Jayajit Das, Ph.D. :: Nationwide Children's Hospital, Columbus, Ohio

Jayajit Das, Ph.D.

Jayajit  Das, Ph.D.

Contact Information

The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355-5632
FX: (614) 355.2728
E-mail Me

Biography

Jayajit Das, PhD, is a principal investigator in the Battelle Center for Mathematical Medicine at the Research Institute and an Assistant Professor of Pediatrics at the Ohio State University. He is also an investigator at the Biophysics program at the Ohio State University, and has a courtesy appointment in the Physics Department at the Ohio State University. Dr. Das's research focuses on uncovering mechanisms underlying innate and adaptive responses in higher organisms using computational and mathematical tools rooted in statistical physics and engineering in synergistic collaboration with experimental labs at the Research Institute and outside the campus.

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Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • My lab uses theoretical and computational approaches based on statistical physics to uncover basic mechanistic principles underlying our innate and adaptive immune response. Obtaining such mechanistic principles from experimental observations alone is often difficult because the pertinent processes include co-operative dynamic events with many participating components. A further complication that confounds intuition is stochastic fluctuations in these systems with small numbers of molecules. However, by synergistically integrating observations from experiments with transgenic animals, single molecule techniques and imaging studies probing molecular events in live animals with these theoretical and computational approaches we can provide system-level understanding into such complex systems. The mechanistic insight gained from such studies not only will help develop future experiments to unravel basic principles of our immune system, but may also help envision therapeutic strategies for infectious diseases and autoimmune disorders.

Education and Training

Graduate School

  • Institute of Mathematical Sciences
    Date Completed: 06/30/1996

Post Doctoral

  • Raman Research Institute
    Date Completed: 06/30/2000

Professional Experience

2008–present

  • Assistant Professor, Department of Pediatrics, The Ohio State University

2008–present

  • Assistant Professor, Battelle Center for Mathematical Medicine, The Research Institute at Nationwide Children's Hospital

2005–2008

  • Postdoctoral Fellow, Massachusetts Institute of Technology

2002–2005

  • Postdoctoral Fellow, University of California at Berkeley

2000–2002

  • Postdoctoral Fellow, Virginia Institute of Polytechnic and State University

Publications

  • Mukherjee S., Seok S-C., Vieland V.J., Das J.,. 2013. Data-driven quantification of the robustness and sensitivity of cell signaling networks.  Physical Biology. Vol. 10, no. December: e66002.
  • Rohan P.J., Schmidt A., Das J., Pytel D., Riese M.J., Lester M., Diehl J.A., Behrens E.M., Kambayashi T., Koretzky G.A. 2013. A predominant role for the isoform of diacylglycerol kinase in regulatory T cell development and TCR-mediated Ras signaling.  Science Signaling. Vol. 6, no. November: era102.
  • Mukherjee S., Seok S-C., Vieland V.J., Das J.,. 2013. Cell responses only partially shape cell-to-cell variations in protein abundances in Escherichia coli chemotaxis.  Proceedings of National Academy of Sciences USA. Vol. 110, no. November: 18531-6.
  • Mukherjee S., Rigaud S., Seok S-C., Fu G., Porchenka A., Gascoigne N., Vieland V.J., Sauer K., Das J. 2013. In silico Modeling of Itk Activation Kinetics in Thymocytes Suggests Competing Positive and Negative IP4 Mediated Feedbacks Increase Robustness.  PLOS ONE. Vol. 8, no. September: ee73937.
  • Vieland V.J., Das J., Hodge S., and Seok S-C. 2013. Measurement of Statistical Evidence On An Absolute Scale Following Theromodynamic Principles.  Theory in Biosciences. Vol. 132, no. March: 181-194.
  • Mukherjee,Sayak; Zhu,Jing; Zikherman,Julie; Parameswaran,Ramya; Kadlecek,Theresa,A; Wang,Qi; Au-Yeung,Byron; Ploegh,Hidde; Kuriyan,John; Das,Jayajit; Weiss,Arthur. 2013. Monovalent and Multivalent Ligation of the B Cell Receptor Exhibit Differential Dependence upon Syk and Src Family Kinases.  SCIENCE SIGNALING. Vol. 6, no. 256. (January): era1.
  • Das,Jayajit. 2013. Positive feedback produces broad distributions in maximum activation attained within a narrow time window in stochastic biochemical reactions.  JOURNAL OF CHEMICAL PHYSICS. Vol. 138, no. 1. (January): e015101.
  • Dworkin M, Mukherjee S, Jayaprakash C, Das Jayajit. 2012. Dramatic reduction of dimensionality in large biochemical networks owing to strong pair correlations.  Journal of the Royal Society Interface. Vol. 9, no. February: e1824.
  • Riese M, Grewal J, Das J, Zou T, Patil V, Chakraborty AK, Koretzky GA. 2011. Decreased Diacylglycerol Metabolism Enhances ERK Activation and Augments CD8(+) T Cell Functional Responses.  Journal Of Biological Chemistry. Vol. 286, no. 7. (February): 5254-5265.
  • Das Jayajit. 2010. Activation or Tolerance of Natural Killer Cells Is Modulated by Ligand Quality in a Nonmonotonic Manner.  Biophysical Journal. Vol. 99, no. 7. (October): 2028-2037.
  • Chakraborty Arup K, Das Jayajit. 2010. Pairing computation with experimentation: a powerful coupling for understanding T cell signalling.  Nature Reviews Immunology. Vol. 10, no. 1. (January): 59-71.
  • Das Jayajit, Frechet JMJ, Chakraborty Arup K. 2009. Self-Assembly of Dendronized Polymers.  Journal of Physical Chemistry B. Vol. 113, no. 42. (October): 13768-13775.
  • Das Jayajit, Kardar Mehran, Chakraborty Arup K. 2009. Positive feedback regulation results in spatial clustering and fast spreading of active signaling molecules on a cell membrane.  Journal of Chemical Physics. Vol. 130, no. 24. (June): e245102.
  • Chakraborty Arup K, Das Jayajit, Zikherman Julie, Yang Ming, Govern Christopher, Ho Mary, Weiss Arthur, Roose Jeroen. 2009. Molecular Origin and Functional Consequences of Digital Signaling and Hysteresis During Ras Activation in Lymphocytes.  Science Signaling. Vol. 2, no. 66. (April): ept2.
  • Das Jayajit, Ho Mary, Zikherman Julie, Govern Christopher, Yang Ming, Weiss Arthur, Chakraborty Arup K, Roose Jeroen. 2009. Digital Signaling and Hysteresis Characterize Ras Activation in Lymphoid Cells.  Cell. Vol. 136, no. 2. (January): 337-351.
  • Prasad Ashok, Zikherman Julie, Das Jayajit, Roose Jeroen, Weiss Arthur, Chakraborty Arup K. 2009. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 106, no. 2. (January): 528-533.
  • Bullard TJ, Das J, Daquila GL,Tauber UC. 2008. Vortex washboard voltage noise in type-II superconductors.  European Physical Journal B. Vol. 65, no. 4. (October): 469-484.
  • Cemerski Saso, Das Jayajit, Giurisato Emanuele, Markiewicz Mary A, Allen Paul M, Chakraborty Arup K, Shaw Andrey S. 2008. The balance between T cell receptor signaling and degradation at the center of the immunological synapse is determined by antigen quality.  Immunity. Vol. 29, no. 3. (September): 414-422.
  • Artyomov Maxim, Das Jayajit, Kardar Mehran, Chakraborty Arup K. 2007. Purely stochastic binary decisions in cell signaling models without underlying deterministic bistabilities.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 48. (November): 18958-18963.
  • Wylie Dennis, Das Jayajit, Chakraborty Arup K. 2007. Sensitivity of T cells to antigen and antagonism emerges from differential regulation of the same molecular signaling module.  Proceedings of the National Academy of Sciences of the United States of America. Vol. 104, no. 13. (March): 5533-5538.
  • Cemerski Saso, Das Jayajit, Locasale Jason, Arnold Phoebe, Giurisato Emanuele, Markiewicz Mary A, Fremont Daved, Allen Paul M, Chakraborty Arup K, Shaw Andrey S. 2007. The stimulatory potency of T cell antigens is influenced by the formation of the immunological synapse.  Immunity. Vol. 26, no. 3. (March): 345-355.
  • Gomez,Enrique,D; Das,Jayajit; Chakraborty,Arup,K; Pople,John,A; Balsara,Nitash,P. 2006. Effect of cross-linking on the structure and thermodynamics of lamellar block copolymers.  MACROMOLECULES. Vol. 39, no. 14. (July): 4848-4859.
  • Chakraborty Arup K, Das Jayajit, Yoshida Masaru, Fresco Zachary, Choi Tae Lim, Frechet JMJ. 2005. Single molecule properties and self assembly of dendronized polymers. In 230th National Meeting of the American-Chemical-Society
  • Das J, Yoshida M, Fresco ZA, Choi TL, Frechet JMJ, Chakraborty AK. 2005. A dendronized polymer is a single-molecule glass.  Journal of Physical Chemistry B. Vol. 109, no. 14. (April): 6535-6543.
  • Hahn H, Chakraborty AK, Das J, Pople JA, Balsara NP. 2005. Order-disorder transitions in cross-linked block copolymer solids.  Macromolecules. Vol. 38, no. 4. (February): 1277-1285.
  • Jayajit Das, Thomas J Bullard, Uwe C. Tauber. 2004. "Dynamics of Magnetic Flux lines in the Presense of Correlated Disorder". In Trends in Superconductivity Research. New York, NY: Nova Science Publishers, Inc..
  • Das,J; Bullard,T,J; Tauber,U,C. 2003. Vortex transport and voltage noise in disordered superconductors.  PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS. Vol. 318, no. 1-2. (February): 48-54.
  • Das J, Bullard TJ, Tauber UC. 2003. Vortex transport and voltage noise in disordered superconductors. In International Conference on Statistical Physics
  • Das J, Rao M, Ramaswamy S. 2002. Driven Heisenberg magnets: Nonequilibrium criticality, spatiotemporal chaos and control.  Europhysics Letters. Vol. 60, no. 3. (November): 418-424.
  • Das J, Rao M. 2000. Ordering dynamics of Heisenberg spins with torque: Crossover, spin waves, and defects.  Physical Review E. Vol. 62, no. 2. (August): 1601-1612.
  • Das J, Rao M. 1999. Dynamics of ordering of isotropic magnets. In International Conference on Statistical Physics (Statphys - Calcutta III)
  • Das,J; Rao,M. 1999. Dynamics of ordering of isotropic magnets.  PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS. Vol. 270, no. 1-2. (August): 253-262.
  • Das J, Rao M. 1998. Dynamics of ordering of Heisenberg spins with torque: Nonconserved case.  Physical Review E. Vol. 57, no. 5. (May): 5069-5078.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000