Lauren O. Bakaletz, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Lauren O. Bakaletz, PhD

Lauren O. Bakaletz, PhD

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Childrens Drive
Columbus, OH 43205 [ map ]
PH: (614) 722-2915
FX: (614) 722-2818
E-mail Me

Biography

Lauren O. Bakaletz, PhD, is a principal investigator in and the director of the Center for Microbial Pathogenesis at the Research Institutes at Nationwide Children’s Hospital. She is a Professor in the Departments of Pediatrics and of Otolaryngology at The Ohio State University College of Medicine. The research program of the Bakaletz Lab is focused on determining the molecular mechanisms that underlie polymicrobial infections of the respiratory tract, with a primary emphasis on otitis media or middle ear infections, a highly prevalent pediatric disease worldwide.

View CV »

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Our laboratory’s research focus is attempting to understand the pathogenic mechanisms operational in the highly prevalent pediatric disease, otitis media (OM) (or middle ear infection). Specifically, we are interested in elucidating how upper respiratory tract viruses predispose the middle ear to invasion by any of the three predominant bacterial pathogens of OM (nontypeable Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae). We are also interested in understanding how bacterial biofilms contribute to the recurrence and chronicity of OM, chronic rhinosinusitis, bronchitis, chronic cough and exacerbations of both COPD and CF. With this enhanced understanding, we then attempt to identify potential molecular targets for the design, development and pre-clinical testing of novel vaccine candidates or therapeutics using an animal model of viral-bacterial superinfection that closely mimics the polymicrobial nature of OM in children. Our long-term goal is to develop novel methods to more effectively treat or preferably, to prevent, otitis media and other respiratory tract infections where there is a biofilm component to the disease course.

Education and Training

Post Doctoral

  • The Ohio State University
    Date Completed: 06/30/1984

Section:

  • Center for Microbial Pathogenesis

Professional Experience

2008–present

  • Professor, Dept. of Otolaryngology (joint appointment), The Research Institute at Nationwide Children's Hospital, The Ohio State University

2007–present

  • Vice President for Basic Science Research, The Research Institute at Nationwide Children's Hospital

2007–present

  • Professor, Dept. of Pediatrics, The Research Institute at Nationwide Children's Hospital, The Ohio State University

2006–2007

  • Vice President for Basic Science Research, Columbus Children's Research Institute

2000–2007

  • Professor, Dept. of Pediatrics, Children's Research Institute, The Ohio State University

1998–2000

  • Associate Professor, Dept. of Pediatrics, Children's Research Institute, The Ohio State University

1993–1998

  • Associate Professor, Dept. of Otolaryngology, The Ohio State University

1987–1993

  • Assistant Professor, Dept. of Otolaryngology, The Ohio State University

1985–1986

  • Post-doctoral Researcher, Dept. of Otolaryngology, The Ohio State University

Publications

  • Taneja N-K, Ganguly T, Bakaletz LO, Dubey P, Poole L, Deora R. 2013. D-alanine modification of a protease-susceptible outer membrane component by the Bordetella pertussis dra locus promotes cellular adherence and resistance to antimicrobial peptides and PMN-mediated killing.  J Bacteriol. Vol. 195, no. 22. (November): 5102-5111.
  • Das S, Rosas LE, Jurcisek JA, Novotny LA, Bakaletz LO. 2013. Improving patient care via development of a protein-based diagnostic test for microbe-specific detection of chronic rhinosinusitis.  Laryngoscope. Vol. epub ahead of print 10/2/13, no. October: edoi: 10.1002/lary.24333.
  • Gustave JE, Jurcisek JA, McCoy KS, Goodman SD, Bakaletz LO. 2013. Targeting bacterial integration host factor to disrupt biofilms associated with cystic fibrosis.  J Cystic Fibrosis. Vol. 12, no. 4. (July): 384-389.
  • Dagan R, Leibovitz E, Greenberg D, Bakaletz LO, Givon-Lavi N. 2013. Mixed pneumococcal - nontypeable Haemophilus influenzae otitis media is a distinct clinical entity with unique epidemiologic characteristics and pneumococcal serotype distribution.  J Infect Dis. Vol. 208, no. 7. (July): 1152-1160.
  • Novotny LA, Clements, JD, Bakaletz LO. 2013. Kinetic analysis and evaluation of the mechanisms involved in the resolution of experimental nontypeable Haemophilus influenzae-induced otitis media after transcutaneous immunization.  Vaccine. Vol. 31, no. July: 3417-3426.
  • Cywes-Bentley C, Skurnik D, Zaidi T, Roux D, DeOliveira RB, Garrett WS, Lu X, O'Malley J, Kinzel K, Zaidi T, Rey A, Perrin C, Fichorova RN, Kayatani AK, Maira-Litràn T, Gening ML, Tsvetkov YE, Nifantiev NE, Bakaletz LO, Pelton SI, Golenbock DT, Pier GB. 2013. Antibody to a conserved antigenic target is protective against diverse prokaryotic and eukaryotic pathogens.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 110, no. 24. (June): E2209-18.
  • Abu Khweek A, Fernández Dávila NS, Caution K, Akhter A, Abdulrahman BA, Tazi M, Hassan H, Novotny LA, Bakaletz LO, Amer AO. 2013. Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.  Frontiers in cellular and infection microbiology. Vol. 3, no. May: e18.
  • Brandstetter KA, Jurcisek JA, Goodman SD, Bakaletz LO, Das S. 2013. Antibodies directed against integration host factor mediate biofilm clearance from nasopore.  Laryngoscope. Vol. 123, no. 11. (May): 2626-2623.
  • Li J-D, Hermansson A, Ryan A, Bakaletz LO, Brown SD, Cheeseman MT, Juhn SK, Jung TTK, Lim DJ, Lim JH, Lin J, Moon S-K, Post JC. 2013. Panel 4: Recent Advances in Otitis Media in Molecular Biology, Biochemistry, Genetics, and Animal Models.  OTOLARYNGOLOGY-HEAD AND NECK SURGERY. Vol. 148, no. April: E52-E63.
  • Caye-Thomasen P, Hermansson A, Bakaletz LO, Hellstrom S, Kanzaki S, Kerschner J, Lim D, Lin J, Mason K, Spratley J. 2013. Panel 3: Recent Advances in Anatomy, Pathology, and Cell Biology in Relation to Otitis Media Pathogenesis.  OTOLARYNGOLOGY-HEAD AND NECK SURGERY. Vol. 148, no. April: E37-E51.
  • Pelton SI, Pettigrew MM, Barenkamp SJ, Godfroid F, Grijalva CG, Leach A, Patel J, Murphy TF, Selak A, Bakaletz LO. 2013. Panel 6: Vaccines.  OTOLARYNGOLOGY-HEAD AND NECK SURGERY. Vol. 148, no. April: E90-E101.
  • Kunthalert D, Novotny LA, Massa HM, Ulett GC, Bakaletz LO, Kyd JM, Cripps AW. 2013. Epitope-specific immune recognition of the nontypeable Haemophilus influenzae outer membrane protein 26.  Hum Vaccin Immunother. Vol. 9, no. 3. (March): 625-635.
  • Jones EA, McGillivary G, Bakaletz LO. 2013. Extracellular DNA within a Nontypeable Haemophilus influenzae-Induced Biofilm Binds Human Beta Defensin-3 and Reduces Its Antimicrobial Activity.  J Innate Immun. Vol. 5, no. 1. (January): 24-38.
  • Novotny LA, Amer AO, Brockson ME, Goodman SD, Bakaletz LO. 2013. Structural Stability of Burkholderia cenocepacia Biofilms Is Reliant on eDNA Structure and Presence of a Bacterial Nucleic Acid Binding Protein.  PLoS One. Vol. 8, no. 6. (January): ee67629.
  • McGillivary G, Jordan ZB, Peeples ME, Bakaletz LO. 2013. Replication of Respiratory Syncytial Virus Is Inhibited by the Host Defense Molecule Viperin.  J Innate Immun. Vol. 5, no. 1. (January): 60-71.
  • Brockson ME, Novotny LA, Jurcisek JA, McGillivary G, Bowers MR, Bakaletz LO. 2012. Respiratory Syncytial Virus Promotes Moraxella catarrhalis-Induced Ascending Experimental Otitis Media.  PLoS One. Vol. 7, no. 6. (June): ee40088.
  • Bakaletz, LO. 2012. Bacterial biofilms in the airway – evidence for role in pathology and implications for treatment.  Paediatr Respir Rev. Vol. 13, no. 3. (April): 154-159.
  • Harrison A, Bakaletz LO, Munson Jr, RS. 2012. Haemophilus influenzae and oxidative stress.  Front Cell Inf Microbio. Vol. 2, no. 40. (March): edoi: 10.3389/fcimb.2012.00040.
  • Kolappan S, Tracy EN, Bakaletz LO, Munson Jr RS, Craig L. 2012. Expression, purification, crystallization and preliminary crystallographic analysis of PilA from the nontypeable Haemophilus influenzae type IV pilus.  Acta Crystallographica. Vol. F68, no. March: e284.
  • Hoopman T, Liu W, Joslin S, Pybus C, Sedillo J, Labandeira-Rey M, Laurence C, Wang W, Richardson J, Bakaletz LO, Hansen E. 2012. Use of the chinchilla model for nasopharyngeal colonization to study gene expression by Moraxella catarrhalis.  Infect Immun. Vol. 80, no. 3. (March): e982.
  • Carruthers MD, Tracy EN, Dickson AC, Ganser K, Munson Jr RS, Bakaletz LO. 2012. Nontypeable Haemophilus influenzae type IV pili: biological roles of the products encoded by the pil and com operons.  J Bacteriol. Vol. 194, no. 8. (February): 1927-1933.
  • Mason KM, Raffel FK, Ray WC, Bakaletz LO. 2011. Heme utilization by nontypeable Haemophilus influenzae is essential and dependent on Sap transporter function.  J Bacteriol. Vol. 193, no. 10. (January): e2527.
  • Goodman SD, Obergfell KP, Jurcisek JA, Novotny LA, Downey JS, Ayala EA, Tjokro N, Li B, Justice SS, Bakaletz LO. 2011. Biofilms can be dispersed by focusing the immune system on a common family of bacterial nucleoid-associated proteins.  Mucosal Immunol. Vol. 4, no. 6. (January): e625.
  • Novotny LA, Clements JD, Bakaletz LO. 2011. Transcutaneous immunization as preventative and therapeutic regimens to protect against experimental otitis media due to nontypeable Haemophilus influenzae.  Mucosal Immunol. Vol. 4, no. 4. (January): e456.
  • Johnson RW, McGillivary G, Denoël P, Poolman J, Bakaletz LO. 2011. Abrogation of nontypeable Haemophilus influenzae protein D function reduces phosphorylcholine decoration, adherence to airway epithelial cells, and fitness in a chinchilla model of otitis media.  Vaccine. Vol. 29, no. 6. (January): 1211-1221.
  • Underwood M, Bakaletz LO. 2011. Innate immunity and the role of defensins in otitis media.  Current Allergy And Asthma Reports. Vol. 11, no. 6. (January): e499.
  • Jurcisek JA, Dickson AC, Bruggeman ME, Bakaletz LO. 2011. In vitro biofilm formation in an 8-well chamber slide.  J Vis Exp. Vol. 47, no. January: edoi: 10.3791/2481.
  • McGillivary G, Bakaletz LO. 2010. The multifunctional host defense peptide SPLUNC1 is critical for homeostasis of the mammalian upper airway.  PLoS One. Vol. 5, no. 10. (October): ee13224.
  • Bakaletz LO. 2010. Immunopathogenesis of polymicrobial otitis media.  J Leukoc Biol. Vol. 87, no. 2. (January): e213.
  • Grieves JL, Jurcisek JA, Quist B, Durbin RK, Peeples ME, Durbin JE, Bakaletz LO. 2010. Mapping the anatomy of respiratory syncytial virus infection of the upper airways in chinchillas (Chinchilla lanigera).  Comp Med. Vol. 60, no. 3. (January): e225.
  • Bakaletz LO. 2009. Chinchilla as a robust, reproducible and polymicrobial model of otitis media and its prevention.  Expert Rev Vaccines. Vol. 8, no. 8. (January): 1063-1082.
  • Murphy TF, Faden H, Bakaletz LO, Kyd JM, Forsgren A, Campos J, Virji M, Pelton SI. 2009. Nontypeable Haemophilus influenzae as a pathogen in children.  Pediatr Infect Dis J. Vol. 28, no. 1. (January): 43-48.
  • Novotny LA, Adams LD, Kang DR, Wiet GJ, Cai X, Sethi S, Murphy TF, Bakaletz LO. 2009. Epitope mapping immunodominant regions of the PilA protein of nontypeable Haemophilus influenzae (NTHI) to facilitate the design of two novel chimeric vaccine candidates.  Vaccine. Vol. 28, no. 1. (January): 279-289.
  • Morton DJ, Seale TW, Bakaletz LO, Jurcisek JA, Smith A, VanWagoner TM, Whitby PW, Stull TL. 2009. The heme-binding protein (HbpA) of Haemophilus influenzae as a virulence determinant.  Int J Med Microbiol. Vol. 299, no. 7. (January): 479-488.
  • Murphy TF, Bakaletz LO, Smeesters PR. 2009. Microbial interactions in the respiratory tract.  Pediatr Infect Dis J. Vol. 28, no. 10 Suppl. (January): eS121.
  • Bakaletz LO. 2009. Moraxella catarrhalis and non-typable Haemophilus influenzae vaccines to prevent otitis media. In New Generation Vaccines. 4th ed ed. Edited by Levine, M.M., Dougan, G., Good, M.F., Liu, M.A., Nabel, G.J., Nataro, J.P. and Rappuoli, R.. New York: Informa Healthcare.
  • McGillivary G, Mason KM, Jurcisek JA, Peeples ME, Bakaletz LO. 2009. Respiratory syncytial virus-induced dysregulation of expression of a mucosal beta-defensin augments colonization of the upper airway by non-typeable Haemophilus influenzae.  Cell Microbiol. Vol. 11, no. 9. (January): 1399-1408.
  • Novotny LA, Partida-Sanchez S, Munson Jr RS, Bakaletz LO. 2008. Differential uptake and processing of a Haemophilus influenzae P5-derived immunogen by chinchilla dendritic cells.  Infect Immun. Vol. 76, no. 3. (January): 967-977.
  • McGillivary G; Bakaletz LO. 2008. Innate immune defenses: finding a new way to calm the storm.  Immunol Cell Biol. Vol. 86, no. 8. (January): e639.
  • McGillivary G, Bakaletz LO. 2008. Innate immune defenses: finding a new way to calm the storm.  Immunol Cell Biol. Vol. 86, no. 8. (January): 639-640.
  • Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO. 2008. Spotlight.  Infect Immun. Vol. 76, no. 1. (January): e21.
  • Bookwalter JE, Jurcisek JA, Gray-Owen SD, Fernandez S, McGillivary G, Bakaletz LO. 2008. A carcinoembryonic antigen-related cell adhesion molecule 1 homologue plays a pivotal role in nontypeable Haemophilus influenzae colonization of the chinchilla nasopharynx via the OMP P5-homologous adhesin.  Infect Immun. Vol. 76, no. 1. (January): 48-55.
  • Bakaletz LO. 2007. Bacterial biofilms in otitis media: evidence and relevance.  Pediatr Infect Dis J. Vol. 26, no. 10 Suppl. (January): S17-S19.
  • McGillivary G, Ray WC, Bevins CL, Munson Jr RS, Bakaletz LO. 2007. A member of the cathelicidin family of antimicrobial peptides is produced in the upper airway of the chinchilla and its mRNA expression is altered by common viral and bacterial co-pathogens of otitis media.  Mol Immunol. Vol. 44, no. 9. (January): 2446-2458.
  • Jurcisek JA, Bookwalter JE, Baker BD, Fernandez S, Novotny LA, Munson RS Jr, Bakaletz LO. 2007. The PilA protein of non-typeable Haemophilus influenzae plays a role in biofilm formation, adherence to epithelial cells and colonization of the mammalian upper respiratory tract.  Mol Micro. Vol. 65, no. 5. (January): 1288-1299.
  • Harrison A, Ray WC, Baker BD, Armbruster DW, Bakaletz LO, Munson Jr RS. 2007. The OxyR regulon in nontypeable Haemophilus influenzae.  J Bacteriol. Vol. 189, no. 3. (January): 1004-1012.
  • Jurcisek JA, Bakaletz LO. 2007. Biofilms formed by nontypeable Haemophilus influenzae in vivo contain both double-stranded DNA and type IV pilin protein.  J Bacteriol. Vol. 189, no. 10. (January): 3868-3875.
  • Hong W, Mason KM, Jurcisek JA, Novotny LA, Bakaletz LO, Swords WE. 2007. Phosphorylcholine decreases early inflammation and promotes the establishment of stable biofilm communities of nontypeable Haemophilus influenzae strain 86-028NP in a chinchilla model of otitis media.  Infect Immun. Vol. 75, no. 2. (January): 958-965.
  • Luke NR, Jurcisek JA, Bakaletz LO, Campagnari AA. 2007. Contribution of Moraxella catarrhalis type IV pili to nasopharyngeal colonization and biofilm formation.  Infect Immun. Vol. 75, no. 12. (January): 5559-5564.
  • Jewell NA, Vaghefi N, Mertz SE, Akter P, Peebles Jr RS, Bakaletz LO, Durbin RK, Flano E, Durbin JE. 2007. Differential type I interferon induction by respiratory syncytial virus and influenza a virus in vivo.  J Virol. Vol. 81, no. 18. (January): 9790-9800.
  • Mason KM, Bruggeman ME, Munson Jr RS, Bakaletz LO. 2006. The nontypeable Haemophilus influenzae Sap transporter provides a mechanism of antimicrobial peptide resistance and SapD-dependent potassium acquisition.  Mol Micro. Vol. 62, no. 5. (January): 1357-1372.
  • Wang HH, Manuzon M, Lehman M, Wan K, Luo H, Wittum TE, Yousef A, Bakaletz LO. 2006. Food commensal microbes as a potentially important avenue in transmitting antibiotic resistance genes.  FEMS Microb Lett. Vol. 254, no. 2. (January): 226-231.
  • Novotny LA, Jurcisek JA, Godfroid F, Poolman JT, Denoel PA, Bakaletz LO. 2006. Passive immunization with human anti-protein D antibodies induced by polysaccharide protein D conjugates protects chinchillas against otitis media after intranasal challenge with Haemophilus influenzae.  Vaccine. Vol. 24, no. 22. (January): 4804-4811.
  • Bakaletz LO. 2006. Peptide Vaccine for Otitis Media. In Handbook of Biologically Active Peptides. Edited by Kastin, A.J.. San Diego: Elsevier.
  • Avadhanula A, Rodriguez CA, Ulett GC, Bakaletz LO, Adderson EE. 2006. Nontypeable Haemophilus influenzae adheres to intercellular adhesion molecule 1 (ICAM-1) on respiratory epithelial cells and upregulates ICAM-1 expression.  Infect Immun. Vol. 74, no. 2. (January): 830-838.
  • Barenkamp SJ, Kurono Y, Ogra PL, Leiberman, A, Bakaletz LO, Murphy TF, Chonmaitree T, Patel JA, Heikkinen T, Sih TM, Hurst DS, St Geme 3rd JW, Kawauchi H, Stenfors L-E. 2005. Recent advances in otitis media. 5. Microbiology and immunology.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194, no. January: 60-85.
  • Gitiban N, Jurcisek JA, Harris RH, Mertz S, Durbin RK, Bakaletz LO, Durbin JE. 2005. Chinchilla and murine models of upper respiratory tract infection with respiratory syncytial virus.  J Virol. Vol. 79, no. 10. (January): 6035-6042.
  • Lim DJ, Hermansson A, Hellstrom SO, Hussl B, Alper CM, Iino Y, Andalibi A, Jung TTK, Bakaletz LO, Kawauchi H, Buchman CA, Kerschner J, Caye-Thomasen P, Lin J, Chole RA, Merchant SN, Herman P, Paparella MM, Lee H-Y, Kang S-H. 2005. Recent advances in otitis media. 3. Animal models; anatomy and pathology; pathogenesis; cell biology and genetics.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, no. January: 31-41.
  • Bakaletz LO, Baker BD, Jurcisek JA, Harrison A, Novotny LA, Bookwalter JE, Mungur R, Munson Jr RS. 2005. Demonstration of Type IV pilus expression and a twitching phenotype by Haemophilus influenzae.  Infect Immun. Vol. 73, no. 3. (January): 1635-1643.
  • Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4C. Interaction between middle ear and inner ear in otitis media.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194, no. January: 56-59.
  • Giebink GS, Kurono Y, Bakaletz LO, Kyd JM, Barenkamp SJ, Murphy TF, Green B, Ogra PL, Gu X-X, Patel JA, Heikkinen T, Pelton SI, Hotomi M, Karma P. 2005. Recent advances in otitis media. 6. Vaccine.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, no. January: 86-103.
  • Mason KM, Munson Jr RS, Bakaletz LO. 2005. A mutation in the sap operon attenuates survival of nontypeable Haemophilus influenzae in a chinchilla model of otitis media.  Infect Immun. Vol. 73, no. 1. (January): 599-608.
  • Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4A. Molecular biology.  Ann Otol Rhinol Otolaryngol. Supplement. Vol. 194, no. January: 42-49.
  • Jurcisek JA, Greiner L, Watanabe H, Zaleski A, Apicella MA, Bakaletz LO. 2005. The role of sialic acid and complex carbohydrate biosynthesis in biofilm formation by nontypeable Haemophilus influenzae in the chinchilla middle ear.  Infect Immun. Vol. 73, no. 6. (January): 3210-3218.
  • Murphy TF, Bakaletz LO, Kyd JM, Watson B, Klein DL. 2005. Vaccines for otitis media: proposals for overcoming obstacles to progress.  Vaccine. Vol. 23, no. 21. (January): 2696-2702.
  • Novotny LA, Mason KM, Bakaletz LO. 2005. Development of a chinchilla model to allow direct, continuous, biophotonic imaging of bioluminescent nontypeable Haemophilus influenzae during experimental otitis media.  Infect Immun. Vol. 73, no. 1. (January): 609-611.
  • Ryan AF, Jung TTK, Juhn SK, Li J-D, Andalibi A, Lin J, Bakaletz LO, Post CJ, Ehrlich GD. 2005. Recent advances in otitis media. 4B. Biochemistry.  Ann Otol Rhinol Laryngol. Supplement. Vol. 194, no. January: 50-55.
  • Harrison A, Dyer DW, Gillaspy A, Ray WC, Mungur R, Carson MB, Zhong H, Gipson J, Gipson M, Johnson LS, Lewis L, Bakaletz LO, Munson Jr. RS. 2005. The genomic sequence of an otitis media isolate of nontypeable Haemophilus influenzae: comparative study with H. influenzae serotype d, strain KW20.  J Bacteriol. Vol. 187, no. 13. (January): 4627-4636.
  • Munson Jr RS, Harrison A, Gillaspy A, Ray WC, Carson M, Armbruster D, Gipson J, Gipson M, Johnson L, Lewis L, Dyer DW, Bakaletz LO. 2004. Partial analysis of the genomes of two nontypeable Haemophilus influenzae otitis media isolates.  Infect Immun. Vol. 72, no. 5. (January): 3002-3010.
  • Bakaletz LO. 2004. Developing animal models for polymicrobial diseases.  Nat Rev Microbiol. Vol. 2, no. 7. (January): 552-568.
  • Morton DJ, Bakaletz LO, Jurcisek JA, Van Wagoner TM, Seale TW, Whitby PW, Stull TL. 2004. Reduced severity of middle ear infection caused by NTHI lacking the hemoglobin/ hemoglobin-haptoglobin binding proteins (Hgp) in a chinchilla model of otitis media.  Microb Pathog. Vol. 36, no. 1. (January): 25-33.
  • Harris RH, Wilk D, Bevins CL, Munson Jr RS, Bakaletz LO. 2004. Identification and characterization of a mucosal antimicrobial peptide expressed by the chinchilla (Chinchilla lanigera) airway.  J Biol Chem. Vol. 279, no. 19. (January): 20250-20256.
  • Kyd JM, Cripps AW, Novotny LA, Bakaletz LO. 2003. Efficacy of OMP26 and two P5-fimbrin derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx.  Infect Immun. Vol. 71, no. 8. (January): 4691-4699.
  • Jurcisek JA, Durbin JE, Kusewitt DF, Bakaletz LO. 2003. Anatomy of the nasal cavity in the chinchilla.  Cell, Tissues, Organs. Vol. 174, no. 3. (January): 136-152.
  • Novotny LA, Bakaletz LO. 2003. The fourth surface-exposed region of the OMP P5-homologous adhesin of nontypeable H. influenzae is an immunodominant but non-protective decoy epitope.  J Immunol. Vol. 71, no. 4. (January): 1978-1983.
  • Mason KM, Munson RS, Bakaletz LO. 2003. Nontypeable Haemophilus influenzae gene expression induced in vivo in a chinchilla model of otitis media.  Infect Immun. Vol. 71, no. 6. (January): 3454-3462.
  • Alper CM, Andalibi A, Bakaletz LO, Buchman C, Cayé-Thomasen P, Hellstrom SOM, Herman P, Hermansson A, Hussl B, Iino Y, Kawauchi H, Paparella MM, Sando I, Swarts JD, Takasaka T. 2002. Recent advances in otitis media. 4. Anatomy, cell biology, pathology, and animal models.  The Annals of otology, rhinology & laryngology. Supplement. Vol. 188, no. March: 36-51.
  • Bakaletz LO, Barenkamp SJ, Eskola J, Green B, Gu X-X, Harada T, Heikkinen T, Karma P, Klein JO, Kurono Y, Mogi G, Murphy TF, Ogra PL, Patel JA, Suzuki M, Yamanaka N. 2002. Recent advances in otitis media. 7. Vaccine.  The Annals of otology, rhinology & laryngology. Supplement. Vol. 188, no. March: 82-94.
  • Bakaletz LO, Juhn SK, Jung TTK, Li JD. 2002. Recent advances in otitis media. 5. Molecular biology and biochemistry.  The Annals of otology, rhinology & laryngology. Supplement. Vol. 188, no. March: 52-61.
  • DeMaria TF, Bakaletz LO, ChonmaitreeT, Heikkinen T, Hurst DS, Kawauchi H, Kurono Y, Patel JA, Sih TM, Stenfors L-E, Suzuki M. 2002. Recent advances in otitis media. 6. Microbiology and immunology.  The Annals of otology, rhinology & laryngology. Supplement. Vol. 188, no. March: 62-81.
  • Visweswaraiah A, Novotny LA, Hjemdahl-Monsen EJ, Bakaletz LO, Thanavala Y. 2002. Tracking the tissue distribution of marker dye following intranasal delivery in mice and chinchillas: a multifactorial analysis of parameters affecting nasal retention.  Vaccine. Vol. 20, no. 25-26. (January): 3209-3220.
  • Novotny LA, Pichichero ME, Denoel PA, Neyt C, Vanderschrick S, Dequesne G, Bakaletz LO. 2002. Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media.  Vaccine. Vol. 20, no. 29-30. (January): 3590-3597.
  • Bakaletz LO. 2002. Otitis Media. In Polymicrobial Diseases. Edited by Brogden, K.A. and Guthmiller, J.M.. Washington, D.C.: American Society for Microbiology Press.
  • Bakaletz LO. 2001. Peptide and recombinant antigens for protection against bacterial middle ear infection.  Vaccine. Vol. 19, no. 17-19. (January): 2323-2328.
  • Kennedy B, Novotny LA, Jurcisek JA, Lobet Y, Bakaletz LO. 2000. Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge.  Infect Immun. Vol. 68, no. 5. (January): 2756-2765.
  • Novotny LA, Jurcisek JA, Bakaletz LO. 2000. Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae.  Infect Immun. Vol. 68, no. 4. (January): 2119-2128.
  • Poolman JT, Bakaletz LO, Cripps A, Denoël P, Forsgren A, Kyd J, Lobet Y. 2000. Developing a nontypeable Haemophilus influenzae (NTHi) vaccine.  Vaccine. Vol. 19, no. Suppl 1. (January): eS108.
  • Bakaletz LO, Kennedy BJ, Novotny LA, Dequesne G, Cohen J, Lobet Y. 1999. Protection against development of otitis media induced by nontypeable H. influenzae by both active and passive immunization in a chinchilla model of viral-bacterial superinfection.  Infect Immun. Vol. 67, no. 6. (January): 2746-2762.
  • Jiang A, Nagata N, Molina E, Bakaletz LO, Hawkins H, Patel JA. 1999. Fimbriae-mediated enhanced attachment of nontypeable Haemophilus influenzae to respiratory syncytial virus-infected respiratory epithelial cells.  Infect Immun. Vol. 67, no. 1. (January): 187-192.
  • Bakaletz LO, Post JC, Ehrlich GD. 1998. Blinded multiplex PCR analysis of middle ear and nasopharyngeal fluids recovered from experimental chinchilla models of single and mixed pathogen induced otitis media.  Clin Diag Lab Immunol. Vol. 5, no. 2. (January): 219-224.
  • Welling DB, Parnes LS, O'Brien B, Bakaletz LO, Brackmann DE, Hinojosa R. 1997. Particulate matter in the posterior semicircular canal.  Laryngoscope. Vol. 107, no. 1. (January): 90-94.
  • Bakaletz LO, Leake ER, Billy JM, Kaumaya PTP. 1997. Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla.  Vaccine. Vol. 15, no. 9. (January): 955-961.
  • Holmes K, Bakaletz LO. 1997. Adherence of nontypeable H. influenzae promotes re-organization of the actin cytoskeleton in human or chinchilla epithelial cells in vitro.  Microb Pathog. Vol. 23, no. 3. (January): 157-166.
  • Miyamoto N, Bakaletz LO. 1997. Kinetics of the ascension of NTHi from the nasopharynx to the middle ear of the chinchilla coincident with adenovirus-induced compromise.  Microb Pathog. Vol. 23, no. 2. (January): 119-126.
  • Bakaletz LO, Holmes KA. 1997. Evidence of transudation of specific antibody into the middle ears of parenterally immunized chinchillas after an upper respiratory tract infection with adenovirus.  Clin Diag Lab Immunol. Vol. 4, no. 2. (January): 223-225.
  • Miyamoto N, Bakaletz LO. 1996. Selective adherence of nontypeable H.influenzae (NTHi) to mucus or epithelial cells in the chinchilla Eustachian tube and middle ear.  Microb Pathog. Vol. 21, no. 5. (January): 343-356.
  • Bakaletz LO. 1995. Viral potentiation of bacterial superinfection of the airway.  Trends Microbiol. Vol. 3, no. 3. (January): 110-114.
  • Karma PH, Bakaletz LO, Giebink GS, Mogi G, Rynnel-Dagöö B. 1995. Immunological aspects of otitis media with special reference to immunoprophylaxis of acute otitis media in infants and children.  Intl J Ped Otolaryngol. Vol. 32, no. January: S127-S134.
  • Bakaletz LO, Murwin DM, Billy JM. 1995. Adenovirus serotype 1 does not act synergistically with Moraxella catarrhalis to induce otitis media in the chinchilla.  Infect Immun. Vol. 63, no. 10. (January): 4188-4190.
  • Kunin CM, Tong H-H, Bakaletz LO. 1995. Effect of salicylate on expression of flagella by Escherichia coli, Proteus, Providencia and Pseudomonas.  Infect Immun. Vol. 63, no. 5. (January): 1796-1799.
  • Bakaletz LO, Barenkamp SJ. 1994. Localization of high molecular weight adhesion proteins of nontypable Haemophilus influenzae by immunoelectron microscopy.  Infect Immun. Vol. 62, no. 10. (January): 4460-4468.
  • Kunin CM, Hua T, Bakaletz LO, Guerrant RL. 1994. Effect of salicylate, bismuth, osmolytes, and tetracycline resistance on expression of fimbriae by Escherichia coli.  Infect Immun. Vol. 62, no. 6. (January): 2178-2186.
  • Suzuki K, Bakaletz LO. 1994. Synergistic effect of adenovirus type 1 and nontypeable Haemophilus influenzae in a chinchilla model of experimental otitis media.  Infect Immun. Vol. 62, no. 5. (January): 1710-1718.
  • Hesseling SC, van Blitterswijk CA, Lim DJ, DeMaria TF, Bakaletz LO, Grote JJ. 1994. The effect of endotoxin on cultured rat middle ear epithelium, rat meatal epidermis and human keratinocytes.  Amer J Otology. Vol. 15, no. 6. (January): 762-768.
  • Sirakova T, Kolattukudy PE, Murwin D, Billy J, Leake E, Lim DJ, DeMaria TF, Bakaletz LO. 1994. The role of fimbriae expressed by nontypeable Haemophilus influenzae in the pathogenesis of and protection against otitis media and relatedness of the fimbrin subunit to outer membrane protein A.  Infect Immun. Vol. 62, no. 5. (January): 2002-2020.
  • Bakaletz LO, Daniels RL, Lim DJ. 1993. Modeling adenovirus type 1-induced otitis media in the chinchilla: effect on ciliary activity and fluid transport function of Eustachian tube mucosal epithelium.  J Infect Dis. Vol. 168, no. 4. (January): 865-872.
  • Park K, Bakaletz LO, Coticchia JM, Lim DJ. 1993. Effect of influenza A virus on ciliary activity and dye transport function in the chinchilla Eustachian tube.  Ann Otol Rhinol Laryngol. Vol. 102, no. 7. (January): 551-558.
  • Gilsdorf JR, Chang HY, McCrea KW, Bakaletz LO. 1992. Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae.  Infect Immun. Vol. 60, no. 2. (February): 374-379.
  • Bakaletz LO, Ahmed MA, Kolattukudy PE, Lim DJ, Forney LJ. 1992. Cloning and sequence analysis of a pilin-like gene from an otitis media isolate of nontypeable Haemophilus influenzae.  J Infect Dis. Vol. 165 Suppl 1, no. January: S201-S203.
  • Lim DJ, Bakaletz LO. 1992. An investigation of the molecular basis of nontypable Haemophilus influenzae adherence to mucosal epithelium.  Rhinology, Supplement. Vol. 14, no. January: 37-41.
  • DeMaria TF, Yamaguchi T, Bakaletz LO, Lim DJ. 1992. Serum and middle ear antibody response in the chinchilla during otitis media with effusion induced by nonviable nontypeable Haemophilus influenzae.  J Infect Dis. Vol. 165 Suppl 1, no. January: S196-S197.
  • Gilsdorf JR, Chang HY, McCrea KW, Bakaletz LO. 1992. Comparison of hemagglutinating pili of Haemophilus influenzae type b with similar structures of nontypeable H. influenzae.  Infect Immun. Vol. 60, no. 2. (January): 374-379.
  • Liauw L, Lim DJ, Bakaletz LO, van Blitterswijk C. 1991. Effect of vitamin A on the growth and differentiation of rat external auditory canal epithelium in organ culture.  Amer J Otolaryngol. Vol. 12, no. 2. (January): 67-75.
  • Lim DJ, Coticchia JM, Ueno K, Heiselman FA, Bakaletz LO. 1991. Glycoconjugates in the chinchilla tubotympanum.  Ann Otol Rhinol Laryngol. Vol. 100, no. 11. (January): 933-943.
  • Bakaletz LO, Tallan BM, Andrzejewski WJ, DeMaria TF, Lim DJ. 1989. Immunological responsiveness of chinchillas to outer membrane and isolated fimbrial proteins of nontypeable Haemophilus influenzae.  Infect Immun. Vol. 57, no. 10. (January): 3226-3229.
  • Ogra PL, Giebink GS, Barenkamp SJ, DeMaria TF, Juhn SK, Shurin PA, Andersson B, Bakaletz LO, Bernstein JM, Brinton CC. 1989. Recent advances in otitis media. Microbiology, immunology, biochemistry, and vaccination.  Ann Otol Rhinol Laryngol. Vol. 139, no. January: 23-32.
  • Bakaletz LO, Griffith SR, Lim DJ. 1989. Effect of prostaglandin E2 and bacterial endotoxin on the rate of dye transport in the Eustachian tube of the chinchilla.  Ann Otol Rhinol Laryngol. Vol. 98, no. 4 Pt 1. (January): 278-282.
  • Bakaletz LO, Ohashi Y, Demaria TF, Lim DJ. 1989. Effect of formalin-fixed Hemophilus influenzae and Streptococcus pneumoniae on dye transport by the chinchilla Eustachian tube.  Acta Otolaryngol (Stockh). Vol. 107, no. 3-4. (January): 235-243.
  • DeMaria TF, Enrique R, Dohar J, Bakaletz LO, Lim DJ. 1988. Beta-2-microglobulin in the middle ear effusions and sera from patients with chronic OME.  Arch Otolaryngol. Vol. 114, no. 11. (November): 1259-1261.
  • Lim DJ, DeMaria TF, Bakaletz LO. 1988. Current concepts of pathogenesis of otitis media: a review.  Acta Otolaryngol. Vol. S458, no. January: 174-180.
  • Bakaletz LO, Tallan BM, Hoepf T, DeMaria TF, Birck HG, Lim DJ. 1988. Frequency of fimbriation of nontypable Haemophilus influenzae and its ability to adhere to chinchilla and human respiratory epithelium.  Infect Immun. Vol. 56, no. 2. (January): 331-335.
  • Bakaletz LO, Hoepf TM, DeMaria TF, Lim, DJ. 1988. The effect of antecedent influenza A virus infection on the adherence of Hemophilus influenzae to chinchilla tracheal epithelium.  Am J Otolaryngol. Vol. 9, no. 3. (January): 127-134.
  • DeMaria TF, Enrique R, Dohar J, Bakaletz LO, Lim DJ. 1988. Beta 2-microglobulin in the middle ear effusions and sera from patients with chronic OME.  Arch Otolaryngol. Vol. 114, no. 11. (January): 1259-1261.
  • Lim DJ, DeMaria TF, Bakaletz LO. 1987. Functional morphology of the tubotympanum related to otitis media: a review.  Am J Otol. Vol. 8, no. 5. (January): 385-389.
  • Lim DJ, DeMaria TF, Bakaletz LO. 1987. Functional morphology of the tybotympanum related to otitis media.  Adv Oto-rhino-laryngol. Vol. 37, no. January: 21-25.
  • Bakaletz LO, DeMaria TF, Lim DJ. 1987. Phagocytosis and killing of bacteria by middle ear macrophages.  Arch Otolaryngol. Vol. 113, no. 2. (January): 138-144.
  • Bakaletz LO, DeMaria TF, Lim DJ. 1987. Effect of preopsonization on phagocytosis of Haemophilus influenzae.  Arch Otolaryngol. Vol. 113, no. 5. (January): 526-529.
  • Bakaletz LO, Rheins MS. 1985. A whole-organ perfusion model of Bordetella pertussis adherence to mouse tracheal epithelium.  In Vitro Cell Dev Biol. Vol. 21, no. 6. (January): 314-320.
  • Ompremcak LB, Rheins MS. 1982. Scanning electron microscopy of mouse ciliated oviduct and tracheal epithelium infected in vitro with Bordetella pertussis.  Can J Microbiol. Vol. 29, no. January: 415-420.
  • Harrison, A; Bakaletz, LO; Munson Jr, RS. Haemophilus influenzae and oxidative stress.  Front Cell Inf Microbio.

Awards, Honors and Organizations

  • 2013 College of Medicine Distinguished Professor, The Ohio State University
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000