The Neurology Team


 

E. Steve Roach, MD - Chief of Neurology

Steve Roach, MD

Dr. Roach is Chief of the Division of Pediatric Neurology and Vice-Chair of Pediatrics at Nationwide Children’s Hospital. He is also Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Roach wrote the first textbook on cerebrovascular disorders in children and has written or co-authored five other books along with more than 200 articles and book chapters on stroke and genetic disorders. Dr. Roach was awarded the 2002 Manuel Gomez Award by the Tuberous Sclerosis Alliance in Bethesda, Maryland, for his work to improve our understanding of tuberous sclerosis. Dr. Roach was named among the “Best Doctors in America” in 2009.

Recent publications:
Roach ES. The cost of gullibility. Arch Neurol. 2009 Nov; 66(11): 1418-20.

Jen JC, Klein A, Boltshauser E, Cartwright MS, Roach ES, Mamsa H, Baloh RW. Prolonged hemiplegic episodes in children due to mutations in ATP1A2. J Neurol Neurosurg Psychiatry. 2007 May; 78(5): 523-6.

Au KS, Williams AT, Roach ES, Batchelor L, Sparagana SP, Delgado MR, Wheless JW, Baumgartner JE, Roa BB, Wilson CM, Smith-Knuppel TK, Cheung MY, Whittemore VH, King TM, Northrup H. Genotype/phenotype correlation in 325 individuals referred for a diagnosis of tuberous sclerosis complex in the United States. Genet Med. 2007 Feb; 9(2): 88-100.

Roach ES, Golomb MR, Adams R, Biller J, Daniels S, Deveber G, Ferriero D, Jones BV, Kirkham FJ, Scott RM, Smith ER; American Heart Association Stroke Council; Council on Cardiovascular Disease in the Young. Management of stroke in infants and children: a scientific statement from a Special Writing Group of the American Heart Association Stroke Council and the Council on Cardiovascular Disease in the Young. Stroke. 2008 Sep; 39(9): 2644-91. Epub 2008 Jul 17. Review. Erratum in: Stroke. 2009 Jan 1; 40(1): e8-10.
 
Wasay M, Dai AI, Ansari M, Shaikh Z, Roach ES. Cerebral venous sinus thrombosis in children: a multicenter cohort from the United States. J Child Neurol. 2008 Jan; 23(1): 26-31.

Emily C. de los Reyes, MD


Dr. de los Reyes is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Associate Professor of Pediatrics at The Ohio State University College of Medicine. Dr. de los Reyes established a multidisciplinary clinic for the assessment and management of children with neurodevelopmental delay. Her research interests include the epidemiology of La Crosse encephalitis, as well as neurodevelopmental delay and autism.

Recent publications:
Standridge S, de los Reyes EC. Inflammatory bowel disease and cerebrovascular arterial and venous thromboembolic events in 4 pediatric patients: a case series and review of the literature. Journal of Child Neurology. 2008;23:59-66.

de los Reyes E, et al. Periodic lateralized epileptiform discharges (PLEDS) in LaCrosse encephalitis, a worrisome subgroup.  Clinical presentation, EEG patterns and long-term neurologic outcome.  Journal of Child Neurology. 2008; 23(2):167-172.

Burusnukul P, de los Reyes EC. Phenotypic variations in 3 children with POLG1 mutations. Journal of Child Neurology. 2009;24:482-486.

Kevin M. Flanigan, MD


Photo of Kevin M. Flanigan, MD

Dr. Flanigan is attending physician in the Section of Pediatric Neurology at Nationwide Children’s Hospital. He is certified by the American Board of Psychiatry and Neurology. A principal investigator in the Center for Gene Therapy in The Research Institute at Nationwide Children's Hospital, Dr. Flanigan’s primary research interest is in the genetic and molecular characterization of inherited neuromuscular diseases, and the development of therapies directed toward these diseases. A major focus of the laboratory concerns genotype/phenotype correlation in, with the intention of increasing our understanding of the pathogenesis in this disease and translating this understanding into improved therapies.

Recent publications:
Flanigan KM, Dunn DM, von Niederhausern A, Soltanzadeh P, Gappmaier E, Howard MT, Sampson JB, Mendell JR, Wall C, King WM, Pestronk A, Florence JM, Connolly AM, Mathews KD, Stephan CM, Laubenthal KS, Wong BL, Morehart PJ, Meyer A, Finkel RS, Bonnemann CG, Medne L, Day JW, Dalton JC, Margolis MK, Hinton VJ; United Dystrophinopathy Project Consortium, Weiss RB. Mutational spectrum of DMD mutations in dystrophinopathy patients: application of modern diagnostic techniques to a large cohort. Hum Mutat. 2009 Dec;30(12):1657-66.

Flanigan KM, Dunn DM, von Niederhausern A, Howard MT, Mendell J, Connolly A, Saunders C, Modrcin A, Dasouki M, Comi GP, Del Bo R, Pickart A, Jacobson R, Finkel R, Medne L, Weiss RB. DMD Trp3X nonsense mutation associated with a founder effect in North American families with mild Becker muscular dystrophy. Neuromuscul Disord. 2009 Nov;19(11):743-8.

3: Gurvich OL, Maiti B, Weiss RB, Aggarwal G, Howard MT, Flanigan KM. DMD exon 1 truncating point mutations: amelioration of phenotype by alternative translation initiation in exon 6. Hum Mutat. 2009 Apr;30(4):633-40.

Gloria M. Galloway, MD, FAAN, Diplomat of ABEM

 Gloria M. Galloway, MD

Dr. Galloway is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Professor of Pediatrics at The Ohio State University College of Medicine. She is also Director of the Intraoperative Evoked Potential monitoring program at Nationwide Children's Hospital. Dr. Galloway specializes in neuromuscular disorders and clinical neurophysiology, which are also her research interests.

Recent publications:
Galloway G. Diagnosing neuromuscular disorders. How nerve conduction testing and electromyography can help. Heartbeat. 2009;20:7-9.

Zamel K, Galloway G, et al. Intraoperative neurophysiological monitoring in 80 patients with Chiari 1 Malformation: Role of duraplasty. Journal of Clinical Neurophysiology 2009;26:70-75.

Lorie Hamiwka, MD, FRCPC


Lorie Hamiwka, MD

Dr. Hamiwka is Pediatric Neurologist and Epileptologist in the Division of Pediatric Neurology at Nationwide Children's Hospital and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Her clinical expertise and interests are in the surgical treatment of children with epilepsy and the treatment of children with new onset seizures. Dr. Hamiwka received a Young Investigator Award from the American Epilepsy Society to study the long-term outcome of children following epilepsy surgery.

Recent publications:
Hamiwka LD, et al. Diagnostic inaccuracy in children presenting with “first seizure”: role for a first seizure clinic. Epilepsia 2007;48:1062-1066.

Hamiwka LD, et al. Clinical utility of electroencephalogram in predicting seizures in children prior to renal transplantation: Is this a useful pre-transplant investigation? Pediatric Transplantation. 2008;12:527-530.

Hamiwka LD, EC Wirrell. Co-morbidities in pediatric epilepsy: Beyond “just” seizure control. Journal of Child Neurology. 2009;24:734-742.

Geoffrey L. Heyer, MD


Geoffrey L. Heyer, MD

Dr. Heyer is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Heyer is member of Nationwide Children’s Hospital Stroke Service. His clinical interests include pediatric stroke and genetic diseases.

Recent publications:
Heyer GL, et al. The cerebral vasculopathy of PHACES syndrome. Stroke. 2008;39:308-316.

Hankinson TC, Bohman LE, Heyer GL, et al. Surgical treatment of moyamoya syndrome in patients with sickle cell anemia: outcome following. encephaloduroarteriosynangiosis. Journal of  Neurosurgical Pediatrics. 2008;1:211-216.

Amlie-Lefond C, Bernard TJ, Sébire G, Friedman NR, Heyer GL, et al. International Pediatric Stroke Study Group. Predictors of cerebral arteriopathy in children with arterial ischemic stroke: results of the International Pediatric Stroke Study. Circulation. 2009;119:1417-1423.

Monica P. Islam, MD


Photo of Monica P. Islam, MD

Dr. Islam is an attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Assistant Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Islam completed her fellowship training in neurophysiology with emphasis on EEG/Epilepsy. Her clinical interests include epilepsy/seizures, intraoperative monitoring and strokes in children.

Recent publications:
Islam M; Roach ES. Neurology in Clinical Practice. Bradley W, Daroff R, Fenichel G, Jankovic J, editors. 5th ed. Vol. 2, The Neurological Disorders. Philadelphia: Butterworth Heinemann Elsevier; 2008. Chapter 69, Neurocutaneous syndromes; p. 1821-1853.

Tofil N, Buckmaster M, Winkler M, Callans B, Islam M, Percy A. Deep sedation with propofol in patients with Rett Syndrome. Journal of Child Neurology. 2006;21:210-213.

Neul J, Maricich S, Islam M, Barrish J, O’Brian Smith E, Bottiglieri T, Hyland K, Humphreys P, Percy A, Glaze D. Normal spinal fluid 5-methyltetrahydrofolate levels in Rett Syndrome. Neurology. 2005;64:2151-2152.

A. Latif Khuhro, MD

 A. Latif Khuhro, MD

Dr. Khuhro is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Khuhro’s clinical interests include sleep disorders, and Tourette syndrome and other movement disorders.

Lenora M. Lehwald, MD


Lenora M. Lehwald, MD

Dr. Lehwald is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Her clinical and research interests include electrophysiology and neonatal neurology.

Recent publications:
Jicha GA, Glantz J, Clarke MJ, Lehwald LM, et al. Primary diffuse leptomeningeal gliomatosis. European Neurology. 2009;62:16-22.

Warren D. Lo, MD

 Warren D. Lo, MD

Dr. Lo  is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Associate Professor of Pediatrics at The Ohio State University College of Medicine. His clinical and research interests center on stroke in infants and children. This emphasis led to the development of the Stroke Clinic at Nationwide Children’s, where he serves as director. His clinical research is designed to characterize the social and cognitive impairments that result from stroke and document patient’s recovery following a stroke.

Recent publications:
Lo WD, et al. The cost of pediatric stroke care and rehabilitation. Stroke.2008;39:161-165.

Lo WD, et al. Intracranial hemorrhage in children: An evolving spectrum. Archives of  Neurology. 2008;65:1629-1633.

Lo WD, et al. Pediatric Stroke in the United States and the Impact of Risk Factors. Journal of Child Neurology. 2009;24:194-203.

Jerry R. Mendell, MD – Director, Center for Gene Therapy, Neuromuscular Disorders Program

 Jerry Mendell, MD

Dr. Mendell is Director of the Center for Gene Therapy at The Research Institute of Nationwide Children’s Hospital, as well as Co-Director of the Muscular Dystrophy Association clinic. Dr. Mendell has made fundamental contributions in clinical research and in the molecular genetics of neuromuscular disease. He has published major textbooks on the disorders of muscle and peripheral nerves along with more than 250 scientific articles and book chapters. In 2004, Dr. Mendell was awarded the S. Mouchly Small Scientific Achievement Award from the Muscular Dystrophy Association in recognition of his significant contributions to neuromuscular disease research. Dr. Mendell was named among the “Best Doctors in America” in 2009.

Recent publications:
Rodino-Klapac LR, Lee JS, Mulligan RC, Clark KR, Mendell JR. Lack of toxicity of alpha-sarcoglycan overexpression supports clinical gene transfer trial in LGMD2D.
Neurology. 2008;71:240-247.

Rodino-Klapac LR, Haidet AM, Kota J, Handy C, Kaspar BK, Mendell JR. Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve. 2009;39:283-296.

Thrush PT, Allen HD, Viollet L, Mendell JR. Re-examination of the electrocardiogram in boys with Duchenne muscular dystrophy and correlation with its dilated cardiomyopathy. American Journal of Cardiology. 2009;103:262-265.

Ann Pakalnis, MD

 Ann Pakalnis, MD

Dr. Pakalnis is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Pakalnis is Director of the Comprehensive Headache Clinic at Nationwide Children’s Hospital. Her clinical and research interests involve the diagnosis and management of headache and the identification of co-morbid disorders linked to migraine.

Recent publications:
Pakalnis A, Couch J. Headache therapy with botulinum toxin: form over substance. Archives of Neurology 2008: 65: 149-151.

Pakalnis A, et al. Emotional and behavioral disorders in pediatric episodic tension-type headaches. Journal of Pediatric Neurology. 2008:6:109-113.

Apostol G, Pakalnis A, et al. Safety and tolerability of divalproex dosium extended-release in the prophylaxis of migraine headaches; results of an open-label extension trial in adolescents. Headache. 2009:49:36-44.

Zarife Sahenk, MD, PHD

 Zarife Sahenk, MD, PHD

Dr. Sahenk is Director of Clinical and Experimental Neuromuscular Pathology at Nationwide Children’s Research Institute and a Professor of Pediatrics at The Ohio State University College of Medicine. Her research aims to define the anatomical and molecular basis of hereditary peripheral neuropathies, emphasizing the role of trophic factors secreted by Schwann cells. Dr. Sahenk was named among the “Best Doctors in America” in 2009.

Recent publications:
Zhang X, Chow CY, Sahenk Z, et al. Mutation of FIG4 causes a rapidly progressive, asymmetric neuronal degeneration. Brain. 2008;131(Pt 8):1990-2001.

Sahenk Z, et al. Neurotrophin-3 deficient Schwann cells impair nerve regeneration. Experimental Neurology. 2008;212:552-556.

Tsao CY, Mendell J, Sahenk Z, et al. Hypotonia, weakness, and pontocerebellar hypoplasia in siblings. Seminars in Pediatric Neurology. 2008;15:151-153.

Laurel A. Slaughter, MD

Dr. Slaughter is attending physician in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Slaughter’s focus at Nationwide Children’s is in the burgeoning area of neonatal neurology, both as a consultant in the Neonatal Intensive Care Unit and in outpatient clinical follow-up.

Recent publications:
Slaughter L, Vartzelis G, Arthur T. New GLUT-1 mutation in a child with treatment-resistant epilepsy. Epilepsy Research 2009:84:254-256.

Slaughter L, Egelhoff J, Balmakund T. Neurologic Outcome in neonatal temporal lobe hemorrhagic venous infarcts. Journal of Child neurology. 2009;24:1236-1242.

Chang-Yong Tsao, MD, FAAN, FAAP

 Chang-Yong Tsao, MD, FAAN, FAAP

Dr. Tsao is attending physician at Nationwide Children’s Hospital and a Professor of Pediatrics and Neurology at The Ohio State University. Dr. Tsao’s clinical and research interests include mitochondrial and neuromuscular diseases. Dr Tsao is an active member of the Muscular Dystrophy Association clinic. In 2006, Dr. Tsao was named Nationwide Children’s Hospital Physician of the Year. Dr. Tsao was named among the “Best Doctors in America” in 2009.

Recent publications:
Guenther U, Varon R, Handoko L, Stephani U, Tsao CY, et al. Clinical variability in distal spinal muscular atrophy type 1 (DSMA1): determination of steady-state IGHMBP2 protein levels in five patients with infantile and juvenile disease. Journal of Molecular Medicine. 2009;87:31-41.

Tsao CY, Mendell JR. Partial epilepsy in an adolescent male with limb girdle muscular dystrophy 1B. Journal of Child Neurology. 2009;24:346-348.

Tsao CY. Current trends in the treatment of infantile spasms. Neuropsychiatric Diseases Treatment. 2009;5:289-99.

Jorge Vidaurre, MD


Dr. Vidaurre is Interim Director of Nationwide Children’s Hospital Comprehensive Epilepsy Center, Director of the Clinical Neurophysiology fellowship program at Nationwide Children’s Hospital, and Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His clinical and research interests focus on the treatment of children with difficult-to-treat epilepsy and clinical neurophysiology.

Recent publications:
Galanopoulou AS, Vidaurre J, et al. Under what circumstances can seizures produce hippocampal injury: evidence for age-specific effects. Developmental Neurosciences. 2002;24:355-363.

Pedro Weisleder, MD, PhD - Child Neurology Residency Program Director


Pedro Weisleder, MD, PhD

Dr. Weisleder is director of the Pediatric Neurology training program at Nationwide Children’s Hospital. He is also Associate Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Weisleder’s clinical and research interests include a  wide variety of topics such as the neurobiology of hearing and balance, epilepsy, headaches, medical ethics, and the interplay between medicine and the law.

Recent publications: 
Weisleder, P. Inconsistency among American states on the age at which minors can consent to substance abuse treatment. Journal of the American Academy of Psychiatry and the Law. 2007;35:317-322.

Weisleder, P. Physicians as healthcare surrogate for terminally ill children. Journal of Medical Ethics. 2008;34:e8.

Weisleder, P. Unethical prescriptions: alternative therapies for children with cerebral palsy. Clinical Pediatrics. 2009.

Khaled M. Zamel, MD, FACNS

Khaled Zamel, MD

Dr. Zamel is an attending physician at Nationwide Children’s Hospital and Assistant Professor of Clinical Pediatrics, Pediatric Neurology and Neurology at The Ohio State University. Dr. Zamel is a member of the International Pediatric Stroke Study (IPSS) and helped establish the Ohio pediatric stroke registry. He has clinical and research interest in epilepsy, intraoperative monitoring and pediatric stroke. His current research includes clinical applications of transcranial magnetic stimulation and neurophysiologic changes in patients with Chiari malformation undergoing cranial decompression. He is board-certified in both neurology and clinical neurophysiology.

Jo Ellen Lee RN, MSN, CPNP

Photo of Jo Ellen Lee RN, MSN, CPNP

Jo Ellen Lee RN, MSN, CPNP is nurse practitioner in the Division of Pediatric Neurology at Nationwide Children’s Hospital. She is a member of the Pediatric Stroke and Vascular Anomalies multidisciplinary team. Her clinical interests include pediatric stroke, general pediatric neurology and patient education.

Recent publication:
Lo WD, Lee J, Russin J Perkins E, Roach ES. Changing spectrum of nontraumatic intracranial hemorrhage. Archives of Neurology. 2008;65:1629-1633.

Mary Karn RN, MSN, CNP

Photo of Mary Karn RN, MSN, CNP

Mary Karn RN, MSN, CNP is a nurse practitioner in the Division of Pediatric Neurology at Nationwide Children's Hospital. Her expertise and research interests are in pediatric and adolescent epilepsy. She is part of the ketogenic diet team. She also programs vagus nerve stimulators for patients with implanted devices. She provides education to nursing staff, families and patients related to various neurology issues.

Donna Kring, RN, MS, CNP

Photo of Donna Kring, RN, MS, CNP

Donna Kring, RN, MS, CNP is nurse practitioner in the Division of Pediatric Neurology at Nationwide Children’s Hospital. She is a member of the multidisciplinary team evaluating children and adolescents in the Pediatric Headache Clinic. Her interests include headaches in children and adolescents and research in the area of pediatric headache.

Recent publication:
Pakalnis A, Splaingard D, Kring D, and Colvin A. Serotonin Effects on Sleep and Emotional Disorders in Adolescent Migraine. Headache. 2009;49:1486-1492.

Sally Steward RN, MS, CNP

Photo of Sally Steward RN, MS, CNP

Sally Steward RN, MS, CNP is nurse practitioner in the Division of Pediatric Neurology at Nationwide Children’s Hospital. She participates in the Movement Disorders Clinic and the Batten’s Disease Clinic. Her clinical interests include movement disorders, especially Tourette Syndrome, headaches, and patients with Batten Disease.

Debbie Terry, CNP

Photo of Debbie Terry, CNP

Debbie Terry, CNP is a Pediatric Nurse Practitioner in the Division of Pediatric Neurology at Nationwide Children’s Hospital and Auxiliary Clinical Instructor at The Ohio State University College of Nursing. Her clinical and research interests are in pediatric epilepsy with a focus on parent/family education, ketogenic diet and psychogenic non epileptic seizures.

Recent publications:
Terry D, Paolicchi J, Karn M. (2007). Acceptance of the use of diazepam rectal gel in school and day care settings. Journal of Child Neurology. 22:1135-1138.

Terry, D (2007). Assessment of the Neurologic System. Core Curriculum for Primary Care Pediatric Nurse Practitioners. Nancy A. Ryan Wenger, Editor. St. Louis: C. V. Mosby.

Jacqueline Yinger, RN, MSN,CPNP

Photo of Jacqueline Yinger, RN, MSN,CPNP

Jacqueline Yinger, RN, MSN,CPNP is a nurse practitioner in the Division of Pediatric Neurology at Nationwide Children’s Hospital. She is a member of the multidisciplinary Neurodevelopmental Team and the Ketogenic Diet Team. Her clinical interests include autism, neurodevelopmental delay, and pediatric epilepsy.

Recent publication:
Burusnukul P, de los Reyes E, Yinger J, Boué D. Dannon Disease: An Unusual Presentation of Autism. Pediatric Neurology. 2008;39:52-54.