Christopher R. Pierson, MD, PhD :: Nationwide Children’s Hospital, Columbus, Ohio

Christopher R. Pierson, MD, PhD

Christopher R. Pierson, MD, PhD

Anatomic Pathology
Pathologist, Neuropathology

Pathology and Laboratory Medicine
Anatomic Pathology Team

Pathology Fellowship

Contact Information

Laboratory Medicine/Anatomic Pathology
700 Children's Dr
Columbus, OH 43205 [ map ]
PH: (614) 722-5450
FX: (614) 722-2899
E-mail Me
The Research Institute at Nationwide Children's Hospital
700 Children's Drive
Columbus, Ohio 43205 [ map ]
PH: (614) 355.2723
Business 2: (614) 722.5895


Christopher R. Pierson, MD, PhD, is a staff pathologist in the Section of Anatomic Pathology in the Department of Laboratory Medicine at Nationwide Children’s Hospital and an Assistant Professor of Pathology at The Ohio State University College of Medicine. Dr. Pierson is certified by the American Board of Pathology in neuropathology and anatomic pathology. He is a principal investigator in the Center for Childhood Cancer within The Research Institute at Nationwide Children’s Hospital. His research is supported by the National Institutes of Health and focuses on pediatric neuromuscular diseases and brain tumors. His clinical interests include perinatal neuropathology and neuromuscular pathology.

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  • Male

Languages Spoken:

  • English

Research Interests

Areas of Interest:

  • Dr. Pierson’s research aims to elucidate the pathogenesis of the centronuclear myopathies, especially X-linked myotubular myopathy, and to develop novel therapies for these myopathies. His expertise and interests in neuropathology include perinatal neuropathology, especially the neuropathology of premature infants, pediatric brain tumors and pediatric neuromuscular diseases.

Education and Training

Medical School

  • Wayne State University School of Medicine
    Date Completed: 06/05/1997


  • Wayne State University
    Date Completed: 06/30/2002


  • Harvard - Brigham & Women's Hospital
    Date Completed: 06/30/2004


  • Boston Children's Hospital
    Date Completed: 06/30/2004


  • Pathology & Laboratory Medicine


  • Anatomic Pathology


  • Anatomic Pathology
  • Neuropathology

Date of Appointment at Nationwide Children’s Hospital:

  • 07/01/2007

Professional Experience


  • Assistant Professor in the Department of Pathology at The Ohio State University College of Medicine.


  • Neuropathologist, Anatomic Pathology, Nationwide Children's Hospital


  • Lawlor,Michael,W; Viola,Marissa,G; Meng,Hui; Edelstein,Rachel,V; Liu,Fujun; Yan,Ke; Luna,Elizabeth,J; Lerch-Gaggl,Alexandra; Hoffmann,Raymond,G; Pierson,Christopher,R; Buj-Bello,Anna; Lachey,Jennifer,L; Pearsall,Scott; Yang,Lin; Hillard,Cecilia,J; Beggs,Alan,H. 2014. Differential Muscle Hypertrophy Is Associated with Satellite Cell Numbers and Akt Pathway Activation Following Activin Type IIB Receptor Inhibition in Mtm1 p.R69C Mice.  American journal of pathology. Vol. 184, no. 6. (June): 1831-1842.
  • Dorris,Kathleen; Sobo,Matthew; Onar-Thomas,Arzu; Panditharatna,Eshini; Stevenson,Charles,B; Gardner,Sharon,L; DeWire,Mariko,D; Pierson,Christopher,R; Olshefski,Randal; Rempel,Sandra,A; Goldman,Stewart; Miles,Lili; Fouladi,Maryam; Drissi,Rachid. 2014. Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.  JOURNAL OF NEURO-ONCOLOGY. Vol. 117, no. 1. (March): 67-76.
  • Dorris K, Sobo M, Onar-Thomas A, Panditharatna E, Stevenson CB, Gardner SL, Dewire MD, Pierson CR, Olshefski R, Rempel SA, Goldman S, Miles L, Fouladi M, Drissi R. 2014. Prognostic significance of telomere maintenance mechanisms in pediatric high-grade gliomas.  J Neurooncol. Vol. 117, no. March: 67-76.
  • Hutzen,Brian; Bid,Hemant,Kumar; Houghton,Peter,J; Pierson,Christopher,R; Powell,Kimerly; Bratasz,Anna; Raffel,Corey; Studebaker,Adam,W. 2014. Treatment of medulloblastoma with oncolytic measles viruses expressing the angiogenesis inhibitors endostatin and angiostatin.  BMC CANCER. Vol. 14, no. March: e206.
  • Brownstein CA, Beggs AH, Homer N, there are 199 co-authors on this paper Pierson CR is author number 107. 2014. An international effort towards developing standards for best practices in analysis, interpretation and reporting of clinical genome sequencing results in the CLARITY Challenge.  Genome Biol. Vol. 15, no. 3. (March): eR53.
  • Kaur,Supreet; Powell,Samuel; He,Lili; Pierson,Christopher,R; Parikh,Nehal,A. 2014. Reliability and Repeatability of Quantitative Tractography Methods for Mapping Structural White Matter Connectivity in Preterm and Term Infants at Term-Equivalent Age.  PLOS ONE. Vol. 9, no. 1. (January): ee85807.
  • Graf,Amanda,E; Haines,Krista,M; Pierson,Christopher,R; Bolon,Brad,N; Houston,Ronald,H; Velten,Markus; Heyob,Kathryn,M; Rogers,Lynette,K. 2014. Perinatal inflammation results in decreased oligodendrocyte numbers in adulthood.  LIFE SCIENCES. Vol. 94, no. 2. (January): 164-171.
  • MacDonald,Tobey,J; Vezina,Gilbert; Stewart,Clinton,F; Turner,David; Pierson,Christopher,R; Chen,Lu; Pollack,Ian,F; Gajjar,Amar; Kieran,Mark,W. 2013. Phase II study of cilengitide in the treatment of refractory or relapsed high-grade gliomas in children: A report from the Children's Oncology Group.  NEURO-ONCOLOGY. Vol. 15, no. 10. (October): 1438-1444.
  • Snyder AD, Dulin-Smith AN, Houston RH, Durban AN, Brisbin BJ, Oostra TD, Marshall JT, Kahwash BM, Pierson CR. 2013. Expression Pattern of Id Proteins in Medulloblastoma.  Pathology Oncology Research. Vol. 19, no. July: 437-446.
  • Arnold,Michael,A; Stallings-Archer,Kandi; Marlin,Evan; Grondin,Ronald; Olshefski,Randal; Biegel,Jaclyn,A; Pierson,Christopher,R. 2013. Cribriform Neuroepithelial Tumor Arising in the Lateral Ventricle.  PEDIATRIC AND DEVELOPMENTAL PATHOLOGY. Vol. 16, no. 4. (July): 301-307.
  • Snyder,Andrew,D; Dulin-Smith,Ashley,N; Houston,Ronald,H; Durban,Ashley,N; Brisbin,Bethany,J; Oostra,Tyler,D; Marshall,Jordan,T; Kahwash,Basil,M; Pierson,Christopher,R. 2013. Expression Pattern of Id Proteins in Medulloblastoma.  PATHOLOGY & ONCOLOGY RESEARCH. Vol. 19, no. 3. (July): 437-446.
  • Arnold MA,Stallings-Archer K, Marlin E,Grondin R, Olshefski R, Biegel JA, Pierson CR. 2013. Cribriform Neuroepithelial Tumor Arising in the Lateral Ventricle.  Pediatric and Developmental Pathology. Vol. 16, no. March: 301-307.
  • Haines,Krista,M; Wang,Wei; Pierson,Christopher,R. 2013. Cerebellar hemorrhagic injury in premature infants occurs during a vulnerable developmental period and is associated with wider neuropathology.  Acta neuropathologica communications. Vol. 1, no. 1. (January): 69-?.
  • Hutzen,Brian; Pierson,Christopher,R; Russell,Stephen,J; Galanis,Evanthia; Raffel,Corey; Studebaker,Adam,W. 2012. Treatment of medulloblastoma using an oncolytic measles virus encoding the thyroidal sodium iodide symporter shows enhanced efficacy with radioiodine.  BMC CANCER. Vol. 12, no. November: e508.
  • Dowling,James,J; Joubert,Romain; Low,Sean,E; Durban,Ashley,N; Messaddeq,Nadia; Li,Xingli; Dulin-Smith,Ashley,N; Snyder,Andrew,D; Marshall,Morgan,L; Marshall,Jordan,T; Beggs,Alan,H; Buj-Bello,Anna; Pierson,Christopher,R. 2012. Myotubular myopathy and the neuromuscular junction: a novel therapeutic approach from mouse models.  DISEASE MODELS & MECHANISMS. Vol. 5, no. 6. (November): 852-859.
  • Cajaiba,Mariana,M; Hughes,Anna,MS; Pierson,Christopher,R. 2012. Central nervous system pathology in an infant with short-chain acyl-CoA dehydrogenase deficiency (SCADD): evidence for abnormal neuronal migration as part of its phenotypic spectrum.  CLINICAL NEUROPATHOLOGY. Vol. 31, no. 5. (September): 386-388.
  • Boehm,Johann; Biancalana,Valerie; DeChene,Elizabeth,T; Bitoun,Marc; Pierson,Christopher,R; Schaefer,Elise; Karasoy,Hatice; Dempsey,Melissa,A; Klein,Fabrice; Dondaine,Nicolas; Kretz,Christine; Haumesser,Nicolas; Poirson,Claire; Toussaint,Anne; Greenleaf,Rebecca,S; Barger,Melissa,A; Mahoney,Lane,J; Kang,Peter,B; Zanoteli,Edmar; Vissing,John; Witting,Nanna; Echaniz-Laguna,Andoni; Wallgren-Pettersson,Carina; Dowling,James; Merlini,Luciano; Oldfors,Anders; Ousager,Lilian,Bomme; Melki,Judith; Krause,Amanda; Jern,Christina; Oliveira,Acary,SB; Petit,Florence; Jacquette,Aurelia; Chaussenot,Annabelle; Mowat,David; Leheup,Bruno; Cristofano,Michele; Poza Aldea,Juan,Jose; Michel,Fabrice; Furby,Alain; Barcena Llona,Jose,E; Van Coster,Rudy; Bertini,Enrico; Urtizberea,Jon,Andoni; Drouin-Garraud,Valerie; Beroud,Christophe; Prudhon,Bernard; Bedford,Melanie; Mathews,Katherine; Erby,Lori,AH; Smith,Stephen,A; Roggenbuck,Jennifer; Crowe,Carol,A; Spitale,Allison,Brennan; Johal,Sheila,C; Amato,Anthony,A; Demmer,Laurie,A; Jonas,Jessica; Darras,Basil,T; Bird,Thomas,D; Laurino,Mercy; Welt,Selman,I; Trotter,Cynthia; Guicheney,Pascale; Das,Soma; Mandel,Jean-Louis; Beggs,Alan,H; Laporte,Jocelyn. 2012. Mutation Spectrum in the Large GTPase Dynamin 2, and Genotype-Phenotype Correlation in Autosomal Dominant Centronuclear Myopathy.  HUMAN MUTATION. Vol. 33, no. 6. (June): 949-959.
  • Pierson,Christopher; Rusin,Jerome. 2011. Deep White Matter Venous Infarction in Infants: A Neuroradiologic-Neuropathologic Correlation.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 70, no. 6. (June): 515-515.
  • Pierson,Christopher; Dulin-Smith,Ashley; Durban,Ashley; Marshall,Jordan; Snyder,Andrew; Gladman,Jordan; Chandler,Dawn; Buj-Bello,Anna; Lawlor,Michael; Dowling,James; Beggs,Alan. 2011. Modeling the Human C205T Mutation in Murine Mtm1 Results in Exon 4 Skipping and a Less Severe Myotubular Myopathy Phenotype.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 70, no. 6. (June): 524-524.
  • Smith,Krista; Boesel,Carl; Hughes,Anna; Pierson,Christopher. 2010. Cerebellar Hemorrhagic Injury in Premature Infants and its Associated Neuropathology: A Clinicopathologic Study of 18 Cases.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 545-545.
  • Pierson,Christopher; Snyder,Andrew; Houston,Ronald; Marshall,Jordan; Kahwash,Basil; Dulin-Smith,Ashley. 2010. Id Proteins are Differentially Expressed in Medulloblastoma Tumor Cells and Endothelia.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 544-544.
  • Pierson,Christopher; Dulin-Smith,Ashley; Roth,Kristen; Marshall,Morgan; Naiyer,Nada; Marshall,Jordan; Snyder,Andrew; Gladman,Jordan; Chandler,Dawn; Beggs,Alan. 2010. The Mtm1C205T Knock-In Mouse: A New Model of Myotubular Myopathy With a Mild Phenotype.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 69, no. 5. (May): 548-548.
  • Pierson,C; Darras,B; Xin,W; De Girolami,U. 2004. Late infantile neuronal ceroid lipofuscinosis due to heterozygous CLN2 mutations including a novel T3915G point mutation in one allele.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 534-534.
  • Pierson,C,R; Ligon,K,L; Goumnerova,L,C; Richkind,K; De Girolami,U. 2004. Primary meningeal sarcomatosis (PMS): A case report with cytogenetic findings and a review of the literature.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 544-544.
  • Sima,A,AF; Zhang,W; Pierson,C,R. 2004. Molecular alterations underlie nodal degeneration in type 1 diabetic neuropathy and are prevented by C-peptide.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 63, no. 5. (May): 515-515.
  • Pierson,C,R; Folkerth,R,D; Haynes,R,L; Drinkwater,M,E; Volpe,J,J; Kinney,H,C. 2003. Gray matter injury in premature infants with or without periventricular leukomalacia (PVL).  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 62, no. 5. (May): 578-578.
  • Pierson,C,R; Garbern,J; Golden,J,A; Kupsky,W; Sima,A,A. 2002. Neuronal system degeneration in Pelizaeus-Merzbacher disease with PLP1 gene duplication.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 61, no. 5. (May): 450-450.
  • Sima,A,AF; Sugimoto,K; Zhang,W,X; Pierson,C; Murakawa,Y. 2000. Nodal and paranodal structural and molecular changes in type 1 diabetic neuropathy are preventable by C-peptide.  JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. Vol. 59, no. 5. (May): 456-456.
Nationwide Children's Hospital
700 Children's Drive Columbus, Ohio 43205 614.722.2000