Jonathan R. Wispe, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Jonathan R. Wispe, MD

Jonathan R. Wispe, MD

Neonatology
Physician Team

Contact Information

3555 Olentangy River Rd
Ste 3050
Columbus, OH 43214 [ map ]
PH: (614) 566-4731
FX: (614) 566-6745

Biography

Jonathan R. Wispe, MD, is a member of the Section of Neonatology at Nationwide Children’s Hospital, and a Professor of Pediatrics at The Ohio State University College of Medicine. Dr. Wispe is the Medical Director for the Nationwide Children’s Hospital Transport Team and the Medical Director for the A2 Nationwide Children’s Hospital Inpatient Unit. Dr. Wispe is also a Board Member of the Columbus Fetal Collaborative.

Gender:

  • Male

Languages Spoken:

  • English

Education and Training

Medical School

  • University of Iowa
    Date Completed: 06/30/1979

Residency

  • University of Iowa
    Date Completed: 06/30/1982

Fellowship

  • University of Iowa
    Date Completed: 06/30/1985

Department:

  • Pediatrics

Section:

  • Neonatology

Specialty:

  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/29/2016

Publications

  • Allen,G,L; Menendez,I,Y; Ryan,M,A; Mazor,R,L; Wispe,J,R; Fiedler,M,A; Wong,H,R. 2000. Hyperoxia synergistically increases TNF-alpha-induced interleukin-8 gene expression in A549 cells.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 278, no. 2. (February): L253-L260.
  • Wong,H,R; Ryan,M,A; Menendez,I,Y; Wispe,J,R. 1999. Heat shock activates the I-kappa B alpha promoter and increases I-kappa B alpha mRNA expression.  CELL STRESS & CHAPERONES. Vol. 4, no. 1. (March): 1-7.
  • Wong,H,R; Menendez,I,Y; Ryan,M,A; Denenberg,A,G; Wispe,J,R. 1998. Increased expression of heat shock protein 70 protects A549 cells against hyperoxia.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 275, no. 4. (October): L836-L841.
  • Warner,B,B; Stuart,L,A; Papes,R,A; Wispe,J,R. 1998. Functional and pathological effects of prolonged hyperoxia in neonatal mice.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 275, no. 1. (July): L110-L117.
  • Wong,H,R; Wispe,J,R. 1997. The stress response and the lung.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 273, no. 1. (July): L1-L9.
  • Wong,H,R; Ryan,M; Wispe,J,R. 1997. Stress response decreases NF-kappa B nuclear translocation and increases I-kappa B alpha expression in A549 cells.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 99, no. 10. (May): 2423-2428.
  • Wong,H,R; Ryan,M; Wispe,J,R. 1997. The heat shock response inhibits inducible nitric oxide synthase gene expression by blocking I kappa-B degradation and NF-kappa B nuclear translocation.  BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. Vol. 231, no. 2. (February): 257-263.
  • Arkovitz,M,S; Garcia,V,F; Szabo,C; McConnell,K; Bove,K; Wispe,J,R. 1997. Decreased pulmonary compliance is an early indicator of pulmonary oxygen injury.  JOURNAL OF SURGICAL RESEARCH. Vol. 67, no. 2. (February): 193-198.
  • Wong,H,R; Ryan,M; Gebb,S; Wispe,J,R. 1997. Selective and transient in vitro effects of heat shock on alveolar type II cell gene expression.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 272, no. 1. (January): L132-L138.
  • Arkovitz,M,S; Wispe,J,R; Garcia,V,F; Szabo,C. 1996. Selective inhibition of the inducible isoform of nitric oxide synthase prevents pulmonary transvascular flux during acute endotoxemia.  JOURNAL OF PEDIATRIC SURGERY. Vol. 31, no. 8. (August): 1009-1015.
  • Warner,B,B; Stuart,L; Gebb,S; Wispe,J,R. 1996. Redox regulation of manganese superoxide dismutase.  AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. Vol. 271, no. 1. (July): L150-L158.
  • Arkovitz MS, Szabo C, Wispe JR, Ziegler MM, Garcia VF. 1996. Hyperoxia upregulates alveolar macrophage nitric oxide production.  Surgical Forum. Vol. 1, no. March: 696-698.
  • Warner,B; Papes,R; HEILE,M; Spitz,D; Wispe,J. 1993. EXPRESSION OF HUMAN MN SOD IN CHINESE-HAMSTER OVARY CELLS CONFERS PROTECTION FROM OXIDANT INJURY.  AMERICAN JOURNAL OF PHYSIOLOGY. Vol. 264, no. 6. (June): L598-L605.
  • Wispe,J,R; Warner,B,B; Clark,J,C; Dey,C,R; Neuman,J; Glasser,S,W; Crapo,J,D; Chang,L,Y; Whitsett,J,A. 1992. HUMAN MN-SUPEROXIDE DISMUTASE IN PULMONARY EPITHELIAL-CELLS OF TRANSGENIC MICE CONFERS PROTECTION FROM OXYGEN INJURY.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 267, no. 33. (November): 23937-23941.
  • Whitsett,J,A; Clark,J,C; Wispe,J,R; Pryhuber,G,S. 1992. EFFECTS OF TNF-ALPHA AND PHORBOL ESTER ON HUMAN SURFACTANT PROTEIN AND MNSOD GENE-TRANSCRIPTION INVITRO.  AMERICAN JOURNAL OF PHYSIOLOGY. Vol. 262, no. 6. (June): L688-L693.
  • Wikenheiser,K,A; Wert,S,E; Wispe,J,R; Stahlman,M; DAMOREBRUNO,M; Singh,G; Katyal,S,L; Whitsett,J,A. 1992. DISTINCT EFFECTS OF OXYGEN ON SURFACTANT PROTEIN-B EXPRESSION IN BRONCHIOLAR AND ALVEOLAR EPITHELIUM.  AMERICAN JOURNAL OF PHYSIOLOGY. Vol. 262, no. 1. (January): L32-L39.
  • Warner,B,B; Burhans,M,S; Clark,J,C; Wispe,J,R. 1991. TUMOR-NECROSIS-FACTOR-ALPHA INCREASES MN-SOD EXPRESSION - PROTECTION AGAINST OXIDANT INJURY.  AMERICAN JOURNAL OF PHYSIOLOGY. Vol. 260, no. 4. (April): L296-L301.
  • Wispe,J,R; Clark,J,C; Warner,B,B; Fajardo,D; Hull,W,E; Holtzman,R,B; Whitsett,J,A. 1990. TUMOR-NECROSIS-FACTOR-ALPHA INHIBITS EXPRESSION OF PULMONARY SURFACTANT PROTEIN.  JOURNAL OF CLINICAL INVESTIGATION. Vol. 86, no. 6. (December): 1954-1960.
  • Rivera,A; Roberts,R,J; Wispe,J,R. 1990. A TECHNIQUE FOR INTRAVENOUS NUTRITION IN THE NEWBORN RABBIT.  JOURNAL OF PARENTERAL AND ENTERAL NUTRITION. Vol. 14, no. 1. (January): 101-103.
  • Nogee,L,M; Wispe,J,R; Clark,J,C; Whitsett,J,A. 1989. INCREASED SYNTHESIS AND MESSENGER-RNA OF SURFACTANT PROTEIN-A IN OXYGEN-EXPOSED RATS.  AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. Vol. 1, no. 2. (August): 119-125.
  • Rice,W,R; Burhans,M; Wispe,J,R. 1989. EFFECT OF OXYGEN EXPOSURE ON ATP CONTENT OF RAT BRONCHOALVEOLAR LAVAGE.  PEDIATRIC RESEARCH. Vol. 25, no. 4. (April): 396-398.
  • Wispe,J,R; Clark,J,C; Burhans,M,S; Kropp,K,E; Korfhagen,T,R; Whitsett,J,A. 1989. SYNTHESIS AND PROCESSING OF THE PRECURSOR FOR HUMAN MANGANO-SUPEROXIDE DISMUTASE.  BIOCHIMICA ET BIOPHYSICA ACTA. Vol. 994, no. 1. (January): 30-36.
  • Nogee,L,M; Wispe,J,R. 1988. EFFECTS OF PULMONARY OXYGEN INJURY ON AIRWAY CONTENT OF SURFACTANT-ASSOCIATED PROTEIN-A.  PEDIATRIC RESEARCH. Vol. 24, no. 5. (November): 568-573.
  • Knight,M; Cook,J; Wispe,J; Roberts,R,J. 1987. COMPARISON OF THE ANTIOXIDANT PROPERTIES OF ALPHA-TOCOPHEROL AND ALPHA-TOCOPHERYL ACETATE IN NEWBORN RABBIT LUNG.  DEVELOPMENTAL PHARMACOLOGY AND THERAPEUTICS. Vol. 10, no. 4. (January): 245-264.
  • Wispe,J,R; Knight,M; Roberts,R,J. 1986. LIPID-PEROXIDATION IN NEWBORN RABBITS - EFFECTS OF OXYGEN, LIPID EMULSION, AND VITAMIN-E.  PEDIATRIC RESEARCH. Vol. 20, no. 6. (June): 505-510.
  • Nakazawa,M; Clark,E,B; Hu,N; Wispe,J. 1985. EFFECT OF ENVIRONMENTAL HYPOTHERMIA ON VITELLINE ARTERY BLOOD-PRESSURE AND VASCULAR-RESISTANCE IN THE STAGE 18, 21, AND 24 CHICK-EMBRYO.  PEDIATRIC RESEARCH. Vol. 19, no. 7. (January): 651-654.
  • Wispe,J,R; Bell,E,F; Roberts,R,J. 1985. ASSESSMENT OF LIPID-PEROXIDATION IN NEWBORN-INFANTS AND RABBITS BY MEASUREMENTS OF EXPIRED ETHANE AND PENTANE - INFLUENCE OF PARENTERAL LIPID INFUSION.  PEDIATRIC RESEARCH. Vol. 19, no. 4. (January): 374-379.
  • Wispe,J; Hu,N; Clark,E,B. 1983. EFFECT OF ENVIRONMENTAL HYPOTHERMIA ON DORSAL AORTIC BLOOD-FLOW IN THE CHICK-EMBRYO, STAGE-18 TO STAGE-24.  PEDIATRIC RESEARCH. Vol. 17, no. 12. (January): 945-948.
  • STEGINK,L,D; Freeman,J,B; Wispe,J; Connor,W,E. 1977. ABSENCE OF BIOCHEMICAL SYMPTOMS OF ESSENTIAL FATTY-ACID DEFICIENCY IN SURGICAL PATIENTS UNDERGOING PROTEIN SPARING THERAPY.  AMERICAN JOURNAL OF CLINICAL NUTRITION. Vol. 30, no. 3. (January): 388-393.
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