Michael Bailey, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Michael Bailey, Ph.D.

Michael  Bailey, Ph.D.

Contact Information

700 Children's Drive
Columbus, OH 43025 [ map ]
PH: (614) 722-2764

Biography

Michael Bailey, PhD, is a Principal Investigator in the Center for Microbial Pathogenesis at The Research Institute at Nationwide Children’s Hospital and is an Associate Professor of Pediatrics at Ohio State University. Dr. Bailey has nearly 20 years of experience studying bidirectional interactions between host physiology and the microbes that naturally reside within the gastrointestinal tract (i.e., the gut microbiota). Dr. Bailey’s studies were among the first to show that stressful situations can lead to changes in the composition of the gut microbiota and his current studies are now focused on the impact that changes to gut microbiota composition have on the functioning of the immune system and on nervous system activity.

Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Understanding the role of commensal microbes in the ability of the physiological stress response to enhance pathogen-induced colonic inflammation and to enhance anxiety and depression
  • Understanding the role that commensal microbes play in the worsening of disease symptoms during stressful periods
  • Multi-directional interactions between host physiology, nervous and immune system activity, and the commensal gut microbiota

Education and Training

Undergraduate School

  • Winona State University
    Date Completed: 01/01/1995

Graduate School

  • Minnesota State University Mankato
    Date Completed: 01/01/1997

Doctorate

  • University of Wisconsin
    Date Completed: 01/01/2002

Department:

  • Center for Microbial Pathogenesis

Publications

  • Gur TL, Bailey MT. 2016. Effects of Stress on Commensal Microbes and Immune System Activity.  Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. Vol. 14, no. March: 289-300.
  • Bailey MT. 2016. Psychological Stress, Immunity, and the Effects on Indigenous Microflora.  Microbial Endocrinology: Interkingdom Signaling in Infectious Disease and Health. Vol. 11, no. February: 225-246.
  • Xu J, Galley JD, Bailey MT, Thomas-Ahner JM, Clinton SK, Olivo-Marston SE. 2016. The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice.  Scientific Reports. Vol. 6, no. January 1: 19083-19083.
  • Xu J, Galley JD, Bailey MT, Thomas-Ahner JM, Clinton SK, Olivo-Marston SE. 2016. The Impact of Dietary Energy Intake Early in Life on the Colonic Microbiota of Adult Mice.  Scientific Reports. Vol. 6, no. January: e19083.
  • 2016. Effects of Stress on Commensal Microbes and Immune System Activity.  MICROBIAL ENDOCRINOLOGY: INTERKINGDOM SIGNALING IN INFECTIOUS DISEASE AND HEALTH, 2ND EDITION. Vol. 874, no. January 1.
  • 2016. Psychological Stress, Immunity, and the Effects on Indigenous Microflora.  Adv Exp Med Biol. Vol. 874, no. January 1.
  • 2015. The prebiotics 3'Sialyllactose and 6'Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis.  Brain Behav Immun. Vol. 50, no. November 1.
  • Tarr AJ, Galley JD, Fisher SE, Chichlowski M, Berg BM, Bailey MT. 2015. The prebiotics 3’Sialyllactose and 6’Sialyllactose diminish stressor-induced anxiety-like behavior and colonic microbiota alterations: Evidence for effects on the gut-brain axis.  Brain, Behavior, and Immunity. Vol. 50, no. November: 166-177.
  • Mackos AR, Galley JD, Eubank TD, Easterling RS, Parry NM, Fox JG, Lyte M, Bailey MT. 2015. ocial stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri.  Mucosal Immunology. Vol. 9, no. September 1: 515-526-515-526.
  • Mackos AR, Galley JD, Eubank TD, Easterling RS, Parry NM, Fox JG, Lyte M, Bailey MT. 2015. ocial stress-enhanced severity of Citrobacter rodentium-induced colitis is CCL2-dependent and attenuated by probiotic Lactobacillus reuteri.  Mucosal Immunology. Vol. 9, no. September: 515-526.
  • 2013. Probiotic lactobacillus reuteri attenuates the stressor-enhanced severity of citrobacter rodentium infection.  Infection and Immunity. Vol. 81, no. 9. (September 23).
  • 2013. Stress, asthma, and infection: putting the pieces together.  Brain Behav Immun. Vol. 29, no. March 1.
  • Bailey, MT. 2013. Stress, asthma, and infection: putting the pieces together.  Brain, Behavior, and Immunity. Vol. 29, no. March: 9-10.
  • Hanke, ML, Powell, ND, Stiner-Jones, LM, Bailey, MT, and Sheridan, JF. 2012. Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress.  Brain, Behavior, and Immunity. Vol. 26, no. 7. (October): 1150-1159. PubMed ID: 22841997
  • 2012. Beta adrenergic blockade decreases the immunomodulatory effects of social disruption stress.  Brain Behav Immun. Vol. 26, no. 7. (October 1).
  • 2012. Stressor-Induced Increase in Microbicidal Activity of Splenic Macrophages Is Dependent upon Peroxynitrite Production.  INFECTION AND IMMUNITY. Vol. 80, no. 10. (October 1).
  • 2012. The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation.  Horm Behav. Vol. 62, no. 3. (August 1).
  • Bailey, MT. 2012. The contributing role of the intestinal microbiota in stressor-induced increases in susceptibility to enteric infection and systemic immunomodulation.  Hormones and Behavior. Vol. 62, no. 3. (August): 286-294. PubMed ID: 22366706
  • Allen,Rebecca,G; Lafuse,William,P; Galley,Jeffrey,D; Ali,Mohamed,M; Ahmer,Brian,MM; Bailey,Michael,T. 2012. The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity.  BRAIN BEHAVIOR AND IMMUNITY. Vol. 26, no. 3. (March): 371-382.
  • 2012. The intestinal microbiota are necessary for stressor-induced enhancement of splenic macrophage microbicidal activity.  Brain, Behavior, and Immunity. Vol. 26, no. 3. (March 1).
  • 2012. Stress and the anti-influenza immune response: repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.  J Neuroimmunol. Vol. 243, no. 1-2. (February 29).
  • Mays,Jacqueline,W; Powell,Nicole,D; Hunzeker,John,T; Hanke,Mark,L; Bailey,Michael,T; Sheridan,John,F. 2012. Stress and the anti-influenza immune response: Repeated social defeat augments clonal expansion of CD8(+)T cells during primary influenza A viral infection.  JOURNAL OF NEUROIMMUNOLOGY. Vol. 243, no. 1-2. (February): 34-42.
  • Mays JW, Powell ND, Bailey MT, Sheridan JF. 2012. Environmental Challenges and the Neuroendocrine Mechanisms of Stress-Induced Modulation of Host Resistance to Microbial Infection. In Eco-Immunology. Edited by G. Demas and R.J. Nelson.
  • Mays JW, Powell ND, Bailey MT, Sheridan JF. 2012. Environmental Challenges and the Neuroendocrine Mechanisms of Stress-Induced Modulation of Host Resistance to Microbial Infection. In Eco-Immunology. Edited by G. Demas and R.J. Nelson. New York: Oxford University Press.
  • Wohleb ES; Hanke ML; Corona AW; Powell ND; Stiner LM; Bailey MT; Nelson RJ; Godbout JP; Sheridan JF. 2011. beta-adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.  Journal of Neuroscience. Vol. 31, no. 17. (April): 6277-6288.
  • 2011. ß-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat.  The Journal of neuroscience : the official journal of the Society for Neuroscience. Vol. 31, no. 17. (April 1).
  • Bailey,Michael,T; Dowd,Scot,E; Galley,Jeffrey,D; Hufnagle,Amy,R; Allen,Rebecca,G; Lyte,Mark. 2011. Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation.  BRAIN BEHAVIOR AND IMMUNITY. Vol. 25, no. 3. (March 1): 397-407-397-407.
  • Bailey MT; Dowd SE; Galley JD; Hufnagle AR; Allen RG; Lyte M. 2011. Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation.  Brain, Behavior, and Immunity. Vol. 25, no. 3. (March): 397-407.
  • Bailey,Michael,T; Dowd,Scot,E; Galley,Jeffrey,D; Hufnagle,Amy,R; Allen,Rebecca,G; Lyte,Mark. 2011. Exposure to a social stressor alters the structure of the intestinal microbiota: Implications for stressor-induced immunomodulation.  BRAIN BEHAVIOR AND IMMUNITY. Vol. 25, no. 3. (March): 397-407.
  • 2011. Exposure to a social stressor alters the structure of the intestinal microbiota: implications for stressor-induced immunomodulation.  Brain Behav Immun. Vol. 25, no. 3. (March 1).
  • Powell ND, Allen RG, Hufnagle AR, Sheridan JF, and Bailey MT. 2011. Stressor-Induced Alterations of Adaptive Immunity to Vaccination and Viral Pathogens.  Immunology and Allergy Clinics of North America. Vol. 31, no. 1. (February): 69-79.
  • 2011. Stressor-induced alterations of adaptive immunity to vaccination and viral pathogens.  Immunol Allergy Clin North Am. Vol. 31, no. 1. (February 1).
  • Lin,Y; Roman,K; Foust,K,D; Kaspar,B,K; Bailey,M,T; Stephens,R,L. 2011. Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects.  Pain research and treatment. Vol. 2011, no. January: 507029-?.
  • 2011. Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.  Brain Behav Immun. Vol. 25, no. 1. (January 1).
  • Powell ND; Mays JW; Bailey MT; Hanke ML; Sheridan JF. 2011. Immunogenic dendritic cells primed by social defeat enhance adaptive immunity to influenza A virus.  Brain, Behavior, and Immunity. Vol. 25, no. 1. (January): 46-52.
  • Lin,Y; Roman,K; Foust,K,D; Kaspar,B,K; Bailey,M,T; Stephens,R,L. 2011. Glutamate Transporter GLT-1 Upregulation Attenuates Visceral Nociception and Hyperalgesia via Spinal Mechanisms Not Related to Anti-Inflammatory or Probiotic Effects.  Pain research and treatment. Vol. 2011, no. January 1: 507029-?-507029-?.
  • Belevych N; Buchanan K; Chen Q; Bailey M; Quan N. 2010. Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation.  Brain, Behavior, and Immunity. Vol. 24, no. 7. (October 1): 1137-1147-1137-1147.
  • Belevych N; Buchanan K; Chen Q; Bailey M; Quan N. 2010. Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation.  Brain, Behavior, and Immunity. Vol. 24, no. 7. (October): 1137-1147.
  • Bailey MT, Walton JC, Dowd SE, Weil ZM, and Nelson RJ. 2010. Photoperiod modulates gut bacteria composition in male Siberian hamsters (Phodopus sangorus).  Brain, Behavior, and Immunity. Vol. 24, no. 4. (May): 577-584.
  • Bailey MT, Walton JC, Dowd SE, Weil ZM, and Nelson RJ. 2010. Photoperiod modulates gut bacteria composition in male Siberian hamsters (Phodopus sangorus).  Brain, Behavior, and Immunity. Vol. 24, no. 4. (May 1): 577-584-577-584.
  • 2010. Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium.  Infect Immun. Vol. 78, no. 4. (April 1).
  • Bailey MT, Dowd SE, Parry NMA, Galley JD, Schauer DB, and Lyte M. 2010. Stressor exposure disrupts commensal microbial populations in the intestines and leads to increased colonization by Citrobacter rodentium.  Infection and Immunity. Vol. 78, no. 4. (April): 1509-1519.
  • 2010. Social disruption induces lung inflammation.  Brain Behav Immun. Vol. 24, no. 3. (March 1).
  • Curry JM, Hanke ML, Piper MG, Bailey MT, Bringardner BD, Sheridan JF, Marsh CB. 2010. Social disruption induces lung inflammation.  Brain, Behavior, and Immunity. Vol. 24, no. 3. (March): 394-402.
  • 2010. Influenza virus-specific immunological memory is enhanced by repeated social defeat.  J Immunol. Vol. 184, no. 4. (February 15).
  • 2010. Repeated social stress enhances the innate immune response to a primary HSV-1 infection in the cornea and trigeminal ganglia of Balb/c mice.  Brain Behav Immun. Vol. 24, no. 2. (February 1).
  • Dong-Newsom P, Powell ND, Bailey MT, Padgett DA, Sheridan JF. 2010. Repeated social stress enhances the innate immune response to a primary HSV-1 infection in the cornea and trigeminal ganglia of Balb/c mice.  Brain, Behavior, and Immunity. Vol. 24, no. 2. (February): 273-280.
  • Mays JW, Bailey MT, Hunzeker JT, Powell ND, Papenfuss T, Karlsson EA, Padgett DA, Sheridan JF. 2010. Influenza virus-specific immunological memory is enhanced by repeated social defeat.  Journal of Immunology. Vol. 184, no. 4. (February): 2014-2025.
  • Belevych N, Buchanan K, Chen Q, Bailey M, Quan N. 2010. Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation.  Brain, Behavior, and Immunity.
  • Bailey MT. 2010. The effects of psychological stressors on the intestinal microbiota.  Bioscience and Microflora. Vol. 28, no. 4. (January 1): 119-124-119-124.
  • Bailey MT. 2010. The effects of psychological stressors on the intestinal microbiota.  Bioscience and Microflora. Vol. 28, no. 4. (January): 119-124.
  • Michael T. Bailey. 2010. Stress, immunity, and the effects on the indigenous microflora. In Microbial Endocrinology. Edited by Primrose Freestone and Mark Lyte.
  • Belevych N, Buchanan K, Chen Q, Bailey M, Quan N. 2010. Location-specific activation of the paraventricular nucleus of the hypothalamus by localized inflammation.  Brain, Behavior, and Immunity.
  • Michael T. Bailey and Ronald Glaser. 2010. Immune measures in behavioral medicine research: procedures and implications. In Handbook of Behavioral Medicine: Methods and Applications. Edited by Andrew Steptoe.
  • Michael T. Bailey and Ronald Glaser. 2010. Immune measures in behavioral medicine research: procedures and implications. In Handbook of Behavioral Medicine: Methods and Applications. Edited by Andrew Steptoe. New York: Springer Publishers.
  • Michael T. Bailey. 2010. Stress, immunity, and the effects on the indigenous microflora. In Microbial Endocrinology. Edited by Primrose Freestone and Mark Lyte. New York: Springer Publishers.
  • 2009. Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells.  Physiol Behav. Vol. 98, no. 3. (September 7).
  • Bailey MT; Kinsey SG; Padgett DA; Sheridan JF; Leblebicioglu B. 2009. Social stress enhances IL-1beta and TNF-alpha production by Porphyromonas gingivalis lipopolysaccharide-stimulated CD11b+ cells.  Physiology & Behavior. Vol. 98, no. 3. (September): 351-358.
  • 2009. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production.  J Immunol. Vol. 182, no. 12. (June 15).
  • Bailey MT; Kierstein S; Sharma S; Spaits M; Kinsey SG; Tliba O; Sheridan JF; Panettieri RA; Haczku A. 2009. Social stress enhances allergen-induced airway inflammation in mice and inhibits corticosteroid responsiveness of cytokine production.  Journal Of Immunology (Baltimore, Md.: 1950). Vol. 182, no. 12. (June): 7888-7896.
  • Powell ND; Bailey MT; Mays JW; Stiner-Jones LM; Hanke ML; Padgett DA; Sheridan JF. 2009. Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.  Brain, Behavior, And Immunity. Vol. 23, no. 2. (February): 225-231.
  • 2009. Repeated social defeat activates dendritic cells and enhances Toll-like receptor dependent cytokine secretion.  BRAIN BEHAVIOR AND IMMUNITY. Vol. 23, no. 2. (February 1).
  • Henry CJ; Huang Y; Wynne A; Hanke M; Himler J; Bailey MT; Sheridan JF; Godbout JP. 2008. Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.  Journal of Neuroinflammation. Vol. 5, no. May 1: 15-15.
  • Martin LB; Navarra KJ; Bailey MT; Hutch CR; Powell ND; Sheridan JF; Nelson RJ. 2008. Food restriction compromises immune memory in deer mice (Peromyscus maniculatus) by reducing spleen-derived antibody-producing B cell numbers.  Physiological and Biochemical Zoology. Vol. 81, no. 3. (May): 366-372.
  • Henry CJ; Huang Y; Wynne A; Hanke M; Himler J; Bailey MT; Sheridan JF; Godbout JP. 2008. Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia.  Journal of Neuroinflammation. Vol. 5, no. May: e15.
  • Martin LB; Navarra KJ; Bailey MT; Hutch CR; Powell ND; Sheridan JF; Nelson RJ. 2008. Food restriction compromises immune memory in deer mice (Peromyscus maniculatus) by reducing spleen-derived antibody-producing B cell numbers.  Physiological and Biochemical Zoology. Vol. 81, no. 3. (May 1): 366-372-366-372.
  • 2008. The inflammatory response to social defeat is increased in older mice.  Physiol Behav. Vol. 93, no. 3. (February 27).
  • Kinsey SG; Bailey MT; Sheridan JF; Padgett DA. 2008. The inflammatory response to social defeat is increased in older mice.  Physiology and Behavior. Vol. 93, no. 3. (February): 628-636.
  • Engler H; Bailey MT; Engler A; Stiner-Jones LM; Quan N; Sheridan JF. 2008. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.  Psychoneuroendocrinology. Vol. 33, no. 1. (January): 108-117.
  • 2008. Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen.  PSYCHONEUROENDOCRINOLOGY. Vol. 33, no. 1. (January 1).
  • 2007. Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway.  Am J Physiol Regul Integr Comp Physiol. Vol. 293, no. 3. (September 1).
  • Avitsur R; Kinsey SG; Bidor K; Bailey MT; Padgett DA; Sheridan JF. 2007. Subordinate social status modulates the vulnerability to the immunological effects of social stress.  Psychoneuroendocrinology. Vol. 32, no. 8-10. (September): 1097-1105.
  • Bailey MT; Engler H; Powell ND; Padgett DA; Sheridan JF. 2007. Repeated social defeat increases the bactericidal activity of splenic macrophages through a Toll-like receptor-dependent pathway.  American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Vol. 293, no. 3. (September): R1180-R1190.
  • 2007. Subordinate social status modulates the vulnerability to the immunological effects of social stress.  Psychoneuroendocrinology. Vol. 32, no. 8-10. (September 1).
  • 2007. Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice.  Brain Behav Immun. Vol. 21, no. 4. (May 1).
  • Kinsey SG; Bailey MT; Sheridan JF; Padgett DA; Avitstur R. 2007. Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice.  Brain, Behavior, and Immunity. Vol. 21, no. 4. (May): 458-466.
  • Michael T. Bailey, David A. Padgett, and John F. Sheridan. 2007. Stress-induced modulation of innate resistance and adaptive immunity to influenza viral infection. In Psychoneuroimmunology. 4 ed. Edited by Robert Ader. Burlington, MA: Elsevier Academic Press.
  • Michael T. Bailey, David A. Padgett, and John F. Sheridan. 2007. Stress-induced modulation of innate resistance and adaptive immunity to influenza viral infection. In Psychoneuroimmunology. 4 ed. Edited by Robert Ader.
  • 2004. Prenatal stress alters bacterial colonization of the gut in infant monkeys.  Journal of pediatric gastroenterology and nutrition. Vol. 38, no. 4. (April 1).
  • 2002. Intestinal microbial patterns of the common marmoset and rhesus macaque.  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology. Vol. 133, no. 2. (October 1).
  • Allen, RG, Lafuse, WP, Powell, ND, Marketon, JM, Stiner-Jones, LM, Sheridan, JF, and Bailey, MT. Stressor-induced increase in the microbicidal activity of splenic macrophages is peroxynitrite dependent.  Infection and Immunity. PubMed ID: 22825446
  • Mackos, AR, Eubank, TD, Parry, NM, Bailey, MT. Probiotic Lactobacillus reuteri attenuates the stressor-enhanced severity of Citrobacter rodentium infection.  Infection and Immunity.
  • Allen, RG, Lafuse, WP, Powell, ND, Marketon, JM, Stiner-Jones, LM, Sheridan, JF, and Bailey, MT. Stressor-induced increase in the microbicidal activity of splenic macrophages is peroxynitrite dependent.  Infection and Immunity. PubMed ID: 22825446

Awards, Honors and Organizations

  • Robert Ader New Investigator Award, PsychoNeuroImmunology Research Society, 2012
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000