Mark W. Hall, MD, FAAP, FCCM

Mark W. Hall, MD, FCCM is Director of the Pediatric Critical Care Medicine Fellowship program at Nationwide Children’s Hospital, an investigator in the Center the Clinical and Translational Research at The Research Institute at Nationwide Children’s Hospital, Research Director for Pediatric Critical Care Medicine, and Associate Professor of Pediatrics, Division of Critical Care Medicine at The Ohio State University College of Medicine. He holds appointments to the Davis Heart and Lung Research Institute and the Center for Critical Care Medicine at The Ohio State University. He received his medical degree in 1994 from the University of Virginia in Charlottesville and went on to Children’s Hospital of Pittsburgh for a residency in pediatrics in 1997. He was chief resident there in 1998. He was a fellow in pediatric critical care medicine from 1998 to 2001 and held the Charles Schertz Research Fellowship from 2001 to 2002, both at Children’s Hospital of Pittsburgh. Dr. Hall is currently the Director of the Immune Surveillance Laboratory at The Research Institute at Nationwide Children's Hospital, a high-throughput human immunology lab which serves as a core laboratory for numerous single- and multi-center studies. Dr. Hall’s primary research interest lies in the area of immunobiology of pediatric critical illness, focusing on immune monitoring and modulation in critically ill children. His work spans the spectrum of basic, translational, and clinical research and includes a highly innovative R01-funded clinical trial of immune stimulation in critically injured children.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Clinical and Translational Research

Areas of Interest:

• The focus of my research program is the regulation of the inflammatory response in critically ill children. We have ongoing clinical and translational protocols detailing the mechanisms and natural history of impairment of innate immune function (immunoparalysis) and adaptive immunity in the setting of severe sepsis, septic shock, and other forms of critical illness. The relationships between regulatory T cells, neuroendocrine dysfunction, and monocyte function with overall immune phenotype and clinical outcomes are all subjects of current interest. A specific example of this is our novel work exploring the role of the MEFV gene, coding for the protein pyrin which is known to be mutated in familial Mediterranean fever, in the regulation of the inflammatory response in monocytes during critical illness.

Research Funding*:

• Monocyte Pyrin Expression in Human Sepsis, National Heart, Lung, and Blood Institute

Undergraduate School

• University of Virginia
  Date Completed: 06/30/1990

Medical School

• University of Virginia
  Date Completed: 05/22/1994

Internship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/1995

Residency

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/1997

Residency

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/23/1998

Fellowship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/2001

Fellowship

• Children's Hospital of Pittsburgh of UPMC
  Date Completed: 06/30/2002

Department:

• Pediatrics

Section:

• Critical Care

Speciality:

• Pediatric Critical Care
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 09/27/2002

2012–present

• Associate Professor of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH

2002–2012

• Assistant Professor of Pediatrics, The Ohio State University College of Medicine, Nationwide Children's Hospital, Columbus, OH

2001–2002

• Research Fellow/Instructor, Pediatric Critical Care Med, Children's Hospital of Pittsburgh, Pittsburgh, PA

1998–2001

• Fellow, Pediatric Critical Care Med, Children's Hospital of Pittsburgh, Pittsburgh, PA

1997–1998

• Chief Resident/Instructor, Pediatrics,Children's Hospital of Pittsburgh, Pittsburgh, PA

1994–1997

• Resident, Pediatrics, Children's Hospital of Pittsburgh, Pittsburgh, PA

• Duncan CN, Lehman LE, Cheifetz IM, Greathouse K, Haight AE, Hall MW, et al. 2013. Clinical outcomes of children receiving intensive cardiopulmonary support during hematopoietic stem cell transplant.  Pediatric Critical Care Medicine. Vol. 14, no. 3. (March): 261-67.
• O'Brien NF, Hall MW. 2013. Extracorporeal membrane oxygenation and cerebral blood flow velocity in children.  Pediatric Critical Care Medicine. Vol. 14, no. 3. (February): e pub 126-34.
• Mella C, del Carmen Suarez M, Lopez S, Stephens J, Hall M, Ramilo O, Mejias A. 2013. Respiratory syncytial virus is associated with impaired systemic functional innate immune responses in infants with severe bronchiolitis.  Journal of Infectious Diseases. Vol. 207, no. 4. (February): 564-673.
• Hall MW, Geyer SM, Guo CY, Panoskaltsis-Mortari A, et al. 2013. Innate immune function and mortality in critically ill children with influenza: A multi-center study.  Critical Care Medicine. Vol. 41, no. 1. (January): 219-231.
• Wong HR, Salibury S, Xiao Q, Cvijanovich NZ, Hall M, et al. 2012. The pediatric sepsis biomarker risk model.  Critical Care. Vol. 16, no. 5. (October): eR174.
• Wong HR, Cvijanovich NZ, Hall M, Allen GL, et al. 2012. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children.  Critical Care. Vol. 16, no. 5. (October): eR213.
• Hall MW. 2012. The Inflammatory Response. In Pediatric Critical Care Study Guide. Edited by Lucking S, Maffei F, Thomas NJ. London: Springer-Verlager.
• Cornell TT, Sun L, Hall MW, Gurney JG, Ashbrook MJ, Ohye RG, Shanley TP. 2012. Clinical implications and molecular mechanisms of immunoparalysis following cardiopulmonary bypass.  Journal of Thoracic and Cardiovascular Surgery. Vol. 143, no. 5. (May): 1160-1166.
• Khemani RG, Thomas NJ, Venkatachalam V, Scimeme JP, Bertutti T, Schneider JB, Ross PA, Willson DF, Hall MW, Newth CJL. 2012. Comparison of SpO2 and PaO2 based markers of lung disease severity for children with acute lung injury.  Critical Care Medicine. Vol. 40, no. 4. (April): 1309-1316.
• Muszynski J, Nateri J, Nicol K, Greathouse K, Hanson L, Hall M. 2012. Immunosuppressive effects of packed red blood cells on monocytes are related to both storage time and storage solution.  Transfusion. Vol. 52, no. 4. (April): 794-802.
• Randolph AG, Vaughn F, Sullivan R, Rubinson L, et al. 2011. Critically ill children during the 2009-2010 influenza pandemic in the United States.  Pediatrics. Vol. 128, no. 6. (December): e1450-1458.
• Muszynski JA, Hall MW. 2011. Sepsis-induced innate and adaptive immune suppression.  The Open Inflammation Journal. Vol. 4, no. Suppl 1. (October): 67-73.
• Rocourt DV, Hall M, Kenney BD, Fabia R, Groner JI, Besner GE. 2011. Respiratory failure after pediatric scald injury.  Journal of Pediatric Surgery. Vol. 46, no. 9. (September): 1753-1758.
• Muszynski JA, Knatz NL, Sargel CL, Fernandez SA, Marquardt DJ, Hall MW. 2011. Timing of correct parenteral antibiotic administration and outcomes from severe bacterial community acquired pneumonia in children.  Pediatric Infectious Disease Journal. Vol. 4, no. 30. (April): 295-301.
• Hall MW, Knatz NL, Vetterly C, Tomarello S, Wewers MD, Volk HD, Carcillo JA. 2011. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome.  Intensive Care Medicine. Vol. 3, no. 37. (March): 525-532.
• Goodman DM, Winkler MK, Fiser RT, Abd-Allah S, Mathur M, Rivero N, Weiss IK, Peterson B, Cornfield DN, Mink R, Nozik Grayck E, McCabe ME, Schuette J, Nares MA, Totapally B, Petrillo-Albarano T, Wolfson RK, Moreland JG, Potter KE, Fackler J, Garber N, Burns JP, Shanley TP, Lieh-Lai MW, Steiner M, Tieves KS, Goldsmith M, Asuncion A, Ross SL, Howell JD, Biagas K, Ognibene K, Joshi P, Rubenstein JS, Kocis KC, Cheifetz IM, Turner DA, Doughty L, Hall MW, Mason K, Penfil S, Morrison W, Hoehn KS, Watson RS, Garcia RL, Storgion SA, Fleming GM, Castillo L, Tcharmtchi MH, Taylor RP, Ul Haque I, Crain N, Baden HP, Lee KJ. 2011. The Accreditation Council for Graduate Medical Education proposed work hour regulations.  Pediatric Critical Care Medicine. Vol. 1, no. 12. (January): 120-101.
• Mark W. Hall. 2010. Immune Dysfunction in Sepsis. In Current Concepts in Pediatric Critical Care
• Marquardt DJ, Knatz NL, Wetterau LA, Wewers MD, Hall MW. 2010. Failure to recover somatotropic axis function is associated with mortality from pediatric sepsis-induced multiple organ dysfunction syndrome.  Pediatric Critical Care Medicine. Vol. 11, no. 1. (January): 18-25.
• Brierley J, Carcillo JA, Choong K, Cornell T, Decaen A, Deymann A, Doctor A, Davis A, Duff J, Dugas MA, Duncan A, Evans B, Feldman J, Felmet K, Fisher G, Frankel L, Jeffries H, Greenwald B, Gutierrez J, Hall M, Han YY, Hanson J, Hazelzet J, Hernan L, K. 2009. Clinical practice parameters for hemodynamic support of pediatric and neonatal septic shock: 2007 update from the American College of Critical Care Medicine.  Critical Care Medicine. Vol. 37, no. 2. (February): 666-688.
• Gavrilin MA, Mitra S, Seshadri S, Nateri J, Berhe F, Hall MW, Wewers MD. 2009. Pyrin critical to macrophage IL-1ß response to Francisella challenge.  Journal of Immunology. Vol. 182, no. January: 7982-7989.
• Hall MW, Muszynski JA. 2009. Immune modulation in sepsis.  Journal of Pediatric Infectious Diseases. Vol. 4, no. 2. (January): 127-136.
• Marquardt DJ, Sargel CL, Hall MW. 2009. Broad spectrum antibiotic use in the pediatric ICU: Balancing patient interests against ICU ecology.  Pediatric Critical Care Medicine. Vol. 10, no. 1. (January): 136-137.
• Phan H, Casavant MJ, Crockett S, Lee A, Hall MW, Nahata M. 2008. Serotonin syndrome following a single 50 mg dose of sertraline in a child.  Clinical Toxicology. Vol. 14, no. November: 1-5.
• Swaan PW, Bensman T, Bahadurri PM, Hall MW, Sarkar A, Eakins S, Knoell DL. 2008. Bacterial peptide recognition and immune activation facilitated by human peptide transporter PEPT2.  American Journal of Respiratory Cell and Molecular Biology. Vol. 39, no. 5. (November): 536-542.
• Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J, Carcillo JA. 2008. Intensive plasma exchange increases ADAMTS-13 activity and reverses organ dysfunction in children with Thrombocytopenia-Associated Multiple Organ Failure.  Critical Care Medicine. Vol. 36, no. 10. (October): 2878-2887.
• Frazier WJ, Hall MW. 2008. Immunoparalysis and adverse outcomes from critical illness.  Pediatric Clinics of North America. Vol. 55, no. 3. (June): 647-668.
• Fahy RJ, Exline MC, Gavrilin MA, Bhatt NY, Besecker BY, Sarkar AS, Hollyfield JL, Duncan MD, Nagaraja HN, Knatz NL, Hall MW, Wewers MD. 2008. Inflammasome mRNA expression in human monocyte expression during early septic shock.  American Journal of Respiratory and Critical Care Medicine. Vol. 177, no. 9. (May): 983-988.
• Hall MW. 2008. Immune modulation and immunotherapy in critical illness. In Rogers Textbook of Pediatric Intensive Care. 4 ed. Edited by Nichols DG. Philadelphia, PA: Lippincott, Williams and Wilkins.
• Thomas NJ, Tamburro RF, Hall MW, Rajasekaran S, Venglarcik JS. 2008. Bacterial sepsis and mechanisms of microbial pathogenesis. In Rogers Textbook of Pediatric Intensive Care. 4 ed. Edited by Nichols DG. Philadelphia, PA: Lippincott, Williams and Wilkins.
• Hall MW. 2008. Patient-specific immune monitoring. In Current Concepts in Pediatric Critical Care
• Stoner MJ, Goodman DG, Cohen DM, Fernandez SA, Hall MW. 2007. Rapid fluid resuscitation in pediatrics: testing the American College of Critical Care Medicine guideline.  Annals of Emergency Medicine. Vol. 50, no. 5. (November): 601-607.
• Hall MW, Gavrilin MA, Knatz NL, Duncan MD, Fernandez SA, Wewers MD. 2007. Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome.  Pediatric Research. Vol. 62, no. 5. (November): 597-603.
• Sarkar AS, Hall MW, Exline M, Hart J, Knatz NL, Gatson N, Wewers MD. 2006. Caspase-1 regulates E. coli sepsis and splenic B cell apoptosis independently of IL-1ß and IL-18.  American Journal of Respiratory and Critical Care Medicine. Vol. 174, no. 9. (November): 1003-1110.
• Gavrilin MA, Boakl IJ, Knatz NL, Duncan MD, Hall MW, Gunn JS, Wewers MD. 2006. Internalization and phagosome escape required for Francisella to induce human monocyte IL-1b processing and release.  Proceedings of the National Academy of Sciences. Vol. 103, no. 1. (January): 141-146.
• Felmet KA, Hall MW, Clark RS, Jaffe R, Carcillo JA. 2005. Prolonged lymphopenia, lymphoid depletion, and hypoprolactinemia in children with nosocomial sepsis and multiple organ failure.  Journal of Immunology. Vol. 174, no. 6. (March): 3765-3772.
• Hall MW. 2005. Evaluating corticosteroids in the PICU: A tale of apples and oranges.  Pediatric Critical Care Medicine. Vol. 6, no. 3. (January): 370-371.
• Kim HJ, Hart J, Knatz N, Hall MW, Wewers MD. 2004. JAK3 down-regulates LPS-induced ICE activation by autocrine IL-10.  Journal of Immunology. Vol. 172, no. 8. (April): 4948-4955.
• Venkataraman ST, Carcillo JA, Hall MW, Ruppel RA, Kochanek PM. 2002. Pediatric critical care: Selected aspects of perioperative management of infants and children. In Critical Care Medicine: Perioperative Management. 2 ed. Edited by Coursin, Murray, Prough, Pearl. Philadelphia, PA: Lippincott, Williams and Wilkins.
• Nguyen T, Hall M, Han Y, Fiedor M, Hasset A, Lopez-Plaza I, Watson S, Lum L, Carcillo JA. 2001. Microvascular thrombosis in pediatric multiple organ failure: Is it a therapeutic target?.  Pediatric Critical Care Medicine. Vol. 2, no. 3. (July): 187-196.
• Muszysnki JA, Sartori J, Steele L, Frost R, Wang W, Khan N, Lee A, Lin A, Hall MW, Ayad O. A mutli-disciplinary quality improvement initiative to reduce ventilator-associated tracheobronchitis in the pediatric intensive care unit.  Pediatric Critical Care Medicine.
• Naguib AN, Tobias JD, Hall MW, et al. The role of different anesthetic techniques in altering the stress response during cardiac surgery in children: A prospective, double blinded and randomized study.  Pediatric Critical Care Medicine.
• Cornell TT, Sun L, Hall MW, Gurney JG, Ashbrook MJ, Ohye RG, Shanley TP. 0. Clinical implications and molecular mechanisms of immunoparalysis following cardiopulmonary bypass.  Journal of Thoracic and Cardiovascular Surgery.

• Chief Resident, Children's Hospital of Pittsburgh, 1998
• 2007 Nationwide Children’s Hospital Fellow’s Patient Oriented Research Award (awarded to David J. Marquardt, MD: Fellow; Mark W. Hall: Mentor)
• Fellow, American Academy of Pediatrics
• Listed, Best Doctors in America
• Member, American Association of Immunologists
• Member, American Society of Transplantation
• Member, American Thoracic Society
• Member, Society of Critical Care Medicine (SCCM)