Christopher R. Pierson, MD, PhD

Christopher R. Pierson, MD, PhD, is a staff pathologist in the Section of Anatomic Pathology in the Department of Laboratory Medicine at Nationwide Children’s Hospital and an Assistant Professor of Pathology at The Ohio State University College of Medicine. Dr. Pierson is certified by the American Board of Pathology in neuropathology and anatomic pathology. He is a principal investigator in the Center for Childhood Cancer within The Research Institute at Nationwide Children’s Hospital. His research is supported by the National Institutes of Health and focuses on pediatric neuromuscular diseases and brain tumors. His clinical interests include perinatal neuropathology and neuromuscular pathology.

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Gender:

• Male

Languages Spoken:

• English

Areas of Interest:

• Dr. Pierson’s research aims to elucidate the pathogenesis of the centronuclear myopathies, especially X-linked myotubular myopathy, and to develop novel therapies for these myopathies. His expertise and interests in neuropathology include perinatal neuropathology, especially the neuropathology of premature infants, pediatric brain tumors and pediatric neuromuscular diseases.

Medical School

• Wayne State University School of Medicine
  Date Completed: 06/05/1997

Residency

• Wayne State University
  Date Completed: 06/30/2002

Fellowship

• Boston Children's Hospital
  Date Completed: 06/30/2004

Fellowship

• Harvard - Brigham & Women's Hospital
  Date Completed: 06/30/2004

Department:

• Pathology/Laboratory Medicine

Section:

• Anatomic Pathology

Speciality:

• Anatomic Pathology
  
• Neuropathology
  

Date of Appointment at Nationwide Children’s Hospital:

• 07/01/2007

2007–present

• Assistant Professor in the Department of Pathology at The Ohio State University College of Medicine.

2007–present

• Neuropathologist, Anatomic Pathology, Nationwide Children's Hospital

• Hutzen,Brian; Pierson,Christopher,R; Russell,Stephen,J; Galanis,Evanthia; Raffel,Corey; Studebaker,Adam,W. 2012. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine.  BMC CANCER. Vol. 12, no. November: e508.
• Dowling,James,J; Joubert,Romain; Low,Sean,E; Durban,Ashley,N; Messaddeq,Nadia; Li,Xingli; Dulin-Smith,Ashley,N; Snyder,Andrew,D; Marshall,Morgan,L; Marshall,Jordan,T; Beggs,Alan,H; Buj-Bello,Anna; Pierson,Christopher,R. 2012. Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models.  DISEASE MODELS & MECHANISMS. Vol. 5, no. 6. (November): 852-859.
• Cajaiba,Mariana,M; Hughes,Anna,MS; Pierson,Christopher,R. 2012. Central nervous system pathology in an infant with short-chain acyl-CoA dehydrogenase deficiency (SCADD): evidence for abnormal neuronal migration as part of its phenotypic spectrum.  CLINICAL NEUROPATHOLOGY. Vol. 31, no. 5. (September): 386-388.
• Boehm,Johann; Biancalana,Valerie; DeChene,Elizabeth,T; Bitoun,Marc; Pierson,Christopher,R; Schaefer,Elise; Karasoy,Hatice; Dempsey,Melissa,A; Klein,Fabrice; Dondaine,Nicolas; Kretz,Christine; Haumesser,Nicolas; Poirson,Claire; Toussaint,Anne; Greenleaf,Rebecca,S; Barger,Melissa,A; Mahoney,Lane,J; Kang,Peter,B; Zanoteli,Edmar; Vissing,John; Witting,Nanna; Echaniz-Laguna,Andoni; Wallgren-Pettersson,Carina; Dowling,James; Merlini,Luciano; Oldfors,Anders; Ousager,Lilian,Bomme; Melki,Judith; Krause,Amanda; Jern,Christina; Oliveira,Acary,SB; Petit,Florence; Jacquette,Aurelia; Chaussenot,Annabelle; Mowat,David; Leheup,Bruno; Cristofano,Michele; Poza Aldea,Juan,Jose; Michel,Fabrice; Furby,Alain; Barcena Llona,Jose,E; Van Coster,Rudy; Bertini,Enrico; Urtizberea,Jon,Andoni; Drouin-Garraud,Valerie; Beroud,Christophe; Prudhon,Bernard; Bedford,Melanie; Mathews,Katherine; Erby,Lori,AH; Smith,Stephen,A; Roggenbuck,Jennifer; Crowe,Carol,A; Spitale,Allison,Brennan; Johal,Sheila,C; Amato,Anthony,A; Demmer,Laurie,A; Jonas,Jessica; Darras,Basil,T; Bird,Thomas,D; Laurino,Mercy; Welt,Selman,I; Trotter,Cynthia; Guicheney,Pascale; Das,Soma; Mandel,Jean-Louis; Beggs,Alan,H; Laporte,Jocelyn. 2012. Mutation Spectrum in the Large GTPase Dynamin 2, and Genotype-Phenotype Correlation in Autosomal Dominant Centronuclear Myopathy.  HUMAN MUTATION. Vol. 33, no. 6. (June): 949-959.
• Pierson,Christopher; Rusin,Jerome. 2011. Deep White Matter Venous Infarction in Infants: A Neuroradiologic-Neuropathologic Correlation.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 70, no. 6. (June): 515-515.
• Pierson,Christopher; Dulin-Smith,Ashley; Durban,Ashley; Marshall,Jordan; Snyder,Andrew; Gladman,Jordan; Chandler,Dawn; Buj-Bello,Anna; Lawlor,Michael; Dowling,James; Beggs,Alan. 2011. Modeling the Human C205T Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 70, no. 6. (June): 524-524.
• Smith,Krista; Boesel,Carl; Hughes,Anna; Pierson,Christopher. 2010. Cerebellar Hemorrhagic Injury in Premature Infants and its Associated Neuropathology: A Clinicopathologic Study of 18 Cases.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 545-545.
• Pierson,Christopher; Snyder,Andrew; Houston,Ronald; Marshall,Jordan; Kahwash,Basil; Dulin-Smith,Ashley. 2010. Id Proteins are Differentially Expressed in Medulloblastoma Tumor Cells and Endothelia.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 544-544.
• Pierson,Christopher; Dulin-Smith,Ashley; Roth,Kristen; Marshall,Morgan; Naiyer,Nada; Marshall,Jordan; Snyder,Andrew; Gladman,Jordan; Chandler,Dawn; Beggs,Alan. 2010. The Mtm1C205T Knock-In Mouse: A New Model of Myotubular Myopathy With a Mild Phenotype.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 548-548.
• Pierson,C; Darras,B; Xin,W; De Girolami,U. 2004. Late infantile neuronal ceroid lipofuscinosis due to heterozygous CLN2 mutations including a novel T3915G point mutation in one allele.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 534-534.
• Pierson,C,R; Ligon,K,L; Goumnerova,L,C; Richkind,K; De Girolami,U. 2004. Primary meningeal sarcomatosis (PMS): A case report with cytogenetic findings and a review of the literature.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 544-544.
• Sima,A,AF; Zhang,W; Pierson,C,R. 2004. Molecular alterations underlie nodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 515-515.
• Pierson,C,R; Folkerth,R,D; Haynes,R,L; Drinkwater,M,E; Volpe,J,J; Kinney,H,C. 2003. Gray matter injury in premature infants with or without periventricular leukomalacia (PVL).  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 62, no. 5. (May): 578-578.
• Pierson,C,R; Garbern,J; Golden,J,A; Kupsky,W; Sima,A,A. 2002. Neuronal system degeneration in Pelizaeus-Merzbacher disease with PLP1 gene duplication.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 61, no. 5. (May): 450-450.
• Sima,A,AF; Sugimoto,K; Zhang,W,X; Pierson,C; Murakawa,Y. 2000. Nodal and paranodal structural and molecular changes in type 1 diabetic neuropathy are preventable by C-peptide.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 59, no. 5. (May): 456-456.