Peter White, Ph.D.

Peter White, PhD is a principal investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University. He is also Director of Molecular Bioinformatics, serving on the research computing executive governance committee, and Director of the Biomedical Genomics Core, a nationally recognized microarray and next-gen sequencing facility that help numerous investigators design, perform and analyze genomics research. His research program focuses on molecular bioinformatics and high performance computing solutions for “big data”, including discovery of disease associated human genetic variation and understanding the molecular mechanism of transcriptional regulation in both eukaryotes and prokaryotes.

View CV »

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Microbial Pathogenesis

Areas of Interest:

• The focus of our laboratory is in the area of Biomedical Genomics, developing and using state of the art genomic technologies to investigate and understand the mechanisms of transcriptional regulation as it relates to human health and disease. Our approach is to utilize DNA microarray technologies to produce genome wide expression profiles, of both mRNAs and small RNAs, SNP analysis, array CGH, and promoter occupancy analysis. In addition to the array based application we are also exploring the tremendous possibilities of Next Generation Sequencing technologies. Together with the Research Faculty here at Nationwide Children’s Hospital we are utilizing the genomic information gained from these technologies to better understand, treat and prevent human disease.

Medical School

• University of Cambridge
  Date Completed: 06/30/1998

• The Cancer Genome Atlas Network, White, P. 2013. Integrated genomic characterization of endometrial carcinoma.  Nature. Vol. 497, no. 7447. (May): 67-73.
• Harrison A, Santana EA, Szelestey BR, Newsom DE, White P, and Mason KM. 2013. The ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzea.  Infection and Immunity. Vol. 81, no. 4. (February): 1221-1233.
• Lamounier RN, Coimbra CN, White P, Costal FL, Oliveira LS, Giannella 0, Neto D, Kaestner KH, Correa-Giannella ML. 2013. Apoptosis rate and trasncriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone.  Diabetol Metab Syndr. Vol. 5, no. 1. (January): e1.
• The Cancer Genome Atlas Network, White P. 2012. Comprehensive molecular portraits of human breast tumors.  Nature. Vol. 490, no. October: 61-70.
• Cancer Genome Atlas Nework, White P. 2012. Comprehensive molecular characterization of human colon and rectal cancer.  Nature. Vol. 487, no. 7407. (July): 330-337.
• Bolton M, Horvath DJ, Li B, Cortado H, Newsom D, White P, Partida-Sanchez S, Justice SS. 2012. Intrauterine Growth Restriction Is a Direct Consequence of Localized Maternal Uropathogenic Escherichia coli Cystitis.  PLOS ONE. Vol. 7, no. 3. (March): ee33897.
• Ecke LE, Cleck JN, White P, Schug J, Mifflin L, Blendy JA. 2011. CREB-mediated alterations in the amygdala transcriptome: coordinated regulation of immune response genes following cocaine.  INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. Vol. 14, no. 8. (September): 1111-1126.
• Li Z, Schug J, Tuteja G, White P, Kaestner KH. 2011. The nucleosome map of the mammalian liver.  NATURE STRUCTURAL & MOLECULAR BIOLOGY. Vol. 18, no. 6. (June): 742-U145.
• Porat S, Weinberg-Corem N, Tomovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y. 2011. Control of Pancreatic beta Cell Regeneration by Glucose Metabolism.  CELL METABOLISM. Vol. 13, no. 4. (April): 440-449.
• White P. 2011. Profiling the miRNome: Detecting Global miRNA Expression Levels with DNA Microarrays. In RNA Interference Techniques. Edited by Harper, SQ. New York: Springer Science+Business Media, LLC.
• Popkie,AP, Zeidner,LC, Albrecht,AM, D'Ippolito,A, Eckardt,S, Newsom,DE, Groden,J, Doble,BW, Aronow,B, McLaughlin,KJ, White,P, Phiel,CJ. 2010. Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 285, no. 53. (December): 41337-41347.
• Simonson ML, Alessio HM, White P, Newsom DL, Hagerman AE. 2010. Acute physical activity effects on cardiac gene expression.  Experimental Physiology. Vol. 11, no. 95. (November): 1071-1080.
• Gu C; Stein GH; Pan N; Goebbels S; Hörnberg H; Nave KA; Herrera P; White P; Kaestner KH; Sussel L; Lee JE. 2010. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.  Cell Metabolism. Vol. 11, no. 4. (April): e298.
• Rieck S; White P; Schug J; Fox AJ; Smirnova O; Gao N; Gupta RK; Wang ZV; Scherer PE; Keller MP; Attie AD; Kaestner KH. 2009. The transcriptional response of the islet to pregnancy in mice.  Molecular Endocrinology (Baltimore, Md.). Vol. 23, no. 10. (October): e1702.
• Le Lay J; Tuteja G; White P; Dhir R; Ahima R; Kaestner KH. 2009. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.  Cell Metabolism. Vol. 10, no. 1. (July): 55-62. PubMed ID: 19583954
• Tuteja, G, White, P, Schug, J, Kaestner, KH. 2009. Extracting transcription factor targets from ChIP-Seq data.  Nucleic Acids Research. Vol. 17, no. 37. (January): ee113. PubMed ID: 19553195
• White P & Kaestner KH. 2009. Gene expression analysis in diabetes research. In Methods of Molecular Medicine: Type 2 Diabetes. Edited by Claire Stocker. New York, NY: The Humana Press Inc. PubMed ID: 19504254
• Anderson KR, White P, Kaestner KH, Sussle L. 2009. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.  BMC Developmental Biology. Vol. 1, no. 9. (January): e65. PubMed ID: 20003319
• Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. 2009. Foxa1 and Foxa2 regulate bile duct development in mice.  Journal of Clinical Investigation. Vol. 119, no. 6. (January): 1537-1545. PubMed ID: 19436110
• Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM. Oakey R, May CL, White P, Kaestner KH. 2009. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.  Mechanisms of Development. Vol. 126, no. 8-9. (January): e687. PubMed ID: 19501159
• Gao N, White P, Kaestner KH. 2009. Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2.  Developmental Cell. Vol. 16, no. 4. (January): 588-599. PubMed ID: 19386267
• Bochkis, IM, Rubins NE, White P, Friedman JR, Kaestner KH. 2008. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.  Nature Medicine. Vol. 14, no. 8. (January): 828-836. PubMed ID: 18660816
• Mullany LK, White P, Hanse EA, Nelsen CJ, Goggin MM, Mullany JE, Anttila CK, Greenbaum LE, Kaestner KH, Albrecht JH. 2008. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo.  Cell Cycle. Vol. 7, no. 14. (January): 2215-2224. PubMed ID: 18635970
• White P, Lee MC, Lamounier RN, Brestelli JE, Kaestner KH. 2008. Defining pancreatic endocrine precursors and their descendants.  Diabetes. Vol. 57, no. 3. (January): 654-668. PubMed ID: 18660816
• Tuteja G, Jensen ST, White P, Kaestner KH. 2008. Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.  Nucleic Acids Research. Vol. 36, no. 12. (January): 4149-4157. PubMed ID: 18556755
• Keller DM; McWeeney S; Arsenlis A; Drouin J; Wright CV; Wang H; Wollheim CB; White P; Kaestner KH; Goodman RH. 2007. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.  The Journal Of Biological Chemistry. Vol. 282, no. 44. (November): e32084.
• HardyOT, Hohmeier HE, Becker TC. Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH. 2007. Functional genomics of the beta-cell: Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.  MOLECULAR ENDOCRINOLOGY. Vol. 21, no. 3. (March): 765-773.
• Ku HT, Chai J, Kim YJ, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS. 2007. Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors.  Diabetes. Vol. 56, no. 4. (January): 921-929. PubMed ID: 17395739
• Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH. 2007. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.  Genes and Development. Vol. 21, no. 7. (January): 756-769. PubMed ID: 17403778
• Mazzarelli JM, Brestelli J, Gorski RK, Liu J, Manduchi E, Pinney DF, Schug J, White P, Kaestner KH, Stoeckert CJ Jr. 2007. EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.  Nucleic Acids Research. Vol. 35, no. January: D751-D755. PubMed ID: 17071715
• Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH. 2007. Functional genomics of the ß-cell: SCHAD regulates insulin secretion independent of K+ currents.  Molecular Endocrinology. Vol. 21, no. 3. (January): 765-773. PubMed ID: 17185391
• Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. 2007. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.  Cell Metabolism. Vol. 6, no. 4. (January): 267-279. PubMed ID: 17908556
• Mazzarelli JM, White P, Gorski R, Brestelli J, Pinney DF, Arsenlis A, Katokhin A, Belova O, Bogdanova V, Elisafenko E, Gubina M, Nizolenko L, Perelman P, Puzakov M, Shilov A, Trifonoff V, Vorobjeva N, Kolchanov N, Kaestner KH, Stoeckert CJ Jr. 2006. Novel genes identified by manual annotation and microarray expression analysis in the pancreas.  Genomics. Vol. 88, no. 6. (December): e752.
• Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA. 2006. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).  Gene. Vol. 369, no. January: 134-141. PubMed ID: 16412588
• White P, Brestelli JE, Kaestner KH, Greenbaum LE. 2005. Identification of transcriptional networks during liver regeneration.  Journal of Biological Chemistry. Vol. 280, no. 5. (January): 3715-3722. PubMed ID: 15546871
• Dauncey MJ and White P. 2004. Nutrition and cell communication: Insulin signalling in development, health and disease. In Recent Research Developments in Nutrition. Kerala: Research Signpost.
• Dauncey MJ, Katsumata M and White P. 2004. Nutrition, hormone receptor expression, and gene interactions: implications for development and disease. In Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. Oxfordshire: CAB International Publishing.
• White P, Liebhaber SA, Cooke NE. 2002. 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.  The Journal of Immunology. Vol. 168, no. 2. (January): 869-874. PubMed ID: 11777984
• Dauncey MJ, White P, Burton KA, Katsumata M. 2001. Nutrition-hormone receptor-gene interactions: implications for development and disease.  PROCEEDINGS OF THE NUTRITION SOCIETY. Vol. 60, no. 1. (February): 63-72.
• White P, Burton KA, Fowden AL and Dauncey MJ. 2001. Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles.  FASEB Journal. Vol. 15, no. 8. (January): 1367-1376. PubMed ID: 11387234
• Dauncey MJ, White P, Burton KA, and Katsumata M. 2001. Nutrition-hormone receptor-gene interactions: implications for development and disease.  Proceedings of the Nutrition Society. Vol. 60, no. 1. (January): 63-72. PubMed ID: 11310425
• 2000.
• Katsumata M, Cattaneo D, White P, Burton KA, Dauncey MJ. 2000. Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.  JOURNAL OF NUTRITION. Vol. 130, no. 10. (October): 2482-2488.
• White P and Cooke NE. 2000. The multifunctional properties and characteristics of Vitamin D Binding Protein.  Trends in Endocrinology and Metabolism. Vol. 11, no. 8. (January): 320-327. PubMed ID: 10996527
• White P, Cattaneo D and Dauncey MJ. 2000. Postnatal regulation of myosin heavy chain isoform and metabolic enzyme expression by nutrition.  British Journal of Nutrition. Vol. 84, no. 2. (January): 185-194. PubMed ID: 11029969
• Katsumata M, Cattaneo D, White P, Burton KA and Dauncey MJ. 2000. Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.  Journal of Nutrition (USA). Vol. 130, no. 10. (January): 2482-2488. PubMed ID: 11015477
• White P and Dauncey MJ. 1999. Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development.  Journal of Molecular Endocrinology. Vol. 23, no. 2. (January): 241-254. PubMed ID: 10514561
• White P, Burton KA, Cattaneo D, Harrison AP and Dauncey MJ. 1995. Biotechnological approach to the study of the interactions between nutritional status and animal growth. In State of the Art of Italian Research. Breshia: The Field of Biotechnologies Applied to Veterinary Medicine.
• Dauncey MJ, Burton KA, White P, Harrison AP, Gilmour RS, Duchamp C and Cattaneo D. 1994. Nutritional regulation of growth hormone receptor gene expression.  FASEB Journal. Vol. 8, no. 1. (January): 81-88. PubMed ID: 7507871