Jonathan L. Slaughter, MD

Jonathan L. Slaughter, MD, MPH is a principal investigator in the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital and an Assistant Professor of Pediatrics at The Ohio State University. Dr. Slaughter's patient centered research program focuses on neonatal comparative effectiveness research to determine which treatments work best for neonatal patients given specific clinical circumstances and patient demographics.

Gender:

• Male

Languages Spoken:

• English

Research Center:

• Center for Perinatal Research

Areas of Interest:

• Prevention of Prematurity
• Neonatal Global Health
• Newborn Screening
• My research focus is Neonatal Comparative Effectiveness Research. My goal is to determine which treatments work best for neonatal patients given specific clinical circumstances and patient demographics. The aim of my KL2 grant is to utilize the methodology of cross-design synthesis to synthesize both randomized controlled trial data and "real-world" patient data to inform clinical practice decisions and future research design. I am currently using cross-design synthesis to examine the benefit of pharmacological, patent ductus arteriosus (PDA) closure and hope to determine which patient populations might or might not benefit from PDA closure. Randomized controlled trials are the gold-standard for efficacy or comparison of how well an intervention works in controlled conditions. But due to strict inclusion/exclusion criteria, external validity or generalizability might be compromised. To inform effectiveness, or "real-world patient centered outcomes," the complexities or heterogeneity of each patient must be taken into account. The addition of actual, de-identified patient data to my synthesis allows us to investigate how, given the same therapy, specific patient differences (birth weight, age, past medical history, etc) might lead to different treatment results and patient outcomes.

Undergraduate

• Catawba College, Salisbury, North Carolina
  Date Completed: 06/30/2000

Medical School

• Wake Forest University Baptist Medical Center
  Date Completed: 05/17/2004

Residency

• Medical University of South Carolina
  Date Completed: 06/30/2007

Fellowship

• Cincinnati Children's Hospital Medical Center
  Date Completed: 06/30/2010

Masters

• The Ohio State University
  Date Completed: 03/01/2012

Department:

• Pediatrics

Section:

• Neonatology

Speciality:

• Neonatal-Perinatal Medicine
  
• Pediatrics, Certified
  

Date of Appointment at Children's Hospital:

• 07/19/2010

• Slaughter J, Annibale D, Suresh G. False-negative results of pre-discharge neonatal bilirubin screening to predict severe hyperbilirubinemia: a need for caution. Eur J Pediatr. 2009;168(12):1461-1466. PubMed ID: 19255782
• Slaughter JL, Espinoza L, Molinero I, Wood T, Duron C, Flores A, Porter R, Tomashitis K, Holden KR. Utilization of blood-spot testing for metabolic-genetic disorders in Honduras: Is it time for newborn screening? J Child Neurol. 2010; 25(3): 306-311. PubMed ID: 19850562
• Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The Effects of Gestation and Birth Weight on False-Positive Newborn Screening Rates. Pediatrics. 2010; 126(5): 910-916. PubMed ID: 20974783
• Stenger MR, Slaughter JL, Kelleher K, Shepherd EG, Klebanoff MA, Reagan P, Nelin LD, Gardner W. Hospital variation in nitric oxide use for premature infants. Pediatrics. 2012; 129: e945-e951.
• Slaughter JL, Pakrashi T, Jones DE, South AP, Shah TA. Echocardiographic Detection of Pulmonary Hypertension in Extremely Low Birth Weight Infants with Bronchopulmonary Dysplasia Requiring Prolonged Positive Pressure Ventilation. J Perinatol. 2011;31: 635-640. PubMed ID: 21311503