Jonathan R. Honegger, MD

J. Robert Honegger, MD, is a member of the Section of Infectious Diseases and the Center for Vaccines and Immunity at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His clinical interests include education of medical students and residents, and the management of children and adolescents with infectious diseases. He is the principal investigator on an NIH K-12 award to study Hepatitis C virus (HCV) infection and immunity in mothers and infants, the effects of pregnancy on maternal T-cell responses and HCV evolution, and HCV-specific immunity in perinatally exposed infants.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Vaccines and Immunity

Areas of Interest:

• Dr. Honegger’s research is focused on understanding the role of T-cell immunity in the vertical transmission of the hepatitis C virus (HCV). Vertical transmission (passage from mother to child during pregnancy or birth) of HCV occurs in approximately 5% of pregnancies to HCV infected mothers and is now the leading route of infection in children. Although T-cell immunity is known to be critical for control of acute infection in adults and animal models of HCV, the roles of maternal and infant T-cell responses in preventing vertical transmission and reasons for their failure remain unknown. To address these issues Dr. Honegger is studying ex-vivo T-cell responses to HCV antigens in a cohort of HCV-infected pregnant women and their subsequent infants.

Undergraduate School

• Purdue University School of Science
  Date Completed: 06/30/1995

Medical School

• Indiana University School of Medicine
  Date Completed: 05/14/2000

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2003

Residency

• The Ohio State University, Nationwide Children's Hospital
  Date Completed: 06/30/2004

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2008

Department:

• Pediatrics

Section:

• Infectious Diseases

Speciality:

• Internal Medicine
  
• Pediatric Infectious Diseases
  
• Pediatrics
  

Date of Appointment at Nationwide Children’s Hospital:

• 07/14/2008

2008–present

• Investigator, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital

2008–present

• Assistant Professor, Department of Pediatrics, Division of Pediatric Infectious Diseases, The Ohio State University College of Medicine and Nationwide Children's Hospital

2004–2005

• Internal Medicine-Pediatrics Practice, Columbus Neighborhood Health Centers, Columbus, OH.

• Prasad, M.R., Honegger, J.R. 2013. Hepatitis C Virus in Pregnancy.  Am J Perinatology. Vol. 30, no. 2. (February): 149-60.
• Prasad,Mona; Honegger,Jonathan; Markham,Kara,B; Walker,Christopher. 2012. Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV). In 32nd Annual Scientific Meeting/Pregnancy Meeting of the Society-for-Maternal-Fetal-Medicine
• Dotson JL; Crandall W; Mousa H; Honegger JR; Denson L; Samson C; Cunningham D; Balint J; Dienhart M; Jaggi P; Carvalho R. 2011. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: a case series.  Inflammatory Bowel Diseases. Vol. 17, no. 1. (January): 56-61.
• Jonathan Honegger and Michael Brady. 2011. Viral Respiratory Infections. In Rudolph's Pediatrics. 22nd ed. Edited by Colin Rudolph, Abraham Rudolph, George Lister, Lewis First, Anne Gershon. New York, NY: McGraw-Hill Publishers.
• Bowen,David,G; Cawthon,Andrew,G; Honegger,Jonathan,R; Rutkiewicz,Jennifer; Murthy,Krishna,K; Walker,Christopher,M. 2006. High-level HCV replication during acute infection occurring in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations. In 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases
• Honegger J, Potter C, Cawthon D, Walker C,. 0. Intrahepatc cellular immunity in vertically acquired hepatitis C virus infection. In St. Jude’s/Pediatric Infectious Diseases Society Meeting