Jonathan M. Gisser, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Jonathan M. Gisser, MD

Jonathan M. Gisser, MD

Contact Information

Gastroenterology & Hepatology & Nutrition
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3450
FX: (614) 722-3454
Email Me
The Research Institute Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
FX: (614) 722.5892


Jonathan M. Gisser, MD, is an attending pediatric gastroenterologist at Nationwide Children’s and an Assistant Professor of Pediatrics at The Ohio State University College of Medicine. His clinical interest spans all of general pediatric gastroenterology, including abdominal pain, functional constipation, and inflammatory bowel diseases. Dr. Gisser’s research has focused on the development of the enteric nervous system (the “brain-in-the-gut”), which controls intestinal motility, and, more recently, the use of fecal microbiota transplantation as a treatment for gastrointestinal disease. He has presented his work at numerous national conferences and he has developed Ohio’s only pediatric fecal microbiota transplantation program at Nationwide Children’s Hospital.


  • Male

Languages Spoken:

  • Hebrew
  • Yidish
  • French
  • English

Research Interests

Areas of Interest:

  • Researchers theorize that patients with Irritable Bowel Syndrome (IBS), who experience frequent abdominal pain, diarrhea and constipation, have abnormal movement within in their gut and are extra sensitive to feeling these changes. Gastroenterologist Jonathan Gisser, MD, believes that an attack on the enteric nervous system (ENS) causes these sensitivities. He’s collecting blood samples from children with IBS and other GI disorders. Their blood is then mixed with an artificial, in vitro version of the ENS to see if attacking antibodies are present. If these antibodies prove to be more common in kids with IBS, new diagnostic tests could be developed and new research could test whether or not blocking these antibodies could prevent IBS symptoms.

Education and Training

Undergraduate School

  • McGill University
    Date Completed: 06/30/1993

Graduate School

  • Concordia University
    Date Completed: 06/30/1997

Medical School

  • Technion-Israel Institute of Technology
    Date Completed: 06/30/2002


  • MetroHealth System
    Date Completed: 06/30/2005


  • Rainbow Babies & Children's Hospital
    Date Completed: 06/30/2008


  • Pediatrics


  • Gastroenterology & Hepatology & Nutrition


  • Pediatric Gastroenterology

Date of Appointment at Nationwide Children’s Hospital:

  • 12/31/2008

Professional Experience


  • Assistant Professor of Pediatrics, The Ohio State University/Attending Physician, Division of Pediatric Gastroenterology, Nationwide Children’s Hospital, Columbus, Ohio 


  • Gisser, JG, Cohen, AR, Yin, H, Gariepy, CE. 2013. A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.  PLoS One. Vol. 8, no. 9. (September): ee74331.
  • Gisser J. and Gariepy, C.E. 2013. Genetics of motility disorders: gastroesophageal reflux, triple A, Hirschsprung’s disease, and chronic intestinal pseudo-obstruction. In Pediatric Neurogastroenterlogy: Gastrointestinal Motility and Functional Disorders in Children. Edited by Edited by C. Faure, C. DiLorenzo, N. Thapar, Springer. New York: Springer-Verlag, LLC.
  • Wunderlich,Jacqueline,E; Gisser,Jonathan,M; Gariepy,Cheryl,E; Grants,Iveta; Williams,Kent,C; Christofi,Fievos,L. 2012. Neural Circuit Behavior in Enteric Neural Plexus Developed From Neural Crest-Derived Stem Cells (ENPCs).  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S45-S45.
  • Gisser,Jonathan,M; Gariepy,Cheryl,E. 2012. Endothelin-3 is a Potent Regulator of Retinoic Acid Metabolism in Cultured Enteric Nervous System Precursors.  GASTROENTEROLOGY. Vol. 142, no. 5. (May): S332-S332.
  • Gisser,Jonathan,M; Gariepy,Cheryl,E. 2011. Retinoic Acid and Endothelin-3 Reciprocally Regulate Enteric Nervous System Precursor Survival, Differentiation, and Plexus Formation.  GASTROENTEROLOGY. Vol. 140, no. 5. (May): S83-S83.
  • Gisser JM, Blanchard SS, Parry RL, Redline RW, Chelimsky G. 2009. A Rare Cause of Upper Gastrointestinal Bleeding in Children: Gastric Schwannoma.  Current Pediatric Reviews. Vol. 5, no. 1. (January): 52-55.
  • Gisser,J,M; Fields,M,C; Pick,N; Moses,A,E; Srugo,I. 2002. Invasive group A Streptococcus associated with an intrauterine device and oral sex.  SEXUALLY TRANSMITTED DISEASES. Vol. 29, no. 8. (August): 483-485.
  • Gisser JM, Fields MC, Pick N, Moses AE, Srugo I. 2002. Invasive group a streptococcus associated with an intrauterine device and oral sex.  Sexually Transmitted Disease. Vol. 29, no. 8. (January): 483-485.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000