Peter White, Ph.D.

Peter White, PhD is a principal investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University. He is also Director of Molecular Bioinformatics, serving on the research computing executive governance committee, and Director of the Biomedical Genomics Core, a nationally recognized microarray and next-gen sequencing facility that help numerous investigators design, perform and analyze genomics research. His research program focuses on molecular bioinformatics and high performance computing solutions for “big data”, including discovery of disease associated human genetic variation and understanding the molecular mechanism of transcriptional regulation in both eukaryotes and prokaryotes.

View CV »

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Microbial Pathogenesis

Areas of Interest:

• The focus of our laboratory is in the area of Biomedical Genomics, developing and using state of the art genomic technologies to investigate and understand the mechanisms of transcriptional regulation as it relates to human health and disease. Our approach is to utilize DNA microarray technologies to produce genome wide expression profiles, of both mRNAs and small RNAs, SNP analysis, array CGH, and promoter occupancy analysis. In addition to the array based application we are also exploring the tremendous possibilities of Next Generation Sequencing technologies. Together with the Research Faculty here at Nationwide Children’s Hospital we are utilizing the genomic information gained from these technologies to better understand, treat and prevent human disease.

Medical School

• University of Cambridge
  Date Completed: 06/30/1998

• Porat S; Weinberg-Corem N; Tornovsky-Babaey S; Schyr-Ben-Haroush R; Hija A; Stolovich-Rain M; Dadon D; Granot Z; Ben-Hur V; White P; Girard CA; Karni R; Kaestner KH; Ashcroft FM; Magnuson MA; Saada A; Grimsby J; Glaser B; Dor Y. 2011. Control of pancreatic ? cell regeneration by glucose metabolism.  Cell Metabolism. Vol. 13, no. 4. (April 6): 440-449.
• White, P. 2011. Profiling the miRNome: Detecting Global miRNA Expression Levels with DNA Microarrays. In RNA Interference Techniques. Neuromethods. Vol. 58. Edited by Harper, SQ. New York: Springer Science+Business Media, LLC.
• Li, Z., Schug, J., Tuteja, G., White, P. and Kaestner, K.H. 2011. The nucleosome map of the mammalian liver.  Nature Structural and Molecular Biology. Vol. 18, no. 6. : 742-747.
• Harper SQ, ed. 2011. Profiling the miRNome: Detecting global miRNA expression levels with DNA microarrays. In" RNA Interference Techniques. New York, NY, USA: Humana Press, c/o Springer Science+Business Media, LLC.
• Popkie AP; Zeidner LC; Albrecht AM; D'Ippolito A; Eckardt S; Newsom DE; Groden J; Doble BW; Aronow B; McLaughlin KJ; White P; Phiel CJ. 2010. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci.  The Journal Of Biological Chemistry. Vol. 285, no. 53. (December 31): 41337.
• Simonson ML, Alessio HM, White P, Newsom DL, Hagerman AE. 2010. Acute physical activity effects on cardiac gene expression.  Experimental Physiology. Vol. 11, no. 95. (November): 1071-1080.
• Gu C; Stein GH; Pan N; Goebbels S; Hörnberg H; Nave KA; Herrera P; White P; Kaestner KH; Sussel L; Lee JE. 2010. Pancreatic beta cells require NeuroD to achieve and maintain functional maturity.  Cell Metabolism. Vol. 11, no. 4 (April 7): 298.
• Rieck S; White P; Schug J; Fox AJ; Smirnova O; Gao N; Gupta RK; Wang ZV; Scherer PE; Keller MP; Attie AD; Kaestner KH. 2009. The transcriptional response of the islet to pregnancy in mice.  Molecular Endocrinology (Baltimore, Md.). Vol. 23, no. 10. (October 1): 1702.
• Le Lay J; Tuteja G; White P; Dhir R; Ahima R; Kaestner KH. 2009. CRTC2 (TORC2) contributes to the transcriptional response to fasting in the liver but is not required for the maintenance of glucose homeostasis.  Cell Metabolism. Vol. 10, no. 1. (July 1): 55-62. . PubMed ID: 19583954
• Li Z, White P, Tuteja G, Rubins N, Sackett S, Kaestner KH. 2009. Foxa1 and Foxa2 regulate bile duct development in mice.  Journal of Clinical Investigation. Vol. 119, no. 6. : 1537-1545. . PubMed ID: 19436110
• Golson ML, Le Lay J, Gao N, Brämswig N, Loomes KM. Oakey R, May CL, White P, Kaestner KH. 2009. Jagged1 is a competitive inhibitor of Notch signaling in the embryonic pancreas.  Mechanisms of Development. Vol. 126, no. 8-9. : 687. . PubMed ID: 19501159
• Tuteja, Geetu. White, Peter. Schug, Jonathan. Kaestner, Klaus H. 2009. Extracting transcription factor targets from ChIP-Seq data.  Nucleic Acids Research. Vol. 17, no. 37: e113. . PubMed ID: 19553195
• Anderson KR, White P, Kaestner KH, Sussle L. 2009. Identification of known and novel pancreas genes expressed downstream of Nkx2.2 during development.  BMC Developmental Biology. Vol. 1, no. 9. . PubMed ID: 20003319
• White P & Kaestner KH. 2009. Gene expression analysis in diabetes research. In Methods of Molecular Medicine: Type 2 Diabetes. Vol. 560. Edited by Claire Stocker. New York, New York, USA: The Humana Press Inc. 239-261. PubMed ID: 19504254
• Gao N, White P, Kaestner KH. 2009. Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2.  Developmental Cell. Vol. 16, no. 4. : 588-599. . PubMed ID: 19386267
• Bochkis, IM, Rubins NE, White P, Friedman JR, Kaestner KH. 2008. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress.  Nature Medicine. Vol. 14, no. 8: 828-836. . (IF: 26.382) PubMed ID: 18660816
• Tuteja G, Jensen ST, White P, Kaestner KH. 2008. Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Research. Vol. 36, no. 12: 4149-4157. . (IF: 6.954) PubMed ID: 18556755
• White P, Lee MC, Lamounier RN, Brestelli JE, Kaestner KH. 2008. Defining pancreatic endocrine precursors and their descendants.  Diabetes. Vol. 57, no. 3. : 654-668. . (IF: 8.261) PubMed ID: 18660816
• Mullany LK, White P, Hanse EA, Nelsen CJ, Goggin MM, Mullany JE, Anttila CK, Greenbaum LE, Kaestner KH, Albrecht JH. 2008. Distinct proliferative and transcriptional effects of the D-type cyclins in vivo. Cell Cycle. Vol. 7, no. 14: 2215-2224. . (IF: 3.314) PubMed ID: 18635970
• Keller DM; McWeeney S; Arsenlis A; Drouin J; Wright CV; Wang H; Wollheim CB; White P; Kaestner KH; Goodman RH. 2007. Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy.  The Journal Of Biological Chemistry. Vol. 282, no. 44. (November 2): 32084.
• Mazzarelli JM, Brestelli J, Gorski RK, Liu J, Manduchi E, Pinney DF, Schug J, White P, Kaestner KH, Stoeckert CJ Jr. 2007. EPConDB: a web resource for gene expression related to pancreatic development, beta-cell function and diabetes.  Nucleic Acids Research. Vol. 35. : D751-D755. . PubMed ID: 17071715
• Hardy OT, Hohmeier HE, Becker TC, Manduchi E, Doliba NM, Gupta RK, White P, Stoeckert CJ Jr, Matschinsky FM, Newgard CB, Kaestner KH. 2007. Functional genomics of the ß-cell: SCHAD regulates insulin secretion independent of K+ currents.  Molecular Endocrinology. Vol. 21, no. 3: 765-773. . PubMed ID: 17185391
• Gupta RK, Gao N, Gorski RK, White P, Hardy OT, Rafiq K, Brestelli JE, Chen G, Stoeckert CJ Jr, Kaestner KH. 2007. Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha.  Genes and Development. Vol. 21, no. 7: 756-769. . PubMed ID: 17403778
• Gao N, White P, Doliba N, Golson ML, Matschinsky FM, Kaestner KH. 2007. Foxa2 controls vesicle docking and insulin secretion in mature Beta cells.  Cell Metabolism. Vol. 6, no. 4: 267-279. . PubMed ID: 17908556
• Ku HT, Chai J, Kim YJ, White P, Purohit-Ghelani S, Kaestner KH, Bromberg JS. 2007. Insulin-expressing colonies developed from murine embryonic stem cell-derived progenitors.  Diabetes. Vol. 56, no. 4: 921-929. . PubMed ID: 17395739
• Mazzarelli JM; White P; Gorski R; Brestelli J; Pinney DF; Arsenlis A; Katokhin A; Belova O; Bogdanova V; Elisafenko E; Gubina M; Nizolenko L; Perelman P; Puzakov M; Shilov A; Trifonoff V; Vorobjeva N; Kolchanov N; Kaestner KH; Stoeckert CJ Jr. 2006. Novel genes identified by manual annotation and microarray expression analysis in the pancreas.  Genomics. Vol. 88, no. 6. (December 1): 752.
• Burkhardt BR, Greene SR, White P, Wong RK, Brestelli JE, Yang J, Robert CE, Brusko TM, Wasserfall CH, Wu J, Atkinson MA, Gao Z, Kaestner KH, Wolf BA. 2006. PANDER-induced cell-death genetic networks in islets reveal central role for caspase-3 and cyclin-dependent kinase inhibitor 1A (p21).  Gene. Vol. 369: 134-141. . PubMed ID: 16412588
• White P, Brestelli JE, Kaestner KH, Greenbaum LE (2005). Identification of transcriptional networks during liver regeneration. Journal of Biological Chemistry; 280(5): 3715-3722. PubMed ID: 15546871
• White P, Brestelli JE, Kaestner KH, Greenbaum LE. 2005. Identification of transcriptional networks during liver regeneration.  Journal of Biological Chemistry. Vol. 280, no. 5: 3715-3722. . PubMed ID: 15546871
• Dauncey MJ, Katsumata M and White P. 2004. Nutrition, hormone receptor expression, and gene interactions: implications for development and disease. In Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. Oxfordshire, UK: CAB International Publishing. 105-124.
• te Pas MFW, Everts ME and Haagsman HP, ed. 2004. Nutrition, hormone receptof expression, and gene interactions: implications for development and disease. in: Muscle Development of Livestock Animals: Physiology, Genetics and Meat Quality. Oxfordshire, UK: CAB International Publishing.
• Dauncey MJ and White P. 2004. Nutrition and cell communication: Insulin signalling in development, health and disease. In Recent Research Developments in Nutrition. Kerala, India: Research Signpost. 49-81.
• Palli SR, Kapitskaya M, Kumar M, Kumar P, White P, Hoff III H, and Cress DE. 2002. Ecdysone receptorbasedinducible gene regulation systems for simultaneous regulation of two genes. [Abstract]. Molecular Therapy. Vol. 5, no. 5: S169-512. [Peer Reviewed] (Published)
• White P, Liebhaber SA, Cooke NE. 2002. 129X1/SvJ mouse strain has a novel defect in inflammatory cell recruitment.  The Journal of Immunology. Vol. 168, no. 2: 869-874. . PubMed ID: 11777984
• White P, Burton KA, Fowden AL and Dauncey MJ. 2001. Developmental expression analysis of thyroid hormone receptor isoforms reveals new insights into their essential functions in cardiac and skeletal muscles.  FASEB Journal. Vol. 15, no. 8: 1367-1376. . PubMed ID: 11387234
• Dauncey MJ, White P, Burton KA, and Katsumata M. 2001. Nutrition-hormone receptor-gene interactions: implications for development and disease.  Proceedings of the Nutrition Society. Vol. 60, no. 1: 63-72. . PubMed ID: 11310425
• 2000. Review of The multifunctional properties and characteristics of vitamin D-binding protein., by White P; Cooke N. (October 1): 320. (Published)
• White P, Cattaneo D and Dauncey MJ. 2000. Postnatal regulation of myosin heavy chain isoform and metabolic enzyme expression by nutrition.  British Journal of Nutrition. Vol. 84, no. 2: 185-194. . PubMed ID: 11029969
• White P, Murphy ML, Farrell JP, Hunter CA, Liebhaber SA and Cooke NE. 2000. The absence of vitamin D binding protein (DBP) slows immune responses during Leishmania donovani infection in vivo. [Abstract]. FASEB Journal. Vol. 6, no. 14: A1031-91.23. [Peer Reviewed] (Published)
• White P and Cooke NE. 2000. The multifunctional properties and characteristics of Vitamin D Binding Protein.  Trends in Endocrinology and Metabolism. Vol. 11, no. 8: 320-327. . PubMed ID: 10996527
• Katsumata M, Cattaneo D, White P, Burton KA and Dauncey MJ. 2000. Growth hormone receptor gene expression in porcine skeletal and cardiac muscles is selectively regulated by postnatal undernutrition.  Journal of Nutrition (USA). Vol. 130, no. 10: 2482-2488. . PubMed ID: 11015477
• White P and Dauncey MJ. 1999. Differential expression of thyroid hormone receptor isoforms is strikingly related to cardiac and skeletal muscle phenotype during postnatal development.  Journal of Molecular Endocrinology. Vol. 23, no. 2: 241-254. . PubMed ID: 10514561
• White P and Dauncey MJ. 1998. Postnatal undernutrition markedly upregulates cardiac ?1 and ?2 thyroidhormone receptor gene expression. [Abstract]. Proceedings of the Nutrition Society. Vol. 1, no. 57: 79A. [Peer Reviewed] (Published)
• White P, Lachuer J, Duchamp C and Dauncey MJ. 1997. Porcine thyroid hormone receptor isoforms: cloning and expression in liver and functionally distinct muscles. [Abstract]. Journal of Endocrinology. no. 152: P306. (Published)
• White P, Burton KA, Cattaneo D, Harrison AP and Dauncey MJ. 1995. Biotechnological approach to the study of the interactions between nutritional status and animal growth. In State of the Art of Italian Research. Breshia, Italy: The Field of Biotechnologies Applied to Veterinary Medicine. 271-279.
• Dauncey MJ, Burton KA, White P, Harrison AP, Gilmour RS, Duchamp C and Cattaneo D. 1994. Nutritional regulation of growth hormone receptor gene expression.  FASEB Journal. Vol. 8, no. 1: 81-88. . PubMed ID: 7507871
• Peter White, David Newsom, Huachun Zhong and Kim McBride, Lecturer. 2011. Whole-Exome Sequencing Identifies an Autosomal Recessive Mutation in Familial Congenital Heart Disease. Presented at Advances in Genome Biology and Technology Conference. Marco Island Marriott Beach Resort, Golf Club & Spa. Marco Island, FL, USA. (February)
• Harrison, A., Baker, B., Newsom, D., White, P., and Munson Jr., R., Poster Presenter. 2011. The RpoE regulon in nontypeable Haemophilus influenzae. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• White, P., Sowby, W. and Newsom, D., Poster Presenter. 2010. Elucidating the genomic and epigenomic mechanisms of nutritionally regulated developmental programming. Presented at 2010 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 5)
• White, P., Sowby, W. and Newsom, D., Poster Presenter. 2010. Elucidating the genomic and epigenomic mechanisms of nutritionally regulated developmental programming. Presented at 2010 International Conference on Developmental Origins of Health and Disease. Munich, Germany. (May 7)
• White P, Brestelli JE, Arsenlis A, Gorski RK, Chen G, He H, Mazzarelli JM, Manduchi E, Stoeckert CJ Jr. and Kaestner KH, Poster Presenter. 2005. The human and mouse PancChips: high throughput gene expression analysis of the endocrine pancreas. Presented at Diabetes Mellitus Keystone Symposia. Keystone, CO, USA.
• Peter White, Ph.D., Lecturer. 2011. Needle in a haysatck: Finding causal variants in whole-exome and whole-genome sequencing data. Presented at Epigenomics Group Meeting. Columbus, Ohio, USA. (February)
• Newsom, D., Sowby, W., Zhong, H., Hu, P, Geier, B., Casper, T. and White, P., Poster Presenter. 2011. The Biomedical Genomics Core. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• White P, Brestelli JE, Gorski RK, Arsenlis A, Lee PP, Pizzaro A, Stoeckert CJ Jr. and Kaestner KH, Lecturer. 2003. PancChip 5.0: high throughput gene expression analysis of the endocrine pancreas. Presented at Beta Cell Biology Consortium Investigator Retreat. Atlanta, GA, USA.
• Casper, T., Hu, P., Geier, B., Zhong, H., Newsom, D. and White, P., Poster Presenter. 2011. Surfing the HiSeq 2000 Data Tsunami. Presented at 2011 Annual Research Conference,The Research Institute at Nationwide Children's Hospital. Columbus, Ohi, USA. (April 6)
• White, Peter, Poster Presenter. 2010. The Biomedical Genomics Core. Presented at Association of Biomolecular Resource Facilities (ABRF)2010. Sacremento, CA, USA.
• Peter White, Ph.D., Lecturer. 2011. Needle in a haysatck: Finding causal variants in whole-exome and whole-genome sequencing data. Presented at Cytogenetics/Molecular Genetics Lab Meeting. Columbus, Ohio, USA. (April)
• White, Peter. Sowby, Whitney. Newsom, David, Poster Presenter. 2010. Elucidating the Genomic and Epigenomic Mechanismsof Nutritionally Regulated Developmental Programming. Presented at The Power of Programming, International Conference on the Developmental Origins of Health and Disease. Munich, Germany.
• Hu, Y., Newsom, D., Zhong, H., Casper, T., Geier, B. and White, P., Poster Presenter. 2011. Exome Capture and Sequencing Using the HiSeq 2000. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• White, P., Lecturer. 2011. Whole-Exome Sequencing Identifies an Autosomal Recessive Mutation in Familial Congenital Heart Disease. Presented at 2011 Advances in Genome Biology & Technology Conference (AGBT). Marco Island, Flofida, USA. (February 4)
• Baker, B.D., Harrison, A., Newsom, D.L., White, P. and Munson, Jr., R.S., Poster Presenter. 2011. The RpoE regulon in nontypeable Haemophilus influenzae. Presented at ASM 2011, to American Society for Microbiology. New Orleans, Louisiana, USA. (May)
• White, P., Lecturer. 2010. The Biomedical Genomics Core. Presented at OSU CCC 2010 Biomedical Resources Workshop. Columbus, Ohio, USA. (September 27)
• White, P., Lecturer. 2011. Needle in a haystack: Finding casual variants in whole-exome and whole-genome sequencing data. to The Department of Pharmacology. The Ohio State University. Columbus, Ohio, USA. (January 20)
• Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR and Kaestner KH, Poster Presenter. 2008. Foxa2 regulates bile acid metabolism and prevents ER stress in the liver. Presented at Forkhead Transcription Factor Networks in Development,Signaling, and Disease Keystone Symposia. Midway, UT, USA.
• White, P., Lecturer. 2010. Genomics at Nationwide Children's Hosptial. Presented at OSU CCC Genomics Consortium Meeting. Columbus, Ohio, USA. (October 12)
• Sanatan, E., Hu, P., White, P., Munson Jr., R. and Harrison, A., Poster Presenter. 2011. A whole transcriptome analysis of nontypeable Haemophilus influenzae. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• White P, Smirnova OS, Fox AJ, Tuteja G and Kaestner KH, Poster Presenter. 2007. The Functional Genomics Core. Presented at Annual IDOM Symposium & Spring Genomics Workshop. University of Pennsylvania. Phildadelphia, PA, USA.
• , Lecturer. 2011. Genomics at NCH. Presented at Nationwide Children's Hospital and Battelle Collaboration Workshop. Columbus, Ohio, USA. (May)
• Newsom, D. and White, P., Poster Presenter. 2010. The Biomedical Genomics Core. Presented at 2010 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 5)
• Dauncey MJ and White P, Poster Presenter. 2002. Nutrition-hormone receptor-gene interactions in health and development. Presented at European Association of Animal Production Symposium. Cairo, Egypt.
• Banks III, W., Hansen, E., Cunningham, D., Varga, E., Evans, J., Butter, E., White, P., Geier, B., McBride, K., Zernzach, T. and Herman, G., Poster Presenter. 2011. Analysis of Candidate Genes for ASDs within the Central Ohio Registry for Autism. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• Geier, B., Kurmasheve, R., White, P., and Houghton, P., Poster Presenter. 2011. Evaluating pediatric preclinical trial therapeutics. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• Sowby, W., Nick, E., Rudraraju, S., Zhong, H., Newsom, D. and White, P., Poster Presenter. 2011. Elucidating the Gemonic and Epigenomic Mechanisms of Nutritionally Regulated Developmental Programming. Presented at 2011 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 6)
• White, P., Lecturer. 2010. Next Generation Sequencing at Nationwide Children's Hospital. Presented at The Battelle Whole Genome Sequencing Collaborative Group. Columbus, Ohio, USA. (November 4)
• White P, Tuteja G, Schug J, Gorski RK, Stoeckert CJ and Kaestner KH, Poster Presenter. 2006. The Mouse PromoterChip BCBC-5: A Powerful Tool for Genome-wide Location Analysis. Presented at IBC Chips-to-Hits Symposia. Boston, MA, USA.
• White P, A. Arsenlis, O. Smirnova and Kaestner KH, Poster Presenter. 2006. The BCBC Functional Genomics Core. Presented at Beta Cell Biology Consortium Investigator Retreat. Boston, MA, USA.
• White P, Brestelli JE, Gorski RK, Arsenlis A, Lee PP, Pizzaro A, Stoeckert CJ Jr. and Kaestner KH, Poster Presenter. 2003. PancChip 5.0: high throughput gene expression analysis of the endocrine pancreas. Presented at Beta Cell Biology Consortium Investigator Retreat. Atlanta, GA, USA.
• Zheng, M., Newsom, D., Sowby, W. and White, P., Poster Presenter. 2010. IUGR Results in Delated Islet Formation and a Significantly Reduced Beta Cell Mass. Presented at 2010 Annual Research Conference, The Research Institute at Nationwide Children's Hospital. Columbus, Ohio, USA. (April 5)
• Newsom, David. Wang, Meng. White, Peter, Poster Presenter. 2010. Sample Labeling and Analysis Approaches for theAffymetrix Whole-Transcript Gene ST Array. Presented at Association of Biomolecular Resource Facilities (ABRF) 2010. Sacremento, CA, USA.
• Dauncey MJ, White P and Burton KA, Poster Presenter. 2000. Nuclear thyroid hormone receptors and nutrition: developmental and functional significance. Presented at Rank Prize Funds Symposium. UK.