Nuclear Receptor and MAP Kinase Signaling in Podocyte Injury (R01)
R01 DK095059-01-A1 (William E. Smoyer) 07/1/2013 - 08/24/2018
The goal of this project is to define specific molecular signaling pathways able to regulate podocyte injury in NS to develop more targeted and less toxic therapies for NS. The objective is to determine the ability of the glucocorticoid receptor (GR), peroxisome proliferator-activated receptor g (PPARg), and MAPK signaling pathways to regulate podocyte injury, and to exploit this knowledge to develop more effective novel therapies for NS.
Integrative Proteomics & Metabolomics for Pediatric Glomerular Disease Biomarkers
UM1 DK 100866-01 (William E. Smoyer) 9/16/2013-3/24/2017
The overall objective of this proposal is to successfully recruit 600 children with four glomerular diseases (Minimal Change Nephrotic Syndrome [MCNS], Focal Segmental Glomerulosclerosis [FSGS], IgA Nephropathy [IgAN], and Idiopathic Membranous Nephropathy [IMN]) into a three-year longitudinal cohort study that will include integrated proteomic and metabolic analyses of highly phenotyped biological samples to identify predictive biomarkers for pediatric glomerular disease.
Rituximab against Mycophenolate Mofetil in Children with Refractory Nephrotic Syndrome (RAMP Study)
Investigator-Initiated Clinical Trial (William E. Smoyer) 12/1/2013-11/30/2016
The goal of this study is to test the hypothesis that the anti-CD20 monoclonal antibody Rituximab will be more effective than MMF in maintaining remission in children who have had one relapse while receiving MMF using a randomized, multi-center clinical trial to directly compare the ability of MMF and Rituximab to maintain remission for 6 months in children with SDNS and FRNS.
Ribonuclease7: Antimicrobial Activity in the Human Kidney and Urinary Tract
K08 DK094970-02 (John David Spencer) 08/01/2012 – 08/31/2017
The goal of this proposal is to study the structure, function, and biological relevance of ribonuclease 7, a novel AMP that has potent antimicrobial properties in the human urinary tract.