Neonatology Annual Report :: Nationwide Children's Hospital

Neonatology 2014-2015 Annual Report

View the Nationwide Children's Hospital 2014-2015 Annual Report.

Nationwide Children’s Hospital is home to one of the largest networks of clinical neonatal care in the United States. The Section of Neonatology at Nationwide Children’s is an integral component of the neonatal program, which includes a full range of newborn care and innovative research programs, conducted through the division and in collaboration with the Center for Perinatal Research.

Innovative Programs

The section has developed a variety of innovative, unique programs, including the Comprehensive Center for Bronchopulmonary Dysplasia (BPD), Small Baby Program, Infant Feeding Disorders Program, and the Ohio Better Birth Outcomes (OBBO) initiative.

Comprehensive Center for Bronchopulmonary Dysplasia

The BPD Center fosters relationships between the health care team and families of infants with BPD and includes both inpatient and outpatient services The interdisciplinary team consists of a core group of neonatologists, pulmonologists, nurse practitioners, nurses, nutritionists, occupational therapists, physical therapists, social workers, case managers, pharmacists, speech therapists, respiratory therapists, parent support staff and pediatricians. The composition of the team is designed to address the individualized, and often highly complex, needs of the infant and family.

The mission of the CCBPD team is two-fold: First, to serve each infant and family by using the latest evidence-based practice and research to continuously improve care, and second, to foster a physical and therapeutic environment that empowers the family to actively participate in the care of their child.

Infant Feeding Disorders Program

Sudarshan R. Jadcherla, MD, leads the IFDP, which consists of both a clinical component and a National Institutes of Health-funded research component. The IFDP is dedicated to improving quality of life for all infants through the development of personalized feeding-management strategies based on clinical and translational research. Our advanced care optimizes the outcomes for infants with feeding disorders, allowing them to go home sooner, while simultaneously lowering readmission rates. Our physician-scientists are using innovative approaches to find and treat the cause of feeding difficulty in developing infants.

Neonatal Aerodigestive Program

In 2014, the Section of Neonatology developed a new, innovative program to address feeding and breathing issues in complex neonatal patients. The Neonatal Aerodigestive Program at Nationwide Children’s brings together a wide-range of specialists, including neonatologists, pulmonologists, otolaryngologists, radiologists, behavioral pediatricians, pediatricians, nursing, respiratory therapy, occupational therapy and speech therapy to develop comprehensive, holistic treatment plans for these complex patients.

Small Baby Program

Extreme prematurity is one of the leading causes of infant mortality. The Small Baby Program is changing that for babies born at less than 27-weeks’ gestation. At the heart of the program is a standardized protocol for care, developed by the Neonatology team at Nationwide Children’s and tested at the bedside, providing a uniform, interdisciplinary approach to the family centered care of extremely premature babies.

Ohio Better Birth Outcomes

The Section of Neonatology is dedicated to the concept that to improve infant mortality, a concerted clinical and research effort must be undertaken to not only prevent prematurity and the complications of prematurity but also to excel at treating any complications that do occur. To achieve these goals, the section actively participates in OBBO, a partnership between Nationwide Children’s Hospital, all other hospital systems in Franklin County and health care providers as well as government and community organizations.

2014-2015 Grants Awarded


Neonatology and Center for Perinatal Research

Besner, Gail
Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis
National Institute of General Medical Sciences (NIGMS)
Research Diversity Supplement on Parent Grant: Exosomes and HB-EGF in Stem Cell-Mediated Therapy for Necrotizing Enterocolitis
National Institute of General Medical Sciences
Probiotics and HB-EGF: a novel therapy for necrotizing enterocolitis
American College of Surgeons
Buhimschi, Irina
DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth
National Institute of Child Health & Human Development
Sociobiology of Racial Disparities and Preterm Birth
Children's Hospital Medical Center Cincinnati
March of Dimes
Chen, Bernadette
Regulation of Arginase in Models of Pulmonary Hypertension
National Heart, Lung, and Blood Institute (NHLBI)
Harrison, Tondi
Parent Communication for Feeding an Infant with a Heart Defect
University of Wisconsin at Madison
American Heart Association - National
Jadcherla, Sudarshan
Pathophysiology of Aerodigestive Reflexes in Infants
National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK)
Neonatal Esophagus and Airway Interaction in Health and Disease
Medical College of Wisconsin
National Institutes of Health
Klebanoff, Mark
Individual Patient Data Meta-Analysis of Treatment of Bacterial Vaginosis to Preterm Birth
The George Washington University
National Institutes of Health
Longitudinal Study of the Vaginal Microbiome Prior To Incident STI
University of Maryland
National Institutes of Health
Optimizing Management of the second stage of labor: Muticenter Randomized Trial.
Washington University
National Institutes of Health
Liu, Yusen
Modulating Nrf2-Regulated GSH Production to Prevent Hospital-Acquired Infections
National Institutes of Health
Role and regulation of MKP1 in Sarcoidosis
Wayne State University
National Institutes of Health (NIH)
McClead, Richard
MEDTAPP/BEACON Neonatal Abstinence Syndrome (NAS) Project (ODM Federal Funding)
Cincinnati Children's Hospital Medical Center
The Ohio State University
Moallem, Mohannad
Cardiac Secondary to Hydrocortisone BPD
Wayne State University
National Institutes of Health
Nelin, Leif
NICHD Neonatal Research Network
RTI International
National Institutes of Health
Decreasing Child Mortality in Guyana Neonatal Service Delivery
Guyana Help the Kids
Cerebral oxygenation and auto regulation in preterm infants:  Association with Morbidity and Mortality
Stanford University
Oza-Frank, Reena
Sociobiology of Racial Disparities in Preterm Birth and Fetal/Infant Mortality.
Children's Hospital Medical Center Cincinnati
March of Dimes
Quality Improvement Project for T2DM (Type 2 Diabetes Mellitus) Post-Partum Screening among Women with a History of Gestational Diabetes Mellitus
Ohio State University
Ohio Department of Health
Rogers, Lynette
DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
National Center for Complementary and Alternative Medicine (NCCAM
DHA attenuates Inflammatory Responses Through Altering RAGE Signaling
National Center for Complementary and Alternative Medicine
Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary Dysplasia
University of Alabama at Birmingham
National Institutes of Health
Industry Study
Industry Sponsor
National Institutes of Health (NIH)
Targeting Thioredoxin Reductase-1 to Prevent Bronchopulmonary Dysplasia
University of Alabama at Birmingham
National Institutes of Health
Sanchez, Pablo
NICHD Cooperative Multicenter Neonatal Research Network – Ohio State
National Institute of Child Health & Human Development (NICHD)
A Phase 1b/2a Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of a Monoclonal Antibody with an Extended Half-Life Against Respiratory Syncytial Virus 
Industry Sponsor
CASG #11-0067
University of Alabama at Birmingham
National Institutes of Health
Slaughter, Jonathan
Comparative Effectiveness of NSAID Treatment Versus No Treatment for PDA in Preterm Infants
National Heart, Lung, and Blood Institute (NHLBI)
Zaghloul, Nahla
Developing a New Therapeutic Approach for Periventricular Leukomalacia by Inhibiting NF-KB in the Microglia
The OSU Center for Clinical and Translational Science
National Institutes of Health (NIH)
$ 97,745

Neonatology Faculty

Leif D. Nelin, MD
Division Chief

Sudarshan Jadcherla, MD
Associate Division Chief

Kristina M. Reber, MD
Associate Division Chief

Edward G. Shepherd, MD
Section Chief

View Our Faculty »

Selected Neonatology Clinical and Research Publications

Buhimschi IA, Nayeri UA, Zhao G, Shook LL, Pensalfini A, Funai EF, Bernstein IM, Glabe CG, Buhimschi CS. Protein misfolding, congophilia, oligomerization, and defective amyloid processing in preeclampsia. Science Translational Medicine. 2014 Jul;6(245):245ra92.

Chen B, Xue J, Meng X, Slutzky JL, Calvert AE, Chicoine LG. Resveratrol prevents hypoxia-induced arginase II expression and proliferation of human pulmonary artery smooth muscle cells via Akt-dependent signaling. American Journal of Physiology - Lung Cellular and Molecular Physiology. 2014 Aug;307(4):L317-25.

Hanin M, Nuthakki S, Malkar MB, Jadcherla SR. Safety and efficacy of oral feeding in infants with BPD on nasal CPAP. Dysphagia. 2015 April;30(2):121-7.

Jadcherla SR, Dail J, Malkar MB, McClead R, Kelleher K, Nelin L. Impact of process optimization and quality improvement measures on neonatal feeding outcomes at an all-referral neonatal intensive care unit. Journal of Parenteral and Enteral Nutrition. 2015 Mar 2.

Lopez-Medina E, Cantey JB, Sánchez PJ. The mortality of neonatal herpes simplex virus infection. Journal of Pediatrics. 2015 Jun;166(6):1529-32.

Murthy K, Yanowitz TD, DiGeronimo R, Dykes FD, Zaniletti I, Sharma J, Sullivan KM, Mirpuri J, Evans JR, Wadhawan R, Piazza A, Adams-Chapman I, Asselin JM, Short BL, Padula MA, Durand DJ, Pallotto EK, Reber KM. Short-term outcomes for preterm infants with surgical necrotizing enterocolitis. Journal of Perinatology. 2014 Oct;34(10):736-40.

Oza-Frank R, Kachoria R, Keim SA, Klebanoff MA. Provision of specific preconception care messages and associated maternal health behaviors before and during pregnancy. American Journal of Obstetrics and Gynecology. 2015 Mar;212(3):372.e1-8.

Slaughter JL, Stenger MR, Reagan PB, Jadcherla SR. Inhaled bronchodilator use for infants with bronchopulmonary dysplasia. Journal of Perinatology. 2015 Jan;35(1):61-6.

Talavera MM, Kralik N, Jin Y, Chen B, Liu Y, Nelin LD. Mitogen-activated protein kinase phosphatase-1 prevents lipopolysaccharide-induced apoptosis in immature rat intestinal epithelial cells. Pediatric Research. 2015 Aug;78(2):128-36.

Trittmann JK, Peterson E, Rogers LK, Chen B, Backes CH, Kelbanoff MA, Nelin LD. Plasma asymmetric dimethylarginine levels are increased in neonates with bronchopulmonary dysplasia-associated pulmonary hypertension. Journal of Pediatrics. 2015 Feb;166(2):230-3.

View Team Publications »

Center for Perinatal Research

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