, Ryuji Kobayashi, Abdul R Khokhar and Jian Kuang. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr 21, 24(18):2929-43.
  • Liu G1, Bi Y2, Xue L3, Zhang Y4, Yang H4, Chen X4, Lu Y4, Zhang Z4, Liu H4, Wang X4, Wang R5, Chu Y4, Yang R2. Dendritic cell SIRT1-HIF1a axis programs the differentiation of CD4+ T cells through IL-12 and TGF-ß1. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):E957-65. doi: 10.1073/pnas.1420419112. Epub 2015 Feb 17. PubMed ID: 25730867
  • Liu G1, Bi Y, Wang R, Yang H, Zhang Y, Wang X, Liu H, Lu Y, Zhang Z, Chen W, Chu Y, Yang R. Targeting S1P1 receptor protects against murine immunological hepatic injury through myeloid-derived suppressor cells. J Immunol. 2014 Apr 1;192(7):3068-79. doi: 10.4049/jimmunol.1301193. Epub 2014 Feb 24. PubMed ID: 24567529
  • Tait SW1, Oberst A2, Quarato G3, Milasta S3, Haller M4, Wang R5, Karvela M4, Ichim G4, Yatim N6, Albert ML7, Kidd G8, Wakefield R9, Frase S9, Krautwald S10, Linkermann A10, Green DR11. Widespread mitochondrial depletion via mitophagy does not compromise necroptosis. Cell Rep. 2013 Nov 27;5(4):878-85. doi: 10.1016/j.celrep.2013.10.034. Epub 2013 Nov 21. PubMed ID: 24268776
  • Wang T1, Liu G2, Wang R3. The Intercellular Metabolic Interplay between Tumor and Immune Cells. Front Immunol. 2014 Jul 28;5:358. doi: 10.3389/fimmu.2014.00358. eCollection 2014. PubMed ID: 25120544
  • Caro-Maldonado A1, Wang R, Nichols AG, Kuraoka M, Milasta S, Sun LD, Gavin AL, Abel ED, Kelsoe G, Green DR, Rathmell JC. Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. J Immunol. 2014 Apr 15;192(8):3626-36. doi: 10.4049/jimmunol.1302062. Epub 2014 Mar 10. PubMed ID: 24616478
  • Chuan-Fen Wu*, Shuaishuai Liu*, Yu-Chen Lee, Ruoning Wang, Sheng Sun, Fumin Yin, William Bornmann, Wei Zhang, Li-Yuan Yu-Lee, Gary E. Gallick, sue-Hwa Lin, Jian Kuang. The signaling kinase RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 2013. (*Contributed equally to this work).
  • Guangwei Liu*, Yujing Bi, Ruoning Wang and Xianghui Wang. Self-eating and self-defense: autophagy controls innate immunity and adaptive immunity. J Leukoc Biol. 2013 (Review). (*Corresponding author).
  • Ruoning Wang and Douglas Green. The immune diet: Meeting the metabolic demands of lymphocyte activation. F1000 Biol Reports. 2012, 4:9 (Review).

Awards, Honors and Organizations

  • Research Achievement Award (1st Place), Genes & Development Program, UT-MD Anderson Cancer Center, 2006
  • AACR-Bristol-Myers Squibb Oncology Scholar-in-Training Award, American Cancer Society, 2011
  • Presidents’ Research Scholar Award, UTH-GSBS and UT-MD Anderson Cancer Center, 2007
  • Alfred G. Knudson Outstanding Dissertation Award, UT-MD Anderson Cancer Center, 2007
  • George J. Mitchell Fellowship, St. Jude Children's Research Hospital, 2009-2012
  • V Scholar, 2014
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000