Michael R. Stenger, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Michael R. Stenger, MD

Michael R. Stenger, MD

Neonatology
Physician Team

Neonatology Fellowship
Faculty

Contact Information

Neonatology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4559
FX: (614) 722-4541

Location Information for Patients

Main Campus

Biography

Michael Stenger, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital, an investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and a Clinical Assistant Professor of Pediatrics at The Ohio State University College of Medicine. The primary focus of Dr. Stenger’s research is the role of nitric oxide and hyperoxia on lung growth and development. On the one hand, NO can combine with oxygen to form nitrogen dioxide (NO2) or with superoxide to form the potent oxidant peroxynitrite, both of which have been shown to cause lung injury. In contrast, NO may also act as an antioxidant and may protect against cellular damage and cytotoxicity caused by reactive oxygen species. Currently, a newborn mouse model is used while future studies will involve human samples such as tracheal aspirates to evaluate the impact of nitric oxide on lung growth and development.

Gender:

  • Male

Languages Spoken:

  • English

Education and Training

Medical School

  • University of Kentucky College of Medicine
    Date Completed: 05/19/2001

Residency

  • Nationwide Children's Hospital
    Date Completed: 06/30/2004

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2007

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2007

Publications

  • Slaughter JL, Reagan PB, Stenger MR, Jadcherla SR. 2014. H2RA and PPI Administration to Infants Within the Neonatal ICU: Evidence of Overuse?. In Pediatric Academic Societies' 2014 Annual Meeting
  • Jadcherla,Sudarshan,R; Slaughter,Jonathan,L; Stenger,Michael,R; Klebanoff,Mark; Kelleher,Kelly; Gardner,William. 2013. Practice Variance, Prevalence, and Economic Burden of Premature Infants Diagnosed With GERD.  Hospital pediatrics. Vol. 3, no. 4. (October): 335-341.
  • SLAUGHTER,J,L; Stenger,M,R; Jadcherla,S,R; Reagan,P,B. 2013. VARIATION IN THE USE OF INHALED RESPIRATORY MEDICATIONS FOR PRETERM INFANTS WITH BRONCHOPULMONARY DYSPLASIA.
  • Slaughter JL, Stenger MR, Reagan PB, Jadcherla SR. 2013. Variation in the Use of Acid Suppressive Medications for Infants with BPD. In Pediatric Academic Societies' 2013 Annual Meeting
  • Slaughter JL, Stenger MR, Reagan PB, Jadcherla SR. 2013. Combination Medication Strategies for the Respiratory Management of BPD. In Pediatric Academic Societies' 2013 Annual Meeting
  • Slaughter JL, Stenger MR, Jadcherla SR, Reagan PB. 2013. Variation in the Use of Inhaled Respiratory Medications for Infants with BPD. In Pediatric Academic Societies' 2013 Annual Meeting
  • Slaughter,Jonathan,L; Stenger,Michael,R; Reagan,Patricia,B. 2013. Variation in the Use of Diuretic Therapy for Infants With Bronchopulmonary Dysplasia.  PEDIATRICS. Vol. 131, no. 4. (April): 716-723.
  • Stenger,Michael,R; Slaughter,Jonathan,L; Kelleher,Kelly; Shepherd,Edward,G; Klebanoff,Mark,A; Reagan,Patricia; Nelin,Leif,D; Gardner,William. 2012. Hospital Variation in Nitric Oxide Use for Premature Infants.  PEDIATRICS. Vol. 129, no. 4. (April): E945-E951.
  • Gardner W, Nelin L, Reagan P, Slaughter J, Klebanoff M, Stenger M. 2011. Hospital Effects on the Survival of Premature Infants in NICUs. In Pediatric Academic Societies' 2011 Annual Meeting
  • Stenger MR, Slaughter JL, Shepherd EG, Reagan P, Nelin LD, Gardner W. 2011. Hospital Variation in Nitric Oxide Use for Premature Infants. In Pediatric Academic Societies' 2011 Annual Meeting
  • Malkar MB, Gardner W, Stenger MR, Nelin LD, Jadcherla SR, Welty SE, Shepherd EG. 2011. Respiratory Severity Score on Day of Life 30 Predicts Mortality and Length of Mechanical Ventilation in Premature Infants with Chronic Lung Disease. In Pediatric Academic Societies' 2011 Annual Meeting
  • Chicoine,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 300, no. 4. (April): L596-604.
  • Chicione,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 300, no. 4. (April): L596-L604.
  • Chicoine,Louis,G; Stenger,Michael,R; Cui,Hongmei; Calvert,Andrea; Evans,Rebecca,J; English,B,Keith; Liu,Yusen; Nelin,Leif,D. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  American journal of physiology. Lung cellular and molecular physiology. Vol. 300, no. 4. (April): L596-604.
  • Stenger,Michael,R; Reber,Kristina,M; Giannone,Peter,J; Nankervis,Craig,A. 2011. Probiotics and prebiotics for the prevention of necrotizing enterocolitis.  Current infectious disease reports. Vol. 13, no. 1. (February): 13-20.
  • Chicoine LG, Stenger MR, Cui H, Calvert A, Evans RJ, English BK, Liu Y, Nelin LD. 2011. Nitric oxide suppression of cellular proliferation depends on cationic amino acid transporter activity in cytokine-stimulated pulmonary endothelial cells.  Am J Physiol Lung Cell Mol Physiol. Vol. 300, no. 4. (January): L596-L604.
  • Stenger MR, Reber KM, Giannone PJ, Nankervis CA. 2011. Probiotics and prebiotics for the prevention of necrotizing enterocolitis.  Curr Infect Dis Rep. Vol. 13, no. 1. (January): 13-20.
  • Stenger MR, Jin Y, Liu Y, Nelin LD. 2010. MKP-1 Deficiency Increases Mortality in Newborn Mice Exposed to Hyperoxia. In Pediatric Academic Societies' 2010 Annual Meeting
  • Malkar MB, Gardner WP, Mandy GT, Stenger MR, Nelin LD, Shepherd EG, Welty SE. 2010. Respiratory severity score on day of life 30 is predictive of mortality and the length of mechanical ventilation in premature infants with protracted ventilation.  Pediatric Pulmonology. Vol. doi: 10.1002/ppul.23020. [Epub ahead of print], no. March: ePMID: 24616279.
  • Stenger MR, Rose MJ, Joshi MS, Rogers LK, Chicoine LG, Bauer JA, Nelin LD. 2010. Inhaled nitric oxide prevents 3-nitrotyrsoine formation in the lungs of neonatal mice exposed to > 95% oxygen.  Lung. Vol. 188, no. 3. (January): 217-227.
  • Rose MJ, Stenger MR, Joshi MS, Welty SE, Bauer JA, Nelin LD. 2010. Inhaled nitric oxide decreases leukocyte trafficking in the neonatal mouse lung during exposure to >95% oxygen.  Pediatr Res. Vol. 67, no. 3. (January): 244-249.
  • Stenger,Michael,R; Tipple,Trent,E; Rogers,Lynette,K; Liu,Yusen; Nelin,Leif,D. 2008. Inhaled Nitric Oxide Prevents the Hyperoxia-Induced Activation of P38 and JNK in Neonatal Mice Lungs. In 15th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Stenger MR, Rose MJ, Joshi MS, Chicoine LG, Bauer JA, Nelin LD. 2007. Nitric Oxide Decreases Protein Nitration in the Lungs of Neonatal Mice Exposed to Hyperoxia. In Pediatric Academic Societies' 2007 Annual Meeting
  • Rose MJ, Stenger MR, Joshi MS, Nelin LD, Bauer JA. 2007. Nitric Oxide Decreases Protein Nitration in the Lungs of Neonatal Mice Exposed to Hyperoxia. In Pediatric Academic Societies' 2007 Annual Meeting
  • Nelin LD, DT Malleske, MR Stenger, and LG Chicoine. 2007. Vascular arginase and hypertension.  Current Hypertension Reviews. Vol. 3, no. January: 242-249.
  • Nelin LD, Stenger MR, Rogers LK, Welty SE, Liu Y. 2006. Mitogen Activated Protein Kinase Phosphatase-1 Regulates Nitric Oxide Production in LPS Stimulated Peritoneal Macrophages. In Society for Free Radical Biology & Medicine
  • Nelin LD, Young TL, Hatch DM, Stenger MR, Chicoine LG, English BK, Liu Y. 2006. Inhaled Nitric Oxide Prevents the Hyperoxia-Induced Activation of p38 and JNK in Neonatal Mice Lungs. In Pediatric Academic Societies' 2006 Annual Meeting
  • Stenger MR, Chicoine LG, Rogers LK, Hatch DM, Welty SE, Nelin LD. 2006. Adding Nitric Oxide to a Hyperoxic Exposure Results in 3-Nitrotyrosine Formation and Neutrophil Influx in the Lungs of Neonatal Mice. In Pediatric Academic Societies' 2006 Annual Meeting
  • Chicoine LG, Metropoulos MJ, Girton MJ, Stenger MR, Nelin LD. 2006. Maturational Changes in NO Sensitivity Are Due to Increases in Soluble Guanylyl Cyclase in the Developing Rat Lung. In Pediatric Academic Societies' 2006 Annual Meeting
  • Hatch DM, Stenger MR, Young TL, Chicoine LG, Rogers LK, Nelin LD. 2006. Nitric Oxide Preserves Lung Growth and Increases FGF Signaling in Neonatal Mice Exposed to Hyperoxia. In Pediatric Academic Societies' 2006 Annual Meeting
  • Chicoine,L,G; Stenger,M,R; Metroupolus,M,J; Girton,M,R; Nelin,L,D. 2006. Maturational changes in NO sensitivity are due to increases in soluble gaunylyl cyclase in the developing rat lung. In Experimental Biology 2006 Annual Meeting
  • Stenger,M,R; Chicoine,L,G; Liu,Y,S; Hatch,D,M; Nelin,L,D. 2006. Nitric oxide increases mortality and prevents MKP-1 expression in neonatal mice exposed to hyperoxia. In Experimental Biology 2006 Annual Meeting
  • Stenger,Michael,R; Hatch,Dionna,M; Rogers,Lynette,K; Joshi,Mandar; Chicoine,Luis; Bauer,John,A; Nelin,Leif,D. 2006. Nitric oxide prevents the hyperoxia-induced arrested alveolarization and decreased FGF-10 levels in neonatal mice. In 13th Annual Meeting of the Society-for-Free-Radical-Biology-and-Medicine
  • Stenger MR, Chicoine LG, Young TL, Liu Y, Nelin LD. 2005. L-Lysine Decreases Both Nitric Oxide and Urea Production in Bovine Pulmonary Arterial Endothelial Cells Transfected with Inducible Nitric Oxide Synthase. In Pediatric Academic Societies' 2005 Annual Meeting
  • Stenger MR, Chicoine LG, Smith CV, Rogers LK, Welty SE, Nelin LD. 2005. Survival and Growth of Neonatal Mice Exposed to Nitric Oxide and Hyperoxia. In Pediatric Academic Societies' 2005 Annual Meeting
  • Stenger,M; Chicoine,L; Smith,C; Welty,S; Rogers,L; Nelin,L. 2005. Nitric oxide exposure increases mortality in neonatal mice exposed to hyperoxia. In 12th Annual Meeting Society-for-Free-Radical-Biology-and-Medicine
  • Singh PK, Jones MM, Lane JE, Nesset A, Zimmerman LJ, Ribeiro-Rodrigues R, Richter A, Stenger MR, Carter CE. 1997. Synthesis and in vitro trypanocidal activity of some novel iron chelating agents.  Arzneimittelforschung. Vol. 47, no. January: 311-315.
  • Slaughter JL, Stenger MR, Reagan PB, Jadcherla SR. Inhaled Bronchodilator Use for Infants with Bronchopulmonary Dysplasia.  Journal of Perinatology.
  • Giannone PJ, Nankervis CA, Stenger MR, Schanbacher B, Bauer JA. Necrotizing Enterocolitis and Oxidative Stress. In Studies on Perinatal and Prenatal Disorders. Edited by Buonocore G, Dennery P, Saugstad O.
  • Nelin LD, Stenger MR, Malleske DT, Chicoine LG. Vascular arginase and hypertension. Current Hypertension Reviews 3: 242-249, 2007.
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