Jonathan R. Honegger, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Jonathan R. Honegger, MD

Jonathan R. Honegger, MD

Contact Information

Infectious Diseases
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4494
FX: (614) 722-4458
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355.2873
FX: (614) 722.3680

Biography

J. Robert Honegger, MD, is a member of the Section of Infectious Diseases and the Center for Vaccines and Immunity at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His clinical interests include education of medical students and residents, and the management of children and adolescents with infectious diseases. He is the principal investigator on an NIH K-12 award to study Hepatitis C virus (HCV) infection and immunity in mothers and infants, the effects of pregnancy on maternal T-cell responses and HCV evolution, and HCV-specific immunity in perinatally exposed infants.

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Gender:

  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. Honegger’s research is focused on understanding the role of T-cell immunity in the vertical transmission of the hepatitis C virus (HCV). Vertical transmission (passage from mother to child during pregnancy or birth) of HCV occurs in approximately 5% of pregnancies to HCV infected mothers and is now the leading route of infection in children. Although T-cell immunity is known to be critical for control of acute infection in adults and animal models of HCV, the roles of maternal and infant T-cell responses in preventing vertical transmission and reasons for their failure remain unknown. To address these issues Dr. Honegger is studying ex-vivo T-cell responses to HCV antigens in a cohort of HCV-infected pregnant women and their subsequent infants.

Education and Training

Undergraduate School

  • Purdue University School of Science
    Date Completed: 06/30/1995

Medical School

  • Indiana University School of Medicine
    Date Completed: 05/14/2000

Internship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2003

Residency

  • The Ohio State University, Nationwide Children's Hospital
    Date Completed: 06/30/2004

Fellowship

  • Nationwide Children's Hospital
    Date Completed: 06/30/2008

Department:

  • Pediatrics

Section:

  • Infectious Diseases

Specialty:

  • Internal Medicine
  • Pediatric Infectious Diseases
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/14/2008

Professional Experience

2008–present

  • Investigator, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital

2008–present

  • Assistant Professor, Department of Pediatrics, Division of Pediatric Infectious Diseases, The Ohio State University College of Medicine and Nationwide Children's Hospital

2004–2005

  • Internal Medicine-Pediatrics Practice, Columbus Neighborhood Health Centers, Columbus, OH.

Publications

  • Barson WJ, Honegger JR, Texter K. 2014. Acute myopericarditis associated with cat scratch disease in an adolescent.  Pediatric Infectious Disease Journal. Vol. ePublished, no. May: eahead of print.
  • Price AA, Grakoui A, Honegger JR. 2014. Hepatitis C virus adaptions to altered CD8+ T-cell immunity during pregnancy.  Future Virology. Vol. 9, no. 4. (April): 333-336.
  • Honegger JR, Zhou Y, Walker CM. 2014. Will there be a vaccine to prevent HCV infection?.  Seminars in Liver Diseases. Vol. 34, no. 1. (January): 79-88.
  • Honegger JR, Kim S, Price AA, Kohout JA, McKnight KL, Prasad MR, Lemon SM, Grakoui A, Walker CM. 2013. Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses.  Nature Medicine. Vol. 19, no. 11. (November): 1529-1533.
  • Prasad MR, Honegger JR. 2013. Hepatitis C Virus in Pregnancy.  American Journal of Perinatology. Vol. 30, no. 2. (February): 149-159.
  • Prasad MR, Honegger JR, Markham KB; Walker CM. 2012. Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV). In 32nd Annual Scientific Meeting/Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine
  • Honegger JR, Kohout JA, Kim S, et al. 2011. Reversion of cytotoxic T-cell escape mutation during pregnancy permits vertical transmission of most fit hepatitis C variant. In 18th International Meeting on Hepatitis C and Related Viruses
  • Omikunle A, Walker CM, Honegger JR. 2011. Hepatitis C virus specific T-cell responses in vertically exposed infants. In Pediatric Academic Societies Annual Meeting
  • Dotson JL, Crandall W, Mousa H, Honegger JR, Denson L, Samson C, Cunningham D, Balint J, Deinhart M, Jaggi P, Carvalho R. 2011. Presentation and Outcome of Histoplasmosis in Pediatric Inflammatory Bowel Disease Patients Treated with Antitumor Necrosis Factor alpha Therapy: A Case Series.  Inflammatory Bowel Diseases. Vol. 17, no. 1. (January): 56-61.
  • Honegger JR, Brady MT. 2011. Viral Respiratory Infections. In Rudolph's Pediatrics. 22nd ed. Edited by Colin Rudolph, Abraham Rudolph, George Lister, Lewis First, Anne Gershon. New York, NY: McGraw-Hill Publishers.
  • Honegger JR, Prasad MR, Kohout JA, Walker CM. 2010. Influence of Pregnancy on Hepatitis C Virus Evolution. In HCV 2010; 17th International Meeting on Hepatitis C and Related Viruses
  • Honegger JR, Prasad MR, Colombo D, Bowen DG, Walker CM. 2008. HCV-specific T-cell responses during acute Hepatitis C Virus infection in pregnancy. In Fourth Dominique International Conference. Maternal chronic viral infections transmitted to infants: from mechanisms to prevention and care
  • Bowen DG, Cawthon AG, Honegger JR, Rutkiewicz J, Murthy KK, Walker CM. 2006. High-level HCV replication during acute infection occurring in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations. In 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases
  • Honegger JR, Zhou Y, Walker CM. Will there be a vaccine to prevent HCV infection?.  Seminars in Liver Disease.
  • Honegger J, Potter C, Cawthon D, Walker C,. 0. Intrahepatc cellular immunity in vertically acquired hepatitis C virus infection. In St. Jude’s/Pediatric Infectious Diseases Society Meeting
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000