Edward G. Shepherd, MD :: Nationwide Children’s Hospital, Columbus, Ohio

Edward G. Shepherd, MD

Edward G. Shepherd, MD Best Doctors 2011-2012

Hospital-Based Research Faculty
Principal Investigator

Section Chief

Neonatology Fellowship

Medical Director

Contact Information

700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-4530
FX: (614) 722-4541

Location Information for Patients

Main Campus


Edward G. Shepherd, MD, is the Section Chief of Neonatology at Nationwide Children’s Hospital and an Associate Professor of Clinical Pediatrics at The Ohio State University College of Medicine. Dr. Shepherd’s clinical interests focus on bronchopulmonary dysplasia (BPD) and developmental care of the vulnerable infant. Dr. Shepherd serves as Physician co-chair of developmental steering committees at Nationwide Children’s Hospital and Riverside Methodist Hospital, units that have a combined capacity of 137 beds. Dr. Shepherd’s clinical interests have lead to his research focus into BPD and developmental care, and he is currently involved in several studies of the diagnosis and progression of BPD as well as the best developmental care for infants so afflicted. Dr. Shepherd regularly presents invited lectures, most recently focusing on the presentation, diagnosis and management of infants with congenital anomalies and the ethics of neonatal care.


  • Male

Languages Spoken:

  • English

Research Interests

Education and Training

Medical School

  • University of Texas Medical School
    Date Completed: 05/22/1999


  • Nationwide Children's Hospital
    Date Completed: 06/30/2002


  • Nationwide Children's Hospital
    Date Completed: 06/30/2005


  • Pediatrics


  • Neonatology


  • Neonatal-Perinatal Medicine
  • Pediatrics

Date of Appointment at Nationwide Children’s Hospital:

  • 06/30/2005


  • Jennifer Curtiss, Huayan Zhang, Pamela Griffiths, Edward G. Shepherd, Susan Lynch. 2015. Nutritional Management of the Infant With Severe Bronchopulmonary Dysplasia,.  NeoReviews. Vol. 16, no. 12. (December): e674-e679.
  • Bartman,Thomas; Bapat,Roopali; Martin,Elizabeth,M; Shepherd,Edward,G; Nelin,Leif,D; Reber,Kristina,M. 2015. Apgar Score at 5 Minutes Is Associated with Mortality in Extremely Preterm Infants Even after Transfer to an All Referral NICU.  AMERICAN JOURNAL OF PERINATOLOGY. Vol. 32, no. 13. (November): 1268-1272.
  • Shepherd,Edward,G; Kelly,Tami,J; Vinsel,Jodi,A; Cunningham,Dennis,J; Keels,Erin; Beauseau,Wendi; McClead,Richard,E. 2015. Significant Reduction of Central-Line Associated Bloodstream Infections in a Network of Diverse Neonatal Nurseries.  JOURNAL OF PEDIATRICS. Vol. 167, no. 1. (July): 41-U395.
  • Shepherd,Emma; Stuart,Graham; Martin,Rob; Walsh,Mark,A. 2015. Extraction of Select Secure leads compared to conventional pacing leads in patients with congenital heart disease and congenital atrioventricular block.  HEART RHYTHM. Vol. 12, no. 6. (June): 1227-1232.
  • Malkar,Manish,B; Gardner,William,P; Mandy,George,T; Stenger,Michael,R; Nelin,Leif,D; Shepherd,Edward,G; Welty,Stephen,E. 2015. Respiratory Severity Score on Day of Life 30 is Predictive of Mortality and the Length of Mechanical Ventilation in Premature Infants With Protracted Ventilation.  PEDIATRIC PULMONOLOGY. Vol. 50, no. 4. (April): 363-369.
  • Robbins,M; Trittmann,J; Martin,E; Reber,Kristina,M; Nelin,L; Shepherd,E. 2015. Early extubation attempts reduce length of stay in extremely preterm infants even if re-intubation is necessary.  Journal of neonatal-perinatal medicine. Vol. 8, no. 2. (January): 91-97.
  • Thomas Bartman and Edward G. Shepherd. 2015. Beyond adverse drug events and blood stream infections: broadening the scope of harm events.  Pediatric Critical Care Medicine. Vol. 16, no. 1. (January): 84-5.
  • Shankaran,Seetha; Laptook,Abbot,R; Pappas,Athina; McDonald,Scott,A; Das,Abhik; Tyson,Jon,E; Poindexter,Brenda,B; Schibler,Kurt; Bell,Edward,F; Heyne,Roy,J; Pedroza,Claudia; Bara,Rebecca; Van Meurs,Krisa,P; Grisby,Cathy; Huitema,Carolyn,MPetrie; Garg,Meena; Ehrenkranz,Richard,A; Shepherd,Edward,G; Chalak,Lina,F; Hamrick,Shannon,EG; Khan,Amir,M; Reynolds,Anne,Marie; Laughon,Matthew,M; Truog,William,E; Dysart,Kevin,C; Carlo,Waldemar,A; Walsh,Michele,C; Watterberg,Kristi,L; Higgins,Rosemary,D. 2014. Effect of Depth and Duration of Cooling on Deaths in the NICU Among Neonates With Hypoxic Ischemic Encephalopathy A Randomized Clinical Trial.  JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION. Vol. 312, no. 24. (December): 2629-2639.
  • Laptook,Abbot,R; Kilbride,Howard; Shepherd,Edward; McDonald,Scott,A; Shankaran,Seetha; Truog,William; Das,Abhik; Higgins,Rosemary,D. 2014. Temperature Control During Therapeutic Hypothermia for Newborn Encephalopathy Using Different Blanketrol Devices.  THERAPEUTIC HYPOTHERMIA AND TEMPERATURE MANAGEMENT. Vol. 4, no. 4. (December): 193-200.
  • Tarun Bhalla, Edward G. Shepherd, and Joseph Tobias. 2014. Neonatal pain management.  Saudi Journal of Anaesthesia. Vol. 8(Supplement 1), no. 5. (November): 89-97.
  • Michael A. Hokenson and Edward G. Shepherd. 2014. Neonatal pressure support ventilation: are we doing what we think we are doing?.  Respiratory Care. Vol. 59, no. 10. (October): 1606-1607.
  • Gonya,J; Martin,E; McClead,R; Nelin,L; Shepherd,E. 2014. Empowerment programme for parents of extremely premature infants significantly reduced length of stay and readmission rates.  ACTA PAEDIATRICA. Vol. 103, no. 7. (July): 727-731.
  • Jenn Gonya, Elizabeth Martin, Richard E. McClead, Leif D. Nelin, Edward Shepherd. 2014. Reducing Length of Stay and Readmission Rates of Extremely Premature Infants Using COPE©.  Acta Pediatrica. Vol. 103, no. 7. (July): 727-731.
  • Begun, A.L, Barnhart, S. M., Gregoire, T. K., Shepherd, E.G. 2014. If Mothers Had Their Say: Research-Informed Intervention Design for Empowering Mothers to Establish Smoke-Free Homes.  Social Work in Health Care. Vol. 53, no. 5. (May): 446-459.
  • Begun,Audrey,L; Barnhart,Sheila,M; Gregoire,Thomas,K; Shepherd,Edward,G. 2014. If Mothers Had Their Say: Research-Informed Intervention Design for Empowering Mothers to Establish Smoke-Free Homes.  SOCIAL WORK IN HEALTH CARE. Vol. 53, no. 5. (May): 446-459.
  • Kimberly D Farney, Brandon T Kuehn, Laurie A Gibson, Leif D Nelin, Edward G Shepherd. 2014. In Vitro Evaluation of Aerosolized Medication Delivery via a Variable Flow Infant CPAP System.  Respiratory Care. Vol. 59, no. 3. (March): 340-4.
  • Malkar MB, Gardner WP, Mandy GT, Stenger MR, Nelin LD, Shepherd EG, Welty SE. 2014. Respiratory severity score on day of life 30 is predictive of mortality and the length of mechanical ventilation in premature infants with protracted ventilation.  Pediatr Pulmonol. Vol. epub, no. March: eepub.
  • Shepherd,Edward; Brilli,Richard,J. 2013. What's to Be Learned From 10 Patients in One Pediatric ICU?.  RESPIRATORY CARE. Vol. 58, no. 8. (August): 1386-1387.
  • George Mandy, Manish Malkar, Stephen E. Welty, Rachel Brown, Edward Shepherd, William Gardner, Alicia Moise, and Alfred Gest. 2013. Tracheostomy Placement In Infants With Bronchopulmonary Dysplasia: Safety and Outcomes.  Pediatric Pulmonology. Vol. 48, no. 3. (March): 245-249.
  • Michelle LeRige, Arlyne Thung, Karen Diefenbach, Edward Shepherd, Erin Wishloff, Joseph D. Tobias. 2012. Case Report: Elective use of high frequency oscillatory ventilation with transcutaneous carbon dioxide monitoring during thoracoscopic diaphragmatic hernia repair.  Anaesth, Pain &Intensive Care. Vol. 16, no. 3. (December): 287-292.
  • Pamela A. Moorehead, Elizabeth M Martin, Edward G Shepherd, Nehal A Parikh, Patricia B Reagan, William Gardner, Keith O Yeates, and Leif D Nelin. 2012. Factors Associated with Survival of less than 27 Week Infants in an All-Referral Neonatal Intensive Care Unit.  Journal of Neonatal-Perinatal Medicine. Vol. 5, no. 2. (June): 105-11.
  • Stenger,Michael,R; Slaughter,Jonathan,L; Kelleher,Kelly; Shepherd,Edward,G; Klebanoff,Mark,A; Reagan,Patricia; Nelin,Leif,D; Gardner,William. 2012. Hospital Variation in Nitric Oxide Use for Premature Infants.  PEDIATRICS. Vol. 129, no. 4. (April): E945-E951.
  • Jadcherla,Sudarshan,R; Peng,Juan; Moore,Rebecca; Saavedra,Jason; Shepherd,Edward; Fernandez,Soledad; Erdman,Steven,H; Dilorenzo,Carlo. 2012. Impact of Personalized Feeding Program in 100 NICU Infants: Pathophysiology-based Approach for Better Outcomes.  JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. Vol. 54, no. 1. (January): 62-70.
  • Shepherd,E,G; Knupp,A,M; Welty,S,E; Susey,K,M; Gardner,W,P; Gest,A,L. 2012. An interdisciplinary bronchopulmonary dysplasia program is associated with improved neurodevelopmental outcomes and fewer rehospitalizations.  JOURNAL OF PERINATOLOGY. Vol. 32, no. 1. (January): 33-38.
  • Yates AR; Hoffman TM; Shepherd E; Boettner B; McBride KL. 2011. Pediatric Sub-specialist Controversies in the Treatment of Congenital Heart Disease in Trisomy 13 or 18.  Journal Of Genetic Counseling. Vol. 20, no. 5. (October): e495.
  • Yates,Andrew,R; Hoffman,Timothy,M; Shepherd,Edward; Boettner,Bethany; McBride,Kim,L. 2011. Pediatric Sub-specialist Controversies in the Treatment of Congenital Heart Disease in Trisomy 13 or 18.  JOURNAL OF GENETIC COUNSELING. Vol. 20, no. 5. (October): 495-509.
  • Edward G Shepherd, Lori J Alexander, Brandon Kuehne, Kristina M Reber, Leif D Nelin. 2011. The FiO2 is Associated with the Successful Extubation of Mechanically Ventilated Neonates.  Research and Reports in Neonatology. Vol. 1, no. September: e55.
  • Green,Alex; Shepherd,Edward,G; Erdman,Steven,H. 2011. Sedated Percutaneous Endoscopic Gastrostomy (PEG) Placement in the Neonate.  GASTROENTEROLOGY. Vol. 140, no. 5. (May): S687-S687.
  • Edward G. Shepherd, Thomas J. Calvert, Elizabeth M. Marting, John C. Hitchner, Stephen E. Welty, and Leif D. Nelin. 2011. Outcomes of extremely premature infants admitted to a children’s hospital depends on referring hospital.  Journal of Neonatal-Perinatal Medicine. Vol. 2011, no. 4. (January): 45-53.
  • Jadcherla SR, Peng J, Moore R, Saavedra J, Shepherd EG, Fernandez F, Erdman SH, DiLorenzo C. 2011. Impact of Personalized Feeding Program in 100 NICU Infants: A Novel Pathophysiology-Based Approach for Better Outcomes.  Journal of Pediatric Gastroenterology & Nutrition.
  • Edward G. Shepherd, Amy M. Knupp, Stephen E. Welty, Kelly, M. Susey, William P. Gardner, and Alfred L. Gest. 2011. An Interdisciplinary Bronchopulmonary Dysplasia Program is Associated with Improved Neurodevelopmental Outcomes and Fewer Rehospitalizations.  Journal of Perinatology.
  • Melissa Hanin, Kelly Susey, Chris Beck, Alfred Gest, Edward Shepherd. 2009. Behavioral Signs of Respiratory Instability: The Development and Administration of a Scale to Monitor Signs of Respiratory Distress During Developmental Interventions in Infants With Bronchopulmonary Dysplasia.  Newborn and Infant Nursing Reviews. Vol. 9, no. 3. (January): 175-181.
  • Liu,Yusen; Shepherd,Edward,G; Nelin,Leif,D. 2007. MAPK phosphatases - regulating the immune response.  NATURE REVIEWS IMMUNOLOGY. Vol. 7, no. 3. (March): 202-212.
  • Zhao,Q; Shepherd,E,G; Manson,M,E; Nelin,L,D; Sorokin,A; Liu,Y,S. 2005. The role of mitogen-activated protein kinase phosphatase-1 in the response of alveolar macrophages to lipopolysaccharide - Attenuation of proinflammatory cytokine biosynthesis via feedback control of p38.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 280, no. 9. (March): 8101-8108.
  • Shepherd,E,G; Zhao,Q; Welty,S,E; Hansen,T,N; Smith,C,V; Liu,Y,S. 2004. The function of mitogen-activated protein kinase phosphatase-1 in peptidoglycan-stimulated macrophages.  JOURNAL OF BIOLOGICAL CHEMISTRY. Vol. 279, no. 52. (December): 54023-54031.
  • Marliese Dion Nist, Elizabeth A. Rodgers, Brenda Ruth, Leah Keller, James Dail, Renee Gardikes-Gingery, Edward G. Shepherd. Determination of Pressure Ulcer Incidence among Neonatal Intensive Care Patients.  Journal of Obstetrics, Gynecologic, Neonatal Nursing.
  • Kimberly D Farney, Brandon T Kuehne, Laurie A Gibson, Leif D Nelin, Edward G Shepherd. In Vitro Evaluation of Radiolabeled Aerosol Delivery via a Variable Flow Infant CPAP System.  Respiratory Care.
  • William E. Truog, Steven Abman, Edward Shepherd, Haresh Kirpalani. Role of Pharmacology in Treatment of Severe Bronchopulmonary Dysplasia.
  • Edward G. Shepherd, Mohannad Moallem, Kris Reber. Lung Disease and Ventilatory Strategies for Infants with Necrotizing Enterocolitis. In Necrotizing Enterocolitis: New Insights into Diagnosis, Pathogenesis, and Treatment. Edited by David J. Hackam.
  • Abbot R. Laptook, Howard Kilbride, Edward Shepherd, Scott A. McDonald, Seetha Shankaran, William Truog, Abhik Das, Rosemary D. Higgins and the Optimizing Cooling Sub-Committee. Temperature Control during Therapeutic Hypothermia for Newborn Encephalopathy using Different Blanketrol Devices.  Therapeutic Hypothermia and Temperature Management.
  • Joseph M. Collaco, Linda Gratny, Paul Moore, Edward Shepherd, Christopher Baker, Pamela Donohue, Sharon A. McGrath-Morrow. Outpatient Transition and Care of Infants with Severe BPD.
  • Liu Y, Shepherd EG, Nelin LD. MAPK phosphatases — regulating the immune response. Nature Reviews Immunology 7: 202-212, March 2007.
  • Liu Y, Shepherd EG, Nelin LD. MAP kinase phosphatases-regulating the immune response. Nature Reviews Immunology 7: 202-12, 2007.
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