Gail E. Besner, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Dr. Besner appointed to National Advisory General Medical Sciences Council

Gail E. Besner, MD has been appointed to the National Advisory General Medical Sciences Council by Health and Human Services Secretary Kathleen Sebelius. This council of 17 of America’s most distinguished and accomplished scientists advises Secretary Sebelius,  National Institutes of Health (NIH) Director Francis Collins, the Director of the National Institute of General Medical Sciences (NIGMS) and other key government leaders on grant applications to support biomedical research and research training activities.

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Finding a Cure for Necrotizing Enterocolitis

Gail E. Besner, MD

Gail E. Besner, MD Best Doctors 2011-2012

Burn Program
Co-Director

Center for Perinatal Research
Principal Investigator

Chest Wall Clinic
Pediatric Surgeon

Intestinal Support Service
Surgeon Team

Neonatology
Principal Investigator

Pediatric Colorectal Fellowship
Faculty

Pediatric Surgery
Chief

Pediatric Surgery Residency
Associate Program Director

Surgical Critical Care Fellowship
Faculty

Surgical Services
Service Line Chief

Trauma
Surgeon Team

Contact Information

Pediatric Surgery
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-3900
FX: (614) 722-3903
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 722-2700

Location Information for Patients

Main Campus

Biography

Gail E. Besner, MD, is a member of the Center for Perinatal Research at The Research Institute at Nationwide Children’s Hospital. She holds the H. William Clatworthy Jr Professorship in Surgery at The Ohio State University College of Medicine, is a Professor of Surgery and Pediatrics at The Ohio State University College of Medicine, and is the Co-Director of the Burn Program at Nationwide Children’s Hospital. She is the Program Director of the Residency in Pediatric Surgery. Her clinical interests include neonatal surgery, necrotizing enterocolitis, and pediatric burn care. Her research interests involve a growth factor known as heparin-binding EGF-like growth factor, HB-EGF, a growth factor that Dr. Besner identified in the early 1990s. Dr. Besner’s research is funded by three grants from the National Institutes of Health. In addition, Dr. Besner works with a biotechnology company to produce HB-EGF for clinical use, with Phase I and II clinical trials of the use of HB-EGF in the prevention of necrotizing enterocolitis anticipated in the near future. Dr. Besner is a 4-year term as a full-time member of the Surgery, Anesthesia member of the American College of Surgeons Executive Committee of the Surgical Research Committee, and recently completed a and Trauma Study Section of the National Institutes of Health.

View CV »

Gender:

  • Female

Languages Spoken:

  • English

Research Interests

Research Center:

Areas of Interest:

  • Dr. Gail Besner's primary research began in 1990 with the identification of the growth factor "heparin-binding EGF-like growth factor" (HB-EGF). The long range goal of this research is determine whether or not HB-EGF could be used in therapies to protect and treat intestinal damage in high-risk neonates.
  • Her studies have shown that HB-EGF's anti-inflammatory effects and chemical properties play a vital role in the regenerating of intestinal cells after they have been damaged. Lab research has shown that HB-EGF can protect the intestine from damage caused by hemorrhagic shock, blood supply restriction and necrotizing enterocolitis. Clinical studies are on the horizon to further test HB-EGF as a treatment option.

Research Funding*:

  • HB-EGF and Intestinal Ischemia/Reperfusion, National Institutes of General Medical Sciences
  • HB-EGF Therapy for Necrotizing Enterocolitis, National Institute of Diabetes and Digestive and Kidney Diseases
  • Role of NO and Endothelin in Human NEC, National Institute of Diabetes and Digestive and Kidney Diseases

Education and Training

Medical School

  • University of Cincinnati
    Date Completed: 06/30/1982

Internship

  • Harvard - Brigham & Women's Hospital
    Date Completed: 06/30/1983

Residency

  • Harvard - Brigham & Women's Hospital
    Date Completed: 06/30/1987

Fellowship

  • Boston Children's Hospital
    Date Completed: 06/30/1989

Residency

  • Buffalo Children's Hospital
    Date Completed: 06/30/1991

Fellowship

  • Children's Hospital of Buffalo
    Date Completed: 06/30/1991

Department:

  • Pediatric Surgery

Section:

  • General Pediatric Surgery

Specialty:

  • General Pediatric Surgery
  • Surgery
  • Surgical Critical Care

Date of Appointment at Nationwide Children’s Hospital:

  • 11/26/1991

Professional Experience

2012–present

  • Member, The Jackson Laboratory Informatics Scientific Advisory Board

2012–present

  • Contributing Member Faculty of 1000, Section of Medical Genetics

2011–present

  • President-elect, American College of Medical Genetics

2005–present

  • Associate Program Director, Residency in Pediatric Surgery, Nationwide Children's Hospital and The Ohio State University College of Medicine, Columbus, Ohio

2003–present

  • Professor of Surgery and Pediatrics, The Ohio State University, Division of Pediatric Surgery at Nationwide Children's Hospital, Columbus, OH

2001–present

  • Member, Integrated Biomedical Sciences Graduate Program, The Ohio State University College of Medicine, Columbus, Ohio

1994–present

  • Member, Comprehensive Cancer Center, The Arthur James Cancer Hospital and Research Institute, Ohio State University, Columbus, OH

1992–present

  • Member, Molecular and Cellular Developmental Biology Program, Ohio State University, Columbus, OH

2004–2008

  • Full-time Member, Surgery, Anesthesia and Trauma Study Section, National Institutes of Health 

2004–2006

  • Chair, NIH Genetics of Health and Disease Study Section

2002–2004

  • Regular Member, NIH Mammalian Genetic Study Section

1999–2001

  • Co-Director, Medical Scientist Training Program, Ohio State University, Columbus, OH

1997–2003

  • Associate Professor of Surgery and Pediatrics, The Ohio State University, Division of Pediatric Surgery at Nationwide Children's Hospital, Columbus, OH 

1994–1997

  • Regular Member, NIH Genome Study Section

1991–1997

  • Assistant Professor of Surgery and Pediatrics, Ohio State University, Division of Pediatric Surgery at Columbus Children's Hospital, Columbus, OH

1991–1991

  • Pediatric Surgeon, Children's Hospital, Buffalo, NY

1989–1989

  • Surgical Research, Children's Hospital, Boston, MA

1987–1989

  • Research Fellow, Department of Surgery, Children's Hospital and Harvard Medical School, Boston, MA Mentors: Dr. M. Judah Folkman and Dr. Michael Klagsbrun Project: Identification of a novel growth factor (heparin-binding EGF-like growth factor (HB-EGF)) from cultured human macrophages.

1987–1987

  • Surgeon, Brigham & Women's Hospital, Boston, MA

1977–1978

  • Undergraduate Research Fellowship, Cornell University, Division of Nutritional Sciences, Ithaca, NY Mentor: Dr. V. Utermohlen Project: The effect of exogenously added fatty acids on cell mediated immunity.

Publications

  • Radulescu A; Zhang HY; Yu X; Olson JK; Darbyshire AK; Chen Y; Besner GE. 2010. Heparin-binding epidermal growth factor-like growth factor overexpression in transgenic mice increases resistance to necrotizing enterocolitis.  Journal Of Pediatric Surgery. Vol. 45, no. 10. (October): e1933.
  • James IA; Chen CL; Huang G; Zhang HY; Velten M; Besner GE. 2010. HB-EGF protects the lungs after intestinal ischemia/reperfusion injury.  The Journal Of Surgical Research. Vol. 163, no. 1. (September): e86.
  • Askegard-Giesmann JR; Besner GE; Fabia R; Caniano DA; Preston T; Kenney BD. 2010. Extracorporeal membrane oxygenation as a lifesaving modality in the treatment of pediatric patients with burns and respiratory failure.  Journal Of Pediatric Surgery. Vol. 45, no. 6. (June): e1330.
  • Chen CL; Mehta VB; Zhang HY; Wu D; Otabor I; Radulescu A; El-Assal ON; Feng J; Chen Y; Besner GE. 2010. Intestinal phenotype in mice overexpressing a heparin-binding EGF-like growth factor transgene in enterocytes.  Growth Factors (Chur, Switzerland). Vol. 28, no. 2. (April): e82.
  • Radulescu A; Yu X; Orvets ND; Chen Y; Zhang HY; Besner GE. 2010. Deletion of the heparin-binding epidermal growth factor-like growth factor gene increases susceptibility to necrotizing enterocolitis.  Journal Of Pediatric Surgery. Vol. 45, no. 4. (April): e729.
  • Michalsky M, Besner G. 2010. Alimentary Tract Duplications.  eMedicine.
  • Christensen RD; Wiedmeier SE; Baer VL; Henry E; Gerday E; Lambert DK; Burnett J; Besner GE. 2010. Antecedents of Bell stage III necrotizing enterocolitis.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 30, no. 1. (January): e54.
  • Christensen RD; Gordon PV; Besner GE. 2010. Can we cut the incidence of necrotizing enterocolitis in half--today?.  Fetal And Pediatric Pathology. Vol. 29, no. 4. (January): e185.
  • Zhang HY; Radulescu A; Besner GE. 2009. Heparin-binding epidermal growth factor-like growth factor is essential for preservation of gut barrier function after hemorrhagic shock and resuscitation in mice.  Surgery. Vol. 146, no. 2. (August): e334.
  • Otabor IA; Balint JP; Besner GE. 2009. Myectomy-myotomy for long segment Hirschsprung's disease in a patient with Haddad syndrome.  Journal Of Pediatric Surgery. Vol. 44, no. 3. (March): e620.
  • Radulescu A, Zorko NA, Yu X, Besner GE. 2009. Pre-Clinical Neonatal Rat Studies of Heparin-binding EGF-like Growth Factor in Protection of the Intestines from Necrotizing Enterocolitis.  Pediatr Res..
  • Otabor IA; Abdessalam SF; Erdman SH; Hammond S; Besner GE. 2009. Gastric outlet obstruction due to adenocarcinoma in a patient with Ataxia-Telangiectasia syndrome: a case report and review of the literature.  World Journal Of Surgical Oncology. Vol. 7, no. January: e29.
  • El-Assal ON, Paddock H, Marquez A, Besner GE. 2008. Heparin-binding epidermal growth factor-like growth factor gene disruption is associated with delayed intestinal restitution, impaired angiogenesis, and poor survival after intestinal ischemia in mice.  J Pediatr Surg.. Vol. 43, no. 6. (January): 1182-1190.
  • Arora A, Caniano DA, Hammond S, Besner GE. 2008. Inversion appendectomy acting as a lead point for intussusception.  Pediatr Surg Int.. Vol. 24, no. 11. (January): 1261-1264.
  • Mehta VB, Zhou Y, Radulescu A, Besner GE. 2008. HB-EGF stimulates eNOS expression and nitric oxide production and promotes eNOS dependent angiogenesis.  Growth Factors. Vol. 26, no. 6. (January): 301-315.
  • Shiels WE 2nd, Kenney BD, Caniano DA, Besner GE. 2008. Definitive percutaneous treatment of lymphatic malformations of the trunk and extremities.  J Pediatr Surg.. Vol. 43, no. 1. (January): 136-139.
  • Lambert DK; Christensen RD; Henry E; Besner GE; Baer VL; Wiedmeier SE; Stoddard RA; Miner CA; Burnett J. 2007. Necrotizing enterocolitis in term neonates: data from a multihospital health-care system.  Journal Of Perinatology: Official Journal Of The California Perinatal Association. Vol. 27, no. 7. (July): e437.
  • Paddock HN; Fabia R; Giles S; Hayes J; Lowell W; Besner GE. 2007. A silver impregnated antimicrobial dressing reduces hospital length of stay for pediatric patients with burns.  Journal Of Burn Care & Research: Official Publication Of The American Burn Association. Vol. 28, no. 3. (May): e409.
  • Feng, Jiexiong; Besner, Gail E. 2007. Heparin-binding epidermal growth factor-like growth factor promotes enterocyte migration and proliferation in neonatal rats with necrotizing enterocolitis.  Journal of pediatric surgery. Vol. 42, no. 1. (January): 214-20.
  • Nowicki PT; Caniano DA; Hammond S; Giannone PJ; Besner GE; Reber KM; Nankervis CA. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  The Journal Of Pediatrics. Vol. 150, no. 1. (January): e40.
  • Nowicki, Philip, T; Caniano, Donna, A; Hammond, Sue; Giannone, Peter, J; Besner, Gail, E; Reber, Kristina, M; Nankervis, Craig A. 2007. Endothelial nitric oxide synthase in human intestine resected for necrotizing enterocolitis.  The Journal of pediatrics. Vol. 150, no. 1. (January): 40-5.
  • Paddock HN; Fabia R; Giles S; Hayes J; Lowell W; Adams D; Besner GE. 2007. A silver-impregnated antimicrobial dressing reduces hospital costs for pediatric burn patients.  Journal Of Pediatric Surgery. Vol. 42, no. 1. (January): e211.
  • Feng, Jiexiong; El-Assal, Osama, N; Besner, Gail E. 2006. Heparin-binding epidermal growth factor-like growth factor decreases the incidence of necrotizing enterocolitis in neonatal rats.  Journal of pediatric surgery. Vol. 41, no. 1. (January): 144-9; discussion 144.
  • Nowicki, Philip, T; Reber, Kristina, M; Giannone, Peter, J; Nankervis, Craig, A; Hammond, Sue; Besner, Gail, E; Caniano, Donna A. 2006. Intestinal O2 consumption in necrotizing enterocolitis: role of nitric oxide.  Pediatric research. Vol. 59, no. 4 Pt 1. (January): 500-5.
  • Feng, Jiexiong; El-Assal, Osama, N; Besner, Gail E. 2006. Heparin-binding epidermal growth factor-like growth factor reduces intestinal apoptosis in neonatal rats with necrotizing enterocolitis.  Journal of pediatric surgery. Vol. 41, no. 4. (January): 742-7; discussion 742.
  • Feng, Jiexiong; Mehta, Veela, B; El-Assal, Osama, N; Wu, Dan; Besner, Gail E. 2006. Tissue distribution and plasma clearance of heparin-binding EGF-like growth factor (HB-EGF) in adult and newborn rats.  Peptides. Vol. 27, no. 6. (January): 1589-96.
  • Rocourt, Dorothy, V; Shiels, William, E; Hammond, Sue; Besner, Gail E. 2006. Contemporary management of benign hepatic adenoma using percutaneous radiofrequency ablation.  Journal of pediatric surgery. Vol. 41, no. 6. (January): 1149-52.
  • Paddock H, Nguyen L, Kay S, Besner G. 2006. Choledochal Cyst: Surgical Perspective.  eMedicine.
  • El-Assal ON; Besner GE. 2005. HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation.  Gastroenterology. Vol. 129, no. 2. (August): e609.
  • Feng, Jiexiong; El-Assal, Osama, N; Besner, Gail E. 2005. Heparin-binding EGF-like growth factor (HB-EGF) and necrotizing enterocolitis.  Seminars in pediatric surgery. Vol. 14, no. 3. (January): 167-74.
  • Mehta, Veela, B; Besner, Gail E. 2005. Heparin-binding epidermal growth factor-like growth factor inhibits cytokine-induced NF-kappa B activation and nitric oxide production via activation of the phosphatidylinositol 3-kinase pathway.  Journal of immunology (Baltimore, Md. : 1950). Vol. 175, no. 3. (January): 1911-8.
  • Besner, Gail, E; Bates, Gregory, D; Boesel, Carl, P; Singh, Vivekanand; Welty, Stephen, E; Corpron, Cynthia A. 2005. Total absence of the small bowel in a premature neonate.  Pediatric surgery international. Vol. 21, no. 5. (January): 396-9.
  • El-Assal, Osama, N; Besner, Gail E. 2005. HB-EGF enhances restitution after intestinal ischemia/reperfusion via PI3K/Akt and MEK/ERK1/2 activation.  Gastroenterology. Vol. 129, no. 2. (January): 609-25.
  • Nowicki, Philip, T; Dunaway, David, J; Nankervis, Craig, A; Giannnone, Peter, J; Reber, Kristina, M; Hammond, Susan, B; Besner, Gail, E; Caniano, Donna A. 2005. Endothelin-1 in human intestine resected for necrotizing enterocolitis.  The Journal of pediatrics. Vol. 146, no. 6. (January): 805-10.
  • Martin, Abigail, E; Luquette, Mark, H; Besner, Gail E. 2005. Timing, route, and dose of administration of heparin-binding epidermal growth factor-like growth factor in protection against intestinal ischemia-reperfusion injury.  Journal of pediatric surgery. Vol. 40, no. 11. (January): 1741-7.
  • Provenzano, Aaron, P; Besner, Gail, E; James, Paul, F; Harding, Paul A. 2005. Heparin-binding EGF-like growth factor (HB-EGF) overexpression in transgenic mice downregulates insulin-like growth factor binding protein (IGFBP)-3 and -4 mRNA.  Growth factors (Chur, Switzerland). Vol. 23, no. 1. (January): 19-31.
  • El-Assal, Osama, N; Besner, Gail E. 2004. Heparin-binding epidermal growth factor-like growth factor and intestinal ischemia-reperfusion injury.  Seminars in pediatric surgery. Vol. 13, no. 1. (January): 2-10.
  • Corpron, Cynthia, A; Martin, Abigail, E; Roberts, Georgianna; Besner, Gail E. 2004. The pediatric burn unit: a profit center.  Journal of pediatric surgery. Vol. 39, no. 6. (January): 961-3; discussion 961.
  • Xia G; Martin AE; Besner GE. 2003. Heparin-binding EGF-like growth factor downregulates expression of adhesion molecules and infiltration of inflammatory cells after intestinal ischemia/reperfusion injury.  Journal Of Pediatric Surgery. Vol. 38, no. 3. (March): e434.
  • Besner G. 2003. Burn Care.  Critical Measures.
  • Besner G. 2003. Burn Care at Children’s Hospital.  Critical Measures.
  • Xia, Guliang; Rachfal, Amy, W; Martin, Abigail, E; Besner, Gail E. 2003. Upregulation of endogenous heparin-binding EGF-like growth factor (HB-EGF) expression after intestinal ischemia/reperfusion injury.  Journal of investigative surgery : the official journal of the Academy of Surgical Research. Vol. 16, no. 2. (January): 57-63.
  • O’Connor A, Besner G. 2002. Burns.  eMedicine.
  • Kuhn A, Besner G. 2002. Breast Disorders. In Surgical Directives: Pediatric Surgery. Philadelphia, PA: Lippincott, Williams & Wilkins, Inc..
  • Davis-Fleische, K, M; Brigstock, D, R; Besner, G E. 2001. Site-directed mutagenesis of heparin-binding EGF-like growth factor (HB-EGF): analysis of O-glycosylation sites and properties.  Growth factors (Chur, Switzerland). Vol. 19, no. 2. (January): 127-43.
  • Davis-Fleische KM; Brigstock DR; Besner GE. 2001. Site-directed mutagenesis of heparin-binding EGF-like growth factor (HB-EGF): analysis of O-glycosylation sites and properties.  Growth Factors (Chur, Switzerland). Vol. 19, no. 2. (January): e127.
  • Pillai, S, B; Bethel, C, A; Besner, G, E; Caniano, D, A; Cooney, D R. 2000. Fall injuries in the pediatric population: safer and most cost-effective management.  The Journal of trauma. Vol. 48, no. 6. (January): 1048-50; discussion 1050.
  • Coley, B, D; Mutabagani, K, H; Martin, L, C; Zumberge, N; Cooney, D, R; Caniano, D, A; Besner, G, E; Groner, J, I; Shiels, W E 2nd. 2000. Focused abdominal sonography for trauma (FAST) in children with blunt abdominal trauma.  The Journal of trauma. Vol. 48, no. 5. (January): 902-6.
  • Vegunta, R, K; Morotti, R, A; Shiels, W E 2nd; Rauck, A; Besner, G E. 2000. Collision tumors in children: a review of the literature and presentation of a rare case of mesoblastic nephroma and neuroblastoma in an infant.  Journal of pediatric surgery. Vol. 35, no. 9. (January): 1359-61.
  • Besner G. 2000. Burns. In Pediatric Surgical Secrets. Edited by Glick P, Caty M, Pearl R, Irish M. Philadelphia, PA: Hanley and Belfus, Inc..
  • Besner G. 2000. Testicular Problems and Varicoceles. In Pediatric Surgical Secrets. Edited by Glick P, Caty M, Pearl R, Irish M. Philadelphia, PA: Hanley and Belfus, Inc..
  • McCarthy, D, W; Qualman, S, J; Rudman, D, T; Wiet, G, J; Besner, G E. 1999. Herpetic tracheitis and brachial plexus neuropathy in a child with burns.  The Journal of burn care & rehabilitation. Vol. 20, no. 5. (January): 377-81.
  • Zubair M, Besner G. 1999. Pediatric Electrical Burns: Management Strategies. In Year Book of Surgery. Edited by Deitch E. Chicago, IL: Mosby-Year Book, Inc..
  • Harding, P, A; Davis-Fleischer, K, M; Crissman-Combs, M, A; Miller, M, T; Brigstock, D, R; Besner, G E. 1999. Induction of anchorage independent growth by heparin-binding EGF-like growth factor (HB-EGF).  Growth factors (Chur, Switzerland). Vol. 17, no. 1. (January): 49-61.
  • Pillai, S, B; Hinman, C, E; Luquette, M, H; Nowicki, P, T; Besner, G E. 1999. Heparin-binding epidermal growth factor-like growth factor protects rat intestine from ischemia/reperfusion injury.  The Journal of surgical research. Vol. 87, no. 2. (January): 225-31.
  • Mutabagani, K, H; Menke, J, A; McCoy, K, S; Besner, G E. 1999. Bronchopexy for congenital bronchomalacia in the newborn.  Journal of pediatric surgery. Vol. 34, no. 8. (January): 1300-3.
  • Mutabagani, K, H; Coley, B, D; Zumberge, N; McCarthy, D, W; Besner, G, E; Caniano, D, A; Cooney, D R. 1999. Preliminary experience with focused abdominal sonography for trauma (FAST) in children: is it useful?.  Journal of pediatric surgery. Vol. 34, no. 1. (January): 48-52; discussion 52.
  • Besner GE; Klamar JE. 1998. Integra Artificial Skin as a useful adjunct in the treatment of purpura fulminans.  The Journal Of Burn Care & Rehabilitation. Vol. 19, no. 4. (July): e324.
  • Davis-Fleischer, K, M; Besner, G E. 1998. Structure and function of heparin-binding EGF-like growth factor (HB-EGF).  Frontiers in bioscience : a journal and virtual library. Vol. 3, no. January: d288-99.
  • Besner, G, E; Klamar, J E. 1998. Integra Artificial Skin as a useful adjunct in the treatment of purpura fulminans.  The Journal of burn care & rehabilitation. Vol. 19, no. 4. (January): 324-9.
  • Pillai, S, B; Luquette, M, H; Nowicki, P, T; Besner, G E. 1998. Segmental intestinal ischemia: an improved method of producing small bowel injury.  Journal of investigative surgery : the official journal of the Academy of Surgical Research. Vol. 11, no. 2. (January): 123-8.
  • Cribbs, R, K; Luquette, M, H; Besner, G E. 1998. Acceleration of partial-thickness burn wound healing with topical application of heparin-binding EGF-like growth factor (HB-EGF).  The Journal of burn care & rehabilitation. Vol. 19, no. 2. (January): 95-101.
  • Cribbs, R, K; Luquette, M, H; Besner, G E. 1998. A standardized model of partial thickness scald burns in mice.  The Journal of surgical research. Vol. 80, no. 1. (January): 69-74.
  • Pillai, S, B; Turman, M, A; Besner, G E. 1998. Heparin-binding EGF-like growth factor is cytoprotective for intestinal epithelial cells exposed to hypoxia.  Journal of pediatric surgery. Vol. 33, no. 7. (January): 973-8; discussion 978.
  • Bethel, C, A; Mutabagani, K; Hammond, S; Besner, G, E; Caniano, D, A; Cooney, D R. 1998. Nonteratomatous germ cell tumors in children.  Journal of pediatric surgery. Vol. 33, no. 7. (January): 1122-6; discussion 1126.
  • Bethel, C, A; Luquette, M, H; Besner, G E. 1998. Cystic degeneration of heterotopic pancreas.  Pediatric surgery international. Vol. 13, no. 5-6. (January): 428-30.
  • Pillai, S, B; Besner, G E. 1998. Pediatric testicular problems.  Pediatric clinics of North America. Vol. 45, no. 4. (January): 813-30.
  • Besner G. 1997. Taking Burn Care into the 21st Century.  Pediatric Directions.
  • Singh, S, P; Besner, G, E; Schauer, G M. 1997. Pulmonary endodermal tumor resembling fetal lung: report of a case in a 14-year-old girl.  Pediatric pathology & laboratory medicine : journal of the Society for Pediatric Pathology, affiliated with the International Paediatric Pathology Association. Vol. 17, no. 6. (January): 951-8.
  • Zubair, M; Besner, G E. 1997. Pediatric electrical burns: management strategies.  Burns : journal of the International Society for Burn Injuries. Vol. 23, no. 5. (January): 413-20.
  • Downing, M, T; Hamoudi, A, B; Besner, G E. 1997. Brain heterotopia: choristoma of the back.  Pediatric surgery international. Vol. 12, no. 2-3. (January): 183-5.
  • Downing, M, T; Brigstock, D, R; Luquette, M, H; Crissman-Combs, M; Besner, G E. 1997. Immunohistochemical localization of heparin-binding epidermal growth factor-like growth factor in normal skin and skin cancers.  The Histochemical journal. Vol. 29, no. 10. (January): 735-44.
  • McCarthy D, Besner G, Gosche J, Qualman S, Chan D, Olson T. 1996. Retroperitoneal Yolk Sac Tumor with Spinal Cord Compression and Intracardiac Extension.  Int J Pediatr Heme/Oncol.
  • McCarthy, D, W; Downing, M, T; Brigstock, D, R; Luquette, M, H; Brown, K, D; Abad, M, S; Besner, G E. 1996. Production of heparin-binding epidermal growth factor-like growth factor (HB-EGF) at sites of thermal injury in pediatric patients.  The Journal of investigative dermatology. Vol. 106, no. 1. (January): 49-56.
  • Besner, G, E; Qualman, S, J; Gosche, J R. 1996. Identification of a duplicated undescended testicle (polyorchia): an unexpected benefit of laparoscopic localization.  Journal of laparoendoscopic surgery. Vol. 6 Suppl 1, no. January: S107-14.
  • Harding, P, A; Brigstock, D, R; Shen, L; Crissman-Combs, M, A; Besner, G E. 1996. Characterization of the gene encoding murine heparin-binding epidermal growth factor-like growth factor.  Gene. Vol. 169, no. 2. (January): 291-2.
  • Bensard, D, D; Beaver, B, L; Besner, G, E; Cooney, D R. 1996. Small bowel injury in children after blunt abdominal trauma: is diagnostic delay important?.  The Journal of trauma. Vol. 41, no. 3. (January): 476-83.
  • Davis, K, M; Brigstock, D, R; Johnson, P, R; Crissman-Combs, M, A; McCarthy, D, W; Downing, M, T; Besner, G E. 1996. Production of glycosylated heparin-binding EGF-like growth factor in HeLa cells using vaccinia virus.  Protein expression and purification. Vol. 8, no. 1. (January): 57-67.
  • Mutabagani K, Beaver B, Cooney D, Besner G. 1996. Penetrating Neck Trauma in Children: A Reappraisal. In Year Book of Emergency Medicine. Edited by King BR. Chicago, IL: Mosby-Year Book, Inc.
  • Mutabagani, K, H; Beaver, B, L; Cooney, D, R; Besner, G E. 1995. Penetrating neck trauma in children: a reappraisal.  Journal of pediatric surgery. Vol. 30, no. 2. (January): 341-4.
  • Kim, G, Y; Besner, G, E; Steffen, C, L; McCarthy, D, W; Downing, M, T; Luquette, M, H; Abad, M, S; Brigstock, D R. 1995. Purification of heparin-binding epidermal growth factor-like growth factor from pig uterine luminal flushings, and its production by endometrial tissues.  Biology of reproduction. Vol. 52, no. 3. (January): 561-71.
  • Martinez, D, A; O'Dorisio, M, S; O'Dorisio, T, M; Qualman, S, J; Caniano, D, A; Teich, S; Besner, G, E; King, D R. 1995. Intraoperative detection and resection of occult neuroblastoma: a technique exploiting somatostatin receptor expression.  Journal of pediatric surgery. Vol. 30, no. 11. (January): 1580-9.
  • Vegunta, R, K; Cooney, D, R; Downing, M, T; Besner, G, E; Brigstock, D R. 1995. Unique protein expression by the TBJ clonal derivative of C1300 murine neuroblastoma.  Journal of pediatric surgery. Vol. 30, no. 12. (January): 1668-72.
  • Teitelbaum D; Teich S; Cassidy S; Karp M; Cooney D; Besner G. 1994. Highly vascularized sacrococcygeal teratoma: description of this atypical variant and its operative management.  Journal Of Pediatric Surgery. Vol. 29, no. 1. (January): e98.
  • Besner G, Fisher J, Nazzadri F, Karp M, Jewett T, Cooney D. 1993. Teratoma in a Thyroglossal Duct Cyst: A Rare Occurrence.  Pediatr Surg Int.
  • Besner, G, E; Whelton, D; Crissman-Combs, M, A; Steffen, C, L; Kim, G, Y; Brigstock, D R. 1992. Interaction of heparin-binding EGF-like growth factor (HB-EGF) with the epidermal growth factor receptor: modulation by heparin, heparinase, or synthetic heparin-binding HB-EGF fragments.  Growth factors (Chur, Switzerland). Vol. 7, no. 4. (January): 289-96.
  • Higashiyama, S; Lau, K; Besner, G, E; Abraham, J, A; Klagsbrun, M. 1992. Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein.  The Journal of biological chemistry. Vol. 267, no. 9. (January): 6205-12.
  • Glick, P, L; Leach, C, L; Besner, G, E; Egan, E, A; Morin, F, C; Malanowska-Kantoch, A; Robinson, L, K; Brody, A; Lele, A, S; McDonnell, M. 1992. Pathophysiology of congenital diaphragmatic hernia. III: Exogenous surfactant therapy for the high-risk neonate with CDH.  Journal of pediatric surgery. Vol. 27, no. 7. (January): 866-9.
  • Stannard VA; Fowler C; Robinson L; Besner G; Glick PL; Allen JE; Jewett TC; Cooney DR. 1991. Familial Hirschsprung's disease: report of autosomal dominant and probable recessive X-linked kindreds.  Journal Of Pediatric Surgery. Vol. 26, no. 5. (May): e591.
  • Besner, G, E; Klagsbrun, M. 1991. Macrophages secrete a heparin-binding inhibitor of endothelial cell growth.  Microvascular research. Vol. 42, no. 2. (January): 187-97.
  • Besner G; Higashiyama S; Klagsbrun M. 1990. Isolation and characterization of a macrophage-derived heparin-binding growth factor.  Cell Regulation. Vol. 1, no. 11. (October): e811.
  • Besner G, Tilney N. 1986. Peripheral Arterial Embolus. In Current Surgical Therapy. Edited by Cameron JL. New York, NY: BC Dexter and CV Mosby.
  • Utermohlen V; Coniglio J; Mao D; Sierra J; Smith R; Besner G; Hutchins S; Spitzer K; Tomasso J; Boyar A. 1981. Unsaturated fatty acids and human mononuclear cell function.  Progress In Lipid Research. Vol. 20, no. January: e739.
  • Utermohlen V; Besner G; Berkowitz MG. 1980. The effect of fatty acid addition in vitro on direct migration inhibition with paramyxoviral antigens.  Clinical Immunology And Immunopathology. Vol. 16, no. 3. (July): e324.

Awards, Honors and Organizations

  • Health Care Heroes Award, Business First, Provider Category
  • Council Member, National Advisory General Medical Sciences Council
  • Listed Best Doctors in America, 1996-present
Nationwide Children's Hospital
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