Vidu Garg Lab :: The Research Institute at Nationwide Children's Hospital

Garg Lab


 The Garg Laboratory focuses on understanding the genetic basis of congenital heart disease and the molecular pathways regulating normal and abnormal cardiac development.

We have identified familial cases of congenital heart disease and used traditional
 
linkage studies to discover novel genetic etiologies of human congenital cardiac malformations. In addition, we are interesting in understanding how these mutations disrupt normal cardiac development and are generating mouse models to gain insight into the molecular basis of congenital heart disease.


 

Garg Lab Images and Movies


Image 1 :: Pedigree and GATA4 mutation in family with cardiac septation defects




Image 2 :: Embryonic lethality and cardiac malformations in Gata4/Tbx5 heterozygous mouse embryos


 


Image 3 :: Pedigree and NOTCH1 mutations in family with bicuspid aortic valve and aortic valve calcification

 

Image 4 :: Cryptic Chromosomal Abnormalities Uncovered by Array CGH


 

Movie 1

View a movie showing 3D reconstruction of atrioventricular septal defect in Gata4/Tbx5 compound heterozygote embryo.

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