Peter White, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Peter White, Ph.D.

Peter  White, Ph.D.

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, Oh 43205 [ map ]
PH: (614) 722-5786
FX: (614) 722-2817
Email Me

Biography

Peter White, PhD is a principal investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University. He is Director of the Biomedical Genomics Core, a nationally recognized microarray and next-generation sequencing facility assisting numerous investigators in the design, production and analysis of genomics data. He is also Director of Molecular Bioinformatics, serving on the Research Computing Executive Governance Committee and the Data and Analytics Strategy Executive Committee. Dr. White has established multiple genomics initiatives as part of Nationwide Children's strategic goal to develop a cutting edge genomic medicine program. As developer and inventor of the balanced parallelization strategy for human genome analysis (named “Churchill”), Dr. White is a co-founder of GenomeNext LLC.

Dr. White’s research program focuses on developing high performance computing solutions for "big data", utilizing disruptive technologies to rapidly analyze and interpret genomic data sets. Through genomic analysis of individuals, families and populations, his team is discovering genetic variation associated with diseases such as congenital heart defects, autism spectrum disorders and rare genetic diseases.

Dr. White received his PhD in Molecular Biology from the University of Cambridge, England and completed his postdoctoral training in the Department of Genetics at The University of Pennsylvania, Philadelphia. He has over 15 years of experience in the field of genomics and computational biology, is the recipient of multiple awards from the National Institutes of Health and has authored over 50 peer reviewed publications.

View CV »

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. White’s research program at Nationwide Children's Hospital focuses on developing high performance computing solutions for "big data", utilizing disruptive technologies to rapidly analyze and interpret genomic data sets. Through genomic analysis of individuals, families and populations, his team is discovering genetic variation associated with diseases such as congenital heart defects, autism spectrum disorders and rare genetic diseases.

    Specialties: Genomics, bioinformatics, computational biology, molecular biology, genetics, cloud computing

Education and Training

Undergraduate School

  • Brunel University
    Date Completed: 06/30/1994

Doctoral

  • University of Cambridge
    Date Completed: 06/30/1998

Publications

  • Kelly B, Fitch JR, Hu Y, Corsmeier DY, Zhong H, Wetzel AN, Nordquist RD, Newsom DL, White P. 2015. Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetic variation in clinical and population-scale genomics.  Genome biology. Vol. 16, no. 6. (January): 1-14.
  • Naughton BJ, Duncan FJ, Murrey DA, Meadows AS, Newsom DE, Stoicea N, White P, Scharre DW, McCarty DM, Fu H. 2015. Blood Genome-Wide Transcriptional Profiles Reflect Broad Molecular Impairments and Strong Blood-Brain Links in Alzheimer's Disease.  Journal of Alzheimers Disease. Vol. 43, no. 1. (January): 93-108.
  • Kelly BJ, Fitch JR, Hu Y, Corsmeier DJ, Zhong H, Wetzel AN, Nordquist RD, Newsom DL, White P. 2015. Churchill: an ultra-fast, deterministic, highly scalable and balanced parallelization strategy for the discovery of human genetifc variation in clinical and poplulation-scale genomics.  Genome Biology. Vol. 16, no. 1. (January): e6.
  • Duncan FJ, Naughton BJ, Zaraspe K, Murrey DA, Meadows AS, Clark KR, Newsom DE, White P, Fu H, McCarty DM. 2015. Broad functional correction of molecular impairments by systemic delivery of scAAVrh74hSGSH gene delivery in MPS IIIA mice.  Journal of the American Society of Gene Therapy. Vol. 10, no. January: e1038.
  • Bonachea EM, Zender G, White P, Corsmeier D, Newsom D, Fitzgerald-Butt S, Garg V, McBride KL. 2014. Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve.  BMC Medical Genomics. Vol. 7, no. September: e56.
  • Elgamal S, Katz A, Hersch SJ, Newsom D, White P, Navarre WW, Ibba M. 2014. EF-P Dependent Pauses Integrate Proximal and Distal Signals during Translation.  PLoS Genetics. Vol. 10, no. 8. (August): ee1004553.
  • Santana EA, Harrison A, Zhang X, Baker BD, Kelly BJ, White P, Liu Y, Munson RS. 2014. HrrF Is the Fur-Regulated Small RNA in Nontypeable Haemophilus influenzae.  PLoS One. Vol. 9, no. 8. (August): ee105644.
  • Ali MM, Newsom DL, Gonzalez JF, Sabag-Daigle A, Stahl C, Steidley B, Dubena J, Dyszel JL, Smith JN, Dieye Y, Arsenescu R, Boyaka PN, Krakowka S, Romeo T, Behrman EJ, White P, Ahmer BM. 2014. Fructose-Asparagine Is a Primary Nutrient during Growth of Salmonella in the Inflamed Intestine.  PLoS Pathogens. Vol. 10, no. 6. (June): ee1004209.
  • Jones CJ, Newsom D, Kelly B, Irie Y, Jennings LK, Xu B, Limoli DH, Harrison JJ, Parsek MR, White P, Wozniak DJ. 2014. ChIP-Seq and RNA-Seq reveal an AmrZ-mediated mechanism for cyclic di-GMP synthesis and biofilm development by Pseudomonas aeruginosa.  PLoS Pathogens. Vol. 10, no. 3. (March): ee1003984.
  • Brownstein CA, Beggs AH, Homer N, Merriman B, Yu TW, Flannery KC, DeChene ET, Towne MC, Savage SK, Price EN, Holm IA, Luquette LJ, Lyon E, Majzoub J, Neupert P, McCallie D, Szolovits P, Willard HF, Mendelsohn NJ, Temme R, Finkel RS, Yum SW, Medne L, Sunyaev SR, Adzhubey I, Cassa CA, de Bakker PIW, Duzkale H, Dworzynski P, Fairbrother W, Francioli L, Funke BH, Giovanni MA, Handsaker RE, Lage K, Lebo MS, Lek M, Leshchiner I, MacArthur DG, McLaughlin HM, Murray MF, Pers TH, Polak PP, Raychaudhuri S, Rehm HL, Soemedi R, Stitziel NO, Vestecka S, Supper J, Gugenmus C, Klocke B, Hahn A, Schubach M, Menzel M, Biskup S, Freisinger P, Deng M, Braun M, Perner S, Smith RJH, Andorf JL, Huang J, Ryckman K, Sheffield VC, Stone EM, Bair T, Black-Ziegelbein EA, Braun TA, Darbro B, DeLuca AP, Kolbe DL, Scheetz TE, Shearer AE, Sompallae R, Wang K, Bassuk AG, Edens E, Mathews K, Moore SA, Shchelochkov OA, Trapane P, Bossler A, Campbell CA, Heusel JW, Kwitek A, Maga T, Panzer K, Wassink T, Van Daele D, Azaiez H, Booth Kl Meyer N, Segal MM, Williams MS, Tromp G, White P, Corsmeier D, Fitzgerald-Butt,S, Herman,G, Lamb-Thrush,D, McBride,KL, Newsom D, Pierson CR, Rakowsky AT, Maver A, Lovrecic L, Palandacic A, Peterlin B, Torkamani A. Wedell A, Huss M, Alexeyenko A, Lindvall JM, Magnusson M, Nilsson D, Stranneheim H, Taylan F, Gilissen C, Hoischen A, van Bon B, Yntema H, Nelen M, Zhang W, Sager J, Zhang L, Blair K, Kural D, Cariaso M, Lennon GG, Javed A, Agrawal S, Ng PC, Sandhu KS, Krishna S, Veeramachaneni V, Isakov O, Halperin E, Friedman E, Shomron N, Glusman G, Roach JC, Caballero J, Cox HC, Mauldin, D, Ament SA, Rowen L, Richards DR, San Lucas FA, Gonzalez-Garay ML, Caskey CT, BaiY, Huang Y, Fang F, Zhang,Y, Wang Z, Barrera J, Garcia-Lobo JM, Gonzalez-Lamuno D, Llorca J, Rodriguez MC, Varela I, Reese MG, De La Vega FM, Kiruluta E, Cargill M,Reece K, Sorenson JM, Lyon GJ, Stevenson DA, Bray BE, Moore BM, Eilbeck K, Yandell M, Zhao H, Hou L, Chen X, Yan X, Chen M, Li C, Yang C, Gunel M. 2014. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.  Genome Biology. Vol. 15, no. 3. (January): eR53.
  • The Cancer Genome Atlas Network, White P. 2013. Integrated genomic characterization of endometrial carcinoma.  Nature. Vol. 497, no. 7447. (May): 67-73.
  • Harrison A, Santana EA, Szelestey BR, Newsom DE, White P, Mason KM. 2013. The ferric uptake regulator and its role in the pathogenesis of nontypeable Haemophilus influenzea.  Infection and Immunity. Vol. 81, no. 4. (February): 1221-1233.
  • Lamounier RN, Coimbra CN, White P, Costal FL, Oliveira LS, Giannella 0, Neto D, Kaestner KH, Correa-Giannella ML. 2013. Apoptosis rate and trasncriptional response of pancreatic islets exposed to the PPAR gamma agonist Pioglitazone.  Diabetology and Metabolic Syndrome. Vol. 5, no. 1. (January): e1.
  • The Cancer Genome Atlas Network, White P. 2012. Comprehensive molecular portraits of human breast tumors.  Nature. Vol. 490, no. October: 61-70.
  • Cancer Genome Atlas Nework, White P. 2012. Comprehensive molecular characterization of human colon and rectal cancer.  Nature. Vol. 487, no. 7407. (July): 330-337.
  • Bolton M, Horvath DJ, Li B, Cortado H, Newsom D, White P, Partida-Sanchez S, Justice SS. 2012. Intrauterine Growth Restriction Is a Direct Consequence of Localized Maternal Uropathogenic Escherichia coli Cystitis.  PloS One. Vol. 7, no. 3. (March): ee33897.
  • Ecke LE, Cleck JN, White P, Schug J, Mifflin L, Blendy JA. 2011. CREB-mediated alterations in the amygdala transcriptome: coordinated regulation of immune response genes following cocaine.  International Journal of Neuropsychopharmacy. Vol. 14, no. 8. (September): 1111-1126.
  • Li Z, Schug J, Tuteja G, White P, Kaestner KH. 2011. The nucleosome map of the mammalian liver.  Nature Structural & Molecular Biology. Vol. 18, no. 6. (June): 742-746.
  • Porat S, Weinberg-Corem N, Tomovsky-Babaey S, Schyr-Ben-Haroush R, Hija A, Stolovich-Rain M, Dadon D, Granot Z, Ben-Hur V, White P, Girard CA, Karni R, Kaestner KH, Ashcroft FM, Magnuson MA, Saada A, Grimsby J, Glaser B, Dor Y. 2011. Control of Pancreatic beta Cell Regeneration by Glucose Metabolism.  Cell Metabolism. Vol. 13, no. 4. (April): 440-449.
  • White P. 2011. Profiling the miRNome: Detecting Global miRNA Expression Levels with DNA Microarrays. In RNA Interference Techniques. Edited by Harper, SQ. New York: Springer Science+Business Media, LLC.
  • Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. 2010. Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci.  Journal of Biological Chemistry. Vol. 285, no. 53. (December): 41337-41347.
  • Simonson ML, Alessio HM, White P, Newsom DL, Hagerman AE. 2010. Acute physical activity effects on cardiac gene expression.  Experimental Physiology. Vol. 11, no. 95. (November): 1071-1080.
  • Gu C, Stein GH, Pan N, Goebbels S, Hörnberg H, Nave KA, Herrera P, White P, Kaestner KH, Sussel L, Lee JE. 2010. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.  Cell Metabolism. Vol. 11, no. 4. (April): e298.
  • Rieck S, White P, Schug J, Fox AJ, Smirnova O, Gao N, Gupta RK, Wang ZV, Scherer PE, Keller MP, Attie AD, Kaestner KH. 2009. The transcriptional response of the islet to pregnancy in mice.  Molecular Endocrinology. Vol. 23, no. 10. (October): e1702.
  • Le Lay J, Tuteja G, White P, Dhir R, Ahima R, Kaestner KH. 2009. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.  Cell Metabolism. Vol. 10, no. 1. (July): 55-62. PubMed ID: 19583954
  • White P, Kaestner KH. 2009. Gene expression analysis in diabetes research.  Methods in molecular biology. Vol. 560, no. June: 239-61.
  • Tuteja G, White P, Schug J, Kaestner KH. 2009. Extracting transcription factor targets from ChIP-Seq data.  Nucleic Acids Research. Vol. 17, no. 37. (January): ee113. PubMed ID: 19553195
  • White P and Kaestner KH. 2009. Gene expression analysis in diabetes research. In Methods of Molecular Medicine: Type 2 Diabetes. Edited by Claire Stocker. New York, NY: The Humana Press Inc. PubMed ID: 19504254
  • Anderson KR, White P, Kaestner KH, Sussle L. 2009. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.  BMC Developmental Biology. Vol. 1, no. 9. (January): e65. PubMed ID: 20003319
  • Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. 2009. Foxa1 and Foxa2 regulate bile duct development in mice.  Journal of Clinical Investigation. Vol. 119, no. 6. (January): 1537-1545. PubMed ID: 19436110
  • Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM, Oakey R, May CL, White P, Kaestner KH. 2009. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.  Mechanisms of Development. Vol. 126, no. 8-9. (January): e687. PubMed ID: 19501159
  • Gao N, White P, Kaestner KH. 2009. Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2.  Developmental Cell. Vol. 16, no. 4. (January): 588-599. PubMed ID: 19386267
  • White P, Kaestner KH. 2009. Gene expression analysis in diabetes research.  Methods in Molecular Biology. Vol. 560, no. January: 239-261.
  • Bochkis IM, Rubins NE, White P, Friedman JR, Kaestner KH. 2008. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.  Nature Medicine. Vol. 14, no. 8. (January): 828-836. PubMed ID: 18660816
  • Mullany LK, White P, Hanse EA, Nelsen CJ, Goggin MM, Mullany JE, Anttila CK, Greenbaum LE, Kaestner KH, Albrecht JH. 2008. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo.  Cell Cycle. Vol. 7, no. 14. (January): 2215-2224. PubMed ID: 18635970
  • White P, Lee MC, Lamounier RN, Brestelli JE, Kaestner KH. 2008. Defining pancreatic endocrine precursors and their descendants.  Diabetes. Vol. 57, no. 3. (January): 654-668. PubMed ID: 18660816
  • Tuteja G, Jensen ST, White P, Kaestner KH. 2008. Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site.  Nucleic Acids Research. Vol. 36, no. 12. (January): 4149-4157. PubMed ID: 18556755
  • Keller DM, McWeeney S, Arsenlis A; Drouin J, Wright CV, Wang H, Wollheim CB, White P, Kaestner KH, Goodman RH. 2007. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.  The Journal of Biological Chemistry. Vol. 282, no. 44. (November): e32084.
  • Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ, Matschinsky FM, Newgard CB, Kaestner KH. 2007. Functional genomics of the beta-cell: Short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents.  Molecular Endocrinology. Vol. 21, no. 3. (March): 765-773.
  • Ku HT, Chai J, Kim YJ, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS. 2007. Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors.  Diabetes. Vol. 56, no. 4. (January): 921-929. PubMed ID: 17395739
  • Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH. 2007. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.  Genes and Development. Vol. 21, no. 7. (January): 756-769. PubMed ID: 17403778
  • Mazzarelli JM, Brestelli J, Gorski RK, Liu J, Manduchi E, Pinney DF, Schug J, White P, Kaestner KH, Stoeckert CJ Jr. 2007. EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.  Nucleic Acids Research. Vol. 35, no. January: D751-D755. PubMed ID: 17071715
  • Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH. 2007. Functional genomics of the ß-cell: SCHAD regulates insulin secretion independent of K+ currents.  Molecular Endocrinology. Vol. 21, no. 3. (January): 765-773. PubMed ID: 17185391
  • Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. 2007. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.  Cell Metabolism. Vol. 6, no. 4. (January): 267-279. PubMed ID: 17908556
  • Mazzarelli JM, White P, Gorski R, Brestelli J, Pinney DF, Arsenlis A, Katokhin A, Belova O, Bogdanova V, Elisafenko E, Gubina M, Nizolenko L, Perelman P, Puzakov M, Shilov A, Trifonoff V, Vorobjeva N, Kolchanov N, Kaestner KH, Stoeckert CJ Jr. 2006. Novel genes identified by manual annotation and microarray expression analysis in the pancreas.  Genomics. Vol. 88, no. 6. (December): e752.
  • Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA. 2006. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).  Gene. Vol. 369, no. January: 134-141. PubMed ID: 16412588
  • White P, Brestelli JE, Kaestner KH, Greenbaum LE. 2005. Identification of transcriptional networks during liver regeneration.  Journal of Biological Chemistry. Vol. 280, no. 5. (January): 3715-3722. PubMed ID: 15546871
  • Dauncey MJ and White P. 2004. Nutrition and cell communication: Insulin signalling in development, health and disease. In Recent Research Developments in Nutrition. Kerala: Research Signpost.
  • Dauncey MJ, Katsumata M and White P. 2004. Nutrition, hormone receptor expression, and gene interactions: implications for development and disease. In Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. Oxfordshire: CAB International Publishing.
  • White P, Liebhaber SA, Cooke NE. 2002. 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.  The Journal of Immunology. Vol. 168, no. 2. (January): 869-874. PubMed ID: 11777984
  • Dauncey MJ, White P, Burton KA, Katsumata M. 2001. Nutrition-hormone receptor-gene interactions: implications for development and disease.  Proceedings of the Nutrition Society. Vol. 60, no. 1. (February): 63-72.
  • White P, Burton KA, Fowden AL, Dauncey MJ. 2001. Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles.  FASEB Journal. Vol. 15, no. 8. (January): 1367-1376. PubMed ID: 11387234
  • Dauncey MJ, White P, Burton KA, and Katsumata M. 2001. Nutrition-hormone receptor-gene interactions: implications for development and disease.  Proceedings of the Nutrition Society. Vol. 60, no. 1. (January): 63-72. PubMed ID: 11310425
  • 2000.
  • Katsumata M, Cattaneo D, White P, Burton KA, Dauncey MJ. 2000. Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.  Journal of Nutrition. Vol. 130, no. 10. (October): 2482-2488.
  • White P,Cooke NE. 2000. The multifunctional properties and characteristics of vitamin D binding protein.  Trends in Endocrinology and Metabolism. Vol. 11, no. 8. (January): 320-327. PubMed ID: 10996527
  • White P, Cattaneo D and Dauncey MJ. 2000. Postnatal regulation of myosin heavy chain isoform and metabolic enzyme expression by nutrition.  British Journal of Nutrition. Vol. 84, no. 2. (January): 185-194. PubMed ID: 11029969
  • Katsumata M, Cattaneo D, White P, Burton KA and Dauncey MJ. 2000. Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.  Journal of Nutrition (USA). Vol. 130, no. 10. (January): 2482-2488. PubMed ID: 11015477
  • White P, Dauncey MJ. 1999. Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development.  Journal of Molecular Endocrinology. Vol. 23, no. 2. (January): 241-254. PubMed ID: 10514561
  • White P, Burton KA, Cattaneo D, Harrison AP and Dauncey MJ. 1995. Biotechnological approach to the study of the interactions between nutritional status and animal growth. In State of the Art of Italian Research. Breshia: The Field of Biotechnologies Applied to Veterinary Medicine.
  • Dauncey MJ, Burton KA, White P, Harrison AP, Gilmour RS, Duchamp C, Cattaneo D. 1994. Nutritional regulation of growth hormone receptor gene expression.  FASEB Journal. Vol. 8, no. 1. (January): 81-88. PubMed ID: 7507871

Awards, Honors and Organizations

  • Member, International Society for Computational Biology (ISCB), 2011-Present
  • Member, American Society of Human Genetics (ASHG), 2010-Present
  • Member, Association of Biomolecular Resource Facilities (ABRF), 2009-Present
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000