Jonathan R. Honegger, MD

J. Robert Honegger, MD, is a member of the Section of Infectious Diseases and the Center for Vaccines and Immunity at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His clinical interests include education of medical students and residents, and the management of children and adolescents with infectious diseases. He is the principal investigator on an NIH K-12 award to study Hepatitis C virus (HCV) infection and immunity in mothers and infants, the effects of pregnancy on maternal T-cell responses and HCV evolution, and HCV-specific immunity in perinatally exposed infants.

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Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Vaccines and Immunity

Areas of Interest:

• Dr. Honegger’s research is focused on understanding the role of T-cell immunity in the vertical transmission of the hepatitis C virus (HCV). Vertical transmission (passage from mother to child during pregnancy or birth) of HCV occurs in approximately 5% of pregnancies to HCV infected mothers and is now the leading route of infection in children. Although T-cell immunity is known to be critical for control of acute infection in adults and animal models of HCV, the roles of maternal and infant T-cell responses in preventing vertical transmission and reasons for their failure remain unknown. To address these issues Dr. Honegger is studying ex-vivo T-cell responses to HCV antigens in a cohort of HCV-infected pregnant women and their subsequent infants.

Undergraduate

• Purdue University School of Science
  Date Completed: 06/30/1995

Medical School

• Indiana University School of Medicine
  Date Completed: 05/14/2000

Internship

• Nationwide Children's Hospital
  Date Completed: 06/30/2003

Residency

• The Ohio State University, Nationwide Children's Hospital
  Date Completed: 06/30/2004

Fellowship

• Nationwide Children's Hospital
  Date Completed: 06/30/2008

Department:

• Pediatrics

Section:

• Infectious Diseases

Speciality:

• Internal Medicine, Certified
  
• Pediatric Infectious Diseases, Certified
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 07/14/2008

2008–present

• Investigator, Center for Vaccines and Immunity, The Research Institute at Nationwide Children's Hospital

2008–present

• Assistant Professor, Department of Pediatrics, Division of Pediatric Infectious Diseases, The Ohio State University College of Medicine and Nationwide Children's Hospital

2004–2005

• Internal Medicine-Pediatrics Practice, Columbus Neighborhood Health Centers, Columbus, OH.

• Jonathan Honegger and Michael Brady. 2011. Viral Respiratory Infections. In Rudolph's Pediatrics. 22nd ed. Edited by Colin Rudolph, Abraham Rudolph, George Lister, Lewis First, Anne Gershon. New York, New York, USA: McGraw-Hill Publishers.
• Dotson JL; Crandall W; Mousa H; Honegger JR; Denson L; Samson C; Cunningham D; Balint J; Dienhart M; Jaggi P; Carvalho R. 2011. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: a case series.  Inflammatory Bowel Diseases. Vol. 17, no. 1. (January 1): 56. (IF: 4.613)
• Dotson JL, Crandall W, Mousa H, Honegger JR, Denson L, Samson C, Cunningham D, Balint J, Dienhart M, Jaggi P, Carvalho R. 2010. Presentation and outcome of histoplasmosis in pediatric inflammatory bowel disease patients treated with antitumor necrosis factor alpha therapy: A case series.  Inflamm Bowel Dis. (July 19)
• Jonathan Honegger, Mona Prasad, David Colombo, David Bowen, Christopher Walker. 2008. HCV-specific T-cell responses during acute Hepatitis C Virus infection in pregnancy [Abstract]. Retrovirology. Vol. 5, no. Supplement 1. London, UK: BioMed Central. (April 9): O8-O8. http://www.retrovirology.com/content/5/S1/O8. [Non-Refereed] (Published)
• Honegger J, Potter C, Cawthon D, WalkerC. 2007. Intrahepatic Cellular Immunity in Vertically Acquired Hepatitis C Virus Infection. [Abstract]. PIDS. (February) (Published)
• Bowen, David G.; Cawthon, Andrew G.; Honegger, Jonathan R.; Rutkiewicz, Jennifer; Murthy, Krishna K.; Walker, Christopher M. 2006. High-level Hcv replication during acute infection occurring in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations.  Hepatology. Vol. 44, no. 4, Suppl. 1. : 296A.
• Bowen D, Cawthon A, Honegger J, Rutkiewicz J, Murthey K, Walker, C. 2006. High-level HCV replication during acute infection in the absence of reversion of previously acquired cytotoxic T lymphocyte escape mutations [Abstract]. Hepatology. Vol. 44, no. no 4, Suppl. 1: 296A. (Published)
• Honegger JR, Presenter. 2008. Maternal Immunity to the Hepatitis C Virus. Presented at Immunology Journal Club/Work in Progress. The Research Institute at Nationwide Children's Hospital. Columbus, OH, USA. (September)
• Honegger JR, Presenter. 2007. Perinatal HIV and Hepatitis Infections. Presented at Neonatal Nurse Practitioner Lecture. Columbus Children's Hospital. Columbus, OH, USA. (April)
• Honegger JR, Presenter. 2008. Relatively New Adolescent Immunizations. Presented at Grand Rounds. The Ohio State University. Columbus, OH, USA. (April)
• Honegger J, Lecturer. 2010. Neonatal Sepsis. Presented at Chairman's Case Conference for Pediatric Medical Students. Nationwide Children's Hospital. Columbus, OH, USA. (July)
• Honegger JR, Presenter. 2009. Adaptive Immune Features of Natural Killer Cells. Presented at Immunology Journal Club. The Research Institute at Nationwide Children's Hospital. Columbus, OH, USA. (June)
• Honegger JR, Prasad M, Colombo D, Bowen D, Potter C, and Walker CM, Presenter. 2008. T-cell Immunity to Hepatitis C Virus Infection During Pregnancy. Presented at Research Institute Annual Retreat. Nationwide Children's Hospital. Columbus, OH, USA. (March)
• Honegger JR, Presenter. 2007. Viral Hepatitis. Presented at Housestaf Conference. Columbus Children's Hospital. Columbus, OH, USA. (April)
• Honegger J, Walker C, Chair. 2011. Hepatitis C in Pregnancy and Vertical Transmission. Presented at Nationwide Children's Hospital Gastroenterology Morning Conference. Nationwide Children's Hospital. Columbus, OH, USA. (July 14)
• Jonathan Honegger, Lecturer. 2009. Postpartum Surge in T-cell Immunity to the Hepatitis C Virus. Presented at NIH (NICHD) Child Health Research Centers Annual Retreat. Seattle, WA. (September)
• Honegger JR, Presenter. 2010. Perinatal and Pediatric HIV. Presented at Housestaff Conference. Nationwide Children's Hospital. Columbus, OH, USA. (May)
• Honegger JR, Presenter. 2008. Maternal and Infant T-cell Immunity to the Hepatitis C Virus. Presented at Clinical Research Seminar. The Research Institute at Nationwide Children's Hospital. Columbus, OH, USA. (June)
• Honegger JR, Kohout J, Kim S, Lemon S, Grakoui A, Walker C, Poster Presenter. 2011. Reversion of cytotoxic T-cell escape mutation during pregnancy permits vertical transmission of most fit hepatitis C variant. Presented at 18th International Meeting on Hepatitis C and Related Viruses. Seattle, WA, USA. (September)
• Jonathan Honegger, Lecturer. 2009. Postpartum Surge in T-cell Immunity to the Hepatitis C Virus. Presented at Infectious Diseases Society of America Annual Meeting. Philadelphia, PA, USA. (October)
• Honegger JR, Presenter. 2011. Perinatal and Pediatric HIV. Presented at Housestaff Conference. Columbus, OH, USA. (October)
• Honegger JR, Presenter. 2010. Viral Hepatitides. Presented at Pediatric Infectious Diseases Fellow Lecture. Nationwide Children's Hospital. Columbus, OH, USA. (January)
• Honegger JR, Lecturer. 2008. Primary Immunodeficiences. Presented at Integrated Biomedical Graduate Program Course 703 Lecture. The Ohio State University. Columbus, OH, USA. (April)
• Honegger JR, Prasad M, and Walker CM, Presenter. 2007. Hepatitis C: Transmission from Mother to Baby. Presented at Pediatric Grand Rounds. Columbus Children's Hospital. Columbus, OH, USA. (April)
• Honegger JR, Presenter. 2008. Perinatal and Pediatric HIV. Presented at Housestaff Conference. Nationwide Children's Hospital. Columbus, OH, USA. (December)
• Jonathan Honegger, Lecturer. 2009. Preventing Mother to Child Transmission of the Hepatitis C Virus. Presented at BOSS Seminar. Nationwide Children's Hospital. Columbus, OH. (May)
• Honegger J, Prasad M, Kohout J, Walker C., Poster Presenter. 2010. Influence of Pregnancy on Hepatitis C Virus Evolution. (Postor Presentation). Presented at 17th International Meeting on Hepatitis C and Related Viruses. Yokohama, Japan. (September)