Jonathan R. Honegger, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Jonathan R. Honegger, MD

Jonathan R. Honegger, MD Best Doctors 2011-2012

Contact Information

Infectious Diseases
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4494
FX: (614) 722-4458
Email Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355.2873
FX: (614) 722.3680

Location Information for Patients

Main Campus


J. Robert Honegger, M.D., is a member of the Section of Infectious Diseases and the Center for Vaccines and Immunity at Nationwide Children’s Hospital and an Assistant Professor of Clinical Pediatrics at The Ohio State University College of Medicine. His clinical interests include management of children and adolescents with HIV, hepatitis C, and other infectious diseases. He is co-investigator on an NIH RO1 award to study hepatitis C virus (HCV) infection and immunity in pregnancy.

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  • Male

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. Honegger’s research is focused on understanding the role of T-cell immunity to the hepatitis C virus (HCV) in mothers and infants. Vertical transmission (passage from mother to child during pregnancy or birth) of HCV occurs in approximately 5% of pregnancies to HCV infected mothers and is now the leading route of infection in children. Although T-cell immunity is known to be critical for control of acute infection in adults and animal models of HCV, the roles of maternal and infant T-cell responses in preventing vertical transmission and reasons for their failure remain unknown. To address these issues Dr. Honegger is studying ex-vivo T-cell responses to HCV antigens in a cohort of HCV-infected pregnant women and their subsequent infants.

Education and Training

Undergraduate School

  • Purdue University School of Science
    Date Completed: 06/30/1995

Medical School

  • Indiana University School of Medicine
    Date Completed: 05/14/2000


  • Nationwide Children's Hospital
    Date Completed: 06/30/2003


  • The Ohio State University, Nationwide Children's Hospital
    Date Completed: 06/30/2004


  • Nationwide Children's Hospital
    Date Completed: 06/30/2008


  • Pediatrics


  • Infectious Diseases


  • Internal Medicine
  • Pediatric Infectious Diseases
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 07/14/2008

Professional Experience


  • Investigator, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital


  • Assistant Professor, Department of Pediatrics, Division of Pediatric Infectious Diseases, The Ohio State University College of Medicine and Nationwide Children's Hospital


  • Internal Medicine-Pediatrics Practice, Columbus Neighborhood Health Centers, Columbus, OH.


  • Barson WJ, Honegger JR, Texter K. 2014. Acute myopericarditis associated with cat scratch disease in an adolescent.  Pediatric Infectious Disease Journal. Vol. 33, no. 9. (September): 982-984.
  • Price AA, Grakoui A, Honegger JR. 2014. Hepatitis C virus adaptions to altered CD8+ T-cell immunity during pregnancy.  Future Virology. Vol. 9, no. 4. (April): 333-336.
  • Honegger JR, Zhou Y, Walker CM. 2014. Will there be a vaccine to prevent HCV infection?.  Seminars in Liver Diseases. Vol. 34, no. 1. (February): 79-88.
  • Honegger JR, Kim S, Price AA, Kohout JA, McKnight KL, Prasad MR, Lemon SM, Grakoui A, Walker CM. 2013. Loss of immune escape mutations during persistent HCV infection in pregnancy enhances replication of vertically transmitted viruses.  Nature Medicine. Vol. 19, no. 11. (November): 1529-1533.
  • Prasad MR, Honegger JR. 2013. Hepatitis C Virus in Pregnancy.  American Journal of Perinatology. Vol. 30, no. 2. (February): 149-159.
  • Prasad,Mona; Honegger,Jonathan; Markham,Kara,B; Walker,Christopher. 2012. Clinical risk factors associated with mother-to-child transmission (MTCT) of hepatitis C virus (HCV).  AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY. Vol. 206, no. 1. (January): S270-S270.
  • Dotson JL, Crandall W, Mousa H, Honegger JR, Denson L, Samson C, Cunningham D, Balint J, Deinhart M, Jaggi P, Carvalho R. 2011. Presentation and Outcome of Histoplasmosis in Pediatric Inflammatory Bowel Disease Patients Treated with Antitumor Necrosis Factor alpha Therapy: A Case Series.  Inflammatory Bowel Diseases. Vol. 17, no. 1. (January): 56-61.
  • Honegger JR, Brady MT. 2011. Viral Respiratory Infections. In Rudolph's Pediatrics. 22nd ed. Edited by Colin Rudolph, Abraham Rudolph, George Lister, Lewis First, Anne Gershon. New York, NY: McGraw-Hill Publishers.
  • Bowen DG, Cawthon AG, Honegger JR, Rutkiewicz J, Murthy KK, Walker CM. 2006. High-level HCV replication during acute infection occurring in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations. In 57th Annual Meeting of the American-Association-for-the-Study-of-Liver-Diseases
  • Honegger JR, Zhou Y, Walker CM. Will there be a vaccine to prevent HCV infection?.  Seminars in Liver Disease.
  • Honegger J, Potter C, Cawthon D, Walker C,. 0. Intrahepatc cellular immunity in vertically acquired hepatitis C virus infection. In St. Jude’s/Pediatric Infectious Diseases Society Meeting
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000